FLIP - Transgenic Zebrafish Embryos/Larvae for Systems-Wide Analysis of Endocrine Disrupting Chemicals
Lead Research Organisation:
University of Exeter
Department Name: Biosciences
Abstract
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Technical Summary
N/A
Planned Impact
N/A
Publications
Aya Takesono
(2021)
Estrogen regulates development of the olfactory sensory system in the zebrafish embryo
in E-life
Brown AR
(2019)
Cardiovascular Effects and Molecular Mechanisms of Bisphenol A and Its Metabolite MBP in Zebrafish.
in Environmental science & technology
Brown AR
(2015)
Climate change and pollution speed declines in zebrafish populations.
in Proceedings of the National Academy of Sciences of the United States of America
Cooper R
(2021)
Seasonal variation in oestrogenic potency and biological effects of wastewater treatment works effluents assessed using ERE-GFP transgenic zebrafish embryo-larvae.
in Aquatic toxicology (Amsterdam, Netherlands)
Cooper R
(2021)
Health Effects and Life Stage Sensitivities in Zebrafish Exposed to an Estrogenic Wastewater Treatment Works Effluent.
in Frontiers in endocrinology
Green JM
(2018)
Early life exposure to ethinylestradiol enhances subsequent responses to environmental estrogens measured in a novel transgenic zebrafish.
in Scientific reports
Green JM
(2016)
High-Content and Semi-Automated Quantification of Responses to Estrogenic Chemicals Using a Novel Translucent Transgenic Zebrafish.
in Environmental science & technology
Lee O
(2015)
Transgenic fish systems and their application in ecotoxicology.
in Critical reviews in toxicology
Matthew J. Winter
(2021)
Functional imaging in larval zebrafish for characterising the effects of proconvulsant compounds acting via a range of pharmacological mechanisms
in British Journal of Pharmacology
Miyaoku K
(2021)
Characterization of G protein-coupled estrogen receptors in Japanese medaka, Oryzias latipes.
in Journal of applied toxicology : JAT
| Description | Our collective research on the TG(ERE) reporter zebrafish model has demonstrated its potential application in guiding ecotoxicological and toxicological assessments of extrogenic chemicals, which constitute 45% of priority endocrine disrupting chemicals. High-content screening highlighting organ and tissue-specific targeting of such chemicals in vivo in unregulated zebrafishs embryos will make a major contribution to chemical safety. From 2017: We have applied transgenic fish embryos to identify body targets in fish for chemicals that mimic oestrogen hormones. We show that different environmental oestrogens can induce different tissue responses with different potential health outcomes. This provides a more intelligent system for assessing biological effects of environmental oestrogens and avoids the use of intact animals. We are in the process of establishing the assay in format that will allow for high throughput screening of chemicals and pharmaceuticals. It is envisaged that the new system will result in a reduction and refinement in the use of animals for chemical testing. Both the estrogenic plasticizer bisphenol A (BPA) and a BPA metabolite (MBP) activate estrogen response elements primarily in the heart valves via the estrogen receptor (ESR1). Subsequent transcriptomic analysis of micro-dissected heart tissues identified downstream transcriptional targets of BPA and MBP to include krt91 - keratin, col28a1a - collagen, tnnc1b - troponin responsible for cardiomyocyte signalling and cardiac contraction. Collagen deficiency in heart valve ultrastructure in larval fish exposed to 25 µg/L MBP was confirmed by transmission electron microscopy and corresponded with impaired cardiovascular function (reduced heart beat and blood flow rates). Conclusions: Our results indicate plausible mechanistic links between BPA exposure and the occurrence of cardiac and/or metabolic disease states, which may be mediated in some part by BPA's metabolite MBP. |
| Exploitation Route | Another URL at ttp://www.thenakedscientists.com/HTML/content/interviews/interview/1000021/ The transgenic fish developed have already been supplied to various research laboratories for screening and testing chemicals for oestrogenic activity. The assay is also being employed in support of an OECD test guideline assay for screening chemicals for hormone disrupting chemicals. |
| Sectors | Chemicals,Communities and Social Services/Policy,Education,Environment,Pharmaceuticals and Medical Biotechnology |
| URL | http://news.nationalgeographic.com/news/2012/04/120423-fish-glowing-pollution-bpa-environment-science |
| Description | 1. Industry interchanger (Brown) trained in the culture of the transgenic ERE-GFP zebrafish, imaging using confocal microscopy and advanced molecular technologies including morpholinos, sequencing and bioinformatics. 2. Academic partners gain experience in quantifying morphological and physiological responses in early life stage zebrafish and practical knowledge relating to the application of transgenic zebrafish models and systems biology (adverse outcome pathways) within a regulatory testing framework. 3. Advancement of the ERE-GFP zebrafish model for screening and testing chemicals for oestrogenic activity. 4. Clear case study examples illustrating the utility of the ERE-GFP zebrafish model for informing on health outcomes of exposure to selected EDCs and their molecular mechanisms. 5. Establishment of stronger research partnership between the University of Exeter AstraZeneca and Syngenta, with a view to securing further co-funded research projects, student exchange and outlets for realizing impact of research work at Exeter. |
| First Year Of Impact | 2014 |
| Sector | Chemicals,Communities and Social Services/Policy,Environment,Pharmaceuticals and Medical Biotechnology |
| Impact Types | Policy & public services |
| Description | EU Commission |
| Geographic Reach | Europe |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Impact | This research project has contributed to the validation process for use of transgenic zebrafish in a new OECD guideline test protocol, in a collaboration developed with Dr Francois Brion , INERIS, France.. |
| Description | GOVERNMENT REPORT |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Contribution to a national consultation/review |
| Description | Government report |
| Geographic Reach | National |
| Policy Influence Type | Contribution to a national consultation/review |
| Impact | Government report: Charles R. Tyler and Taisen Iguchi (2018) Defra , UK, Min of Evn, Japan Workshop Report. The 20th UK-Japan Annual Scientific Workshop on Research into Environmental Endocrine Disrupting Chemicals 37pp |
| Description | Government report |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Participation in a guidance/advisory committee |
| Description | AZ Discovery Science - Discovery Biology team, leading to a pilot study |
| Amount | £45,000 (GBP) |
| Organisation | AstraZeneca |
| Sector | Private |
| Country | United Kingdom |
| Start | 12/2019 |
| End | 03/2020 |
| Description | Advancing understanding of anaesthesia and analgesia in the zebrafish |
| Amount | £566,940 (GBP) |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 02/2021 |
| End | 01/2022 |
| Description | AstraZeneca - £1.3m |
| Amount | £1,300,000 (GBP) |
| Organisation | AstraZeneca |
| Sector | Private |
| Country | United Kingdom |
| Start | |
| End | 02/2016 |
| Description | AstraZeneca/UoExeter ( PhD) Ryan Kean - Investigating uptake and bioavailability of antibiotics and their toxic effects in the environment and applying microfluidics to address these problems |
| Amount | £24,000 (GBP) |
| Organisation | AstraZeneca |
| Sector | Private |
| Country | United Kingdom |
| Start | 10/2019 |
| End | 09/2023 |
| Description | BBSRC China - UK Partnering Award |
| Amount | £42,000 (GBP) |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | |
| Description | BBSRC Industry CASE studentship - Molly Payne |
| Amount | £80,000 (GBP) |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | |
| Description | BBSRC Japan Partnering Award - Engineering novel transgenic zebrafish with CRISPR/Cas9 technology |
| Amount | £42,000 (GBP) |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2017 |
| End | 08/2020 |
| Description | Building confidence in non-protected zebrafish embryo-larvae as a viable alternative to mammalian DART assessment |
| Amount | £120,000 (GBP) |
| Funding ID | NC/X001407/1 |
| Organisation | National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs) |
| Sector | Public |
| Country | United Kingdom |
| Start | 04/2023 |
| End | 03/2027 |
| Description | Characterising the functional homology of drug targets in aquatic animals |
| Amount | £80,000 (GBP) |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 02/2021 |
| End | 01/2025 |
| Description | Characterising the homology of phamaceutical targets in aquatic life |
| Amount | £80,000 (GBP) |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 10/2020 |
| End | 09/2024 |
| Description | Development of CRISPR-Cas and its applications in zebrafish |
| Amount | £612,000 (GBP) |
| Organisation | AstraZeneca |
| Sector | Private |
| Country | United Kingdom |
| Start | 04/2020 |
| End | 03/2022 |
| Description | Development of precise genome editing technology in zebrafish |
| Amount | £675,000 (GBP) |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 01/2023 |
| End | 12/2026 |
| Description | Ecotoxicology of Pharmaceuticals in Fish |
| Amount | € 100,000 (EUR) |
| Organisation | Roche Pharmaceuticals |
| Sector | Private |
| Country | Global |
| Start | 01/2023 |
| End | 12/2025 |
| Description | Effects of water chemistry on the exposure risk for pharmaceutical drugs, including antibiotics |
| Amount | £80,000 (GBP) |
| Organisation | AstraZeneca |
| Sector | Private |
| Country | United Kingdom |
| Start | 10/2018 |
| End | 09/2022 |
| Description | Establishing the links between skin microbiome, pollution and disease susceptibility in a native UK amphibian species. |
| Amount | £70,000 (GBP) |
| Organisation | Natural Environment Research Council |
| Sector | Public |
| Country | United Kingdom |
| Start | 10/2018 |
| End | 09/2022 |
| Description | Investigating the action of AZD9833 -SERD in the estrogen responsive element (ERE) transgenic zebrafish |
| Amount | £41,939 (GBP) |
| Organisation | AstraZeneca |
| Sector | Private |
| Country | United Kingdom |
| Start | 07/2021 |
| End | 06/2022 |
| Description | Lattice Selective Plane Illumination Microscopy (L-SPIM) for the analysis of subcellular dynamics in living specimens. |
| Amount | £653,837 (GBP) |
| Funding ID | BB/T017899/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 07/2020 |
| End | 06/2021 |
| Description | MRC Confidence in Concept funding/AstraZeneca. The zebrafish as a fast and reliable vertebrate model to study gene function to support target validation in the search for new human drug therapies. |
| Amount | £220,000 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2021 |
| End | 08/2023 |
| Description | Merck - Integrated health effects analysis of SSRIs |
| Amount | £75,000 (GBP) |
| Organisation | Merck |
| Department | Merck UK |
| Sector | Private |
| Country | United Kingdom |
| Start | 10/2017 |
| End | 09/2020 |
| Description | NC3Rs/Simonics The human iDART framework |
| Amount | £43,000 (GBP) |
| Organisation | National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs) |
| Sector | Public |
| Country | United Kingdom |
| Start | 01/2018 |
| End | 06/2018 |
| Description | PhD studentship - An alternative approach for assessing drug-induced seizures, using non-protected larval zebrafish |
| Amount | £100,000 (GBP) |
| Funding ID | NC/R001421/1 |
| Organisation | National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs) |
| Sector | Public |
| Country | United Kingdom |
| Start | 05/2018 |
| End | 04/2021 |
| Description | Purchase of the Acquifer advanced plate imager sponsored by support from UoE, Astrazeneca and Ditabis |
| Amount | £90,000 (GBP) |
| Organisation | AstraZeneca |
| Sector | Private |
| Country | United Kingdom |
| Start | |
| Description | Single Molecule Detection Platform for a Leica SP8 TCS |
| Amount | £275,399 (GBP) |
| Funding ID | BB/R013764/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 01/2018 |
| End | 01/2018 |
| Description | Syngenta Industry Case studentship |
| Amount | £80,000 (GBP) |
| Organisation | Syngenta International AG |
| Sector | Private |
| Country | Switzerland |
| Start | |
| Description | Understanding phenotypic plasticity and relevance of behavioural responses to chronic toxicityu in aquatic life |
| Amount | £0 (GBP) |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 10/2020 |
| End | 09/2024 |
| Description | Understanding plasticity and the ecological relevance of behavioural responses in fish to neuroactive pharmaceuticals |
| Amount | £80,000 (GBP) |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2021 |
| End | 09/2025 |
| Description | zebrafish development assays |
| Amount | £80,000 (GBP) |
| Organisation | AstraZeneca |
| Sector | Private |
| Country | United Kingdom |
| Start | |
| Description | • EU/IMI PREMIER |
| Amount | € 8,000,000 (EUR) |
| Organisation | EU-T0 |
| Sector | Public |
| Country | European Union (EU) |
| Start | 01/2020 |
| End | 12/2025 |
| Title | New transgenic fish models |
| Description | • Novel use of transgenic zebrafish we have developed have been applied to a wide series of projects and support major research income from the EU, Industry and RCUK projects ( for work on nanomaterials and pharmaceuticals; see new funding). • Our work on the elav1a transgenic zebrafish has been applied for functional brain imaging in zebrafish for profiling the pharmacology of neuroactive drugs. |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2020 |
| Provided To Others? | Yes |
| Impact | A series of new funded projects co sponsored by EU and various pharmaceutical industry partners |
| Title | Novel use of transgenic zebrafish |
| Description | Ongoing use of previous transgenic lines |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2020 |
| Provided To Others? | Yes |
| Impact | Novel use of transgenic zebrafish we have developed have continued to be applied to a wide series of projects and support major research income from the EU, Industry and RCUK projects |
| Title | Oxidative stress transgenic model |
| Description | New oxidative stress transgenic fish model |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2019 |
| Provided To Others? | Yes |
| Impact | Oxidative stress transgenic model was recently supplied to Dr Harm J. Heusinkveld, Neurotoxicologist, Centre for Health Protection (GZB) | Dept for Innovative Testing Strategies (VTS) Dutch National Institute for Public Health and the Environment PO Box 1 | 3720 BA Bilthoven, Antonie van Leeuwenhoeklaan 9 | 3721 MA Bilthoven |
| Title | Validated proof of concept for a transgenic zebrafish model (i.e. oestrogen responsive ERE-GFP zebrafish) as a reliable, rapid and integrated tool for screening chemical products for endocrine activity in human and environmental safety assessment. |
| Description | Validated proof of concept for a transgenic zebrafish model (i.e. oestrogen responsive ERE-GFP zebrafish) as a reliable, rapid and integrated tool for screening chemical products for endocrine activity in human and environmental safety assessment. |
| Type Of Material | Model of mechanisms or symptoms - non-mammalian in vivo |
| Year Produced | 2015 |
| Provided To Others? | Yes |
| Impact | Validated proof of concept for a transgenic zebrafish model (i.e. oestrogen responsive ERE-GFP zebrafish) as a reliable, rapid and integrated tool for screening chemical products for endocrine activity in human and environmental safety assessment. |
| Description | Astra Zeneca -Science to Go- |
| Organisation | AstraZeneca |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Follows-on from a previous consultancy agreement. The majority of this project aims to evaluate the potential for transgenic zebrafish models to aid the prediction of human side effects of pharmaceuticals - including seizure and bone malformation, amongst others. |
| Collaborator Contribution | Follows-on from a previous consultancy agreement. The majority of this project aims to evaluate the potential for transgenic zebrafish models to aid the prediction of human side effects of pharmaceuticals - including seizure and bone malformation, amongst others. |
| Impact | N/A |
| Start Year | 2017 |
| Description | Astra Zeneca BB/L01548X/1 |
| Organisation | AstraZeneca |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Through the FLIP we have strengthened considerably our research partnership with AstraZeneca UK and built a new partnership with Syngenta AG, including via internships (Ross Brown and Jon Green) and regular face-to-face meetings. The partnerships have played a role in securing further major research support to Exeter from AstraZeneca for work on pharmaceuticals, three CASE studentship(s) for advancing the use of transgenic fish/imaging and modeling in chemical hazard identification (Syngenta/AstraZeneca) with further grants (Syngenta) and CASE studentships (AstraZeneca) submitted/being developed for submission to BBSRC. |
| Collaborator Contribution | as above |
| Impact | As above |
| Start Year | 2014 |
| Description | Syngenta BB/L01548X/1 |
| Organisation | Syngenta International AG |
| Country | Switzerland |
| Sector | Private |
| PI Contribution | Tyler, Brown, Hetheridge have continued to work to secure follow-on research collaboration with Richard Currie and Katy Wolton at Syngenta AG UK. They are currently finalising a BBSRC IPA research proposal for submission in April 2018: "Defining critical stages and mechanisms of cleft palate development, which are particularly susceptible to environmental perturbation". The new proposal is a substantial improvement on the previous unsuccessful bid, benefiting from a new collaboration with Dr Steffen Scholpp (formerly from the Karlsruhe Institute of Technology, Germany) concerning imaging of palatal cell signalling events (sonic hedgehog and retinoic acid) and Single Molecule Detection (SMD) for studying protein-protein interactions. The team will also continue to collaborate with Dr Chrissy Hammond from the University of Bristol's Biomedical Science Department, providing expertise in the regulation of cartilage and bone homeostasis, including in the orofacial skeleton. Tyler and Hetheridge have negotiated a further research collaboration with AstraZeneca: Drug Safety Assay Development Research (£252k), which follows-on from a previous consultancy agreement. The majority of this project aims to evaluate the potential for transgenic zebrafish models to aid the prediction of human side effects of pharmaceuticals - including seizure and bone malformation, amongst others. From 2017: Through the FLIP we have strengthened considerably our research partnership with AstraZeneca UK and built a new partnership with Syngenta AG, including via internships (Ross Brown and Jon Green) and regular face-to-face meetings. The partnerships have played a role in securing further major research support to Exeter from AstraZeneca for work on pharmaceuticals, three CASE studentship(s) for advancing the use of transgenic fish/imaging and modeling in chemical hazard identification (Syngenta/AstraZeneca) with further grants (Syngenta) and CASE studentships (AstraZeneca) submitted/being developed for submission to BBSRC. |
| Collaborator Contribution | as above |
| Impact | as above |
| Start Year | 2014 |
| Description | 19th UK-Japan Annual Scientific Workshop for Research into Environmental Endocrine Disrupting Chemicals 2017 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Anke Lange presented data from this work on roach at the 19th UK-Japan Annual Scientific Workshop for Research into Environmental Endocrine Disrupting Chemicals, Japan December 2017. The conference was attended by UK and Japanese government regulators, and environmental consultants. |
| Year(s) Of Engagement Activity | 2017 |
| Description | 24th UK-Japan Annual Scientific Workshop |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Prof Charles Tyler was Chair of this workshop and gave the opening talk |
| Year(s) Of Engagement Activity | 2022 |
| Description | 50th Anniversary of the Fisheries Society of the British Isles |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | The Jack Jones Lecture, 50th Anniversary of the Fisheries Society of the British Isles. Feminisation of Nature - An Unnatural History, Exeter, July 2017. C.R.Tyler Assessing the oestrogenic potency and health impacts of wastewater treatment work effluents using ERE-GFP transgenic zebrafish. FSBI Annual Symposium, Exeter, UK 3-7 July 2017 Oral presentation Cooper, R.; Kudoh, T.; Tyler, C.R.; David, A.; Hill, E. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Annual Scientific Workshop |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | The 20th UK-Japan Annual Scientific Workshop on Research into Environmental Endocrine Disrupting Chemicals, Downing College, Cambridge |
| Year(s) Of Engagement Activity | 2019 |
| Description | Aya Takesono: Oral presentation at South West Zebrafish Meeting 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | Oral presentation at South West Zebrafish Meeting 2019, 9th September, 2019, University of Bristol, UK. Title: Novel oestrogen-responding glia that regulates olfactory development and function. Authors: Aya Takesono*, Paula Schirrmacher, Aaron Scott, Jon M. Green, Okhyun Lee, Matthew J. Winter, Tetsuhiro Kudoh and Charles R. Tyler |
| Year(s) Of Engagement Activity | 2019 |
| Description | Chalkstream Headwaters |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Feminisation of Freshwater Nature - Chalk Stream Headwaters Annual Meeting at Sparsholt College, 24th November 2017 |
| Year(s) Of Engagement Activity | 2017 |
| Description | Development and Application of Transgenic Zebrafish for Understanding Chemical and Nanoparticle Exposure Effects The 23rd UK-Japan Annual Scientific Workshop on Research into Environmental Endocrine Disrupting Chemicals & Chemicals of Emerging Concern Virtual meeting |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Annual international research conference/workshop |
| Year(s) Of Engagement Activity | 2021 |
| Description | International Congress on Comparative Endocrinology, Canada |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Endocrine Disruption in Aquatic Systems. International Congress on Comparative Endocrinology, Canada. June 2017. Keynote speech. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Invited Opening Keynote Speech for international society for the Developmental Origins of Health and Disease, Melbourne , Australia |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | The Chemical Environment and Health. International Society for the Developmental Origins of Health and Disease, Melbourne , Australia, Invited Opening Keynote 22nd October 2019 |
| Year(s) Of Engagement Activity | 2019 |
| Description | KEYNOTE PRESENTATION |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | International Symposium on the Reproductive Physiology of Fish, Manaus Brazil. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Opening talk for the UK-Japan Partnership for studies into Endocrine Disrupting Chemicals and Chemicals of Environmental Concern |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | The 22nd UK-Japan Annual Scientific Workshop on Research into Environmental Endocrine Disrupting Chemicals |
| Year(s) Of Engagement Activity | 2020 |
| Description | Presentation at 23rd UK-Japan Annual Scientific Workshop on Research into Environmental Endocrine Disrupting Chemicals & Chemicals of Emerging Concern - Virtual meeting |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Presentation at 23rd UK-Japan Annual Scientific Workshop on Research into Environmental Endocrine Disrupting Chemicals & Chemicals of Emerging Concern - Virtual meeting |
| Year(s) Of Engagement Activity | 2021 |
| Description | SETAC Barcelona 2015 - seminar/workshop 'The use of transgenic zebrafish in ecotoxocology' |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | We also coordinated and ran an international seminar/workshop on "The use of transgenic fish in ecotoxicology" held at the Society for Ecotoxicology And Chemistry (SETAC) European Meeting in Barcelona. |
| Year(s) Of Engagement Activity | 2015 |
| Description | Scientific workshop |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | The 20th UK-Japan Annual Scientific Workshop on Research into Environmental Endocrine Disrupting Chemicals, Downing College, Cambridge |
| Year(s) Of Engagement Activity | 2019 |
| Description | South-west Zebrafish Meeting 2020: Chemicals, Environmental Health and Zebrafish Models, Exeter |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Other audiences |
| Results and Impact | Talks, research findings shared |
| Year(s) Of Engagement Activity | 2020 |
| Description | Symposium |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | CRU Symposium attended by international audience, peers and others |
| Year(s) Of Engagement Activity | 2018 |
| Description | Talk at 24th UK-Japan Annual Scientific Workshop - Research into Environmental Endocrine Disrupting Chemicals & Chemicals of Emerging Concern |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Talk - Aya Takesono, Paula Schirrmacher, Aaron Scott, Jon M. Green, Okhyun Lee, Matthew J. Winter,Tetsuhiro Kudoh and Charles R. Tyler, Estrogens regulate early embryonic development of the olfactory sensory system via estrogen-responsive glia, (November 2022, ), 24th UK-Japan Annual Scientific Workshop - Research into Environmental Endocrine Disrupting Chemicals & Chemicals of Emerging Concern |
| Year(s) Of Engagement Activity | 2022 |
| Description | Talk at XXXII European Chemoreception Research Organization |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Talk- Aya Takesono, Paula Schirrmacher, Aaron Scott, Jon M. Green, Okhyun Lee, Matthew J. Winter, Tetsuhiro Kudoh and Charles R. Tyler, Estrogens regulate early embryonic development of the olfactory sensory system via estrogen-responsive glia, (Sep 2022, Berlin), XXXII European Chemoreception Research Organization |
| Year(s) Of Engagement Activity | 2022 |
| Description | The UK-Japan Partnership for studies into Endocrine Disrupting Chemicals |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Policymakers/politicians |
| Results and Impact | The UK-Japan Partnership for studies into Endocrine Disrupting Chemicals. The 21st UK-Japan Annual Scientific Workshop on Research into Environmental Endocrine Disrupting Chemicals, Otsu, Japan. Opening Address. 12 November 2019 |
| Year(s) Of Engagement Activity | 2019 |
| Description | Waking up to Planetary Health 2020: Chemicals and Environmental Health conference Royal Devon and Exeter Hospital and the University of Exeter Medical School |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other audiences |
| Results and Impact | Keynote speech 30/04/2020 |
| Year(s) Of Engagement Activity | 2020 |