The molecular control of glial progenitor proliferation in Drosophila and mammals: investigation of Prox1 conditional knock-out mutant mice.

Lead Research Organisation: University of Birmingham
Department Name: Sch of Biosciences

Abstract

Publications

10 25 50
 
Description We discovered that the gene network that promotes repair after CNS injury has been evolutionarily conserved between flies and mammals.
See

Kato K, KonnoD, Berry M, MatsuzakiF, Logan A, Hidalgo (2015) Prox1 inhibits proliferation and is required for differentiation of the oligodendrocyte cell lineage in the mouse. PLoS One 10(12): e0145334

Kato K, Forero MG, Fenton JC and Hidalgo A (2011) The glial regenerative response to central nervous system injury is enabled by Pros-Notch and Pros-NFkB feedback. PLoS Biology 9: e1001133
Exploitation Route It will have an impact in mammalian research and finding solutions to spinal cord injury
Sectors Healthcare,Pharmaceuticals and Medical Biotechnology

URL http://www.biosciences-labs.bham.ac.uk/hidalgo/Regeneration_and_Glia.html
 
Description This was a travel grant to enable the post-doc Kentaro Kato to go to the laboratory of Dr Fumio Matsuzaki at the Riken Centre for Developmental Biology in Japan to carry out experiments in Prox-1 knock-out mice.
First Year Of Impact 2013
Sector Healthcare
 
Description BBSRC Committee A Core Member
Geographic Reach National 
Policy Influence Type Membership of a guidance committee
 
Description BBSRC Pool of Experts
Geographic Reach National 
Policy Influence Type Participation in advisory committee
 
Title DeadEasy Glia 
Description software programme to count the number of glial cells in Drosophila in vivo 
Type Of Material Technology assay or reagent 
Year Produced 2012 
Provided To Others? Yes  
Impact sharing tools 
URL http://www.biosciences-labs.bham.ac.uk/hidalgo/Software.html
 
Description Prox1: functions in the oligodendrocyte lineage 
Organisation RIKEN
Country Japan 
Sector Private 
PI Contribution My postdoctoral researcher Dr Kentaro Kato - employed by a BBSRC grant to work with me in Birningham - travelled to Riken for 2 months to perform experiments in Prox1 knock-out mice in the lab of Dr Fumio Matusaki. This was to investigate the function of Prox1 in the oligodendrocyte cell lineage.
Collaborator Contribution The partner - Dr Fumio Matzusaki - provided the Prox1 knock-out mice, carried out the genetics to generate the conditional knock-outs prior to Dr Kato's visit, and provided assistance with the experiments.
Impact The work is currently in preparation as a manuscript to be submitted for publication in the next few months.
Start Year 2013
 
Description British Science Festival 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? Yes
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Engagement with the general public

Public understanding of science and research
Year(s) Of Engagement Activity 2014
 
Description Community Day 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Communicating scientific discovery to the public using fruit-flies

outrach
Year(s) Of Engagement Activity 2013
 
Description Community Day 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Communicating science to the general public

outreach
Year(s) Of Engagement Activity 2014
 
Description Lab web-site 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Soon after starting this project, I created a lab web-site where information on this project, and other lab projects, can be found. www.biosciences.bham.ac.uk/labs/hidalgo

making our work known to the public
Year(s) Of Engagement Activity 2006,2007,2008,2009,2010