An International UK-Brazil Collaboration using Synchrotron Radiation Circular Dichroism Spectroscopy to Study Protein Structure and Function

Lead Research Organisation: Birkbeck, University of London
Department Name: Biological Sciences

Abstract

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

Publications

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Felizatti AP (2020) Interactions of amphipathic a-helical MEG proteins from Schistosomamansoni with membranes. in Biochimica et biophysica acta. Biomembranes

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Lopes JL (2014) Deconstructing the DGAT1 enzyme: Binding sites and substrate interactions. in Biochimica et biophysica acta

 
Description publications on collaborative studies and continued international collaboration
Exploitation Route Brazil may develop their own SRCD beamline, with the advice of UK partners
Sectors Agriculture

Food and Drink

Education

Pharmaceuticals and Medical Biotechnology

 
Description this has directly lead to the design and building of an SRCD beamline at the new Brazil Synchrotron, and the Brazilian postdoc on this project (Yoneda) has recently been hired as its Beamline Scientist
First Year Of Impact 2020
Sector Agriculture, Food and Drink,Chemicals,Education,Pharmaceuticals and Medical Biotechnology
Impact Types Societal

Economic

 
Description BBSRC-FAPSP partnering grant
Amount £35,000 (GBP)
Funding ID BB/N012763/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 01/2016 
End 12/2018
 
Description Binding and interactions of Brazilian toxins to voltage-gated sodium channels: The Rational Search for New Drugs
Amount £12,648 (GBP)
Funding ID BB/T01153X/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 01/2020 
End 01/2022
 
Description Biophysical studies of the structure/function of antimicrobial peptides and enzymes isolated from extremophile organisms
Amount £35,426 (GBP)
Funding ID BB/N012763/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 01/2016 
End 10/2018
 
Description Brazil Senior Visiting Fellowship
Amount R$ 115,240 (BRL)
Organisation National Council for Scientific and Technological Development (CNPq) 
Sector Public
Country Brazil
Start 03/2014 
End 02/2016
 
Description Science without Borders Visiting Researcher
Amount R$ 11,524,000 (BRL)
Organisation National Council for Scientific and Technological Development (CNPq) 
Sector Public
Country Brazil
Start 03/2014 
End 02/2016
 
Description Science without Borders psotdoctoral fellowships (3)
Amount R$ 1 (BRL)
Organisation National Council for Scientific and Technological Development (CNPq) 
Sector Public
Country Brazil
Start 08/2012 
End 01/2016
 
Description Collaboration with University of Sao Paulo 
Organisation Universidade de São Paulo
Department Physics Institute of São Carlos
Country Brazil 
Sector Academic/University 
PI Contribution i have been involved in helping my brazilian collaborators prepare a proposal for an SRCD beamline at the Brazilian synchrotron
Collaborator Contribution we have worked together on the proposal and planning
Impact several publications, a long term partnership leading to several BBSRC partnering grants, development of a new SRCD beamline at the Brazilian synchrotron, submission and funding of a new BBSRC partnering award
Start Year 2012
 
Description collaborations with CD users 
Organisation Beijing Synchotron Radiation Facility
Country China 
Sector Academic/University 
PI Contribution cd data collection and analyses
Collaborator Contribution beamtime made available
Impact publications
Start Year 2013
 
Description Running training workshops for students, postdocs and industrial scientists on CD spectroscopy 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Teaching Lectures and Practicals in multi-day workshops to provide new skills training and ideas and information for researchers both nationally and internationally
Year(s) Of Engagement Activity Pre-2006,2006,2007,2008,2009,2010,2011,2012,2013,2014,2015,2016,2017,2018
 
Description Talks at UK and international sites and meetings: Brazil Synchrotron Symposium, ), University of Vienna Austria (Chemistry Dept), Biochemical Society Training Course (Aston University, UK) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Talks about Tools and Resources developed in the course of this grant at Universities and International meetings, including the headline talk at the inauguration of the Brazil Synchrotron SRCD beamline (CEDRO) held for the international community of SRCD users and potential users, The Biochemical Society training course on Membrane Proteins at Aston University, the chemistry dept at the University of Vienna.
Year(s) Of Engagement Activity 2022
 
Description Teaching workshops for students, faculty and industrial scientists 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact A series of workshops on methods of analysis for CD spectroscopy given at national and international meetings and workshops, usually 2-3 days, including hands-on computing practicals. for phd and masters students, postdocs, professors and other academics and industry
Year(s) Of Engagement Activity 2009,2010,2011,2012,2013,2014,2015,2016,2017,2018
 
Description annual talks for the public 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact UCL Science Centre Friday Evening Discourses and Birkbeck SET Talks for the Public talks on science for the public (5th, 6th form, and public) annually and lecture/tour at the Wellcome Collection talks

no actual impacts realised to date
Year(s) Of Engagement Activity 2006,2007,2008,2009,2010,2011,2012,2013,2014,2015,2016,2017,2018,2019,2020,2021
 
Description talks at national and international meetings 
Form Of Engagement Activity Scientific meeting (conference/symposium etc.)
Part Of Official Scheme? No
Type Of Presentation paper presentation
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact in UK, USA, Australia, Austria, Belgium, Taiwan, Denmark, France, Germany, China, Brazil, Japan: talks at international meetings and workshops

established new collaborations
Year(s) Of Engagement Activity Pre-2006,2006,2007,2008,2009,2010,2011,2012,2013,2014