University of Oxford Confidence in Concept – Round 7
Lead Research Organisation:
University of Oxford
Department Name: UNLISTED
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Technical Summary
The Confidence in Concept (CIC) scheme is a key part of MRC’s translational research strategy and provides annual awards to institutions to flexibly support a portfolio of early stage translational research projects. CIC is designed to accelerate the transition from discovery research to viable translational projects by supporting preliminary studies to establish proof-of-concept so that the approach will then become competitive for more substantial translational funding
People |
ORCID iD |
| Matthew Wood (Principal Investigator) |
Publications
Brook M
(2019)
New frontiers: cellular immunotherapy beyond cancer
in Cell and Gene Therapy Insights
Peddle CF
(2020)
CRISPR Interference-Potential Application in Retinal Disease.
in International journal of molecular sciences
Fry LE
(2020)
Promoter Orientation within an AAV-CRISPR Vector Affects Cas9 Expression and Gene Editing Efficiency.
in The CRISPR journal
Kantor A
(2020)
CRISPR-Cas9 DNA Base-Editing and Prime-Editing.
in International journal of molecular sciences
Alzhrani A
(2020)
Identification, selection, and expansion of non-gene modified alloantigen-reactive Tregs for clinical therapeutic use.
in Cellular immunology
Adigbli G
(2021)
Development of LT-HSC-Reconstituted Non-Irradiated NBSGW Mice for the Study of Human Hematopoiesis In Vivo.
in Frontiers in immunology
Beckett J
(2021)
Poor Antibody Responses to SARS-CoV-2 Infection or Vaccination Are Associated With High Re-Infection Rates in Haemodialysis and Renal Transplant Patients
in SSRN Electronic Journal
Mohseni YR
(2021)
Chimeric antigen receptor-modified human regulatory T cells that constitutively express IL-10 maintain their phenotype and are potently suppressive.
in European journal of immunology
Quinn J
(2021)
Genome-Editing Strategies for Treating Human Retinal Degenerations.
in Human gene therapy
Kaiser D
(2021)
Freezing Medium Containing 5% DMSO Enhances the Cell Viability and Recovery Rate After Cryopreservation of Regulatory T Cell Products ex vivo and in vivo.
in Frontiers in cell and developmental biology
Hoogduijn MJ
(2021)
Cellular therapies in organ transplantation.
in Transplant international : official journal of the European Society for Organ Transplantation
Hennessy C
(2021)
Recent advances in our understanding of the allograft response
in Faculty Reviews
Issa F
(2021)
The Fourth International Workshop on Clinical Transplant Tolerance.
in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Kantor A
(2021)
CRISPR genome engineering for retinal diseases.
in Progress in molecular biology and translational science
Stark HL
(2021)
Immune Monitoring for Advanced Cell Therapy Trials in Transplantation: Which Assays and When?
in Frontiers in immunology
Fry LE
(2021)
Analysis of Pathogenic Variants Correctable With CRISPR Base Editing Among Patients With Recessive Inherited Retinal Degeneration.
in JAMA ophthalmology
Bottomley MJ
(2022)
Towards regulatory cellular therapies in solid organ transplantation.
in Trends in immunology
Zamora M
(2022)
DyNeuMo Mk-1: Design and pilot validation of an investigational motion-adaptive neurostimulator with integrated chronotherapy.
in Experimental neurology
Issa F
(2022)
Editorial: Regulatory T Cells
in Frontiers in Cell and Developmental Biology
Pilat N
(2022)
Joining Forces in Basic Science: ITS Meeting 2.0.
in Transplant international : official journal of the European Society for Organ Transplantation
VanDyke D
(2022)
Engineered human cytokine/antibody fusion proteins expand regulatory T cells and confer autoimmune disease protection.
in Cell reports
Staurenghi F
(2022)
Minicircle Delivery to the Neural Retina as a Gene Therapy Approach.
in International journal of molecular sciences
Leng H
(2022)
Modulating glycosphingolipid metabolism and autophagy improves outcomes in pre-clinical models of myeloma bone disease.
in Nature communications
| Description | BRAINSTATE - To develop the DyNeuMo device for use in minimally conscious state (Alex Green) |
| Amount | £697,119 (GBP) |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 07/2022 |
| End | 07/2025 |
| Description | Developing CRISPR delivery strategies for the treatment of inherited retinal diseases |
| Amount | £60,000 (GBP) |
| Organisation | The Royal College of Surgeons of Edinburgh |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 09/2020 |
| End | 09/2021 |
| Description | ReSHAPE |
| Amount | £151,875 (GBP) |
| Funding ID | 825392 |
| Organisation | European Commission H2020 |
| Sector | Public |
| Country | Belgium |
| Start | 01/2019 |
| End | 12/2023 |
| Description | UCB Pharma |
| Organisation | UCB SA |
| Department | UCB Pharma |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | The key preliminary data generated by this project has been used to successfully negotiate a new partnership with our industrial collaborator UCB Pharma |
| Collaborator Contribution | providing antibody production to take place with no associated costs required from Oxford. |
| Impact | n/k |
| Start Year | 2022 |
| Title | MODULATING WAKEFULNESSS AND AROUSAL |
| Description | Arousal of a patient is enhanced and wakefulness modulated by neurostimulation. Bioelectrical activity of the nervous system of the patient is monitored and characteristics of the monitored bioelectrical activity associated with a state of reduced arousal and/or wakefulness are detected. In response to such characteristics, stimulation signals selected to arouse the patient are generated and supplied to stimulation transducers to stimulate a neural network of a patient associated with arousal. |
| IP Reference | WO2022200814 |
| Protection | Patent / Patent application |
| Year Protection Granted | 2022 |
| Licensed | No |
| Impact | NK |
| Description | Experts in Residence meeting with Astra Zeneca |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Industry/Business |
| Results and Impact | The purpose of the session was to discuss the longer term translational implications of the project via the experts in residence scheme. A wealth of information was transmitted to our research team on the validation routes for the project and how to consolidate the engagement and the collaboration prospects on this award. |
| Year(s) Of Engagement Activity | 2020 |
| Description | Industry engagement activities with Kymab / Sanofi |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | The project team has been discussing a collaboration project with Kymab / Sanofi. |
| Year(s) Of Engagement Activity | 2020 |
| Description | Industry engagement activities with UCB Pharma - (Alison Simmons) |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Industry/Business |
| Results and Impact | Discussing potential licensing agreement, pending data from larger sets of efficacy studies and safety/toxicology profiling of our monoclonal antibodies. |
| Year(s) Of Engagement Activity | 2021 |