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Combining advanced polymer-peptide conjugate synthesis with advanced mass spectrometry characterization - a collaborative study.

Lead Research Organisation: University of Warwick
Department Name: Chemistry

Abstract

This project involves study of synthesis and characterisation of polymer-peptide self-assembling conjugates using advanced mass spectrometry methods. The methods to be used include ultra high resolution mass spectrometry, advanced tandem mass spectrometry (ExD, IRMPD, CAD), and two dimensional mass spectrometry. In addition to allowing better control of the chemistry of synthesis of these materials, the advanced analytical methods should allow far more comprehensive data than ever previously achieved on polymeric materials.

This project is a collaborative project among Prof. Peter O'Connor, Prof. Sebastien Perrier, and Dr. Anthony Bristow at Astra Zeneca in Macclesfield.

People

ORCID iD
Tomos Morgan (Student)

Publications

10 25 50
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Lermyte F (2019) Metal Ion Binding to the Amyloid ß Monomer Studied by Native Top-Down FTICR Mass Spectrometry. in Journal of the American Society for Mass Spectrometry

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Lermyte F (2019) Top or Middle? Up or Down? Toward a Standard Lexicon for Protein Top-Down and Allied Mass Spectrometry Approaches. in Journal of the American Society for Mass Spectrometry

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Lermyte F (2019) Emerging Approaches to Investigate the Influence of Transition Metals in the Proteinopathies. in Cells

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Morgan TE (2020) Electron Capture Dissociation of Trithiocarbonate-Terminated Acrylamide Homo- and Copolymers: A Terminus-Directed Mechanism? in Analytical chemistry

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Lam YPY (2020) Determination of the Aggregate Binding Site of Amyloid Protofibrils Using Electron Capture Dissociation Tandem Mass Spectrometry. in Journal of the American Society for Mass Spectrometry

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Chiu CKC (2020) Metallocomplex-Peptide Interactions Studied by Ultrahigh Resolution Mass Spectrometry. in Journal of the American Society for Mass Spectrometry

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Marzullo B (2020) Advantages of Two-Dimensional Electron-Induced Dissociation and Infrared Multiphoton Dissociation Mass Spectrometry for the Analysis of Agrochemicals in Analytical Chemistry

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Paris J (2020) Facile Determination of Phosphorylation Sites in Peptides Using Two-Dimensional Mass Spectrometry. in Analytical chemistry

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Marzullo B (2020) Comparison of Fragmentation Techniques for the Structural Characterization of Singly Charged Agrochemicals in Analytical Chemistry

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Lam YPY (2020) Does deamidation affect inhibitory mechanisms towards amyloid protein aggregation? in Chemical communications (Cambridge, England)

Studentship Projects

Project Reference Relationship Related To Start End Student Name
EP/P510695/1 30/09/2016 31/12/2021
1837376 Studentship EP/P510695/1 30/09/2016 29/03/2020 Tomos Morgan