Role of the endosomal sorting machinery in controlling AMPA receptor trafficking in the hippocampus

Lead Research Organisation: University of Warwick
Department Name: School of Life Sciences

Abstract

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

Publications

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Corrêa SA (2012) MSK1 regulates homeostatic and experience-dependent synaptic plasticity. in The Journal of neuroscience : the official journal of the Society for Neuroscience

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Corrêa SA (2012) The Role of p38 MAPK and Its Substrates in Neuronal Plasticity and Neurodegenerative Disease. in Journal of signal transduction

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DaSilva LL (2016) Activity-Regulated Cytoskeleton-Associated Protein Controls AMPAR Endocytosis through a Direct Interaction with Clathrin-Adaptor Protein 2. in eNeuro

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Eales KL (2014) The MK2/3 cascade regulates AMPAR trafficking and cognitive flexibility. in Nature communications

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Mabb AM (2014) Triad3A regulates synaptic strength by ubiquitination of Arc. in Neuron

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Wall MJ (2018) The mechanistic link between Arc/Arg3.1 expression and AMPA receptor endocytosis. in Seminars in cell & developmental biology

 
Description The objectives of this grant were a) to establish collaborations with the University of Sao Paulo in Brazil, and b) to collect preliminar data to prepare a full application.
We have achieved both of the these aims. In fact, we have applied for a BBSRC/FAPESP Bilateral proposal, which was submitted to the BBSRC(BB/L001381/1) in January/2013.
As this proposal was not funded, we are further collecting preliminary data and we will re-submit a propsal to the BBSRC or MRC in 2015.
Exploitation Route This was a pump-priming grant.
Sectors Pharmaceuticals and Medical Biotechnology
 
Description The purpose of this award was to establish international collaboration with Brazil. The main outcome of this project was knowledge exchange and development of new skills and expertise.
First Year Of Impact 2012
Sector Pharmaceuticals and Medical Biotechnology
Impact Types Economic
 
Description Bilateral BBSRC-FAPESP proposal-BB/L001381/1 
Organisation Universidade de São Paulo
Country Brazil 
Sector Academic/University 
PI Contribution The award of this pump-priming grant allowed University of Warwick and University of Sao Paulo to collect the preliminary data for the application of a Bilateral BBSRC-FAPESP proposal submitted to the BBSRC in January 2013.
Start Year 2013