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Removal of antimicrobial resistance genes from bacterial strains and communities using CRISPR-Cas9.

Lead Research Organisation: UNIVERSITY OF EXETER
Department Name: University of Exeter Medical School

Abstract

Antimicrobial resistance (AMR) is one of the greatest threats to human health of our time and discovering ways to prevent the spread of AMR would be truly ground breaking. This develops the CRISPR-Cas9 genome editing system to target and destroy AMR genes in complex microbial communities present in the lungs of cystic fibrosis patients.

Publications

10 25 50
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Pursey E (2018) CRISPR-Cas antimicrobials: Challenges and future prospects. in PLoS pathogens

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Common J (2019) Diversity in CRISPR-based immunity protects susceptible genotypes by restricting phage spread and evolution

Studentship Projects

Project Reference Relationship Related To Start End Student Name
MR/N013794/1 30/09/2016 29/09/2025
1929915 Studentship MR/N013794/1 30/09/2017 31/12/2021 David Walker-Sünderhauf
NE/W503010/1 31/03/2021 30/03/2022
1929915 Studentship NE/W503010/1 30/09/2017 31/12/2021 David Walker-Sünderhauf
 
Description Junior Scientist Conference Grant, non-GS Meeting
Amount £460 (GBP)
Organisation The Genetics Society 
Sector Charity/Non Profit
Country United Kingdom
Start 05/2019 
End 07/2019
 
Description Microbiology Society Travel Grant
Amount £240 (GBP)
Organisation Microbiology Society 
Sector Learned Society
Country United Kingdom
Start 02/2020 
End 02/2020
 
Description Stall at Royal Cornwall Show 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Royal Cornwall Show (Wadebridge, June 2019). I designed a hands-on science activity centred on antibiotic resistance and the environment and led a team delivering this at the three-day Royal Cornwall Show
Year(s) Of Engagement Activity 2019
URL https://vanhoutelab.wordpress.com/2019/06/10/royal-cornwall-show/