Enzyme Responsive Materials for Biology and Medicine
Lead Research Organisation:
University of Strathclyde
Department Name: Pure and Applied Chemistry
Abstract
This proposal is to develop new routes to rationally designed Enzyme Responsive Materials (ERMs) for biomedical applications. These materials can change properties, for example they can swell/collapse or change from a solution to a gel in response to biochemical reactions. These materials may have applications in the controlled release of drugs in response to disease specific enzymes. They may also be used in triggered assembly of matrixes for cell growth, with applications in tissue engineering. The outcomes of this project will be (i) the development and full characterisation of new interactive biomaterials, (ii) increased fundamental understanding of structure/function relationships in molecular hydrogels, (iii) proof of concept applications in enzyme triggered assembly of scaffolds for 3D cell culture and (iv) enzyme triggered drug delivery.
Organisations
People |
ORCID iD |
| Rein Ulijn (Principal Investigator) |
Publications
Li Y
(2009)
A study of the dynamic interaction of surfactants with graphite and carbon nanotubes using Fmoc-amino acids as a model system.
in Langmuir : the ACS journal of surfaces and colloids
Das AK
(2009)
Evolving nanomaterials using enzyme-driven dynamic peptide libraries (eDPL).
in Faraday discussions
Thornton K
(2009)
Controlling stiffness in nanostructured hydrogels produced by enzymatic dephosphorylation
in Biochemical Society Transactions
Zhou M
(2009)
Self-assembled peptide-based hydrogels as scaffolds for anchorage-dependent cells.
in Biomaterials
Cousins BG
(2009)
Enzyme-activated surfactants for dispersion of carbon nanotubes.
in Small (Weinheim an der Bergstrasse, Germany)
Todd SJ
(2009)
Enzyme-activated RGD ligands on functionalized poly(ethylene glycol) monolayers: surface analysis and cellular response.
in Langmuir : the ACS journal of surfaces and colloids
Williams RJ
(2009)
Enzyme-assisted self-assembly under thermodynamic control.
in Nature nanotechnology
Hirst AR
(2010)
Biocatalytic induction of supramolecular order.
in Nature chemistry
Hughes M
(2011)
Biocatalytic self-assembly of 2D peptide-based nanostructures
in Soft Matter
Javid N
(2011)
Supramolecular Structures of Enzyme Clusters.
in The journal of physical chemistry letters
Caponi P
(2011)
Phosphatase/temperature responsive poly(2-isopropyl-2-oxazoline)
in Polym. Chem.
Zelzer M
(2013)
Enzyme responsive materials: design strategies and future developments.
in Biomaterials science
Thornton K
(2013)
Mechanistic insights into phosphatase triggered self-assembly including enhancement of biocatalytic conversion rate
in Soft Matter
Related Projects
| Project Reference | Relationship | Related To | Start | End | Award Value |
|---|---|---|---|---|---|
| EP/D07410X/1 | 31/07/2006 | 30/08/2008 | £649,958 | ||
| EP/D07410X/2 | Transfer | EP/D07410X/1 | 31/08/2008 | 30/07/2011 | £0 |
| Description | - enzyme-responsive polymer hydrogels for controlled release of proteins. Developed methodology to match polymer functionality with protein payload. Developed two-photon microscopy to monitor controlled release. - demonstrated ability to control and direct supramolecular self-assembly under kinetic control using enzymatic reactions to direct the assembly. |
| Exploitation Route | Our biocatalytic self-assembly approaches are now applied in development of new therapeutics where disease specific enzymes trigger release of therapeutics. |
| Sectors | Chemicals |
| URL | http://www.ulijnlab.com |