Development of an on-demand sensor and monitoring technology based on switchable nanobodies for cell therapy bioprocessing
Lead Research Organisation:
University of Bath
Department Name: Electronic and Electrical Engineering
Abstract
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Organisations
Publications
Bialas K
(2025)
Electrochemical microfluidic biosensor for the detection of CD4+ T cells
in Microsystems & Nanoengineering
| Title | Novel method for affinity biosensor signal enhancement |
| Description | A simple and sensitive approach for affinity biosensor signal enhancement using gold nanoparticles. We introduced a simple pre-treatment approach for targeting proteins in a serum matrix using gold nanoparticles (GNPs) as a signal enhancer. The electrical conductivity of GNPs has a significant impact on the electrochemical doubler-layer and the method was then successfully applied for the enhancement of the electrochemical impedance detection of a protein. The method is generic enough to be applied to a wide range of affinity biosensors and simple enough to make it applicable for point-of-care microfluidic sensing devices. |
| Type Of Material | Improvements to research infrastructure |
| Year Produced | 2023 |
| Provided To Others? | No |
| Impact | None yet. |