Investigating stem cell dynamics in stomach glands by computational models
Lead Research Organisation:
Quadram Institute
Department Name: Gut Health and Food Safety
Abstract
Singapore
People |
ORCID iD |
| Maria Pin Arias (Principal Investigator) |
Publications
Leushacke M
(2016)
Quantifying Lgr5-positive stem cell behaviour in the pyloric epithelium.
in Scientific reports
| Description | We have developed mathematical models for the quantification of the spatio-temporal cell dynamics of pyloric stem cells in health and disease |
| Exploitation Route | The developed models and the fitted parameters inform on how stem cells work under homeostasis. Variation of these parameters may be indicators of disease. Predictions on stem cell proliferation may be applied to estimate time for recovery after injuries or from side effects of some therapies. |
| Sectors | Education,Healthcare,Pharmaceuticals and Medical Biotechnology |
| Description | This project initiated a long-term collaboration with a highly recognized international team working at the forefront of this field that will lead to the publication of important papers and the development of competitive project proposals which will be beneficial to the general UK scientific research landscape. The output of this project is highly valuable for scientific research aimed at promoting the maintenance of a healthy gut which results in societal and economic benefits derived from increased quality of life and reduced pressure on healthcare provision. |
| Sector | Education,Healthcare,Pharmaceuticals and Medical Biotechnology |
| Impact Types | Societal,Economic |