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FLUENCE: Felix Light for the UK: Exploiting Novel Characteristics and Expertise.

Lead Research Organisation: University of Liverpool
Department Name: Physics

Abstract

The FLUENCE proposal is a response to a request from the EPSRC to develop those aspects of the ARTFUL Statement of Need (SoN) for a mid range facility (MRF) that would facilitate a significant increase in the number of UK scientists having access to the FELIX suite of accelerator driven light sources. The EPSRC contract with FELIX has been renewed from the 1st of January 2017 for five years. However if the UK is to obtain the benefits of its subscription to FELIX it will be important to significantly expand and broaden the user community seeking access to these light sources. This follows from the feed-back provided by the panel assessing the last annual report on the FELIX MRF. The panel commented "However the current UK usage as reported is small and could be expanded" and concluded "There is great potential through this subscription, with UK academics being offered access to world-leading facilities. However greater engagement with the broader UK academic community is needed to ensure that this potential is fully realised." This proposal addresses these concerns and demonstrates that the ARTFUL SoN can be refocused to significantly increase the number of UK scientists using FELIX and ensure that the UK gets the full benefits of the renewed access contract.

The MRF capabilities proposed in ARTFUL and the consequent cost to the EPSRC hinged on existing facility infrastructure maintained by two external bodies, the STFC-funded ALICE facility and the Radboud University FELIX Facility. Since the submission the STFC has withdrawn support for ALICE, in the form of a promised £6M capital upgrade, in order to concentrate the available human and capital resources at Daresbury for the new CLARA X-Ray machine. This proposal will facilitate the transfer of a significant fraction of the community that sought access to ALICE to FELIX and familiarise this community, and new users identified in the ARTFUL proposal, with its capabilities. The programme will also provide support for the experimental programmes of early career scientists and new users of FELIX.

The ARTFUL statement of need lists 116 scientists from 59 departments in 33 UK Universities, Hospitals and Companies seeking to exploit the unique capabilities of the FELIX and ALICE light sources in a diverse research programme. The FLUENCE proposal is supported by a significant fraction of the ARTFUL community and it is expected that the research of 74 scientists from 39 departments in 27 Universities and Companies will benefit from access to FELIX. This is a significant expansion of the current use of FELIX by UK scientists. It is possible that this community can be expanded in the future if it is established that an imaging capability can be established on FELIX. A partial survey of the scientists supporting ARTFUL showed that they have produced over 2440 publications in referred journals in the previous 5 years and currently hold 233 research grants of value £ 358M. ARTFUL received excellent referee reports with all four reports giving the highest grade of 6. There were no negative comments and aspects of the capabilities and potential to support scientific research of both ALICE and FELIX were rated as "unique" and "world leading". The statement of need was the top-rated proposal at the Panel.
The proposal is lead by Prof. Weightman who lead the INSPIRE and ARTFUL proposals and will have an Advisory Board to advise the PI and the EPSRC on the progress of the MRF and on how to bring the potential of the MRF to the attention of the UK scientific community.

Planned Impact

The MRF will provide the UK scientific community with world-leading and, in some cases, unique capabilities that will have a major impact on scientific advances over many research fields. It will foster links between members of this diverse community and facilitate the sharing of experimental techniques and the initiation of multidisciplinary collaborations.

Economic and Industrial Impact: The MRF programmes support research priorities in five EPSRC themes: Quantum Technologies, Energy, Engineering, Manufacturing the Future and Physical Sciences and research in all these themes has the potential to make an impact on economic and industrial development through our industrial collaborators. The unique capabilities of the FELIX light sources will foster the development of new scientific instruments through collaborations with industry. UK strength in the emerging THz field will be enhanced by collaborations between Teraview and the Liverpool and Leeds groups in developing instruments for a variety of sectors, the Birmingham group's development of micromachined waveguide technologies and QMC Instruments, which regards access to accelerator driven sources of THz radiation as an ideal test-bed for the characterisation and assessment of its new technologies. Anasys Instruments and the Lancaster group will develop infrared instruments for a wide range of scientific and industrial applications. The Liverpool group's collaborations with ASH Scientific and Applied Photophysics on the development of scientific instruments will also benefit from access to FELIX.

MRF scientists have links with two Quantum Technology Hubs which will foster the commercialisation of quantum technology. The impact of the catalysis, protein dynamics, nanoscale spectroscopy and THz chemistry programmes will benefit from links with the UK Catalysis Hub at Harwell and collaborations with Johnson Matthey.
This proposal will explore with the community seeking access to advanced imaging whether a case can be made to develop an imaging capability on FELIX. It this proves to be feasible it has the potential to make significant impacts on Healthcare Technologies through collaborations between physical scientists and clinicians and the development of THz sensor technology

Professional development and training: The diversity of experimental activities will promote contacts between PhD students and PDRAs from different research groups. This will have a beneficial effect on the experience of younger scientists and give them opportunities to explore future career options.

Publications

10 25 50
 
Description Summary of Progress on the FLUENCE grant.
The primary aim of the FLUENCE grant is to facilitate advances in the research programmes of a large and diverse community of UK scientists by a significant expansion of UK access to the FELIX suite of accelerator based light sources. The award began in July 2017 and has led to a significant increase in UK use of FELIX as summarised below. The main objectives, and progress towards the objectives, are:-

1) To achieve a significant increase in the number of UK users of the FELIX suite of light sources
Outcome: A total of 35 new UK FLUENCE-enabled users have been awarded a total of 19 runs comprising 78 shifts of beamtime. New users needed to become familiar with the capabilities of FELIX, incorporate these into their wider research programmes and seek funding for access to FELIX. FLUENCE has addressed these issues and UK use of FELIX is steadily.

2) To significantly expand and broaden the user community seeking access to these light sources
Outcome. This objective requires the development of apparatus, including new end stations, which is in keeping with the desires of both EPSRC and FELIX.
Apparatus has been developed and commissioned for a number of projects.
a) "The study of polar structure changes in ferrielectrics" by Lloyd-Hughes (Warwick) and B Yang (Chester.)
b) "Astro-Science Experimental End-station, LISA: This activity has been slowly built up by Dr Sergio Ioppolo and has gone from strength to strength. Whilst LISA has many applications, it was specifically designed for the study of interstellar ices by means of IR and THz external radiation from FELIX-1 and -2. This project has successful completed 7 runs (31 shifts), all involving UK groups. There are 7 runs (28 shifts) approved for LISA that have not yet occurred including 4 UK runs (14 shifts) and 3 international runs (14 shifts). Dr Ioppolo has now obtained funding for the project, including a PDRA (yet to be hired due to Covid-19 restrictions) and his PhD student is involved in all the research carried out at FELIX. In the future, LISA (FELIX endstation 8) will be available for FELIX users.
c) Catalysis & Surface Science End-station: This activity has been led by Prof. Martin McCoustra and has significant UK interest. A 2-page Expression of Interest was submitted to the EPSRC Instrumentation Development Fund entitled, "FELIX and CATalysis: Enabling Catalysis and Astrophysics Research on FELIX" (FELACAT). This was led by Profs Martin McCoustra (Heriot-Watt University) and Wendy Brown (University of Sussex) with the latter as the Principle investigator. FELACAT is supported by the UK Catalysis Hub and some 36 UK research groups from 26 departments in 21 UK universities with total research funding exceeding £55M; it is proposed to run for 5 years at a cost of £2.9M FEC (£2.6M to EPSRC). Unfortunately, FELACAT was not successful. The team is evaluating how best to move this initiative forward. The FELACAT Expression of Interest is included in Appendix E.

3) To assess the prospects for developing imaging capabilities on FELIX, and if it is found to be practical then a proposal will be developed to apply for funding for an imaging instrument towards the end of the third year of this proposal
Outcome: We are pleased to report that the imaging concept was found to have significant UK interest and was developed into the "High performance Wide spectral range Nanoprobe" (HiWiN) project, which is led by Prof. Oleg Kolosov (Lancaster University). HiWiN was approved and is now funded (£745,943) via the EPSRC Instrumentation Development Fund (EP/V00767X/1). The grant began 1 September 2020. The full proposal was supported by 31 research groups from 16 departments in 12 universities.

FLUENCE successfully expand the UK community exploiting the FELIX suite of free electron laser in Nijmegen and has a result to contract to allow UK access to FELIX was renewed. this contract is managed by Prof. Ben Murdin of the University risky of Surrey.

Note. FELIX was closed during the Covid-19 pandemic and all UK work at FELIX ceased. It took some time to recover from the effects of COVID but UK access to FELIX has now recovered and continues to grow.
Exploitation Route A significant number of engagement activities as listed in another section.

The results obtained from the experiments conducted by UK scientists using FELIX will advance scientific knowledge and then strength of UK science.
The imaging instrument is available for use by UK scientist.
Sectors Chemicals

Digital/Communication/Information Technologies (including Software)

Electronics

Energy

Environment

Healthcare

Manufacturing

including Industrial Biotechology

Pharmaceuticals and Medical Biotechnology

 
Description The EPSRC FLUENCE award to facilitate access to the FELIX suite of free electron laser by UK scientists ended on the 31st December 2022. It has been very successful and it has met all its aims and objectives as set out below. It was difficult to design a programme to reach such a large number of scientists working in so many different fields of research and I thank the members of our Advisory Board for their advice on how to do this. The discussions we held in the first four years of the award were invaluable in setting up visits and meetings with key people in different fields. The Board also gave some useful advice on how to seek an extension to FLUENCE to deal with the fall-out from the COVID epidemic. The specific objectives of FLUENCE where:_ 1) To coordinate UK access to FELIX for the five years of the renewed access contract. Michele Siggel-King set a up a very efficient system for liaison between the University of Liverpool Finance Office, the administration at FELIX and approximately forty new individual users. This ensured users were re-imbursed for their accommodation at, and travel to and from FELIX. As far as we are aware all these transactions ran smoothly. James Ingham took over this role from Michele for the last year of the award. 2) To achieve a significant increase in the number of UK users of the FELIX suite of light sources. FLUENCE facilitated applications from UK scientist to use FELIX and over forty were successful. This is a fourfold increase in the number of UK scientists using FELIX previously. New research programs initiated on FELIX by new UK users include Quantum Biology & Multi-omics, Astro-Science Ice Studies, Catalysis, Cementation dynamics and Pump probe studies of the dynamics of local vibrational modes 3) If it is found to be practical to develop an imaging capability on FELIX then a proposal will be developed with members of the UK community and with FELIX to apply for funding for an imaging instrument towards the end of the third year of this proposal. A feasibility study established that it was practical to develop an imaging capability on FELIX and this was taken forward by Prof. Oleg Kolosov of Lancaster University. His proposal "High performance Wide spectral range Nanoprobe" (HiWiN) was supported by 31 research groups from 16 departments in 12 universities. It approved and funded by the EPSRC a separate award (EP/V00767X/1). Finally, I think the future is very bright for UK scientists future to access the free electron lasers at FELIX. EPSRC has renewed the contract with FELIX for access for UK scientists. Ben Mudin's submission of the annual report on the FELIX National Research Facility in June 2022 was rated by the Review Committee as "Very High Quality - Leading edge and internationally competitive".
First Year Of Impact 2024
Sector Chemicals,Education,Electronics,Energy,Healthcare,Manufacturing, including Industrial Biotechology,Pharmaceuticals and Medical Biotechnology
Impact Types Cultural

Societal

Economic

 
Description A hand-held infrared probe for cancer diagnosis: Liverpool Diagnostic Infrared Wand (LDIR Wand)
Amount £534,113 (GBP)
Funding ID NIHR204157 
Organisation National Institute for Health and Care Research 
Sector Public
Country United Kingdom
Start 11/2022 
End 07/2025
 
Description Clinical and technical validation of infrared absorbance spectra to predict malignant transformation in oral potentially malignant disorders (OPMDs)
Amount £407,638 (GBP)
Funding ID EDDPJT-May23/100024 
Organisation Cancer Research UK 
Sector Charity/Non Profit
Country United Kingdom
Start 09/2023 
End 09/2026
 
Description High performance Wide spectral range Nanoprobe (HiWiN)
Amount £745,943 (GBP)
Funding ID EP/V00767X/1 
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Public
Country United Kingdom
Start 02/2021 
End 01/2024
 
Description Conference for school children 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact A talk for school children on "Probing the secret of life with accelerator driven light sources."
Year(s) Of Engagement Activity 2018
 
Description Discussions at the Royce Institute in Manchester 10 1 18 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Wide ranging discussions about the organisation of access to scientific equipment in the Royce Institute.
Year(s) Of Engagement Activity 2018
 
Description FLUENCE workshop in Nijmegen 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact This was a workshop to intrude a group of UK scientists to the use of the FELIX free electron lasers in Nijmegen
Year(s) Of Engagement Activity 2018
 
Description HFML-FELIX User Meeting 2019, FELIX, Nijmegen, The Netherlands, (8-9 July 2019) Invited talk by Michele Siggel-King 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact This was a working group to design a scientific instrument.
Year(s) Of Engagement Activity 2019
 
Description Invited Talk 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Invited Talk by Dr Michele Siggel-King
Year(s) Of Engagement Activity 2018
 
Description Invited Talk at Community Meeting: FELIX: Free Electron lasers for the Catalysis Community (18 July 2019) Research Complex at Harwell 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact This was a collaboration meeting of scientists interested in using the FELIX free electron lasers in Nijmegen.
Year(s) Of Engagement Activity 2019
 
Description Invited seminar 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact 2nd Feb 2019 "Recent advances in the application of infrared techniques to the study of cancer." Physics Dept. University of Sheffield
Year(s) Of Engagement Activity 2019
 
Description Invited talk at "the University of the 3rd Age" 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Supporters
Results and Impact Invited talk by Dy Michele Siggel-King on scents advances in the study of cancer
Year(s) Of Engagement Activity 2018
 
Description Invited talk at TERANEW network meeting, National Physics Laboratory (4 Dec 2019) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact This was an invited talk at an EPSRC Network TERANET at the National Physical Laboratory.
Year(s) Of Engagement Activity 2019
 
Description Invited talk by Dr Michele Siggel-King in Finland 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact Invited talk at Physics against cancer meeting in Finland
Year(s) Of Engagement Activity 2018
 
Description National Conference on the application of terahertz radiation to the study of cancer 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other audiences
Results and Impact An invited talk on "Characteristics of cancerous tissue in the THz region of the electromagnetic spectrum."
Year(s) Of Engagement Activity 2018
 
Description National meeting on terahertz radiation 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Industry/Business
Results and Impact National conference on The radiation
Year(s) Of Engagement Activity 2018
 
Description Presentation at the SPEC2018 Conference June 2018 Glasgow 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Presentation on a new approach to cancer diagnosis
Year(s) Of Engagement Activity 2016
 
Description THz Imaging of Cancer, London (12 July 2019) Invited Talk (PW) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact This was an invited talk at a conference on application of Terahertz radiation in health care
Year(s) Of Engagement Activity 2019
 
Description The Fundamentals of Late Stage Cancer Meeting, NorthWest Cancer Research Centre, University of Liverpool (19-20 Sept 2019) Poster Presentation 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact This was a conference on problems in the treatment of late stage cancer.
Year(s) Of Engagement Activity 2019
 
Description University of Sheffield Physics Department Seminar (6 Feb 2019) Invited Talk (PW) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact This was a dempartmental seminar
Year(s) Of Engagement Activity 2019
 
Description Workshop to coordinate the development of a proposal for an imaging system on the FELIX free electron lasers 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact The meeting agreed vin a plan to develop a poroposall for an imaging instrument to be established on the FEKLIX free electron lasers in Nijmegen.
Year(s) Of Engagement Activity 2018
 
Description national Conference on THz radiation Chester 21 5 18 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Postgraduate students
Results and Impact National conference on Thz radiation Chester 21 5 18
Year(s) Of Engagement Activity 2018