Tackling Enterohaemorrhagic E. coli infection across continents

Lead Research Organisation: University of Edinburgh
Department Name: The Roslin Institute

Abstract

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Publications

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Description To date, we have funded valuable exchanges visits leading to a successful BBSRC grant submission (BB/P02095X/1) involving our laboratories and one published manuscript (doi: 10.1128/AAC.02085-15). Through my visit to Argentina in 2016, I have now set up a additional collaboration in Argentina Dr Cataldi around cattle colonisation and vaccine research and have enabled some PacBio sequencing of their cattle isolates in collaboration with the USDA. Futher research is now being planned with CONICET and one further manuscript is being written. We consider the award (£13,163.32) has been invaluable to build collaborations and discuss research.The end date of the award as just been extended to Sept 2018 but to take account of a final series of exchange visits in 2018. The VTEC international meeting (held every 3 years) will be in Florence in May 2018. Therefore, it makes sense for any research visit by scientists from Argentina to us this year (under the partnership award) to also include this international meeting. Dr Romina Brando and Dr Angel Cataldi will both visit Edinburgh for further collaborative work in May/June. Dr Brando plans to stay for several weeks into July 2018 to conduct further experiments in our laboratory towards a publication. We aim to help analyse Argentinian isolate sequences to help understand whether the high rates of infection they have in Argentina are linked to the genetics of their circulating strains.
Exploitation Route full grant applications and international partnership to deal with a significant bacterial zoonosis
Sectors Agriculture, Food and Drink,Environment,Pharmaceuticals and Medical Biotechnology

 
Description Argentina has some of the highest rates of kidney damage (HUS) due to E. coli O157 infection in the world. We have experise in the UK in understanding this organism and why certain strains are more likely to be associated with serious pathology. The partnership award has led to information exchange around this important issue and has allowed us to include Argentinian isolates in current seqeuncing projects for comparative studies. We have submitted a collaborative grant to BBSRC to investigate differences in strain pathogenesis and this was awarded in 2017. This will allow us to further build the collaboration with CONICET. As a result of my visit to visit to CONICET in 2016, we arranged further collaborative visits for spring 2018 that overlap with the 3-yearly VTEC international conference to be held in Florence in 2018. We are supporting to visits, one from Romina Brando to carry out further work in our laboratory to complete investigations of some highly pathogenic EHEC O157 strains, hopefully for publication. The other visit is from Angel Cataldi who works in cattle vaccine development and a relationship is being build there towards further research.
First Year Of Impact 2015
Impact Types Cultural

 
Description Food Standards Scotland Open Tender
Amount £120,000 (GBP)
Funding ID CRF:MRI/104/17 
Organisation Government of Scotland 
Department Food Standards Agency (FSA), Scotland
Sector Public
Country United Kingdom
Start 07/2017 
End 06/2019
 
Description Machine-learning to predict and understand the zoonotic threat of E. coli O157 isolates
Amount £421,490 (GBP)
Funding ID BB/P02095X/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 10/2017 
End 09/2020
 
Description Collaboration with Public Health England 
Organisation Public Health England
Country United Kingdom 
Sector Public 
PI Contribution Provision of animal and human STEC for sequencing, working with PHE to analyse strain phylogeny and epidemiology. We have contributed through further analysis of long read strain sequences to understand changes in strains that occur during outbreaks. We have co-upervised 2 PhD students on STEC bioinformatics projects.
Collaborator Contribution Reduced rate sequencing of STEC, analysis of data, provision of metadata. Co-publication
Impact Publications as in main list
Start Year 2013