Centre for Integrative Physiology and Pharmacology at Imperial
Lead Research Organisation:
Imperial College London
Department Name: Dept of Medicine
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
People |
ORCID iD |
| Julia Buckingham (Principal Investigator) |
Publications
Buckingham J
(2012)
An agenda for UK clinical pharmacology: Integrating pharmacology and clinical pharmacology in universities
in British Journal of Clinical Pharmacology
Lyon AR
(2012)
Plasticity of surface structures and ß(2)-adrenergic receptor localization in failing ventricular cardiomyocytes during recovery from heart failure.
in Circulation. Heart failure
Leinster DA
(2012)
The peritoneal tumour microenvironment of high-grade serous ovarian cancer.
in The Journal of pathology
Abuirmeileh A
(2012)
Exendin-4 treatment enhances L-DOPA evoked release of striatal dopamine and decreases dyskinetic movements in the 6-hydoxydopamine lesioned rat.
in The Journal of pharmacy and pharmacology
Phillips JE
(2012)
Bleomycin induced lung fibrosis increases work of breathing in the mouse.
in Pulmonary pharmacology & therapeutics
Fenske WK
(2012)
Exogenous peptide YY3-36 and Exendin-4 further decrease food intake, whereas octreotide increases food intake in rats after Roux-en-Y gastric bypass.
in International journal of obesity (2005)
Hill NE
(2012)
Ghrelin, appetite and critical illness.
in Current opinion in critical care
Gavins F
(2012)
Leukocyte recruitment in the brain in sepsis: involvement of the annexin 1-FPR2/ALX anti-inflammatory system
in The FASEB Journal
McGavigan AK
(2012)
Gut hormones: the future of obesity treatment?
in British journal of clinical pharmacology
Sam AH
(2012)
Selective ablation of peptide YY cells in adult mice reveals their role in beta cell survival.
in Gastroenterology
Raemdonck K
(2012)
A role for sensory nerves in the late asthmatic response.
in Thorax
Birrell M
(2012)
Selectivity profiling of the novel EP 2 receptor antagonist, PF-04418948, in functional bioassay systems: atypical affinity at the guinea pig EP 2 receptor
in British Journal of Pharmacology
Andreu N
(2012)
Rapid measurement of antituberculosis drug activity in vitro and in macrophages using bioluminescence.
in The Journal of antimicrobial chemotherapy
Hankir M
(2012)
Increased energy expenditure in gastric bypass rats is not caused by activated brown adipose tissue.
in Obesity facts
Hameed AG
(2012)
Inhibition of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) reverses experimental pulmonary hypertension.
in The Journal of experimental medicine
Wojciak-Stothard B
(2012)
Role of RhoB in the regulation of pulmonary endothelial and smooth muscle cell responses to hypoxia.
in Circulation research
Grace MS
(2012)
TRP channel antagonists as potential antitussives.
in Lung
Boughton CK
(2013)
Can neuropeptides treat obesity? A review of neuropeptides and their potential role in the treatment of obesity.
in British journal of pharmacology
Boughton CK
(2013)
Neuromedin B stimulates the hypothalamic-pituitary-gonadal axis in male rats.
in Regulatory peptides
Lynskey NN
(2013)
RocA truncation underpins hyper-encapsulation, carriage longevity and transmissibility of serotype M18 group A streptococci.
in PLoS pathogens
Parker JA
(2013)
Glucagon and GLP-1 inhibit food intake and increase c-fos expression in similar appetite regulating centres in the brainstem and amygdala.
in International journal of obesity (2005)
Hughes EL
(2013)
Role and interactions of annexin A1 and oestrogens in the manifestation of sexual dimorphisms in cerebral and systemic inflammation.
in British journal of pharmacology
Gates KL
(2013)
Hypercapnia impairs lung neutrophil function and increases mortality in murine pseudomonas pneumonia.
in American journal of respiratory cell and molecular biology
Alam FM
(2013)
Non-invasive monitoring of Streptococcus pyogenes vaccine efficacy using biophotonic imaging.
in PloS one
Kinsey-Jones JS
(2014)
Quantification of rat kisspeptin using a novel radioimmunoassay.
in PloS one
Beale KE
(2014)
The physiological role of arcuate kisspeptin neurons in the control of reproductive function in female rats.
in Endocrinology
Wojciak-Stothard B
(2014)
Aberrant chloride intracellular channel 4 expression contributes to endothelial dysfunction in pulmonary arterial hypertension.
in Circulation
Basharat S
(2014)
Leptin fails to blunt the lipopolysaccharide-induced activation of the hypothalamic-pituitary-adrenal axis in rats.
in The Journal of endocrinology
Iannone L
(2014)
miR-21/DDAH1 pathway regulates pulmonary vascular responses to hypoxia.
in The Biochemical journal
Agahi A
(2014)
Models and strategies in the development of antiobesity drugs.
in Veterinary pathology
Zac-Varghese S
(2014)
The Peutz-Jeghers kinase LKB1 suppresses polyp growth from intestinal cells of a proglucagon-expressing lineage in mice.
in Disease models & mechanisms
McGowan BM
(2014)
Relaxin-3 stimulates the neuro-endocrine stress axis via corticotrophin-releasing hormone.
in The Journal of endocrinology
Moreland NJ
(2014)
Working towards a group A streptococcal vaccine: report of a collaborative Trans-Tasman workshop.
in Vaccine
Francis BN
(2014)
Effects of tetrahydrobiopterin oral treatment in hypoxia-induced pulmonary hypertension in rat.
in Pulmonary circulation
Psichas A
(2014)
The short chain fatty acid propionate stimulates GLP-1 and PYY secretion via free fatty acid receptor 2 in rodents
in International Journal of Obesity
Lynskey NN
(2015)
Rapid Lymphatic Dissemination of Encapsulated Group A Streptococci via Lymphatic Vessel Endothelial Receptor-1 Interaction.
in PLoS pathogens
Murphy KG
(2015)
Editorial overview: Endocrine and metabolic diseases: Waistline weapons: new therapeutic avenues for the treatment of obesity and metabolic disease.
in Current opinion in pharmacology
Boateng EK
(2015)
Heterogeneous responses of dorsal root ganglion neurons in neuropathies induced by peripheral nerve trauma and the antiretroviral drug stavudine.
in European journal of pain (London, England)
Lamb L
(2015)
The effect of trauma on invasive group A streptococcal disease.
in Lancet (London, England)
Reglinski M
(2015)
Identification of the Streptococcus pyogenes surface antigens recognised by pooled human immunoglobulin.
in Scientific reports
Kinsey-Jones JS
(2015)
GPRC6a is not required for the effects of a high-protein diet on body weight in mice.
in Obesity (Silver Spring, Md.)
Birrell MA
(2015)
The role of adenylyl cyclase isoform 6 in ß-adrenoceptor signalling in murine airways.
in British journal of pharmacology
McGavigan AK
(2015)
L-cysteine suppresses ghrelin and reduces appetite in rodents and humans.
in International journal of obesity (2005)
Hill NE
(2015)
Detailed characterization of a long-term rodent model of critical illness and recovery.
in Critical care medicine
| Description | As described in previous responses, the programme was responsible for training a number of MRes and PhD students in in vivo skills, and supporting in vivo training, and the careers of researchers working within in vivo research. |
| Exploitation Route | The students trained have gone on to many different careers, including within academic science and industry. The research findings made have contributed significantly to the literature in a number of fields, which have been built on by other researchers. |
| Sectors | Agriculture Food and Drink Education Healthcare Pharmaceuticals and Medical Biotechnology |
| Description | The major aim of the centre was to train young scientists to perform the physiological and pharmacological studies needed to understand the functions of genes, identify new drug targets and biomarkers, explore the pharmacokinetic properties of novel drugs and to facilitate the development of new medicines. The training programmes associated with the Centre trained 48 students to MRes level in such skills, and at least 30 subsequently began PhD training. In addition, the research staff associated with the Centre have continued to be promoted, make new findings and to train their own teams in in vivo techniques. |
| First Year Of Impact | 2012 |
| Sector | Agriculture, Food and Drink,Education,Healthcare,Pharmaceuticals and Medical Biotechnology |
| Impact Types | Societal Economic |
| Description | MRC clinical research fellowship (Anjali Amin). 'Role of T1R1/T1R3 in satiety' 2013-2016 |
| Amount | £294,000 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 02/2013 |
| End | 06/2016 |
| Description | NC3Rs grant |
| Amount | £270,000 (GBP) |
| Funding ID | G0800720/1 |
| Organisation | National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs) |
| Sector | Public |
| Country | United Kingdom |
| Start | |
| Description | Reduction and refinement of murine models of bacterial infection |
| Amount | £270,000 (GBP) |
| Funding ID | G0800720/1 |
| Organisation | National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs) |
| Sector | Public |
| Country | United Kingdom |
| Start | 01/2009 |
| End | 12/2011 |
| Description | Animals in research workshop |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Postgraduate students |
| Results and Impact | Developed and delivered a workshop on the use of animals in research - with examples of how animals are used for PhD work as well as using daphnia to model changes in heart rate from exposure to different chemicals. |
| Year(s) Of Engagement Activity | 2016 |
| Description | Cheltenham Science Festival |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | CIMPP received a grant from the Society for Endocrinology to put on demonstrations at the Cheltenham Science Festival (June 2012). The students (Ellie Hughes, Helen Smith, Renee Schalks, Katherine Banks and Paul Holloway) created ways to present emotions, attraction, appetite and exercise in a programme entitled, 'How Are Your Hormones'. Hundreds of children and adults participated. |
| Year(s) Of Engagement Activity | 2012 |
| Description | Combat my Cough |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Patients, carers and/or patient groups |
| Results and Impact | Event to keep our patients up to date with the work we are doing in our clinic and through our research to find a cure for chronic cough. The event provoked questions and discussion, and patients suggesting they would change behaviours. |
| Year(s) Of Engagement Activity | 2013,2014,2015,2016 |
| URL | https://www.combatmycough.com/events |
| Description | Combat my Cough - Manchester |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Patients, carers and/or patient groups |
| Results and Impact | Presentation explaining our research to a group of chronic cough patients from a specialist cough clinic in Manchester. |
| Year(s) Of Engagement Activity | 2016 |
| URL | https://www.combatmycough.com/events |
| Description | Symposium (Animal Models and their Value in Predicting Drug Efficacy and Toxicity) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | A two day symposium (Animal Models and their Value in Predicting Drug Efficacy and Toxicity, hosted jointly by the CIMPP, King's and New York Academy of Science) attracted approx 200 delegates from academia, pharma and regulatory bodies; discussions were lively and emphasised (a) the importance of scientists informing their studies with a better understanding of disease complexity (reverse translation) and (b) bias in the literature resulting from difficulties of publishing 'negative data' from well designed studies. |
| Year(s) Of Engagement Activity | 2011 |
| Description | Talk at MRC Asthma Centre - "Environmental asthma triggers and sensory irritation in the airway: contribution to the asthma phenotype" (September 2016) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Talk on current research |
| Year(s) Of Engagement Activity | 2016 |
| Description | The Science Museum's Dana Centre, London |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | A series of public discussions at the Science Museum's Dana Centre was organised in 2011/12. Speakers (including students) from CIMPP talked openly about animal research in context with wider health issues such as neurodegeneration. In two events (Greying Matters and Brain Evolution) students put on displays and talked informally to the audience about their research. No Pain, No Gain Breathless Fat of the Land Greying Matters (in collaboration with the Society for Immunology) Magic of Medicine (with the British Pharmacological Society) Brain Evolution (with the British Neuroscience Association) |
| Year(s) Of Engagement Activity | 2011 |
| Description | Workshop on the use of animals in research |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Developed and delivered a workshop on the use of animals in research - with examples of how animals are used for PhD work as well as using daphnia to model changes in heart rate from exposure to different chemicals. |
| Year(s) Of Engagement Activity | 2016 |