Mary Lyon Centre Community Programmes - Genome Editing Mice for Medicine and the National Archive
Lead Research Organisation:
Medical Research Council
Department Name: UNLISTED
Abstract
Genome Editing Mice for Medicine is a programme which provides genetically altered mouse models of human disease to the UK Biomedical community.
Technical Summary
The objectives of the Genome Editing Mice for Medicine programme are to create novel mouse lines for preclinical studies and to refine and improve existing models. To this end, the UK academic research community is invited to nominate mouse lines for production using CRISPR/Cas9 technologies, which are reviewed by an expert panel for their value to research hypotheses or clinical diagnosis and their impact and utility for the wider research community.
The Mary Lyon Centre is the UK node of the European Mouse Mutant Archive (EMMA). The National Archive at Harwell is supported by extensive IT infrastructure and strain curation services, which greatly facilitates access to mouse lines, cryopreservation, import and rederivation services for UK scientists.
The Mary Lyon Centre is the UK node of the European Mouse Mutant Archive (EMMA). The National Archive at Harwell is supported by extensive IT infrastructure and strain curation services, which greatly facilitates access to mouse lines, cryopreservation, import and rederivation services for UK scientists.
Organisations
Publications
Teboul L
(2024)
Improving laboratory animal genetic reporting: LAG-R guidelines.
in Nature communications
Teboul L
(2023)
How much do we know about the function of mammalian genes?
in BMC Biology
McCabe CV
(2024)
Long-read sequencing for fast and robust identification of correct genome-edited alleles: PCR-based and Cas9 capture methods.
in PLoS genetics
Lee CYC
(2024)
Tumour-retained activated CCR7+ dendritic cells are heterogeneous and regulate local anti-tumour cytolytic activity.
in Nature communications
Fray M
(2022)
Cryogenics - Fundamentals, foundations and applications
Dalgliesh C
(2025)
An ultra-conserved poison exon in the Tra2b gene encoding a splicing activator is essential for male fertility and meiotic cell division
in The EMBO Journal
Allen S
(2023)
Why use a biobank? Sharing mutations, gene editing and navigating the COVID-19 pandemic.
in Medical Research Archives
Aguilar C
(2024)
Pleiotropic brain function of whirlin identified by a novel mutation.
in iScience
| Description | Leading a working group to design guidelines for the documentation of animal genetics in scientific publications. |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Participation in a guidance/advisory committee |
| Title | 10 x shipments of strains expressing Cre recombinase under control of ERT2 |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Import |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | 12 x shipments of strains carrying conditional allele |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Import |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | 2 x import shipments -Cys421Ser/Cys424Ser RSK1 |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Import |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | 2 x shipments sent out - C57BL/6J-Acan |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Import |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | 2 x shipments sent out - C57BL/6J-Htra1 |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Import |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | 27 x shipment of strains carrying an IKMC knockout-first allele |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Import |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | 3 x shipments sent out - CD1; B6D2-Tg(Prm1-EGFP)#Ltku/H |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Import |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | 5 x import shipments of wildtype mice |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Import |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | AhCre |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Mouse models |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | AppKI(AppNL.G.F) x C57BL/6J.129P2-Dp(16Mis18a-Runx1)2TybEmcf |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Export |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | Atp2b2 |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Import |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | B6(Cg)-Chd8tm1.2Mabn/H |
| Description | Mouse Models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Export |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | B6-Cg-Sdhb |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Export |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | B6.129-S100A10tm1Jnw/H |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Export |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | B6.Cg-Ddx5 |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Export |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | B6.Cg-Ndrg1 |
| Description | Mouse model |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Export |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | B6;129P2-Anxa6 |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Export |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | B6;129P2-Gt(ROSA)26Sor |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Export |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | B6;129X1-Chm |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Export |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | B6;CBACa-Tg(PMP22)C22Clh/H |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Export |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | B6J.129-Siglec1 |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Export |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | B6J |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Import |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | B6J |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Import |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | B6JFVBF1-3p del |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Import |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | C17S PKA RIa |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Import |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | C195S PKG |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Import |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | C230A EPHX 2 |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Import |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | C3H.Cg-Ankrd11 |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Export |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | C3H/HeH-Pkhd1 |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Export |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | C3H101H-Pax3 |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Export |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | C57BL/6-Gt(ROSA)26Sor |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Export |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | C57BL/6-SpastinN384K knock-in |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Import |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | C57BL/6-Tg(Cdh5-cre/ERT2)1Rha |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Import |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | C57BL/6-Zfp382 |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Import |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | C57BL/6J-App |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Import |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | C57BL/6J-Cx3cr1 |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Import |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | C57BL/6J-Rock1 |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Import |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | C57BL/6J-Tg(Bmx-cre/ERT2)1Rha |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2023 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Import |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | C57BL/6J-Zfp667 |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Import |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | C57BL/6J.129P2-Dp(16Lipi-Hunk)9TybEmcf/TybH |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Import |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | C57BL/6NTac-Cx3cl1 |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Import |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | C57BL/6NTac-Grb10em1H/H |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2021 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Export |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | Cys42Ser PKG1a |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - non-mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Import |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | Cys436Ser/Cys439Ser RSK2 |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Import |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | Cys564Gly Rsk1 |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Import |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | Del(10Map3k5-Map7)2Kcl/H |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Import |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | Espn |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Import |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | Gt(ROSA)26Sor |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Import |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | H11tm1(Cag mCherry, Top1g1)Jtu |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Import |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | Hprt |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Import |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | Hprttm1(CAG-mCherry Top1)Jtu |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Import |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | MPC1 tetO KI |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Import |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | MPC2 tetO KI |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Import |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | MRP-14 (S100a9 - /-) |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Import |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | Mouse models |
| Description | 1 x ENU mutagenised mouse strain |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2024 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Export |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | Mouse models |
| Description | 1 x Floxed mouse strain |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2024 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Import |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | Mouse models |
| Description | 1 x Spontaneously mutated mouse strain |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2024 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Export |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | Mouse models |
| Description | 1 x iPMS mutagenised mouse strain |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2024 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Export |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | Mouse models |
| Description | 1 x individual mouse strains carrying a unique allele |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2023 |
| Provided To Others? | No |
| Impact | Facilities Research - Import |
| Title | Mouse models |
| Description | 1 x mouse strain carrying a floxed allele ready for Cre mediated recombination |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2024 |
| Provided To Others? | No |
| Impact | Facilities Research - Export |
| Title | Mouse models |
| Description | 1 x mouse strain expressing Cre recombinase under the control of a specific promotor |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2024 |
| Provided To Others? | No |
| Impact | Facilities Research - Export |
| Title | Mouse models |
| Description | 1 x mouse strain generated using CRISPR/Cas9 gene editing technology |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2023 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Import |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | Mouse models |
| Description | 1 x mouse strains carrying a specific point mutation |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2023 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Import |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | Mouse models |
| Description | 1 x mouse strains generated using CRISPR/Cas9 technology |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2023 |
| Provided To Others? | No |
| Impact | Facilities Research - Import |
| Title | Mouse models |
| Description | 10 x Transgenic mouse strains |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2024 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Export |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | Mouse models |
| Description | 15 x Targeted mutation mouse strains |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2024 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Import |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | Mouse models |
| Description | 19 x mouse strains carrying transgenes |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2024 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Export |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | Mouse models |
| Description | 19 x mouse strains generated by gene targeting events |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2023 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Import |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | Mouse models |
| Description | 2 x Cre-driver mouse strains |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2024 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Import |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | Mouse models |
| Description | 2 x ENU mutagenised mouse strains |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2024 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Import |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | Mouse models |
| Description | 2 x Transgenic mouse strains |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2024 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Import |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | Mouse models |
| Description | 2 x mouse strains in which specific genes have been knocked out |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2023 |
| Provided To Others? | No |
| Impact | Facilities Research - Import |
| Title | Mouse models |
| Description | 3 x CRISPR mouse strains |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2024 |
| Provided To Others? | No |
| Impact | Facilities Research - Export |
| Title | Mouse models |
| Description | 3 x mouse strains carrying specific point mutations |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2023 |
| Provided To Others? | No |
| Impact | Facilities Research - Import |
| Title | Mouse models |
| Description | 3 x mouse strains carrying transgenes |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2023 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Import |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | Mouse models |
| Description | 3 x mouse strains carrying transgenes |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2023 |
| Provided To Others? | No |
| Impact | Facilities Research - Import |
| Title | Mouse models |
| Description | 3 x mouse strains in which specific genes have been knocked out |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2024 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Export |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | Mouse models |
| Description | 30 x Conditional Knockout mouse strains |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2024 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Import |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | Mouse models |
| Description | 33 x Knock in mouse strains |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2024 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Import |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | Mouse models |
| Description | 34 x mouse strains generated by gene targeting events |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2024 |
| Provided To Others? | No |
| Impact | Facilities Research - Export |
| Title | Mouse models |
| Description | 35 x mouse strains generated using CRISPR/Cas9 gene editing technology |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2024 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Export |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | Mouse models |
| Description | 36 x Targeted mutation mouse strains |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2024 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Export |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | Mouse models |
| Description | 4 x Reporter mouse strains |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2024 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Import |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | Mouse models |
| Description | 4 x mouse strains carrying transgenes |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2024 |
| Provided To Others? | No |
| Impact | Facilities Research - Export |
| Title | Mouse models |
| Description | 4 x mouse strains in which specific genes have been knocked out |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2024 |
| Provided To Others? | No |
| Impact | Facilities Research - Export |
| Title | Mouse models |
| Description | 4 x separate shipments of tissue samples harvested from F1 hybrid mouse strains |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2024 |
| Provided To Others? | No |
| Impact | Facilities Research - Export |
| Title | Mouse models |
| Description | 41 x separate inbred mouse strains |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2024 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Export |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | Mouse models |
| Description | 5 x Knock out mouse strains |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2024 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Import |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | Mouse models |
| Description | 5 x separate inbred mouse strains |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2024 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Export |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | Mouse models |
| Description | 6 x individual mouse strains carrying unique alleles |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2024 |
| Provided To Others? | No |
| Impact | Facilities Research - Export |
| Title | Mouse models |
| Description | 6 x mouse strains generated by gene targeting events |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2023 |
| Provided To Others? | No |
| Impact | Facilities Research - Import |
| Title | Mouse models |
| Description | 60 x mouse strains generated using CRISPR/Cas9 gene editing technology |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2024 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Export |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | Mouse models |
| Description | 7 x CRISPR mouse strains |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2024 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Export |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | Mouse models |
| Description | 71 x mouse strains generated by gene targeting events |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2024 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Export |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | Mouse models |
| Description | 8 x individual mouse strains carrying unique alleles |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2024 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Export |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | Mouse models |
| Description | 9 x CRISPR mouse strains |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2024 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Import |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | PLP-GalNAc T-CFP |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Import |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | Pcdh15 |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Import |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | Pten-R173C |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Import |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | Publication of a research article involving mice derived from frozen sperm obtained from MRC Harwell |
| Description | Publication of ' Bucknor, E. M. V., Johnson, E., Efthymiou, S., Alvi, J. R., Sultan, T., Houlden, H., Maroofian, R., Karimiani, E. G., Finelli, M. J., and Oliver, P. L. (2024) Neuroinflammation and Lysosomal Abnormalities Characterise the Essential Role for Oxidation Resistance 1 in the Developing and Adult Cerebellum, Antioxidants (Basel) 13. 10.3390/antiox13060685' |
| Type Of Material | Biological samples |
| Year Produced | 2024 |
| Provided To Others? | Yes |
| Impact | Impacts include acknowledgment of the work carried out at the MLC to produce this mouse strain, and increased awareness of its availability to the research community |
| URL | https://www.mdpi.com/2076-3921/13/6/685 |
| Title | Publication of a research article involving mice derived from frozen sperm obtained from MRC Harwell |
| Description | Publication of 'Godoy-Corchuelo, J. M., Ali, Z., Brito Armas, J. M., Martins-Bach, A. B., García-Toledo, I., Fernández-Beltrán, L. C., López-Carbonero, J. I., Bascuñana, P., Spring, S., Jimenez-Coca, I., Muñoz de Bustillo Alfaro, R. A., Sánchez-Barrena, M. J., Nair, R. R., Nieman, B. J., Lerch, J. P., Miller, K. L., Ozdinler, H. P., Fisher, E. M. C., Cunningham, T. J., Acevedo-Arozena, A., and Corrochano, S. (2024) TDP-43-M323K causes abnormal brain development and progressive cognitive and motor deficits associated with mislocalised and increased levels of TDP-43, Neurobiol Dis 193, 106437. 10.1016/j.nbd.2024.106437' using material obtained from the Mary Lyon Centre's National Mouse Archive |
| Type Of Material | Biological samples |
| Year Produced | 2024 |
| Provided To Others? | Yes |
| Impact | Impacts include acknowledgment of the work carried out at the MLC to produce this mouse strain, and increased awareness of its availability to the research community. |
| URL | https://pmc.ncbi.nlm.nih.gov/articles/PMC10988218/ |
| Title | Publication of a research article involving mice derived from frozen sperm obtained from MRC Harwell |
| Description | publication of 'Carlton, A. J., Jeng, J. Y., Grandi, F. C., De Faveri, F., Amariutei, A. E., De Tomasi, L., O'Connor, A., Johnson, S. L., Furness, D. N., Brown, S. D. M., Ceriani, F., Bowl, M. R., Mustapha, M., and Marcotti, W. (2024) BAI1 localizes AMPA receptors at the cochlear afferent post-synaptic density and is essential for hearing, Cell Rep 43, 114025. 10.1016/j.celrep.2024.114025' using mice from the Mary Lyon Centre's National Mouse Archive |
| Type Of Material | Biological samples |
| Year Produced | 2024 |
| Provided To Others? | Yes |
| Impact | Impacts include acknowledgment of the work carried out at the MLC to produce this mouse strain, and increased awareness of its availability to the research community. |
| URL | https://www.sciencedirect.com/science/article/pii/S221112472400353X?via%3Dihub |
| Title | Publication of a research article relating to the IL19-/- mouse model |
| Description | Publication of article "IL-24 intrinsically regulates Th17 cell pathogenicity in mice" in the Journal of Experimental Medicine, describing the use of Il19-/- (C57BL/6N-Il19tm2e(EUCOMM)Hmgu/H) mice, which were sourced from the Mary Lyon Centre at MRC Harwell. |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Impacts include acknowledgment of the work carried out at the MLC to produce this mouse strain, and increased awareness of its availability to the research community. |
| URL | https://rupress.org/jem/article-pdf/219/8/e20212443/1435623/jem_20212443.pdf |
| Title | STOCK Adcy1 |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Import |
| Title | STOCK Igf2tm4Wrk/H |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Import |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | STOCK Lhx1 |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Import |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | T178A PKGI |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Import |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | Tbx1 |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Import |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | Tbx5 K339R cKI/H |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Import |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | Thy1-GalNAc T-CFP |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Import |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | Trib1 Rosa TG (Gt(ROSA)26Sor |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Mouse models |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | Utytm1(Flag-Cas9-EGFP)jtu |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Import |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | Zfp189 |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Import |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | Zfp248 |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Import |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | Zfp263 |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Import |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | Zfp263 |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Mouse models |
| URL | https://archive.har.mrc.ac.uk/index |
| Title | Zik1 |
| Description | Mouse models |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| Impact | Facilities Research - Import |
| URL | https://archive.har.mrc.ac.uk/index |
| Description | DMM2024: Pre-clinical Modelling of Human Genetic Disease in Edinburgh |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Rapid advances in gene editing and genetic technologies have revolutionised our ability to model human genetic disease and provided new hope for gene therapies. At this meeting, the very latest advances in modelling human genetic disease, from rare disease, cancer and immune disorders through to genetic modifiers were presented. They discussed the latest technologies and the challenges associated with generating relevant human genetic mutations in multi-modal systems, including advanced complex cellular models, model organisms and large animal models, and how genetic technologies can be applied to genome-wide screens and therapy. In addition, speakers outlined the latest strategies to model genetic mutations in cell type and tissue-specific mechanisms, in a developmental and time-dependent fashion, and in the coding and non-coding genome. Importantly, they discussed the latest approaches to the phenotyping of models and how to computationally align models with human disease to guide therapeutic intervention and, ultimately, translation. Event took place from 8 - 10 May 2024. Sara Wells was a panel member for this meeting. |
| Year(s) Of Engagement Activity | 2024 |
| URL | https://www.biologists.com/meetings/dmmgenetics2024/ |
| Description | IDT at CSHL | 2024 Genome Engineering: CRISPR Frontiers |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Lydia Teboul presented 'Long read sequencing for characterisation of genome engineering'. The specific goal for this meeting is to foster fruitful and creative interactions between researchers interested in applying these systems to genome engineering and related advances in a wide variety of organisms, together with scientists studying the basic biology of CRISPR-Cas and related bacterial defense systems. |
| Year(s) Of Engagement Activity | 2024 |
| URL | https://meetings.cshl.edu/meetings.aspx?meet=CRISPR&year=24 |
| Description | IMPC Meeting |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Production working group report: planning next phase |
| Year(s) Of Engagement Activity | 2024 |
| URL | https://www.phenogenomics.cz/2024/06/impc-fall-meeting/ |
| Description | NMGN boot camp - Genome editing and model validation |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Lydia Teboul gave a talk on Genome editing and model validation |
| Year(s) Of Engagement Activity | 2024 |
| Description | Training course for ISTT on Allele validation |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Talk on Allele validation |
| Year(s) Of Engagement Activity | 2024 |