The Kiang West Longitudinal Population Survey
Lead Research Organisation:
London School of Hygiene and Tropical Medicine
Department Name: UNLISTED
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Technical Summary
To enhance the value and use of the KWLPS1, this grant has two work packages:
1) To reconsent all traceable subjects from among the 12,500 who donated plasma, DNA, urine samples and personal data to the Keneba BioBank (a component of KWLPS). This is to bring consent documents better in to line with best practice as promulgated by H3Africa, and to seek explicit consent to send DNA to commercial entities (initially the Regeneron Genetics Centre (RGC) who will exome sequence all available consented samples and whole-genome sequence a subset of 5000 at their expense).
2) Generation of long-read genetic and epigenetic sequencing data for enhanced molecular characterisation of participants from two key KWLPS cohorts. Research based on the KWLPS has recently generated world-leading insights into the effects of a mother’s periconceptional nutritional status on the epigenetic programming (methylation patterns) of the very early human embryo. Through this grant, we will whole (epi)genome sequence stored DNA from an additional 400 deeply-phenotyped infants using 3rd generation Nanopore PromethION technology recently introduced to our Genetics Platform at MRCG. This will constitute a major step forward and allow further interrogation of these fundamental biological mechanisms that we have demonstrated have implications for life-long health.
1) To reconsent all traceable subjects from among the 12,500 who donated plasma, DNA, urine samples and personal data to the Keneba BioBank (a component of KWLPS). This is to bring consent documents better in to line with best practice as promulgated by H3Africa, and to seek explicit consent to send DNA to commercial entities (initially the Regeneron Genetics Centre (RGC) who will exome sequence all available consented samples and whole-genome sequence a subset of 5000 at their expense).
2) Generation of long-read genetic and epigenetic sequencing data for enhanced molecular characterisation of participants from two key KWLPS cohorts. Research based on the KWLPS has recently generated world-leading insights into the effects of a mother’s periconceptional nutritional status on the epigenetic programming (methylation patterns) of the very early human embryo. Through this grant, we will whole (epi)genome sequence stored DNA from an additional 400 deeply-phenotyped infants using 3rd generation Nanopore PromethION technology recently introduced to our Genetics Platform at MRCG. This will constitute a major step forward and allow further interrogation of these fundamental biological mechanisms that we have demonstrated have implications for life-long health.
Publications
Braithwaite Vickie S.
(2021)
Antenatal iron supplementation, FGF23, and bone metabolism in Kenyan women and their offspring: secondary analysis of a randomized controlled trial
in AMERICAN JOURNAL OF CLINICAL NUTRITION
Mertens A
(2023)
Causes and consequences of child growth faltering in low-resource settings.
in Nature
Mertens A
(2023)
Child wasting and concurrent stunting in low- and middle-income countries.
in Nature
Benjamin-Chung J
(2023)
Author Correction: Early-childhood linear growth faltering in low- and middle-income countries.
in Nature
Caffé B
(2023)
Human milk immune factors, maternal nutritional status, and infant sex: The INSPIRE study.
in American journal of human biology : the official journal of the Human Biology Council
Benjamin-Chung J
(2023)
Early-childhood linear growth faltering in low- and middle-income countries
in Nature
Mertens A
(2023)
Author Correction: Child wasting and concurrent stunting in low- and middle-income countries.
in Nature
Lechner L
(2023)
Early-set POMC methylation variability is accompanied by increased risk for obesity and is addressable by MC4R agonist treatment.
in Science translational medicine
Issarapu P
(2023)
DNA methylation at the suppressor of cytokine signaling 3 (SOCS3) gene influences height in childhood
in Nature Communications
Mohammed NI
(2023)
Quantifying excess mortality during the COVID-19 pandemic in 2020 in The Gambia: a time-series analysis of three health and demographic surveillance systems.
in International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
Nacis JS
(2024)
Barriers and enablers to the effective implementation of omics research in low- and middle-income countries.
in Nature biotechnology
Moore S
(2024)
Improving infant Neurocognitive Development and Growth Outcomes with micronutrients (INDiGO): A protocol for an efficacy trial in rural Gambia
in Wellcome Open Research
Shaver JH
(2024)
Religious Involvement Is Associated With Higher Fertility and Lower Maternal Investment, but More Alloparental Support Among Gambian Mothers.
in American journal of human biology : the official journal of the Human Biology Council
Bonell A
(2024)
Effect of heat stress in the first 1000 days of life on fetal and infant growth: a secondary analysis of the ENID randomised controlled trial.
in The Lancet. Planetary health
Ahmed AN
(2024)
Human-animal contact to inform zoonotic disease risk across gradients of agricultural land use change in the Central River Region (CRR) of The Gambia (ZooContact): a formative study.
in Frontiers in public health
Spake L
(2024)
A practical guide to cross-cultural and multi-sited data collection in the biological and behavioural sciences.
in Proceedings. Biological sciences
Yeung E
(2024)
Maternal age is related to offspring DNA methylation: A meta-analysis of results from the PACE consortium.
in Aging cell
Rangel Bousquet Carrilho T
(2024)
The Impact of Excluding Adverse Neonatal Outcomes on the Creation of Gestational Weight Gain Charts Among Women from Low- and Middle-income Countries with Normal and Overweight BMI
in The American Journal of Clinical Nutrition
| Description | FANUS Council |
| Geographic Reach | Africa |
| Policy Influence Type | Participation in a guidance/advisory committee |
| Impact | FANUS is the overall supervisory body for all African Nutrition Societies |
| URL | https://www.fanus.org/ |
| Description | IUNS Council |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Participation in a guidance/advisory committee |
| Impact | IUNS is the governing body for all National Nutrition Societies and thereby influences governance and outputs |
| URL | https://iuns.org/ |
| Description | WHO Consultation on Risk Stratified Care |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Participation in a guidance/advisory committee |
| Impact | We are refining guidelines for WHO to update their recommendations around risk-stratified patient care. |
| Description | LPS Enhancement |
| Amount | £475,000 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 12/2021 |
| End | 03/2022 |
| Description | DEEP - Diverse Epigenetic Epidemiology Partnership |
| Organisation | University of Bristol |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Co-applicants with Drs Hannah Elliott and Josine Min at Bristol and Prof Giriraj Chandak at CCMB Hyderabad |
| Collaborator Contribution | Contribution of conceptual inputs, epigenetic data and bioinformatics. |
| Impact | https://www.deep-epigenetics.org |
| Start Year | 2024 |
| Description | Harnessing DNA methylation variation between populations to understand disease discordance across ancestries (MR/X021599/1) |
| Organisation | University of Bristol |
| Department | MRC Integrative Epidemiology Unit |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Provision of samples, data and analysis |
| Collaborator Contribution | Generated grant idea and obtained funding |
| Impact | none yet |
| Start Year | 2023 |
| Description | ICHoR |
| Organisation | London School of Hygiene and Tropical Medicine (LSHTM) |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Active participation as one of 2 research sites. |
| Collaborator Contribution | Prpf Perel at LSHTM and Prpf Etiang from KEMRI are CO-Is and initiated the funding application to NIHR. |
| Impact | Training programme delivered. Research under way. |
| Start Year | 2022 |
| Description | Numerous collaborations and data contributions to meta-analyses, GWAS and EWAS studies |
| Organisation | London School of Hygiene and Tropical Medicine (LSHTM) |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | The KWLPS encourages access to our longitudinal data for secondary data analysis and has many outputs (listed in publications) |
| Collaborator Contribution | We have contributed data and samples to numerous national and international studies. Notable recent examples include the Gates Knowledge Integration analysis of longitudinal growth published din 3 Nature papers, our contributions to the Gestational Weight Gain project with numerous meta-analysed outputs, data contribution to the Global Cardiovascular Risk Consortium, to the ICHoR study and to several pan-African GWAS analysis and global EWAS analyses (PACE Consortium). |
| Impact | Listed under publications |
| Start Year | 2020 |
| Description | Multiple engagements nationally (with government stakeholders) and internationally with collaborating institutions |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Multiple engagements with local government (health) stakeholders and international collaborators |
| Year(s) Of Engagement Activity | 2020 |