The molecular control of glial progenitor proliferation in Drosophila and mammals: investigation of Prox1 conditional knock-out mutant mice.
Lead Research Organisation:
University of Birmingham
Department Name: Sch of Biosciences
Abstract
Japan
Publications
Hidalgo A
(2017)
Go and stop signals for glial regeneration.
in Current opinion in neurobiology
| Description | We discovered that the gene network that promotes repair after CNS injury has been evolutionarily conserved between flies and mammals. See Kato K, KonnoD, Berry M, MatsuzakiF, Logan A, Hidalgo (2015) Prox1 inhibits proliferation and is required for differentiation of the oligodendrocyte cell lineage in the mouse. PLoS One 10(12): e0145334 Kato K, Forero MG, Fenton JC and Hidalgo A (2011) The glial regenerative response to central nervous system injury is enabled by Pros-Notch and Pros-NFkB feedback. PLoS Biology 9: e1001133 |
| Exploitation Route | It will have an impact in mammalian research and finding solutions to spinal cord injury |
| Sectors | Healthcare,Pharmaceuticals and Medical Biotechnology |
| URL | http://www.biosciences-labs.bham.ac.uk/hidalgo/Regeneration_and_Glia.html |
| Description | This was a travel grant to enable the post-doc Kentaro Kato to go to the laboratory of Dr Fumio Matsuzaki at the Riken Centre for Developmental Biology in Japan to carry out experiments in Prox-1 knock-out mice. |
| First Year Of Impact | 2013 |
| Sector | Healthcare |
| Title | DeadEasy Glia |
| Description | software programme to count the number of glial cells in Drosophila in vivo |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2012 |
| Provided To Others? | Yes |
| Impact | sharing tools |
| URL | http://www.biosciences-labs.bham.ac.uk/hidalgo/Software.html |
| Description | Prox1: functions in the oligodendrocyte lineage |
| Organisation | RIKEN |
| Country | Japan |
| Sector | Public |
| PI Contribution | My postdoctoral researcher Dr Kentaro Kato - employed by a BBSRC grant to work with me in Birningham - travelled to Riken for 2 months to perform experiments in Prox1 knock-out mice in the lab of Dr Fumio Matusaki. This was to investigate the function of Prox1 in the oligodendrocyte cell lineage. |
| Collaborator Contribution | The partner - Dr Fumio Matzusaki - provided the Prox1 knock-out mice, carried out the genetics to generate the conditional knock-outs prior to Dr Kato's visit, and provided assistance with the experiments. |
| Impact | The work is currently in preparation as a manuscript to be submitted for publication in the next few months. |
| Start Year | 2013 |
| Description | British Science Festival |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | Yes |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Engagement with the general public Public understanding of science and research |
| Year(s) Of Engagement Activity | 2014 |
| Description | Community Day |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Communicating science to the general public outreach |
| Year(s) Of Engagement Activity | 2014 |
| Description | Community Day |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Communicating scientific discovery to the public using fruit-flies outrach |
| Year(s) Of Engagement Activity | 2013 |
| Description | Lab web-site |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Soon after starting this project, I created a lab web-site where information on this project, and other lab projects, can be found. www.biosciences.bham.ac.uk/labs/hidalgo making our work known to the public |
| Year(s) Of Engagement Activity | 2006,2007,2008,2009,2010,2011,2012,2013,2014 |