Neutralising the harmful effects of dental biofilms by bacterial replacement therapy
Lead Participant:
NCIMB LIMITED
Abstract
Dental caries is a widespread oral disease that is costly for health services to treat, and causes pain and loss of
teeth to those affected. It is caused by production of acid by oral bacteria in biofilms on the teeth and gums
commonly known as dental plaque. Brushing teeth can reduce this problem, but many people do not do so
regularly or thoroughly. This project will investigate the application of bacterial replacement therapy in the
form of a lozenge containing a suitable probiotic strain to help develop an anti-caries environment within the
dental plaque biofilm. The project will combine the strengths of two UK SMEs, a world class culture collection
centre and a leading probiotics manufacturer. The project will investigate strains held within the NCIMB culture
collection for their potential to create novel biofilms to combat dental caries..
teeth to those affected. It is caused by production of acid by oral bacteria in biofilms on the teeth and gums
commonly known as dental plaque. Brushing teeth can reduce this problem, but many people do not do so
regularly or thoroughly. This project will investigate the application of bacterial replacement therapy in the
form of a lozenge containing a suitable probiotic strain to help develop an anti-caries environment within the
dental plaque biofilm. The project will combine the strengths of two UK SMEs, a world class culture collection
centre and a leading probiotics manufacturer. The project will investigate strains held within the NCIMB culture
collection for their potential to create novel biofilms to combat dental caries..
Lead Participant | Project Cost | Grant Offer |
---|---|---|
NCIMB LIMITED | £69,894 | £ 48,926 |
  | ||
Participant |
||
PROBIOTICS INTERNATIONAL LTD | £29,811 | £ 17,887 |
MAGNA PARVA LIMITED |
People |
ORCID iD |
Carol Phillips (Project Manager) |