Expanding the potency of stem cells with epigenetic modifiers
Lead Research Organisation:
Babraham Institute
Department Name: Epigenetics
Abstract
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People |
ORCID iD |
| Wolf Reik (Principal Investigator) |
Publications
Eckersley-Maslin MA
(2016)
MERVL/Zscan4 Network Activation Results in Transient Genome-wide DNA Demethylation of mESCs.
in Cell reports
| Description | TET3 was introduced into human embryonic stem cells making them more naive like |
| Exploitation Route | This interesting finding will be published forthwith and this may result in further key insights into human naive pluripotency |
| Sectors | Healthcare,Pharmaceuticals and Medical Biotechnology |
| Description | Patent application on the use of TET on pluripotency expansion. Currently further work in collaboration with a stem cell company to explore the potential of our findings for commercialisation. |
| Sector | Healthcare,Pharmaceuticals and Medical Biotechnology |
| Description | BBSRC LINK Grant |
| Amount | £468,118 (GBP) |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | |
| Description | Jenny Nichols, Austin Smith |
| Organisation | University of Cambridge |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Contributed to conceiving studies. Epigenetic profiling and analysis. |
| Collaborator Contribution | Conceived and conducted studies. |
| Impact | Publications Kalkan et al 2017, Guo et al 2017. Involves embryologists, stem cell biologists, computational biologists, epigeneticists. |
| Start Year | 2016 |
| Title | Novel Method |
| Description | A novel method to manipulate potency of pluripotent cells |
| IP Reference | US20160186207 |
| Protection | Patent application published |
| Year Protection Granted | 2015 |
| Licensed | Commercial In Confidence |
| Impact | In progress |