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Enzyme Responsive Materials for Biology and Medicine

Lead Research Organisation: University of Manchester
Department Name: Materials

Abstract

This proposal is to develop new routes to rationally designed Enzyme Responsive Materials (ERMs) for biomedical applications. These materials can change properties, for example they can swell/collapse or change from a solution to a gel in response to biochemical reactions. These materials may have applications in the controlled release of drugs in response to disease specific enzymes. They may also be used in triggered assembly of matrixes for cell growth, with applications in tissue engineering. The outcomes of this project will be (i) the development and full characterisation of new interactive biomaterials, (ii) increased fundamental understanding of structure/function relationships in molecular hydrogels, (iii) proof of concept applications in enzyme triggered assembly of scaffolds for 3D cell culture and (iv) enzyme triggered drug delivery.

Publications

10 25 50
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Li Y (2009) A study of the dynamic interaction of surfactants with graphite and carbon nanotubes using Fmoc-amino acids as a model system. in Langmuir : the ACS journal of surfaces and colloids

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Hirst AR (2010) Biocatalytic induction of supramolecular order. in Nature chemistry

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Hughes M (2011) Biocatalytic self-assembly of 2D peptide-based nanostructures in Soft Matter

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Thornton K (2009) Controlling stiffness in nanostructured hydrogels produced by enzymatic dephosphorylation in Biochemical Society Transactions

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Todd SJ (2009) Enzyme-activated RGD ligands on functionalized poly(ethylene glycol) monolayers: surface analysis and cellular response. in Langmuir : the ACS journal of surfaces and colloids

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Cousins BG (2009) Enzyme-activated surfactants for dispersion of carbon nanotubes. in Small (Weinheim an der Bergstrasse, Germany)

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Williams RJ (2009) Enzyme-assisted self-assembly under thermodynamic control. in Nature nanotechnology

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Thornton PD (2008) Enzyme-responsive hydrogel particles for the controlled release of proteins: designing peptide actuators to match payload. in Soft matter

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Thornton P (2007) Enzyme-Responsive Polymer Hydrogel Particles for Controlled Release in Advanced Materials

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Das AK (2009) Evolving nanomaterials using enzyme-driven dynamic peptide libraries (eDPL). in Faraday discussions

Related Projects

Project Reference Relationship Related To Start End Award Value
EP/D07410X/1 31/07/2006 30/08/2008 £649,958
EP/D07410X/2 Transfer EP/D07410X/1 31/08/2008 30/07/2011 £0