International exploitation of new reagents and assays for antibiotic discovery

Lead Research Organisation: University of Warwick
Department Name: School of Life Sciences

Abstract

Publications

10 25 50
 
Description Lobbying policy makers and funders to support multidisciplinary research in support of AMR discovery
Exploitation Route Future strategy for AMR development and funding
Sectors Aerospace, Defence and Marine,Government, Democracy and Justice,Pharmaceuticals and Medical Biotechnology

 
Description Enabled further international engagement with industry, defence agencies and government
First Year Of Impact 2015
Sector Aerospace, Defence and Marine,Manufacturing, including Industrial Biotechology,Pharmaceuticals and Medical Biotechnology,Security and Diplomacy
Impact Types Economic,Policy & public services

 
Description Accelerate CHNUK AMR discovery: Establishing joint China/UK training and research platforms enabling highthroughput fragment based inhibitor discovery
Amount £1,000,000 (GBP)
Funding ID MR/P007503/1 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 06/2016 
End 05/2019
 
Description Coventry General Charities
Amount £157,000 (GBP)
Organisation General Charity of the City of Coventry 
Sector Charity/Non Profit
Country United Kingdom
Start 03/2018 
End 09/2022
 
Description MRC AMR theme 1 collaboration award
Amount £3,200,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 09/2015 
End 09/2020
 
Description Newton UK china ANMR hubs
Amount £3,000,000 (GBP)
Funding ID MR/S014934/1 
Organisation University of Warwick 
Sector Academic/University
Country United Kingdom
Start 01/2019 
End 12/2021
 
Description Wellcome Trust Innovation Award
Amount £100,000 (GBP)
Funding ID 109676/Z/15/Z 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 06/2016 
End 06/2017
 
Description Entasis collaboration 
Organisation Entasis Therapeutics
Country United States 
Sector Private 
PI Contribution Biochemistry and assay development
Collaborator Contribution Assay validation and hit characterisation insight
Impact Successful award of Wellcome Trust Pathfinder award
Start Year 2015
 
Description H3D drug discovery University of Cape Town 
Organisation University of Cape Town
Country South Africa 
Sector Academic/University 
PI Contribution Input of reagents assays and protein structures
Collaborator Contribution Input of medicinal chemistry know-how and chemical matter
Impact Interpersonal exchange of postdocs and to be PhD students
Start Year 2017
 
Company Name Antimicrobial Discovery Solutions Ltd 
Description Reagents, assay development and services 
Year Established 2015 
Impact N/A
 
Description 10 Downing Street 2018 Chinese New Year Celebrations 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Policymakers/politicians
Results and Impact Invitation from the PM to attend event to showcase UK China collaborative AMR research
Year(s) Of Engagement Activity 2018
URL https://www.gov.uk/government/news/pm-hosts-chinese-new-year-reception-at-downing-street
 
Description ANTRUK Antibiotic Research UK 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? Yes
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Establishment of new charity and new fundraising campaign

regional and national media interest
Year(s) Of Engagement Activity 2014
URL http://www.antibioticresearch.org.uk
 
Description MRC Milennium Medal Showcase of AMR research Palace of Westminster 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact Presentation of MRC and RCUK funded AMR research to Peers and Politicians at the Palace of Westminster as part of the 2018 MRC Millennium Medal Award event
Year(s) Of Engagement Activity 2018
URL https://www.youtube.com/watch?v=n2Z6Xxs8aA0
 
Description O'Neil AMR review 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Policymakers/politicians
Results and Impact In December we published our first report1
showing that infections caused by
drug-resistant pathogens are one of the biggest health problems the world faces
today. Bacteria and other pathogens have always evolved to resist the new drugs
that modern medicine uses to combat them. But in recent years the rise in drug
resistance has been a particular worry, especially the emergence of antibioticresistant
superbugs. Unless action is taken to address this huge global issue, our
conservative estimate is that it will cost the world an additional 10 million lives
a year by 2050, more than the number of people currently dying from cancer
annually. It will also have a cumulative cost of 100 trillion USD, more than one
and a half times annual world GDP today, or roughly the equivalent to losing the
UK economy from global output every year.
We now turn our attention to how this problem can be tackled. This paper is the
first in a series that works towards global and sustainable solutions. There are
many angles to the problem that we will need more time to consider. In particular,
the focus of our next paper, due to be published in the spring, will be how to
stimulate the market for companies to invest in and develop new antimicrobials and
diagnostics, which is not fully addressed here. There we will assess potential 'push'
and 'pull' incentives to encourage the development of new antimicrobial drugs,
and set out our proposals for action by policy makers. In later papers we will also
focus on important issues such as the use of antibiotics in agriculture and potential
alternatives to antimicrobials
Year(s) Of Engagement Activity 2015
URL https://amr-review.org/sites/default/files/Report-52.15.pdf
 
Description Pew Road Map for Antibiotic Discovery 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Policymakers/politicians
Results and Impact The Pew Charitable Trusts convened a multidisciplinary group of leading industry and academic experts to
identify the key scientific roadblocks to antibiotic discovery and consulted with numerous other public and
private sector stakeholders to develop a Scientific Roadmap for Antibiotic Discovery. The roadmap outlines a
concrete approach-both a scientific plan and organizational structure to support this research-that would lay a
foundation for the sustained and diversified discovery and development of new antibiotics and therapies over the
coming decades.The report's key findings show a need for:
• A targeted approach to tackle the basic scientific barriers impeding antibiotic discovery and development.
• A better understanding of how to overcome the cellular defenses of drug-resistant Gram-negative bacteria,
which cause some of the most difficult-to-treat infections.
• Generation of new chemical matter designed for antibiotic discovery.
• Tools and methodologies to evaluate promising alternatives to traditional antibiotic use.
• A framework for sharing information, expertise, and materials across the research community to foster
innovative science and spur the discovery of novel antibacterial therapies.
Year(s) Of Engagement Activity 2016
URL http://www.pewtrusts.org/~/media/assets/2016/05/ascientificroadmapforantibioticdiscovery.pdf
 
Description Radio 4 3 part drama production 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Radio drama highlighting factors driving antibiotic resistance and global consequences - raising public awareness at the National level
Year(s) Of Engagement Activity 2017
URL http://www.bbc.co.uk/programmes/b08g7y1l
 
Description United Nations General Assembley 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Policymakers/politicians
Results and Impact Invited to attended AMR working group presentations
Year(s) Of Engagement Activity 2016
URL http://www.un.org/pga/71/event-latest/high-level-meeting-on-antimicrobial-resistance/