Development of new tools for genetic selection for a sustainable poultry industry (CHIPSUS)

Lead Research Organisation: University of Edinburgh
Department Name: The Roslin Institute

Abstract

UK public policy is demanding reductions in greenhouse gas emissions and ammonia to meet international targets. In poultry breeding there is a need to maintain competitiveness, and to reduce costs arising from wastage of feed and non-productive birds. Addressing these breeding goals implicates traits such as feed conversion ratio, fertility, performance in commercial traits, and liveability associated with disease resistance and animal welfare. It is these same traits that affect greenhouse gas and ammonia emissions per kilogram of product in broilers or layers. Life Cycle Assessment (LCA) of the impact of broiler production on the environment suggests feed accounts for 80% of supply chain energy use, 82% of greenhouse gas emissions, 98% of ozone depleting emissions, and 96% of acidify and eutrophying gases. In contrast, farm inputs and emissions, mostly from heating and ventilation, only contribute towards these impacts to only a minor degree. Such a breeding goals with this combination of traits has proven difficult to improve through standard trait recording; with sex and age limitations, low heritability and costs of measurement all contributing barriers to progress. Recent developments in DNA technology promise to overcome these barriers, in particular in high throughput processing of dense single nucleotide polymorphisms (SNP). Concurrently, the idea of genomic selection has emerged, in which dense marker information is used primarily as a predictor of the whole breeding value. Progress in developing genomic selection in poultry is hampered by the need to develop and implement a dense and relevant chicken genotyping chip assay, based upon an extensive catalogue of SNP variants. To develop this requires a new research initiative, as proposed here. The overall aim of this project is to develop and implement sustainable evaluation and selection tools using a genome-wide chicken SNP panel and in so doing accelerate the reduction in greenhouse gas and ammonia emissions in the UK and worldwide, and provide the route map and key tools for the whole sector to follow. This will be achieved through five tasks: (i) create a database of genomic variation within and between poultry breeds by high throughput sequence analysis of DNA samples; (ii) design and validate a novel, high-throughput genotyping assay; (iii) genotype broilers with well characterised EBVs for relevant traits; (iv) develop and validate genomic predictors, and (v) optimise methods to implement these tools into the breeding system. The direct benefits of this project lie in the reduction of greenhouse gas potential and ammonia per unit product in poultry, maintaining the competitiveness of the UK industry, and in the improvement of animal welfare through increased liveability, but also opportunities will be created for releasing grain and associated land for other purposes through the improvement of FCR. The acceleration of genetic gain is anticipated to be of the order of 20 to 40% depending on the trait. Benefits accrued by genetic selection will be permanent and accumulate over time, and are achieved at low risk.

Technical Summary

Our current understanding of the genetic variation in the chicken genome is mostly based on between-line comparisons. Yet, it is within-line variation that is crucial for genetic improvement in commercial poultry. Therefore in this project we will expand this resource to encompass extensive polymorphisms within breeds. Whilst this will provide a larger catalogue of SNP for chip design, the power of genomic selection also depends critically upon the properties of the marker set, for example, spacing of markers, allele frequency and level of inter-marker association due to linkage disequilibrium. Therefore we will finalise the design of the 500K SNP panel in the light of this information to maximise its utility for genotyping within/between lines. The accuracy, and hence the value of trait information depends on N*h2, where N is the number of individuals with records and h2 is a measure of the genetic accuracy of these records. Therefore we will develop genomic predictors for specific traits by genotyping, with the new 500K panel, 1000's of individuals with highly accurate breeding values as a training set. These genomic predictors will be validated and their accuracy estimated for selection of both target traits and potential undesired correlated responses. The final part of this project will explore the optimisation of breeding procedures for its implementation into commercial operations. We will consider the use of the technology both to more accurately achieve current breeding goals, with their positive impact on greenhouse gas emissions, and expand these goals with further environmental benefits. This consideration of genetic gain will account for undesirable consequences, including animal welfare, the costs of recording and genotyping strategies. It will also need to be translated into commercial gain and environmental impacts over time, in the UK and globally, using the multi-billion multiplication that is possible in the poultry sector in the UK and globally.

Planned Impact

Summary of Potential Impacts of Research Programme relevant to BBSRC mission Resources generated will have a major impact on avian genetics throughout the world. For example, the tools to genotype over 500,000 genetic markers with known map location and allele frequencies from a database of possibly 20 million SNPs from a diverse set of chicken breeds will change forever our approach for mapping genes that control traits in experimental lines. These may be lines with differences in (i) disease resistance, and so will contribute towards our understanding of host-pathogen interactions, or (ii) physiology, animal behaviour or metabolic disease. Farming/Agricultural/Verterinary communities: This project will provide information on 100,000's of genetic markers of great utility and the cheap, rapid assay to genotype them in a timely manner. This project will provide a practical route to implement genome selection, where in principle, all genetic variation in the genome for a given trait can be utilised. This approach is expected to revolutionise the way we breed animals in both the poultry and other livestock sectors. For the farmer and poultry producer we can expect new products, decreased costs and increased competiveness on a global scale. We can also expect for traits such as feed efficiency to have a reduced impact on the environment and land use. Stakeholders and Policy Makers: UK-based government bodies such as DEFRA, BBSRC and FSA will be better informed on the latest progress in genome wide applications such as genome sequencing, genotyping and genome selection in poultry and other livestock species. In addition they will have access to new tools and approaches to solve national problems, such as impact of poultry industry on the climate and environment (gas emission and land use), welfare of animals (genetic solutions), susceptibility to infectious disease (genetic solution) and human health (contamination of food by pathogens). General Public: Consumers are demanding safe food that is produced cost-effectively from animals maintained in a welfare-friendly environment. They are also demanding an industry with minimal impact on the climate and land use. This project will achieve these aims through the creation and application of novel genetic selection tools capable of acting on traits (e.g. feed efficiency, animal welfare, disease susceptibility and fertility) that have an impact in these areas. Communications and Engagement: Initially, the grant will be announced in the UK and overseas via our Public Relations Departments who will highlight the research through local media and publications. The research will be showcased to academics and industry at national and international meetings. Data and tools from the research will be made publicly available via the Affymetrix web site and public databases at EBI (Ensembl) and NCBI (dbSNP). Exploitation and Application: Consortium IP will be organised based on the collaboration agreement. University of Edinburgh will exploit outcomes, through training opportunities, projects based upon putative QTL and scientific publications. The implementation of the results will give public benefit through enhancement of production efficiency and reduced greenhouse gas emissions, which will be treated as a new trait for selection within the poultry industry. Further public/poultry sector exploitation arises from (i) a greatly extended open access catalogue of SNPs with greater industrial utility (the current resources only address between breed variation based on limited sequence data and our proposal is to expand this greatly to assess within breed variation - the raw material for genetic gain in poultry breeding), (ii) a 500K SNP genotyping chip assay for open use, which will facilitate the comparison of data world-wide and (iii) a route map for the poultry sector to gain from the experience of the Consortium in the use of genome selection.
 
Description BBSRC-CASE-HyLine Evolution and diversity of endogenous retroviral (ERVs) genomes in chicken
Amount £100,000 (GBP)
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 09/2013 
End 09/2017
 
Description BBSRC-HyLine: Genome-wide mapping and identification of genes controlling resistance to Marek's disease in commercial layer chickens
Amount £1,000,000 (GBP)
Funding ID BB/K006916/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 04/2013 
End 04/2017
 
Description ESF Exchange Grant
Amount £30,000 (GBP)
Organisation European Commission 
Sector Public
Country European Union (EU)
Start 04/2012 
End 06/2013
 
Description ESF Exchange Grant
Amount £30,000 (GBP)
Organisation European Commission 
Sector Public
Country European Union (EU)
Start 04/2012 
End 06/2013
 
Description The national avian resource facility (NARF)
Amount £1,242,000 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2012 
End 01/2016
 
Description This project integrates bioinformatics and genomics approaches to characterise the genetic variation in selected lines of chickens
Amount £100,000 (GBP)
Organisation CIMB Foundation 
Sector Private
Country Malaysia
Start 04/2013 
End 04/2016
 
Description This project integrates bioinformatics and genomics approaches to characterise the genetic variation in selected lines of chickens
Amount £100,000 (GBP)
Organisation CIMB Foundation 
Sector Private
Country Malaysia
Start 04/2013 
End 10/2016
 
Description visiting research fellowship from CNPq
Amount £60,000 (GBP)
Organisation National Council for Scientific and Technological Development (CNPq) 
Sector Public
Country Brazil
Start 09/2012 
End 09/2013
 
Description visiting research fellowship from CNPq
Amount £60,000 (GBP)
Organisation National Council for Scientific and Technological Development (CNPq) 
Sector Public
Country Brazil
Start 09/2012 
End 09/2013
 
Title chicken genomic DNA validation set 
Description A set of genomic DNAs used for validation of SNPs was isolated and tested on 1.8 million putative SNPs. This validation set consists of an independent set of 282 individuals including 32 trio samples from three broiler lines, four WEL lines, five BEL lines and 26 individuals from a wide range of diverse traditional breeds of chicken. 
Type Of Material Cell line 
Year Produced 2013 
Provided To Others? Yes  
Impact Used to validate SNPs used to create 600K HD chicken chip, now used by labs internationally by academics and industry. 
 
Title pre-screening chicken HD chips 
Description Created a prototype 3x600K genotyping array based on 1.8 million putative SNPs. Tested these arrays on 282 DNA samples and defined 1.1 million validated SNPs for future use in the production 600K chip. 
Type Of Material Technology assay or reagent 
Year Produced 2013 
Provided To Others? Yes  
Impact Used to validate SNPs used to create 600K HD chicken chip, now used by labs internationally by academics and industry. 
 
Title sequenced genomic DNA from 24 chicken lines 
Description Genomic DNA isolated and sequenced from 243 chickens from 24 chicken lines derived from diverse sources (experimental, commercial broiler and layer lines) by pooling 10?15 samples within each line. 
Type Of Material Model of mechanisms or symptoms - in vitro 
Year Produced 2013 
Provided To Others? Yes  
Impact Used to create 600K HD chicken chip, now used by labs internationally by academics and industry. 
 
Title use of chicken 600K HD array for characterisation of genetic organisation 
Description Using this 600K high density chicken whole genome genotyping array we developed methods for characterisation of population structure/sub-structure, genome-wide selection and genome-wide association studies. 
Type Of Material Technology assay or reagent 
Year Produced 2013 
Provided To Others? Yes  
Impact Used to validate SNPs used to create 600K HD chicken chip, now used by labs internationally by academics and industry. 
 
Title Affymetrix web site for chicken SNP and 600K chips 
Description The information specific to the 600K chip has been made available from the Affymetrix web site www.affymetix.com/genotyping. 
Type Of Material Database/Collection of data 
Year Produced 2013 
Provided To Others? Yes  
Impact academic and industry applications 
 
Title NARF web site 
Description The information specific to the 600K chip has been made available from the NARF http://www.narf.ac.uk/. 
Type Of Material Database/Collection of data 
Year Produced 2014 
Provided To Others? Yes  
Impact research 
 
Title catalogue of putative chicken SNPs 
Description These sequences were used to detect 41 million putative Single Nucleotide Polymorphism (SNP) variants. The position and characteristics of these SNPs are stored in a central database to be made available through the NARF web site. 
Type Of Material Database/Collection of data 
Year Produced 2013 
Provided To Others? No  
Impact No actual impacts realised to date 
 
Title characterised 15 million SNP data set for modern day chicken lines 
Description During the project 15 million SNPs and 1 million indels were also defined. These represent 95% of genetic variation in modern poultry with MAF > 5%. These functional affects, if any, have been defined for these variants. They represent a valuable resource for the definition of causal variants in simple and complex traits in modern poultry. 
Type Of Material Database/Collection of data 
Year Produced 2015 
Provided To Others? Yes  
Impact further research 
 
Title characterised 15 million SNP data set for modern day chicken lines 
Description During the project 15 million SNPs and 1 million indels were also defined. These represent 95% of genetic variation in modern poultry with MAF > 5%. These functional affects, if any, have been defined for these variants. They represent a valuable resource for the definition of causal variants in simple and complex traits in modern poultry. 
Type Of Material Database/Collection of data 
Provided To Others? No  
Impact No actual impacts realised to date 
 
Title characterised 15 million chicken SNPs 
Description After applying stringent filtration criteria and with a predicted error rate of ca. 3% we retained 15M high quality SNPs for further characterisation. Major purpose of this characterisation was to delineate SNPs with potential functional effects, either deleterious or advantageous. We have applied a number of complementary approaches towards this goal, including: • Annotation of SNPs against known protein-coding and non-coding RNA genes • Predicted effects of exon variants on protein-coding regions • Analysed whether changes in amino-acid by non-synonymous variants would be tolerated in terms of evolutionary conservation • Identified SNPs that fall within Conserved Elements, defined as signatures of purifying selection across multiple vertebrate species • Defined regions of low heterozygosity, which may result from positive selection during domestication 
Type Of Material Database/Collection of data 
Year Produced 2013 
Provided To Others? No  
Impact No actual impacts realised to date 
 
Title chicken gnomic DNA validation set 
Description A set of genomic DNAs used for validation of SNPs was isolated and tested on 1.8 million putative SNPs. This validation set consists of an independent set of 282 individuals including 32 trio samples from three broiler lines, four WEL lines, five BEL lines and 26 individuals from a wide range of diverse traditional breeds of chicken. 
Type Of Material Database/Collection of data 
Year Produced 2013 
Provided To Others? Yes  
Impact industry application 
 
Title genome selection for foot pad dermatitis and ascites in chickens 
Description Numerous and extensive genomic evaluations have been made on a range of traits including feed efficiency, foot-pad dermatitis and oximetry measurements (a measure of ascites). In all these evaluations, accuracies of prediction or selection accuracies were obtained and compared with standard techniques. Methods of evaluation have been compared. These were done on as many as 23,000 individuals - much larger than the anticipated 2000 - using 600K SNP data obtained by a combination of direct genotyping and imputation from lower density chips. 
Type Of Material Database/Collection of data 
Year Produced 2013 
Provided To Others? Yes  
Impact industry application 
 
Title genome sequences of chicken lines 
Description Using pooled DNA sequencing on a NGS platform, we have sequenced, in this study, 243 chickens from 24 different populations from diverse breeds including broiler, white and brown egg layers, and several experimental lines. These data are a mix of commercial and public sequences (generated within this project). The public sequences will be made available through the NARF web site. 
Type Of Material Database/Collection of data 
Year Produced 2013 
Provided To Others? No  
Impact No actual impacts realised to date 
 
Title production version of a 600K high density chicken whole genome genotyping array 
Description Created a production version of a 600K high density chicken whole genome genotyping array, designed to be useful in commercial broiler and layer chickens, as well as diverse experimental lines. 
Type Of Material Database/Collection of data 
Year Produced 2013 
Provided To Others? Yes  
Impact industry application 
 
Description Alain Vignal - chicken RH panel 
Organisation French National Institute of Agricultural Research
Department INRA-Génétique Cellulaire, FRANCE
Country France 
Sector Public 
PI Contribution In collaboration with Dr Alain Vignal, INRA-Génétique Cellulaire, FRANCE we have used the 600K chip has been used to characterise a chicken radiation hybrid (RH) panel to create a high density physical map of the chicken genome.
Start Year 2013
 
Description Olivier Hanotte, Professor of Population and Conservation Genetics - Blue Egg Gene 
Organisation University of Nottingham
Country United Kingdom 
Sector Academic/University 
PI Contribution In collaboration with Olivier Hanotte, Professor of Population and Conservation Genetics (The University of Nottingham, UK) the 600K chip was used to map the location of the Blue egg gene segregating in specific lines of chicken. This high resolution mapping study led to the identification of the causal gene and mutation (a retroviral insertion in the promoter regins of this gene).
Start Year 2013
 
Description Saber Qanbari (Germany) 
Organisation University of Göttingen
Country Germany 
Sector Academic/University 
PI Contribution During the project we also received a request from the Synbreed Consortium for Dr Saber Qanbari (Goettingen, Germany) to work with us under an ESF Exchange Grant. During that time he used the SNP data from the layer populations to develop methods to define selection signatures in layer domestication.
Start Year 2011
 
Description chicken SNP consortium 
Organisation Aviagen Group
Country United States 
Sector Private 
PI Contribution Even before this project was in full mode the aims and goals to generate a multi-purpose high density genotyping tools was of wide interest. We were there able to leverage sequence data from multiple resources (with appropriate CDAs in place) to add to the list of 4 chicken lines funded within the project. Aviagen provided sequence data for 4 broiler lines and allowed the use of SNP predicted from that data (the core 15 million set) to be used for the design of the 600K chip and prediction of functional effects of these SNPs. Similarly, sequence data were made available by HyLine (4 lines), a German Consortium Synbreed (4 lines) and experimental lines from Pirbright (8 inbred lines) and Roslin (J line).
Start Year 2010
 
Description chicken SNP consortium 
Organisation HyLine
Country United States 
Sector Private 
PI Contribution Even before this project was in full mode the aims and goals to generate a multi-purpose high density genotyping tools was of wide interest. We were there able to leverage sequence data from multiple resources (with appropriate CDAs in place) to add to the list of 4 chicken lines funded within the project. Aviagen provided sequence data for 4 broiler lines and allowed the use of SNP predicted from that data (the core 15 million set) to be used for the design of the 600K chip and prediction of functional effects of these SNPs. Similarly, sequence data were made available by HyLine (4 lines), a German Consortium Synbreed (4 lines) and experimental lines from Pirbright (8 inbred lines) and Roslin (J line).
Start Year 2010
 
Description chicken SNP consortium 
Organisation Technical University of Munich
Department Synbreed
Country Germany 
Sector Academic/University 
PI Contribution Even before this project was in full mode the aims and goals to generate a multi-purpose high density genotyping tools was of wide interest. We were there able to leverage sequence data from multiple resources (with appropriate CDAs in place) to add to the list of 4 chicken lines funded within the project. Aviagen provided sequence data for 4 broiler lines and allowed the use of SNP predicted from that data (the core 15 million set) to be used for the design of the 600K chip and prediction of functional effects of these SNPs. Similarly, sequence data were made available by HyLine (4 lines), a German Consortium Synbreed (4 lines) and experimental lines from Pirbright (8 inbred lines) and Roslin (J line).
Start Year 2010
 
Description chicken SNP consortium 
Organisation The Pirbright Institute
Country United Kingdom 
Sector Academic/University 
PI Contribution Even before this project was in full mode the aims and goals to generate a multi-purpose high density genotyping tools was of wide interest. We were there able to leverage sequence data from multiple resources (with appropriate CDAs in place) to add to the list of 4 chicken lines funded within the project. Aviagen provided sequence data for 4 broiler lines and allowed the use of SNP predicted from that data (the core 15 million set) to be used for the design of the 600K chip and prediction of functional effects of these SNPs. Similarly, sequence data were made available by HyLine (4 lines), a German Consortium Synbreed (4 lines) and experimental lines from Pirbright (8 inbred lines) and Roslin (J line).
Start Year 2010
 
Title bioinformatics pipeline to select and prioritise SNPs for the creation of high density whole genome genotyping arrays. 
Description Developed bioinformatics pipeline to select and prioritise SNPs for the creation of high density whole genome genotyping arrays. 
Type Of Technology software 
Year Produced 2013 
Impact No actual Impacts realised to date 
URL http://www.biomedcentral.com/1471-2164/13/354
 
Title facility for high throughput genotyping using the 600K high density chicken whole genome genotyping array 
Description Installed and tested a facility for high throughput genotyping using the 600K high density chicken whole genome genotyping array. This is involves both the assays and the management of the data generated by the genotyping assays. 
Type Of Technology New/Improved Technique/Technology 
Year Produced 2013 
Impact No actual Impacts realised to date 
 
Title genome selection software 
Description Tested software using high density genotypes and traits from test/target populations for genome selection of traits 
Type Of Technology software 
Year Produced 2013 
Impact No actual Impacts realised to date 
URL http://t-stor.teagasc.ie/bitstream/11019/380/1/berry_imputation.pdf
 
Title pipeline for SNP discovery 
Description Created bioinformatics pipelines to screen, detect and predict functional effects of genetic variation in the genomes of individual chickens from multiple populations. 
Type Of Technology software 
Year Produced 2013 
Open Source License? Yes  
Impact No actual Impacts realised to date 
URL http://www.biomedcentral.com/1471-2164/13/354
 
Title software to integrate high and low density genotyping data through imputation 
Description Tested software to integrate high and low density genotyping data through imputation 
Type Of Technology software 
Year Produced 2013 
Impact No actual Impacts realised to date 
URL http://www.biomedcentral.com/1753-6561/5/S3/S6
 
Title use of chicken 600K HD array for characterisation of genetic organisation 
Description Using this 600K high density chicken whole genome genotyping array we developed methods for characterisation of population structure/sub-structure, genome-wide selection and genome-wide association studies. 
Type Of Technology New/Improved Technique/Technology 
Year Produced 2013 
Impact No actual Impacts realised to date 
 
Description Animal and Plant Health in the UK 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact working group at Animal and Plant Health in the UK (2014): an assessment of future national capability, emerging technologies, 14 Feb 2014, BIS Conference Centre, London, UK
Year(s) Of Engagement Activity 2014
 
Description Avian genome evolution and the origins of species diversity. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Invited lecture: Avian genome evolution and the origins of species diversity. In "Molecular evolution of avian species", SMBE2016, Queensland's Gold Coast, Australia, 3-7 July, 2016.
Year(s) Of Engagement Activity 2016
 
Description Avian genomics: current status and future opportunities 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Talk at 16th ADNAT Convention on Animal Genetics and Genomics. Talk: Avian genomics: current status and future opportunities. Hyderabad, Dec 17-19, 2012.
Year(s) Of Engagement Activity 2012
 
Description Chicken Genome: Current Status and Future Trends from Next Generation Sequencing 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Presented a talk at the 3rd Annual NGS Asia Congress. Talk: Chicken Genome: Current Status and Future Trends from Next Generation Sequencing. 8 - 9 Oct 2013, Singapore.
Year(s) Of Engagement Activity 2013
 
Description Chicken Genomics: current status and future opportunities 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Participants in your research or patient groups
Results and Impact Opening of the National Avian Research Facility, Roslin, 12th Sept, 2013, Talk: Chicken Genomics: current status and future opportunities.

no actual impacts realised to date
Year(s) Of Engagement Activity 2013
 
Description Chicken genome update, consortia for RNAseq, SNPs and more ... 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Talk at Avian Model Systems 7. Talk: Chicken genome update, consortia for RNAseq, SNPs and more " 14-19 Nov, Nagoya, Japan 2012.
Year(s) Of Engagement Activity 2012
 
Description Development of New Tools for Genetic Selection for a Sustainable Poultry Industry 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Presented a talk: Development of New Tools for Genetic Selection for a Sustainable Poultry Industry (2014), Veterinary Advances in Animal Health and Welfare Research - Impact and Opportunities, Feb 20-24, 2014, NIANP Auditorium, Adugodi, Bangalore, India
Year(s) Of Engagement Activity 2014
 
Description Development of new tools for genetic selection for a sustainable poultry industry. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Food Security Show-and-Tell, 16 May 2012, Edinburgh University: Development of new tools for genetic selection for a sustainable poultry industry.

no actual impacts realised to date
Year(s) Of Engagement Activity 2012
 
Description From Sequences to Consequences 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Industry/Business
Results and Impact talk and meet industry at "21st Century Genomics for Animal Breeding and Animal Health. In "From Sequences to Consequences: What The Roslin Institute can do for you in the livestock sector", Industry Day. The Roslin Institute Building, Edinburgh, 18th March 2016."
Year(s) Of Engagement Activity 2016
 
Description Genome revolution 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach regional
Primary Audience Participants in your research or patient groups
Results and Impact Genome revolution: Reproduction: The BIG Picture, 6th Sept 2013, a conference in honour of Professor Alan McNeilly, The Royal Society of Edinburgh.

no actual impacts realised to date
Year(s) Of Engagement Activity 2013
 
Description ISAG Conference 2012. Talk: NGS of multiple chicken lines and development of a high-density 600K SNP genotyping array, 16-20 July, Cairns, Australia 2012. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Presented a talk at ISAG Conference 2012. Talk: NGS of multiple chicken lines and development of a high-density 600K SNP genotyping array, 16-20 July, Cairns, Australia 2012.
Year(s) Of Engagement Activity 2012
 
Description New tools and prospects for chicken genomics 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Talk at Genetics Society of Australia (GSA), July 2015, University of Adelaide, Australia
Year(s) Of Engagement Activity 2015
 
Description Next Generation Sequencing of multiple chicken lines reveals a rich source of Single nucleotide polymorphisms for high resolution genetic studies 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Talk at The 1st International Conference on Genomics in the Americas. Talk: Next Generation Sequencing of multiple chicken lines reveals a rich source of Single nucleotide polymorphisms for high resolution genetic studies, 27-28 Sept, Philadelphia, USA.
Year(s) Of Engagement Activity 2012
 
Description Opportunities and applications of in poultry genomics 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Industry/Business
Results and Impact Presentation to Agri-Tech Catalyst Funding Consortia Building Workshop - Edinburgh, 27 Jan 2014
Year(s) Of Engagement Activity 2014
 
Description Opportunities in poultry genomics 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Industry/Business
Results and Impact Opportunities in poultry genomics. KTN Agri-tech Catalyst workshop, Edinburgh, 27 Jan 2014. .

no actual impacts realised to date
Year(s) Of Engagement Activity 2014
 
Description Opportunities, Experience and Advice: Successes with LINK Awards 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Opportunities, Experience and Advice: Successes with LINK Awards: David Burt BBSRC KEC seminars, 25 Oct 2012, Edinburgh University

no actual impacts realised to date
Year(s) Of Engagement Activity 2012
 
Description Past, Present and Future of Genomics in Poultry Breeding. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Talk: Past, Present and Future of Genomics in Poultry Breeding. 25th World's Poultry Congress, Beijing, 5-9 September, 2016.
Year(s) Of Engagement Activity 2016
 
Description Poultry Genome: Implications for Immunity, Poultry Productivity and Health, Poultry beyond 2020 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact talk and roundtable discussion to "Poultry Genome: Implications for Immunity, Poultry Productivity and Health, Poultry beyond 2020, 13-17th April, Queenstown, New Zealand."
Year(s) Of Engagement Activity 2014
 
Description Poultry Genomics: Current Status and Future Trends from Next Generation Sequencing 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Talk at Animal Genomics Research Group "The global genomic approaches to climate change impact on livestock production". Talk: Poultry Genomics: Current Status and Future Trends from Next Generation Sequencing. 10-15 July, Seoul, Korea, 2013.
Year(s) Of Engagement Activity 2013
 
Description Poultry Genomics: Current Status and Future Trends from Next Generation Sequencing 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Presented a talk at the 8th International Conference on Genomics (ICG-8). Talk: Poultry Genomics: Current Status and Future Trends from Next Generation Sequencing. 29 Oct - 1 Nov 2013, Shenzhen, China.
Year(s) Of Engagement Activity 2013
 
Description Structural aspects of genomes across species 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Presented a talk at The 8th European Poultry Genetics Symposium. Talk: Structural aspects of genomes across species. 25-27 Sept, Venice Italy, 2013.
Year(s) Of Engagement Activity 2013
 
Description The Chicken and other Avian Genomes: new insights and opportunities for all from high throughput sequencing and bioinformatics. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Talk: the Chicken and other Avian Genomes: new insights and opportunities for all from high throughput sequencing and bioinformatics. In "Avian Model Systems 9: a new integrative platform", Taipei, Taiwan, 38 March to 3 April, 2016.
Year(s) Of Engagement Activity 2016
 
Description The chicken genome 10 years on. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Keynote lecture: chicken genome - 10 years on. Avian Model Systems - the 8th International Meeting, Cold Spring Harbour, USA, 4-8th March, 2014.

CSHL Leading Strand - Keynote Lecture Series (http://theleadingstrand.cshl.edu/Course/Keynote/2014/AVIAN/150

The chicken genome 10 years on - BBSRC (http://www.bbsrc.ac.uk/news/events/1403-chicken-genome.aspx)
Year(s) Of Engagement Activity 2014