China & the UK: supercomputing systems biology

Lead Research Organisation: University of Manchester
Department Name: Chem Eng and Analytical Science

Abstract

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

Publications

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Abudukelimu A (2018) Predictable Irreversible Switching Between Acute and Chronic Inflammation. in Frontiers in immunology

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Westerhoff HV (2015) Network-based pharmacology through systems biology. in Drug discovery today. Technologies

 
Description This project involved collaborations with supercomputer builders and to a lesser extent in Changsha. We have discovered that there is a great distance between computer building and computer intensive systems biology and that in Changsha it is then not easy to involve more of the biologists. Differences in language and culture are making this even more difficult.
Exploitation Route Advise by people with previous experience
Sectors Digital/Communication/Information Technologies (including Software),Pharmaceuticals and Medical Biotechnology

 
Title Candidate pathway finding 
Description Steatosis or fatty liver disease is an important disease sometimes leading to hepatocarcinoma. Most researchers engaged in genomics are searching for so-called candidate genes in their data, which then should identify single-gene causes and single target strategies. We have developed a way to identify/examine 'candidate pathways'. More inn general, the portfolio of projects ahs led to a great increase in number of detailed kinetic models of metabolic pathways (as reported in JWS-Online). these are now of great use for other organisms and the same pathways or other pathways in the same organisms. All these models are also of use for the development of the Infrastructure Systems Biology Europe (ISBE). 
Type Of Material Model of mechanisms or symptoms - human 
Year Produced 2016 
Provided To Others? Yes  
Impact This is now used in multiple research projects. Through JWS online and BioModels our models are used by many. 
 
Description Snoep 
Organisation University of Stellenbosch
Country South Africa 
Sector Academic/University 
PI Contribution Ideas, models, data
Collaborator Contribution Ideas, models, data management
Impact Publications Models Grant proposals