Investigating Novel Stress Response Pathways in Neurological Disease
Lead Research Organisation:
MRC Mammalian Genetics Unit
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Organisations
- MRC Mammalian Genetics Unit (Lead Research Organisation)
- Francis Crick Institute (Collaboration)
- Buck Institute for Age Research (Collaboration)
- University of Genoa (Collaboration)
- University of Oxford (Collaboration)
- Medical University of South Carolina (Collaboration)
- KING'S COLLEGE LONDON (Collaboration)
People |
ORCID iD |
Publications
Ang G
(2018)
Absent sleep EEG spindle activity in GluA1 (Gria1) knockout mice: relevance to neuropsychiatric disorders.
in Translational psychiatry
Crawford K
(2021)
Behavioural Characterisation of Macrod1 and Macrod2 Knockout Mice.
in Cells
Hunn BHM
(2019)
Impairment of Macroautophagy in Dopamine Neurons Has Opposing Effects on Parkinsonian Pathology and Behavior.
in Cell reports
Pomatto LCD
(2019)
Limitations to adaptive homeostasis in an hyperoxia-induced model of accelerated ageing.
in Redox biology
Stewart M
(2019)
Loss of Frrs1l disrupts synaptic AMPA receptor function, and results in neurodevelopmental, motor, cognitive and electrographical abnormalities.
in Disease models & mechanisms
Bucknor EMV
(2024)
Neuroinflammation and Lysosomal Abnormalities Characterise the Essential Role for Oxidation Resistance 1 in the Developing and Adult Cerebellum.
in Antioxidants (Basel, Switzerland)
Williamson MG
(2019)
Neuronal over-expression of Oxr1 is protective against ALS-associated mutant TDP-43 mislocalisation in motor neurons and neuromuscular defects in vivo.
in Human molecular genetics
Finelli M
(2018)
Oxidation Resistance 1 Modulates Glycolytic Pathways in the Cerebellum via an Interaction with Glucose-6-Phosphate Isomerase
in Molecular Neurobiology
Svistunova D
(2019)
Oxidation resistance 1 regulates post-translational modifications of peroxiredoxin 2 in the cerebellum
in Free Radical Biology and Medicine
Simpson DSA
(2020)
ROS Generation in Microglia: Understanding Oxidative Stress and Inflammation in Neurodegenerative Disease.
in Antioxidants (Basel, Switzerland)
| Description | Modulating the communication within brain cells by the epilepsy gene TBC1D24 |
| Amount | £20,000 (GBP) |
| Organisation | Epilepsy Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 12/2018 |
| End | 06/2020 |
| Description | Investigating the protective role of OXR1 in models of Alzheimer's disease |
| Organisation | Buck Institute for Age Research |
| Country | United States |
| Sector | Charity/Non Profit |
| PI Contribution | Supplying mouse models of OXR1 over-expression |
| Collaborator Contribution | Supplying novel models of AD |
| Impact | N/A |
| Start Year | 2019 |
| Description | Protective role of OXR1 in Parkinson's disease |
| Organisation | Medical University of South Carolina |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Investigating the role of OXR1 as a protective factor in rodent models of PD - supplying mice |
| Collaborator Contribution | Investigating the role of OXR1 as a protective factor in rodent models of PD - supplying mice PD models and data analysis |
| Impact | Poster at SFN 2019 |
| Start Year | 2018 |
| Description | Role of TLDc proteins in lysosomal function |
| Organisation | University of Oxford |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Providing novel genetic tools |
| Collaborator Contribution | Providing expertise in lysosomal biology |
| Impact | ERUK Pilot Grant funding |
| Start Year | 2018 |
| Description | Role of TLDc proteins in viral infection |
| Organisation | Francis Crick Institute |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Supplying tissue samples for in vitro cellular assays at The Crick |
| Collaborator Contribution | Assayaing viral infection in vitro |
| Impact | Preliminary in vitro studies |
| Start Year | 2019 |
| Description | Role of TLDc proteins in viral infection |
| Organisation | King's College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Supplying tissue samples for in vitro cellular assays at The Crick |
| Collaborator Contribution | Assayaing viral infection in vitro |
| Impact | Preliminary in vitro studies |
| Start Year | 2019 |
| Description | Synaptic function of TLDc proteins |
| Organisation | University of Genoa |
| Country | Italy |
| Sector | Academic/University |
| PI Contribution | Providing new genetic (mouse) tools |
| Collaborator Contribution | Provided data on synaptic physiology and structure in mouse models |
| Impact | Manuscript is in preparation for submission in 2018 |
| Start Year | 2017 |
| Description | International League Against Epilepsy - meet the scientist session |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Brief presentation explaining new ERUK funding to public attendees to ILAR meeting in Birmingham followed by meet-and-greet session for questions |
| Year(s) Of Engagement Activity | 2019 |
| Description | University of the third age (U3A) site visit |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | MRC Harwell site visit by 20 U3A members including a set of talks on experimental work in the Unit, including one on neurological disease research |
| Year(s) Of Engagement Activity | 2018 |