The CHELL : A Bottom-Up approach to in vitro and in silico Minimal Life-like Constructs
Lead Research Organisation:
University of Oxford
Department Name: Oxford Chemistry
Abstract
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Organisations
Publications
Barry CS
(2013)
'Naked' and hydrated conformers of the conserved core pentasaccharide of N-linked glycoproteins and its building blocks.
in Journal of the American Chemical Society
Gao Z
(2013)
Enhanced aqueous Suzuki-Miyaura coupling allows site-specific polypeptide 18F-labeling.
in Journal of the American Chemical Society
Goodfellow JJ
(2012)
An endoglycosidase with alternative glycan specificity allows broadened glycoprotein remodelling.
in Journal of the American Chemical Society
Harris LG
(2009)
Rewritable glycochips.
in Journal of the American Chemical Society
Chalker JM
(2009)
A convenient catalyst for aqueous and protein Suzuki-Miyaura cross-coupling.
in Journal of the American Chemical Society
Parry AL
(2013)
'Multicopy multivalent' glycopolymer-stabilized gold nanoparticles as potential synthetic cancer vaccines.
in Journal of the American Chemical Society
Lin Y
(2013)
Rapid Cross-Metathesis for Reversible Protein Modifications via Chemical Access to Se -Allyl-selenocysteine in Proteins
in Journal of the American Chemical Society
Cocinero E
(2009)
The Building Blocks of Cellulose: The Intrinsic Conformational Structures of Cellobiose, Its Epimer, Lactose, and Their Singly Hydrated Complexes
in Journal of the American Chemical Society
Floyd N
(2009)
Photoinduced, family-specific, site-selective cleavage of TIM-barrel proteins.
in Journal of the American Chemical Society
Cocinero EJ
(2011)
Exploring carbohydrate-peptide interactions in the gas phase: structure and selectivity in complexes of pyranosides with N-acetylphenylalanine methylamide.
in Journal of the American Chemical Society
| Description | We found that we were not only able to make an artificial chemical cell (something we called the 'chell') but that we could also create sufficient information from its metabolism for it to communicate with living (bacterial cells). This 'conversation' between artificial cells and living cells highlights that our notions of cellularity (and life) can be examined through fundamental experiments. |
| Exploitation Route | These ideas have provoked various communities that examine cells right down to those who are interested in the emergence of complexity and even studying the origins of life. It provoked an analysis of the use of 'chemical cells' as potential 'living drugs', for example - see https://vimeo.com/10274649. |
| Sectors | Education Pharmaceuticals and Medical Biotechnology |
| URL | http://users.ox.ac.uk/~dplb0149/index.html |
| Description | BGD and group members have appeared on the radio, television, (BBD, Channel 5), newspapers (Times, New Scientist) science festivals around the world (Cheltenham, Kent, Edinburgh, Times Lit., Sydney) describing this work. We have given talks in schools to inspire the next generation. This work has been widely featured as one of the very first SynBio grants and that led to an expansion of the UK's SynBio community. It has also provoked a community of those more broadly interested in these concepts, including designers and artists - see https://vimeo.com/10274649 or http://www.daisyginsberg.com/work/synthesis-exchange-laboratory |
| First Year Of Impact | 2009 |
| Sector | Chemicals,Creative Economy,Education,Pharmaceuticals and Medical Biotechnology,Other |
| Impact Types | Cultural Societal Economic Policy & public services |
| Company Name | GlycoForm |
| Description | |
| Year Established | 2002 |
| Impact | Employed >20 people over 10 years and provided a model for how synthetic protein drugs might be constructed and used. The technology for this company has now been used by major US companies. |