DNA Synthesis at the Norwich Research Park

Lead Research Organisation: Earlham Institute
Department Name: Directorate Office

Abstract

We propose to set up a DNA Synthesis facility at the Norwich Research Park (NRP) with the aim to support the design, generation and exploitation of high-value compounds and bioactives obtained from plants and microbes. These are areas of strength within the Norwich Research Park (NRP) which hosts a number of research institutes with strategic programmes that are recognised as international leaders, in particular in areas around the generation of novel antibiotics and other valuable secondary metabolites such as terpenes and anthocyanins. More recently the development of targeted genome editing technologies have emerged as another complementary area of strength within the NRP. The DNA synthesis facility within the NRP will also contribute to enhance the opportunities to develop computational methods in areas relevant to systems biology complementing other technology platforms within the NRP. The focus will be on the modelling of gene networks, which is placed at the interface of systems and synthetic biology.

Technical Summary

The focus of the facility will be on construction of long DNA fragments including whole plasmid-like genomes and the generation of recombinant libraries that could be used for high-throughput screening of advantageous phenotypes. The facility will be hosted by The Genome Analysis Centre (TGAC) and the activities will be focussed around areas of application that are priorities for the NRP. The engineering of specific compounds and the ability to screen for the effect of diverse genotypes will complement the well-established DNA sequencing platform at TGAC positioning the NRP as technologies leaders in the area. We propose to incorporate the DNA synthesis equipment within the current genomics platform which is mainly funded through the BBSRC's National Capability Grant. In this way we will leverage the investment in infrastructure regarding project management support and laboratory set up with the possibility to offer very rapidly a DNA synthesis service accessible to the wider UK plant and microbial community. There is however an intention to develop the services around the areas of expertise and application relevant to the NRP scientific vision. The development of technical expertise in DNA synthesis will be initially focused on three areas of active research: novel antibiotics, exploitation of the NRP yeast resources and plant genome editing. A fourth area of interest is the design of predictive computational and mathematical models. The recently created Industrial Biotechnology and Bioenergy Alliance (IIBA) within the NRP will serve as a catalyser to bring the research groups working in these areas together in a coherent technology development programme led by TGAC.

Planned Impact

The delivery of the Programme's objectives is focused on the deployment of a DNA synthesis facility: an area of technological development that is complementary to the current research programmes within the NRP. In this way the delivery of the proposed objectives will have a direct impact in areas of research relevant to the three BBSRC scientific priorities in food security, bioenergy and biology underpinning health. This facility will aim to integrate established methods in genomics and bioinformatics with emerging areas of research in systems and synthetic biology.

Academic, Economic and Commercial Impacts
The development of the DNA synthesis platform will generate new opportunities for collaborative work with R&D groups in industry and academic institutions within the NRP, nationally and internationally. We will also enhance the service portfolio of TGAC's NCG Genomics with the DNA synthesis capacity, in this way ensuring the UK scientific community remains at the forefront as an international leader in life sciences.

Societal impacts
The deployment of the proposed DNA synthesis within the NRP will directly impact the local and national communities with the generation of new funding opportunities and the development of new skills. TGAC's presence in the Norwich area has strengthened the position of NRP as a technology hub hosting specific expertise in biotechnology and computational biology. The proposed DNA synthesis facility will create new opportunities around the development of services, which will potentially translate into new opportunities for collaborations. TGAC computing facilities and access to expertise and resources has already delivered impact as it is one of the largest data processing centres in the UK.

BBSRC, Research Councils and UK
The deployment of cutting-edge technologies will enhance the NRP reputation and will support the development of expertise on new strategies for data analysis. The development of specific skills in computational methods related to DNA synthesis technologies will deliver impact to a broad range of stakeholders emphasising the key role the Institute will play in enabling researchers to develop innovative science.
 
Title Nicotiana, biofoundry. 
Description An artistic interpretation inspired by plant systems for bioproduction of natural products developed with artist and designer, Karen Ingram. 
Type Of Art Artwork 
Year Produced 2018 
Impact Published as part of 'Convergent Visions' Faesthetic #15 produced in partnership with SXSW for the SXSW Art Program 2018. Presented at SXSW Interactive 2018. 
URL http://think.faesthetic.com/archives/9687
 
Description We have established a DNA foundry with automated protocols for DNA construct fabrication and transformation into a number of scaffolds. We have also co-developed a LIMS.
Exploitation Route We hope to pump prime projects to use the foundry to engage the academic scientific community and also we hope to provide 'research hotel' services to industry
Sectors Agriculture, Food and Drink,Healthcare,Manufacturing, including Industrial Biotechology,Pharmaceuticals and Medical Biotechnology

URL http://www.earlham.ac.uk/earlham-dna-foundry
 
Description The technologies and protocols developed at the foundry have been used in efforts to develop engineered orphan crops for developing countries. Through the open plant initiative the foundry is also involved in the IGems competition which educates young people about synthetic biology
Sector Agriculture, Food and Drink,Education,Healthcare,Manufacturing, including Industrial Biotechology,Pharmaceuticals and Medical Biotechnology
Impact Types Economic

 
Description BBSRC ENWW panel membership
Geographic Reach National 
Policy Influence Type Membership of a guideline committee
Impact The panel advises BBSRC exec and councillor how best to deliver BBSRC strategy. Impact is difficult to quantify
 
Description Engagement with All-Party Parliamentary Group on Agriculture and Food for Development: Implications of the 2018 European Court of Justice ruling on genome editing
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description Engagement with the Parliamentary Scientific Committee: implications of the 2018 European Court of Justice ruling on Genome Editing
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description Expert member of the plant synthetic biology working group for the European Food Standards Agency (EFSA)
Geographic Reach Europe 
Policy Influence Type Participation in a advisory committee
 
Description Invited submission to the ad hoc technical expert group (AHTEG) on digital sequence information on genetic resources of the the Convention on Biological Diversity
Geographic Reach Multiple continents/international 
Policy Influence Type Gave evidence to a government review
URL https://www.cbd.int/abs/dsi-gr/ahteg.shtml#submissions
 
Description Meeting with Professor Lionel Clark (Chair of the Synthetic Biology Leadership Council) to discuss synbio strategy in Agrifood sector
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description Particapited in parliamentary debate on CRISPR CAS and post-BREXIT genetic engineering in crops -APPG Science & Technology in Agriculture
Geographic Reach National 
Policy Influence Type Gave evidence to a government review
 
Description Policy Round Table on Synthetic Biology, UK Cabinet Office
Geographic Reach National 
Policy Influence Type Gave evidence to a government review
 
Description Science and Technology Committee, House of Commons - implications to the UK of the 2018 Euporean Court of Justice ruling on Genome Editing
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description Submission to the International Treaty on Plant Genetic Resources for Food and Agriculture ( ITPGRFA) on access and benefit sharing of digital sequence information
Geographic Reach Multiple continents/international 
Policy Influence Type Gave evidence to a government review
 
Description Synthetic Biology Expert Roundtable, Department for Business, Energy and Industrial Strategy
Geographic Reach National 
Policy Influence Type Gave evidence to a government review
 
Description submission to UKRI infrastructure review
Geographic Reach National 
Policy Influence Type Participation in a national consultation
URL https://www.ukri.org/files/infrastructure/progress-report-summary-document-final-march-2019-pdf/
 
Description 17-ERACoBioTech - SUSPHIRE - Sustainable Bioproduction of Pheromones for Insect Pest Control in Agriculture
Amount £395,317 (GBP)
Funding ID BB/R021554/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 04/2018 
End 03/2021
 
Description 17ALERT Mid-range equipment initiative - Bioreactor capability for the Plant and Microbe DNA Foundry
Amount £358,963 (GBP)
Funding ID BB/R000433/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 08/2017 
End 08/2018
 
Description Bioinformatics and Biological Resources (BBR) Fund
Amount £603,560 (GBP)
Funding ID BBS/E/T/000GP076 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 09/2016 
End 03/2017
 
Description Bioreactor capability for the Plant and Microbe DNA Foundry
Amount £358,963 (GBP)
Funding ID BB/R000433/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 08/2017 
End 08/2018
 
Description IPA Industrial Partnering Award - An improved bioproduction system for proteins and small molecules
Amount £420,676 (GBP)
Funding ID BB/P010490/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 10/2017 
End 09/2020
 
Description IPA Industrial Partnering Award - Germany-UK: The Portable Organelle Project (TPOP)
Amount £20,176 (GBP)
Funding ID BB/R021074/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 04/2018 
End 09/2019
 
Description ENSA Consortium 
Organisation John Innes Centre
Country United Kingdom 
Sector Academic/University 
PI Contribution We have provided knowledge on how to automate and miniaturise synthetic biology workflow processes for the ENSA consortium, developed automation for our hardware platform, provided bench space for ENSA members to work, provided training areas for ENSA consortium partners.
Collaborator Contribution The ENSA consortium brought knowledge on how to construct and develop multi-gene synthetic biology constructs, and worked with us to develop an appropriate suite of automation for the Foundry labs based on their international, Bill and Melinda Gates Foundation funded consortium needs.
Impact Collaboration is multidisciplinary, and combines laboratory automation, synthetic biology, next-generation sequencing. Outcomes are primarily knowledge exchange between the research groups of Prof Giles Oldroyd (JIC) and the DNA Foundry staff.
Start Year 2016
 
Description Software for DNA Foundries 
Organisation University of Liverpool
Country United Kingdom 
Sector Academic/University 
PI Contribution Co-development of LIMS software for DNA foundries
Collaborator Contribution Co-development of LIMS software for DNA foundries
Impact New software and publication of software
Start Year 2015
 
Title Leaf LIMS 
Description Leaf LIMS is a flexible laboratory information management system (LIMS) designed to address the complexity of synthetic biology workflows. At the project's inception there was a lack of a LIMS designed specifically to address synthetic biology processes, with most systems focused on either next generation sequencing or biobanks and clinical sample handling. Leaf LIMS implements integrated project, item, and laboratory stock tracking, offering complete sample and construct genealogy, materials and lot tracking, and modular assay data capture. Hence, it enables highly configurable task-based workflows and supports data capture from project inception to completion. As such, in addition to it supporting synthetic biology it is ideal for many laboratory environments with multiple projects and users. The system is deployed as a web application through Docker and is provided under a permissive MIT license. It is freely available for download at https://leaflims.github.io. 
Type Of Technology Software 
Year Produced 2017 
Open Source License? Yes  
Impact ongoing 
URL https://leaflims.github.io
 
Description 2017 Youth STEMM Gold Awards 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact Presentation on synthetic biology followed by a practical workshop on designing genetic circuits. Sudents then presented their ideas, asked technical questions and discussed the potential impacts of synthetic biology and biotechnology on society.
Year(s) Of Engagement Activity 2017
URL http://ysawards.co.uk
 
Description BBSRC SBRC/SBfG networking event 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact A 4 hour session after the end of the conference on the afternoon of Wednesday 16th November, which was open to the SBRCs, the IKC, DNA Synthesis investments and the CDTs. During the session we coveredtopics such as the Global Challenges Research Fund, encouraging interdisciplinary working through flexible funding mechanisms and flash talks on collaborative industry projects.
Year(s) Of Engagement Activity 2016
 
Description CPSC PhD course: SYNthetic BIOlogy, From pro- to eukaryotic SYStems (SYNBIOSYS) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Delivered lectures and workshops as part of the University of Copenhagen's CPSC PhD course: SYNthetic BIOlogy, From pro- to eukaryotic SYStems (SYNBIOSYS)
Year(s) Of Engagement Activity 2017
URL http://cpsc.ku.dk/calendar/2017/cpsc-phd-summer-course-2017-synbiosys/
 
Description EI DNA Foundry Tour : Nanjing Agricultural University (NAU) delegation 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact The developed activity was related to the presentation of the EI DNA Foundry's capabilities to a Nanjing Agricultural University (NAU) delegation. The goal of the event was to promote UK-China collaboration and the establishment of potential pioneering projects.
Year(s) Of Engagement Activity 2019
 
Description EI DNA Foundry Tours 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact The EI DNA Foundry Tours are organized visits to this facility which aim to voice up the available capabilities and tools for researchers and industry professional. Since March 2018 to date more than 40 tours have been organized, reaching local and international researchers and local SMBs.
The outcomes arisen from the visits are 3 Service Contracts with local researchers, 1 Service contract with SMBs, 3 collaborations with local researchers, 2 quotes for Grant applications and initial discussion for a new collaboration with local researcher.
Year(s) Of Engagement Activity 2018,2019,2020
 
Description Feature article on genomics in the Easton Daily Press 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact The Article was to cover the research activity at the Earlham Institute and at the Norwich Research park and how it would impact the general public
Year(s) Of Engagement Activity 2019
 
Description Gatsby plant science summer school: engineering plants for farming and pharming 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Undergraduate students
Results and Impact Presented a lecture and particilaped in a discussion session with undergraduates as part of the Gatsby Plant Science Summer School. The summer school is an opportunity for first year undergraduate students in the UK to discover the challenge and opportunities of studying plant science. 76% of students rated this particular talk as good or very good with some very positive comments such as, 'I realised how much I loved to learn about Synthetic aspect of biology after the talk by Dr Nicola Patron
Year(s) Of Engagement Activity 2018
URL http://intobiology.org.uk/dr-nicola-patron-engineering-plants-for-farming-and-pharming/
 
Description Industrial Biotechnology Alliance SAB meeting 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact The Industrial Biotechnology Alliance aims to create a portfolio of expertise from across the schools of the University of East Anglia and the research institutes based on the Park, and to facilitate greater interaction with industry.

The implementation and vision for the DNA Synthesis Facility at TGAC was presented to an audience of biotechnology industry and academic specialists.
Year(s) Of Engagement Activity 2016
 
Description Inside Synthetic Biology 2015 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact A one-hour interactive workshop exploring synthetic biology as part of a three-day course for 17 gifted and talented pupils from years 11-13. Three activies explored standards in plant synthetic biology, gene circuits and natural product engineering using synthetic biology.
Year(s) Of Engagement Activity 2015
 
Description Molecular Training Workshop for African Scientists, University of Cambridge 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Lectures deleivered as part of a two week training evint for agricultural research scientists, academics and PhD students from across Africa. This was followed by discussion and follow-up questions by email.
Year(s) Of Engagement Activity 2018
URL http://www.jrbiotekfoundation.org/cambridge-lab-training-2018/
 
Description NRP-UEA 2015 iGEM Team (iGEM Giant Jamboree, Science in Norwich, Norwich Writers Centre Workshop) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Undergraduate students
Results and Impact Instructed an undergraduate iGEM team that presented at the iGEM Giant Jamboree in Boston, MA. The team also interacted with various audiences at Science in Norwich public outreach event, a workshop for scientists and poets at the Norwich Writers Centre, and to large numbers of students at the iGEM Giant Jamboree. The team also collaborated with other teams in Spain and the Netherlands. The project took different approaches to increase butyrate levels in the colon to protect against colonic cancer and also interacted with Cancer charities to discuss preventative measures to combat cancer and the use of bioengineering to make healthy foods and medicines.
Year(s) Of Engagement Activity 2015
URL http://2015.igem.org/Team:NRP-UEA-Norwich
 
Description Neo.Life - 25 Visions for the Future of our Species (Book) 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Contributed a book section to Neo.Life - 25 Visions for the Future of our Species (Book). Editors: Jane Metcalf and Brian Bergstein
Year(s) Of Engagement Activity 2020
URL https://neo.life/visions/
 
Description Newsletter article June 2018: Unleashing the Power of Automation for Plant and Microbial Science 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact This short communication about the DNA foundry at the Earlham had as main goal to voice up its capabilities, and inform the plant research community how to interact with us to help with their research.
Year(s) Of Engagement Activity 2018
URL https://www.garnetcommunity.org.uk/newsletters
 
Description Norwich Biomakers 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Norwich Biomakers brings together an interdisciplinary network of people from across NorwichCity and the Norwich Science Park that share an interest in the cross-over of biology with design, technology, engineering, electronics and software. This group meets monthly at a variety of local spaces for events including talks, training in the use of technologies and to work on projects.
Year(s) Of Engagement Activity 2017,2018,2019
URL https://www.meetup.com/Norwich-Biomakers/
 
Description OpenPlant Intellectual Property Working Group 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Twenty four experts were recruited to the first OpenPlant working group on the topic of IP solutions for OpenPlant and the wider SynBio community, specifically an open Material Transfer Agreement (MTA) that would allow materials such as DNA parts to be exchanged between institutions with a standard contract that allows for redistribution and commercial use. A meeting of the IP Working Group took place on 30 July 2015. The purpose of the meeting was to bring together academic researchers, technical experts, and legal practitioners to explore the challenges and solutions for creating and sustaining an international platform of open technologies for plant synthetic biology. A report on the meeting was drafted and will be made available online along with the draft OpenMTA Linda Kahl from the BioBricks Foundation is compiling. Decisions and refinement of this draft was a direct outcome of the meeting. The working group had regular teleconferences following the meeting and BioBricks Foundation and University of Cambridge have recently entered the Wellcome Trust/NIH/HHMI supported Open Science Prize for additional funding to continue this collaboration.
Year(s) Of Engagement Activity 2015
 
Description Plant Genetics Resources and the Sustainable Development Goals: Needs, Rights, and Opportunities. Rockefeller Bellagio Center, Bellagio, Italy 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Policymakers/politicians
Results and Impact 18 experts from a range of disciplines were hosted by The Rockefeller Foundation at its Bellagio Center in Italy to discuss how plant genetic resources relate to and can be instrumental in meeting the United Nations' Sustainable Development Goals (SDGs).

The group had three objectives, which were to:
• Advance the ongoing global dialogue about how science, technology, data, and digital information about plant genetic resources (PGR) may impact and potentially help agriculture adapt to the changing climate and augment food and nutritional security, particularly in the developing world
• In the context of the SDGs, explore the interaction between emerging R&D opportunities (emanating from scientific and technological advances and increased data sharing capability) and the current policy framework related to access, use, and benefit-sharing of PGR and related information.
• Identify pathways for harmonizing the PGR policy framework with rapid developments in science and information technology to ensure safeguards and enhance opportunities to address the SDGs.
The group agreed to pursue three outputs, to be completed in the next six months:
• As a group, the participants will develop a comprehensive meeting report for public distribution. This report was initiated during the meeting and will be completed early in 2017.
• During the meeting, participants from the Diversity Seek Initiative (DivSeek) gathered input for their response to an invitation by the Secretary of the International Treaty for Plant Genetic Resources in Food and Agriculture (ITPGRFA) "to report on the implications for the objectives of the Treaty of the technologies underlying the DivSeek initiative" (as per paragraph 6 of Resolution 3/2015 of the Sixth Session of the Treaty Governing Body). This outcome can be used by the Secretariat to compile a synthesis on this report for consideration by the Governing Body of the Treaty at its Seventh Session in 2017. Participants agreed to provide additional input on the draft submission to the Treaty upon request from DivSeek.
• Finally, at least one scholarly article will be published as a result of this meeting describing the issues discussed and exploring potential solutions and bottlenecks to progress. The group agreed that it would be ideal to aim to develop a balanced treatment such that all participants would be happy to be identified as authors or contributors where their expertise was relevant to the subject matter. Participants also discussed how best to communicate the results with other audiences and agreed to consult with one another if any developed blog posts or articles related to the meeting.
Year(s) Of Engagement Activity 2016
 
Description Plants in iGem Workshops 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Undergraduate students
Results and Impact Workshop on Plants in synthetic biology held at the iGEM Giant Jamboree every year since 2014. Members of many international iGEM teams, industry and civil society representatives, as well as the iGEM executive team attend. The workshops comprise short talks followed by discussion (with audience participation) and information-sharing about plant synthetic biology tools and techniques.
these workshops, together with other activities have resulted in
- The establishment of a Plant Committee at iGEM
- The acceptance of parts in the Common Plant Syntax in the iGEM Registry
- The establishment of a Special Award for excellence in Plant Synthetic Biology in the iGEM competition (from 2016 onwards)
Year(s) Of Engagement Activity 2014,2015,2016
URL http://2016.igem.org/Resources/Plant_Synthetic_Biology
 
Description Presentation and discussion at Norwich Science Festival 2018 (Engineering Day) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Presentation on biomanufacturing to general public including interactive activity with biochemical pathways and debate about the meaning of the word 'natural', biological vs chemical manufacturing methods and whether manufacturing can be sustainable.
Year(s) Of Engagement Activity 2018
URL https://norwichsciencefestival.co.uk/events/building-with-biology/
 
Description Presentation at Automation in Synthetic Biology Workshop, University of Bristol 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Talk to Introduce the EI DNA Foundry to the UK SynBio community and industry/business attending the workshop.
Year(s) Of Engagement Activity 2018
URL http://www.bristol.ac.uk/brissynbio/events/2018/automation-workshop.html
 
Description Presentation for Norwich Research Park Industrial Biotech Alliance 2016 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Presented OpenPlant industrial biotech case studies to the Industrial Biotechnology Alliance Science Advisory Board
Year(s) Of Engagement Activity 2016
 
Description Science Café, Maddermarket Theatre, Norwich 19th April 2017 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Norwich Science Café at the Maddermarket Theatre entitled "Building with Biology". A presentation and interactive activity for identification of aromatic plant natural products and understanding biosynthetic pathways. This was followed by an extensive discussion on the meaning of the words 'synthetic', 'synthesis' and 'natural' and the relative benefits to the environment and health of synthetic biology approaches for manufacturing. Audience members expressed interest in adult-focussed lab-based workshops and bio-make spaces.
Year(s) Of Engagement Activity 2017
URL https://twitter.com/scicafenorwich
 
Description Scientific Advisory Board for Cluster of Excellence on Plant Sciences (CEPLAS), a joint initiative of Heinrich Heine University Düsseldorf (HHU), University of Cologne (UoC), Max Planck Institute for Plant Breeding Research Cologne (MPIPZ) and Forschungszentrum Jülich (FZJ). 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Member of the Science Advisory Board for the Cluster of Excellence on Plant Sciences (CEPLAS), a joint initiative of Heinrich Heine University Düsseldorf (HHU), University of Cologne (UoC), Max Planck Institute for Plant Breeding Research Cologne (MPIPZ) and Forschungszentrum Jülich (FZJ).
Year(s) Of Engagement Activity 2019,2020
URL https://www.ceplas.eu/en/home/
 
Description Synthetic Biology Foundry meeting, Liverpool 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Representatives from three BBSRC-funded DNA Synthesis Foundry Groups met to discuss knowledge exchange around laboratory workflows, laboratory information management systems (LIMS) and software support required for DNA Synthesis Foundries in Liverpool.

The three foundries represented were:

GeneMill (hosts)
The Genome Analysis Centre
The Edinburgh Genome Foundry
Year(s) Of Engagement Activity 2015
 
Description Synthetic biology session and discussion panel at the London Festival of Genomics 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Industry/Business
Results and Impact Chaired a session on synthetic biology session and participated in a panel discussion at the London Festival of Genomics, 2017. This brought the synthetic biology to a new audience of industry, investors and the general public. There was a lengthy discussion with the general public, investors and industry representatives from diverse fields (e.g. computing and engineering) about the ethics and potential of biological engineering at the panel discussion and also following the workshop.
Year(s) Of Engagement Activity 2017
URL http://www.festivalofgenomicslondon.com/full-agenda
 
Description The Essex Synthetic Biology School (ESBS), University of Essex, UK : 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Presented lectures on "Engineering Plant Genomes for Farming and Pharming" and "Sharing Biology in the Information Age: Perceived Threats of Dematerialisation and Open Data". These were followed by discussions on the use of biotechnologies in agricultures and a debate on access and benefit sharing of genetic resources. Participants reported changes in their views on the common practices used to share information relating to genetic resources as well as physical resources.
Year(s) Of Engagement Activity 2018
URL https://esbs.essex.ac.uk
 
Description Web Article - Spotlight on Synthetic Biology. Yaomin Cao 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Interview with Yaomin Cai of Nicola Patron's DNA Foundry at Earlham Institute, on how he got into synthetic biology, how it can help us to tackle biological questions, and what the future has in store. -SOCIAL MEDIA- Engagement x92, Impressions x70456
Year(s) Of Engagement Activity 2017
URL http://www.earlham.ac.uk/articles/spotlight-on-synthetic-biology
 
Description Web Article - Spotlight on biohacking 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Interview with Elliot Roth, founder of Spira and Indie-lab on biohacking and algae research. -SOCIAL MEDIA- ENgagement x88, Impressions x176657
Year(s) Of Engagement Activity 2017
URL http://www.earlham.ac.uk/articles/spotlight-biohacking-elliot-roth-%E2%80%9Cit%E2%80%99s-algae-time%...
 
Description Web article - Spotlight on Synthetic Biology 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Article with a focus on Synthetic Biology. An interview with John Cumbers, founder of SynBioBeta. -SOCIAL MEDIA- Engagement x160, Impressions x159540
Year(s) Of Engagement Activity 2018
URL http://www.earlham.ac.uk/articles/spotlight-synthetic-biology-john-cumbers
 
Description Web article for Public Engagement - What's in a genome? 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact 'Learning' Article to explain what's in agenome. -SOCIAL MEDIA- Engagement x 285, Impressions x 138027
Year(s) Of Engagement Activity 2017
URL http://www.earlham.ac.uk/articles/whats-genome
 
Description Year 10 Summer Science Camp SynBio day 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Schools
Results and Impact A one-day workshop on synthetic biology as part of a week long Science Camp for 13 promising year 10 pupils with an interest in careers in science. We covered activities from gene circuits and understanding important concepts of standardisation and modularisation, cloning and transformation of E.coli, engineering nitrogen symbiosis into crop plants, the design-build-test cycle. We had a lively debate on responsible research and innovation.
Year(s) Of Engagement Activity 2015