RFI Phase 2
Lead Research Organisation:
Rosalind Franklin Institute
Department Name: Research
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Organisations
Publications
Clarke J
(2024)
A broadly reactive ultralong bovine antibody that can determine the integrity of foot-and-mouth disease virus capsids
in Journal of General Virology
Hudson D
(2024)
A comparison of clustering models for inference of T cell receptor antigen specificity.
in Immunoinformatics (Amsterdam, Netherlands)
Bolton R
(2024)
A redox switch allows binding of Fe(II) and Fe(III) ions in the cyanobacterial iron-binding protein FutA from Prochlorococcus
in Proceedings of the National Academy of Sciences
Brunderová M
(2024)
Addendum: Expedient production of site specifically nucleobase-labelled or hypermodified RNA with engineered thermophilic DNA polymerases
in Nature Communications
Gamage N
(2023)
Advanced Methods in Structural Biology
Kamel W
(2024)
Alphavirus infection triggers selective cytoplasmic translocation of nuclear RBPs with moonlighting antiviral roles.
in Molecular cell
Devlin A
(2023)
Analysis of Heparin Samples by Attenuated Total Reflectance Fourier-Transform Infrared Spectroscopy in the Solid State
in ACS Central Science
Levitz TS
(2022)
Approaches to Using the Chameleon: Robust, Automated, Fast-Plunge cryoEM Specimen Preparation.
in Frontiers in molecular biosciences
Royer C
(2022)
ASPP2 maintains the integrity of mechanically stressed pseudostratified epithelia during morphogenesis.
in Nature communications
Keown J
(2023)
Atomic structure of a nudivirus occlusion body protein determined from a 70-year-old crystal sample
in Nature Communications
Deimel L
(2024)
Author Correction: Covalent penicillin-protein conjugates elicit anti-drug antibodies that are clonally and functionally restricted
in Nature Communications
Fritzsche M
(2022)
Author Correction: Live microscopy: cracking the challenge to image biology unfolding in cells, tissues, and organs.
in Communications biology
Morimoto K
(2022)
Broad-range metalloprotease profiling in plants uncovers immunity provided by defence-related metalloenzyme.
in The New phytologist
Hudson D
(2023)
Can we predict T cell specificity with digital biology and machine learning?
in Nature Reviews Immunology
Chen X
(2023)
Carbon-Centered Radicals in Protein Manipulation.
in ACS central science
LuTheryn G
(2023)
Cationic Microbubbles for Non-Selective Binding of Cavitation Nuclei to Bacterial Biofilms.
in Pharmaceutics
Adjeroh DA
(2024)
Challenges in LncRNA Biology: Views and Opinions.
in Non-coding RNA
Fong I
(2023)
Chamelogator: A Software Tool for Chameleon Data Analysis
in Microscopy and Microanalysis
Alvarez-Borges F
(2022)
Comparison of Methods to Segment Variable-Contrast XCT Images of Methane-Bearing Sand Using U-Nets Trained on Single Dataset Sub-Volumes
in Methane
Nicholls D
(2023)
Compressive Cryo FIB-SEM Tomography
in Microscopy and Microanalysis
Khalid S
(2023)
Computational microbiology of bacteria: Advancements in molecular dynamics simulations
in Structure
Perdigão L
(2022)
Computing for Optimized Biological Microscopy Data Processing and Analysis at The Rosalind Franklin Institute
in Microscopy and Microanalysis
| Description | The Rosalind Franklin Institute phase 2 award covers the full scientific and research remit of this national institute. The award has taken the Institure through it's set up phase and into full operation, and has leveraged significant further funding for research, created new industry collaborations, and has seen the beginnings of an innovation and translation programme from our work. Our role is to create new techologies for life science. Within this phase 2 grant, we have pioneered the technique of cryo-epectron tomography, enabling the structures of biology to be seen within their biological context inside the cell, advanced physical sciences techniques into biology for the first time, and developed a world class laboratory for engineering biology which will bring precise control capabilities to the molecules of biology. The Institute has also been able to develop a sttdentship scheme, and now houses a cohort of ten stdents per year, in collabroation with Universities across the UK. |
| Exploitation Route | Our work can be translated into commercial products for imaging, or as theraputics. Our technolgies can be applied by academics or by industry to understand more about biological problems, and by working with instrument developers, new instruments are now on the market. |
| Sectors | Pharmaceuticals and Medical Biotechnology |
| URL | https://www.rfi.ac.uk/about/annual-reports/ |
| Description | The Franklin has a significant community and public engagement programme, linked both to the work of the institute broadly, and to specific research areas. Our work in public engagement includes a training programme availabe to all staff, created in collaboration with Science Made Simple, opportunities throughout the year to engage local schools, in partnership with the Education Business Partnership, and Citzen science programmes intrinsic to our research activity created with Zooniverse. Working closely woth industry has realised significant non academic impact, including in the bring to market of new instrumentation, leverage by the phase 2 and Wellcome funded Electirfying Life Sciences Grant (e.g. the commercial FIB SEM 'Arctis'), through core activity with Bruker, and with JEOL. Full details on our engagement and non academic impact is available in our annual reports from www.rfi.ac.uk. |
| First Year Of Impact | 2022 |
| Sector | Manufacturing, including Industrial Biotechology,Pharmaceuticals and Medical Biotechnology |
| Impact Types | Societal Economic |
| Description | Challenge reviewer and contributor to Nurse RDI |
| Geographic Reach | National |
| Policy Influence Type | Contribution to a national consultation/review |
| Impact | The RDI review will shape government policy. |
| URL | https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/1140... |
| Description | Structural Biology: From Molecules to Cells. |
| Amount | £159,340 (GBP) |
| Funding ID | 099683 |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 09/2012 |
| End | 09/2016 |
| Title | SINGLE DOMAIN ANTIBODIES THAT TARGET SARS-COV-2 |
| Description | The present invention relates to improved single domain antibodies that target SARS-CoV-2, multivalent polypeptides and fusion proteins comprising the single domain antibodies. The present invention also provides coronavirus binding molecules that bind two different epitopes on the receptor binding domain of a spike protein of a coronavirus. The coronavirus binding molecules are based on joining two antigen binding molecules together via a linker. The present invention provides the use of said single domain antibodies, multivalent polypeptides, fusion proteins and coronavirus binding molecules in treating and/or preventing coronavirus, as well as the use of said single domain antibodies, multivalent polypeptides, fusion proteins and coronavirus binding molecules in the detection and diagnosis of coronavirus using various methods, assays and kits. |
| IP Reference | WO2022053839 |
| Protection | Patent / Patent application |
| Year Protection Granted | 2022 |
| Licensed | Commercial In Confidence |
| Impact | The patent estate is in the final stages of agreement to licence. |
| Title | rosalindfranklininstitute/guanaco: |
| Description | No description provided. |
| Type Of Technology | Software |
| Year Produced | 2021 |
| Open Source License? | Yes |
| Impact | Shaping tomography practice |
| URL | https://zenodo.org/record/5185365 |
| Title | rosalindfranklininstitute/parakeet: |
| Description | Phantom generator |
| Type Of Technology | Software |
| Year Produced | 2022 |
| Open Source License? | Yes |
| Impact | Imported into major software packages |
| URL | https://zenodo.org/record/6493567 |
| Description | Media work for science media centre |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | I have supplied expert commentary on the pandemic and on science policy. |
| Year(s) Of Engagement Activity | 2020,2021,2022,2023 |
| URL | https://www.sciencemediacentre.org/?s=naismith&cat= |