Characterisation and exploitation of novel antimicrobials within the rumen microbiota

Lead Research Organisation: Aberystwyth University
Department Name: IBERS

Abstract

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

Publications

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Linda Oyama , Susan Girdwood , Alan Cookson , Dr. Narcis Fernandez-Fuentes , Florence Privé , Hannah Vallin , Toby Wilkinson , Prof. Peter Golyshin , Dr. Olga Golyshina , Ralf Mikut , Prof. Kai Hilpert , Jennifer Richards , Mandy Wooton , Joan Edwards , Marc Maresca , Josette Perrier , Fionnuala Lundy , Yu Luo , Mei Zhou , Dr. Matthias Hess , Hilario Mantovani , Christopher Creevey (2017) The rumen: An underexplored resource for novel antimicrobial discovery in NPJ Biofilms and Microbiomes

Related Projects

Project Reference Relationship Related To Start End Award Value
BB/L026716/1 01/04/2014 31/05/2017 £41,531
BB/L026716/2 Transfer BB/L026716/1 01/09/2017 30/06/2018 £21,756
 
Description The grant is centred around fostering travel and discussion between the Principal Investigators (PIs) and Co-investigators (COIs) in order to obtain funding in partnership. The PIs and CoIs hosted workshops in the following order to foster partnership:

April, 2014 held in Universidade de Vicosa.
July, 2015 held in IBERS, Aberystwyth University.
August, 2016 Universidade de Vicosa.
The 4th workshop occurred in March 2018 in Queens University Belfast.
The partners and COIs had obtained funding for experimental work via RCUK Newton Brazil institutional links awards in September 2015 (2 grants between Huws and Mantovani and Newbold and Detmann). This meant that in December, 2016 the Brazilian partners were scheduled to come to IBERS as part of these grants, therefore an exchange did occur at that point. Huws also traveled to Brazil and met with the partners in Sao Paulo in November, 2016. As part of this grant and the RCUK-Newton Huws and Mantovani have been able to develop their novel antimicrobials discovered from the rumen microbiome substantially. The below summaries the scientific discoveries and development which would not have occurred without this partnering award:

-Fifteen (15) lead antimicrobial peptide (AMP) candidates
-Low MICs against a range of infections including bacterial, fungal and protozoal infections
-Rapid bactericidal killing <10 minutes in bacteria and complete kill within 120 minutes.
-Little or no cytotoxicity against mammalian cell lines
-Multimodal target/mechanism of action
-No resistance detected
-In vivo efficacy in Methicillin resistant Staphylococcus aureus (MRSA) mice wound infection
-Preliminary data showing in vivo efficacy in carbapenem resistant Pseudomonas aeruginosa lung infection
-A template for the design of antimicrobial therapies
-Opportunities for modifications and positive improvements
-Patent application filed: GB1621737.4
Exploitation Route We are currently seeking continued funding to complete pre-clinical trail phase research. We also seek to partner with industrial partners who may be interested in licensing our antimicrobials.
Sectors Agriculture, Food and Drink,Healthcare,Pharmaceuticals and Medical Biotechnology

 
Description Patent on our novel antimicrobials filed November, 2016. Patent no. GB1621737.4. Data has been communicated to public on many occasions through popular articles and talks. Data has been communicated under confidentiality agreements to appropriate companies to seek licensing agreements. Due to the need to patent our data, publications are only now being submitted.
First Year Of Impact 2016
Sector Agriculture, Food and Drink,Healthcare,Pharmaceuticals and Medical Biotechnology
Impact Types Cultural,Societal,Economic

 
Description Microbiology Society microbiome policy panel for microbiome research
Geographic Reach National 
Policy Influence Type Implementation circular/rapid advice/letter to e.g. Ministry of Health
 
Description DFE studentship: Understanding the rumen microbiome
Amount £60,000 (GBP)
Organisation Department for Education 
Sector Public
Country United Kingdom
Start 10/2017 
End 09/2020
 
Description ERA net Gas Co-fund
Amount £1,500,000 (GBP)
Organisation European Commission 
Sector Public
Country European Union (EU)
Start 10/2017 
End 09/2020
 
Description EU Horizon2020
Amount € 11,000,000 (EUR)
Funding ID Horizon 2020 
Organisation European Union 
Sector Public
Country European Union (EU)
Start 01/2019 
End 12/2023
 
Description Invest Northern Ireland Development of microbiome-derived antimicrobial peptides
Amount £126,000 (GBP)
Organisation Invest Northern Ireland 
Sector Public
Country United Kingdom
Start 11/2018 
End 10/2020
 
Description Monitoring AMR on Brazilian farms
Amount £45,000 (GBP)
Organisation Research Councils UK (RCUK) 
Sector Public
Country United Kingdom
Start 10/2017 
End 04/2018
 
Description NRN life sciences project grant
Amount £50,000 (GBP)
Organisation Life Sciences Research Network Wales 
Sector Academic/University
Country United Kingdom
Start 03/2015 
End 02/2017
 
Description One health approach to the understanding of the agricultural contribution to antimicrobial resistance
Amount £60,000 (GBP)
Organisation Northern Ireland Department of Agriculture, Environment and Rural Affairs (DAERA) 
Sector Public
Country United Kingdom
Start 10/2018 
End 09/2022
 
Description PhD studentship
Amount £60,000 (GBP)
Organisation University of York 
Department Department of Education
Sector Academic/University
Country United Kingdom
Start 09/2018 
End 08/2022
 
Description PhD studentship
Amount £60,000 (GBP)
Organisation British Poultry Council 
Sector Charity/Non Profit
Country United Kingdom
Start 11/2016 
End 11/2020
 
Description AMP lung mouse model work 
Organisation University of British Columbia
Country Canada 
Sector Academic/University 
PI Contribution We own the antimicrobial peptides (patent pending) and have many grants including this Newton grant to further the development of these.
Collaborator Contribution we met the partner who is very renound in antimicrobial peptide research in a Gordons conference in Italy. He offered to complete some mouse Pseudomonas infection model work for our peptides for free for co-authorship and future collaboration.
Impact This collaboration ended as the collaborator insisted on owning IP.
Start Year 2016
 
Description AMP mechanism of action 
Organisation Aix-Marseille University
Country France 
Sector Academic/University 
PI Contribution We own the antimicrobial peptides and have many funding streams including this Newton fund to understand and develop this compounds. We met the partner in a conference in France and he had expertise in terms of mechanism of action technologies which we have not set up in Aberystwyth. Therefore the partner under MTA and CDA agreements has conducted this aspect of the work for us, giving in-kind contribution in return for co-authorship and future collaboration.
Collaborator Contribution As noted above we met the partner in a conference in France and he had expertise in terms of mechanism of action technologies which we have not set up in Aberystwyth. Therefore the partner under MTA and CDA agreements has conducted this aspect of the work for us, giving in-kind contribution in return for co-authorship and future collaboration.
Impact Two co-authored publications so far and more in the pipeline. Exchange of PhD students has also occurred last year (2018).
Start Year 2016
 
Description Antimicrobial peptide synthesis and modification 
Organisation St George's Hospital
Department Orthopaedics
Country United Kingdom 
Sector Hospitals 
PI Contribution We asked Kai Hilpert to become one of our collaborators on the project and the post-doc assigned to this project spent a month in his lab learning peptide synthesis techniques
Collaborator Contribution Kai has provided us with many peptides at very low cost (1/3 of the cost it would be to get them made commercially) and provided some training and valuable suggestions.
Impact We have 2 joint papers
Start Year 2015
 
Description British poultry council 
Organisation British Poultry Council
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution In collaboration with the British Poultry Council we have been testing our novel antimicrobial peptides against a life threatening poultry protozoal parasite, Histomonas meleagridis. We obtained internal funding alongside British Poultry Council funding (£22,000) to this studentship which started in 2016.
Collaborator Contribution They have provided samples for initial testing and the studentship was funded to the value of £22,000.
Impact Initial testing of our antimicrobial peptides against Histomonas PhD studentship
Start Year 2015
 
Description Huws Mantovani collaboration 
Organisation Federal University of Viçosa
Country Brazil 
Sector Academic/University 
PI Contribution The original partnering award is between Drs Huws and Mantovani. Post the first visit by Dr Huws and colleagues to Visosa in july 2014 Drs Huws and Mantovani (alongside other colleagiues as Co-Is) have submitted 2 further grants to RCUK-Confap (one was successful-the newton grant). The grants have been written by myself and Dr Mantovani. Dr Mantovani has send 2 MSc students and 1 post-doctoral scientist to work with Dr Huws. Likewise a post-doctoral scientist from the Huws lab also spent 2 weeks with Dr Mantovani.
Collaborator Contribution The grants have been written by myself and Dr Mantovani. Exchange of staff from both groups has occurred, thus increasing cross-fertilization of ideas and enhanced training. Both the Newton grant and the BBSRC partnering grant have now finished and both partners are seeking opportunities for further fruitful collaboration.
Impact Two collaborative papers published and 2 under review with more in the process of being written.
Start Year 2014
 
Description Neem Biotech 
Organisation NeemBiotech
Country United Kingdom 
Sector Private 
PI Contribution Neem Biotech are sponsoring a PhD studentship centred on work that has arisen from the Newton-RCUK funding which resulted from this BBSRC Brazil partnering award. We are working closely with Neem to try and further understand the novel antimicrobials isolated rom the rumen microbiome and to increase the likelihood of commercialisation.
Collaborator Contribution Neem biotech provide financial and in kind support. They also meet with us on a monthly basis for project updates and to input advice from a commercial perspective.
Impact The partnership started October, 2015 therefore it is early days but outcomes and impact will likely be apparent in the next year or two.
Start Year 2015
 
Description Newbold Shingfield grant 
Organisation Federal University of Viçosa
Country Brazil 
Sector Academic/University 
PI Contribution Professor Jamie Newbold and Kevin Shingfield attended the workshop held in Visosa in July as part of this grant. Subsequently they have worked closely with Edenio Dentman and submitted 2 grants to RCUK-Confap to strengthen the collaboration (awaiting outcome). This collaboration has occurred due to this grant and my involevemnet was to bring the partners together for discussion.
Collaborator Contribution The Brazilian partners held the workshop and help write the subsequent grant proposals that arose from this workshop.
Impact None as yet. Sadly Prof Kevin Shingfield passed away during the project also.
Start Year 2014
 
Description Novabiotics 
Organisation NovaBiotics Ltd, UK
Country United Kingdom 
Sector Private 
PI Contribution Main company in the UK involved in licensing antimicrobial peptides. Under a confidentiality agreement and material transfer agreement, we have sent them our novel peptides for testing against fungal pathogens
Collaborator Contribution TSome of our AMPs have shown potent anti-fungal acitivities after testing in novabiotics. Novabiotics do not license but have collaborated with us since our initial discussions to enhance our data and support grant applications.
Impact None yet
Start Year 2015
 
Description stability antimicrobial peptides 
Organisation Queen's University Belfast
Country United Kingdom 
Sector Academic/University 
PI Contribution Under confidentiality and material transfer agreements we sent Dr Fionnula Lundy our antimicrobial peptides to test stability.
Collaborator Contribution They have tested the stability of our antimicrobial peptides and provided useful data to guide future modifications
Impact Data exchange and ideas for future collaboration
Start Year 2015
 
Title COMPOSITIONS AND METHODS OF TREATMENT 
Description The global rise of antimicrobial resistance in bacteria, combined with the decreasing number of innovative antibacterial agents being developed, poses a serious threat to modern medicine. There is a growing need to discover new alternative therapies as acquired drug resistance to frontline therapies against infections, is rapidly emerging as a major medical problem. Due to their bactericidal and broad-spectrum activity, minimal toxicity to mammalian cells, their ability to disrupt the cell membrane structure or form pores that cause intracellular compounds to leak out of the cell, leading to cellular death and low level of resistance, antimicrobial peptides (AMPs) are considered promising future drugs to combat antimicrobial resistance and research in this is field is advancing. The community of competitive culturable and non-culturable bacteria in the rumen, of which most are as yet unculturable, present an untapped goldmine for the discovery of novel bioactive compounds including antimicrobials. We have taken advantage of this substantially unexplored diversitywithin the rumen to deliver alternative therapies in form of AMPs for the treatment of MDR infections. We employed, metagenomics/omics technologies and bioinformatics in conjunction with bioactivity-led screens to identify potential AMP candidates. Our findings indicate that the rumen microbiome is a reservoir for viable alternative antimicrobials for future therapeutic application. Society economic and health impact of our Technology: The antimicrobial peptides (AMPs) identified/developed in our research are fast acting and bactericidal and show no development of bacterial resistance after prolonged exposure of the bacteria to sub-lethal concentrations of them. They have a multi-modal mechanism of action which indicate that they have multiple targets in the bacterial cell and as such, there is less likelihood of resistance developing in them. Not only do the AMPs have broad spectrum antibacterial activity including activity against methicillin resistant Staphylococcus aureus, multi-drug resistant cystic fibrosis Pseudomonas aeruginosa strains, Klebsiella pneumoniae and Acinetobacter baumannii strains, they are also efficacious against difficult to treat opportunistic fungal pathogens including Candida albicans, Cryptococcus neoformans, Trichophyton rubrum and Aspergillus fumigatus. We also have AMPS with applications in the treatment of histomoniasis. The impact of our research is highly significant in society on a global scale. The economic cost of fighting antimicrobial resistance in hospitals and in the environment to government and the health sector, will be significantly reduced should more alternative therapies such as the AMPs in our research become available to the public. Patients, especially immunocompromised patients, including children, people with chronic diseases, and the elderly suffering from various infections would benefit from the impact. People with numerous skin and topical infections could also benefit from this impact as our in vivo data show that our AMPs have superior efficacy over current treatment options. The food industry, especially the poultry industry could also benefit from this impact, as campylobacteriosis and histomoniasis are major diseases affecting poultry and causing almost a 100% mortality in susceptible birds (in the latter), could be potentially treated with some of our AMPs. This is important as there are currently no approved drug candidates for the treatment of histomoniasis. 
IP Reference GB1621737.4 
Protection Patent application published
Year Protection Granted 2017
Licensed No
Impact Publications are currently in preparation for submission.
 
Title Antimicrobial peptides 
Description We have completed in vitro testing and completed 3 mouse trials. We are still in early development phase and are actively seeking licensing opportunities to develop our technology further. 
Type Therapeutic Intervention - Drug
Current Stage Of Development Initial development
Year Development Stage Completed 2017
Development Status Actively seeking support
Impact Still early phase 
 
Description BSAS conference talk 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact British society of animal science annual conference. Gave a talk on the rumen microbiome.
Year(s) Of Engagement Activity 2017
 
Description Balmoral show general public outreach event 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Balmoral show general public outreach event. Organised an outreach event for the general public and children to enhance understanding of the research area. Activities for children included clay modelling of rumen microbes, DNA extraction etc.
Year(s) Of Engagement Activity 2018
 
Description Eisteddfod 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Gave talks in Welsh on my research in the national eisteddfod.
Year(s) Of Engagement Activity 2015,2016
 
Description Eisteddfod rumen microbiology awareness activities 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Schools
Results and Impact We hosted a stand within in the eisteddfod science hall all encompassing the rumen micrbiome to stimulate understanding and enthusiasm angst school children and their parents

School teachers showed interest in inviting us in to host a similar event within schools
Year(s) Of Engagement Activity 2015
 
Description ITN productions Royal Society for Biology media production 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact ITN productions Royal Society for Biology media production to promote the reasrch area and activities within Queens University, Belfast.
Year(s) Of Engagement Activity 2018
 
Description Interview for BBC 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact BBC interview on women in science and my research
Year(s) Of Engagement Activity 2016
 
Description Invited speaker Sea-climate conference Teagasc, Republic of Ireland 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Invited speaker Sea-climate conference Teagasc, Republic of Ireland. Tlk entitled 'Exploitation of the faecal microbiome of North Ronaldsay algae-eating sheep.
Year(s) Of Engagement Activity 2018
 
Description Keynote speaker for Molecular microbial ecology group conference 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Keynote speaker for Molecular microbial ecology group conference. Talk entitled 'The rumen microbiome: A pandora's box for novel antimicrobials'.
Year(s) Of Engagement Activity 2018
 
Description Keynote talk British Society of Animal science 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Keynote talk at British Society for Animal Science conference. Talk entitled 'Understanding the role of the rumen microbiome in animal phenotype'.
Year(s) Of Engagement Activity 2018
 
Description Keynote talk for Microbiology Society 'Microbiomes underpinning agriculture' conference 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Keynote talk for Microbiology Society 'Microbiomes underpinning agriculture' conference entitled 'The rumen microbiome and it's role in animal phenotype
Year(s) Of Engagement Activity 2018
 
Description Keynote talk for Microbiology Society conference 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Keynote talk for Microbiology Society conference entitled 'Ecological interactionswithin the rumen microbiome play an importnat role in animal phenotype'.
Year(s) Of Engagement Activity 2018
 
Description Microbiology Society conference 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Gave a talk in the Microbiology Society annual conference in Birmingham and displayed numerous posters for the group.
Year(s) Of Engagement Activity 2015
 
Description News report on Women in Science 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact TV news interview on women in science
Year(s) Of Engagement Activity 2017
 
Description Popular article 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact IBERs Magazine article on novel antimicrobial discovery from the rumen microbiome.
Year(s) Of Engagement Activity 2016
 
Description Popular article for Aberystwyth alumni magazine 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Submitted an article on my research focused on the rumen microbiome for the Aberystwyth University alumni magazine
Year(s) Of Engagement Activity 2016
 
Description Presentation to Meat Promotion Wales 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Industry/Business
Results and Impact Gave a talk to the levy board Meat Promotion Wales outlining agricultural challenges and the importance of understanding the rumen microbiome to address these challenges
Year(s) Of Engagement Activity 2015
 
Description Royal Welsh Agricultural Show 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Represented IBERS, Abersytwyth University in the stall/building. Took part in outreach activities with the general public
Year(s) Of Engagement Activity 2006,2007,2008,2009,2010
 
Description Rumen microbial genomics Global Research Alliance annual metting 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Policymakers/politicians
Results and Impact The Global Research Alliance is a grouping of international government representatives, economists, funders and scientists focussed on reducing greenhouse gas emissions from agricultural practices. It is a grouping of influencers throughout the world with influence on government policy and funding opportunities. Dr Huws runs the rumen microbial genomics network which is part of the GRA. The meeting was held in the USDA, Washington DC.
Year(s) Of Engagement Activity 2017
 
Description Rumen microbial genomics workshop 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Dr Huws is the coordinator for the global rumen microbial genomics network which is part of the large research councils and teh global research alliances. as part of this role she ran a rumen microbial genomics workshop linked to the INRA-Rowett gut microbiology meeting held in Clermont Ferrand in June, 2016. the workshop was attended by over 80 international delegates including scientists and industry.
Year(s) Of Engagement Activity 2016
 
Description School engagement 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Microbiology school event sponsored by microbiology society held in Strathhearn preparotory school, Northern Ireland. The event was to raise awareness of microbes will live on us and in the environment to prim Ary school children
Year(s) Of Engagement Activity 2017
 
Description Science cafe for general public 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Aberystwyth Science cafe is an evening evnt intended to communicate research to the general public.
Year(s) Of Engagement Activity 2017
 
Description Soapbox science 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Dr Huws and Dr Linda Oyma took part n a soapbox science event in Swansea city centre in September, 2016 to talk about ruminants and their microbiome to members of the general public. Soapbox science is an internationally known event which has the purpose of communicating your research to the public and also to remove unconscious bias that all scientists are male. Therefore all speakers are female. the event requires a lot of planning and props to engage interactively with the general public.
Year(s) Of Engagement Activity 2016
 
Description Soapbox science participant 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Took part in soapbox science, an event to heighten awareness of women in science. Event occurred in Swansea city centre.
Year(s) Of Engagement Activity 2016
 
Description Society for microbiology microbiome expert working panel 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Policymakers/politicians
Results and Impact Microbiology society expert working panel on microbiomes was set up to provide a document for stakeholder (in particular policy makers/politicians) on microbiome research and influence funding decisions
Year(s) Of Engagement Activity 2017
 
Description TV interview on publication 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Asked to give an interview on BBC on scientific outcomes of a grant on the effects of green odour plant volatiles on ruminant production
Year(s) Of Engagement Activity 2014,2015
 
Description Talk 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact Talk given in an industry led conference on animal microbiomes
Year(s) Of Engagement Activity 2017
 
Description Talk 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact Talk on the turkey gut micro biome in an industry led conference on turkey production.
Year(s) Of Engagement Activity 2018
 
Description Talk in the Chinese Academy of Sciences conference in Nanjing University 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Talk in the Chinese Academy of Sciences conference in Nanjing University entitled 'Towards a greater understanding of the rumen microbiome
Year(s) Of Engagement Activity 2018
 
Description Visit from Vicosa scientists to IBERS 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Participants in your research and patient groups
Results and Impact As part of the BBSRC patterning award Vicosa scientists visited IBERS in September, 2015 to further project discussions and to enhance collaboration within both institutes

More PhD student exchange will occur and more grants will be submitted
Year(s) Of Engagement Activity 2015
 
Description Visit to Visosa 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Type Of Presentation workshop facilitator
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Workshop held in Visosa in July 2014 sparked many collaborations between IBERS staff present and UFV staff present. This has resulted in in-kind advice and submission of many grants to RCUK-Confap

None as yet
Year(s) Of Engagement Activity 2014
 
Description Welsh government 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact Was part of a video created for Welsh government on women in science. this was part of a release on Welsh government action points to increase the number of women in science
Year(s) Of Engagement Activity 2016
 
Description Women in science Welsh government promotional video 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact I was part of a promotional video on women in science for Welsh government. the purpose was to encourage more females to enter and lead in STEM subjects.
Year(s) Of Engagement Activity 2016
 
Description eisteddfod 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Ran a science outreach event in the national eisteddfod in Abergavenny focussed on agriculture and ruminants.
Year(s) Of Engagement Activity 2016
 
Description royal Welsh agricultural show outreach event 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact We hosted a stall encompassing activities to stimulate interest and understanding of the rumen microbiome in the Royal Welsh agricultural show

Stimulated much interest and significant increase in understanding of the rumen microbiome.
Year(s) Of Engagement Activity 2015