Chemo-enzymatic Production of Specialty Glycans

Lead Research Organisation: Imperial College London
Department Name: Metabolism, Digestion and Reproduction


Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

Technical Summary

The vision of the project centres around the translation of traditional and novel methodologies to develop sustainable and versatile platforms for the industrial production of glycans on scale. We will demonstrate the technology by targeting a set of novel glycan materials that are anticipated to have significant transformational potential in human health and disease in diagnostics and glycoengineering applications. This project requires an integrated approach featuring: 1) synthetic chemistry (unnatural building blocks) 2) biocatalysis (enzymatic synthesis of larger glycans) 3) showcasing glycan potential in diagnostics (glycoarray based platforms). The significant anticipated progression of both biocatalysis and glycoarray technologies will reduce commercialisation barriers both in terms of commercial glycan production and 'first in the market' glycan array companies.

Planned Impact

As described in proposal submitted to IUK


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Description Various effects (enhancement or diminution) of the bioactivities of the glycans are being observed associated with fluorination at different positions of glycans. We have received additional fluorinated glycans in March 2021 and have worked with these. The data are completed and the manuscript is being drafted.
Exploitation Route Manuscripts are being prepared. One is in an advanced stage for submission and the second is in the early draft stage.
Sectors Chemicals,Manufacturing, including Industrial Biotechology,Pharmaceuticals and Medical Biotechnology