Development of NanoKick Bioreactor
Lead Research Organisation:
University of Glasgow
Department Name: College of Medical, Veterinary, Life Sci
Abstract
Bone graft is the most transplanted tissue after blood. It is in short supply and demand is increasing with the aging population. Taking graft from a patient to transplant back to the patient is possible but results in morbidity of the donor site (normally the pelvis). We have developed a novel bioreactor, called Nanokick, which can be used to efficiently and effectively convert mesenchymal stem cells (MSCs - the bones natural stem cell supply) into osteoblasts (bone building cells). It works by supplying tiny kicks to cells. Our approach will provide technology that enables provision of 3D living bone derived from a patients own cells that produces effective repair. Areas this would be useful would include all bone reconstructions, spinal fusion and joint replacement. These in no need for chemicals and associated side effects (e.g. widely used bone morphogenic protein is now associated with adverse effects). In this work we will develop our technology towards a commercial product.
Organisations
- University of Glasgow (Lead Research Organisation)
- University of Glasgow (Collaboration)
- Meidrix (Collaboration)
- Bone Cancer Research Trust (Collaboration)
- NHS National Services Scotland (NSS) (Collaboration)
- Geistlich (Collaboration)
- UNIVERSITY OF STRATHCLYDE (Collaboration)
- Instituto de Ciencia de Materiales de Madrid (Collaboration)
- Atelerix (Collaboration)
- Histocell (Collaboration)
- Max Planck Society (Collaboration)
- Queen Elizabeth University Hospital (Collaboration)
- UNIVERSITY OF EDINBURGH (Collaboration)
- University of Valencia (Collaboration)
- Royal College of Surgeons in Ireland (Collaboration)
- UNIVERSITY OF SYDNEY (Collaboration)
- UNIVERSITY OF SOUTHAMPTON (Collaboration)
- UNIVERSITY OF NOTTINGHAM (Collaboration)
- University of Navarra (Collaboration)
- Anacail Ltd (Collaboration)
- University of Bristol (Collaboration)
- University of Galway (Collaboration)
- Trinity College Dublin (Collaboration)
- Eindhoven University of Technology (Collaboration)
- KING'S COLLEGE LONDON (Collaboration)
Publications
Campsie P
(2019)
Design, construction and characterisation of a novel nanovibrational bioreactor and cultureware for osteogenesis.
in Scientific reports
Childs PG
(2020)
Hurdles to uptake of mesenchymal stem cells and their progenitors in therapeutic products.
in The Biochemical journal
Childs PG
(2016)
Use of nanoscale mechanical stimulation for control and manipulation of cell behaviour.
in Acta biomaterialia
Donnelly H
(2018)
Current approaches for modulation of the nanoscale interface in the regulation of cell behavior.
in Nanomedicine : nanotechnology, biology, and medicine
Donnelly H
(2023)
Surface-Modified Piezoelectric Copolymer Poly(vinylidene fluoride-trifluoroethylene) Supporting Physiological Extracellular Matrixes to Enhance Mesenchymal Stem Cell Adhesion for Nanoscale Mechanical Stimulation
in ACS Applied Materials & Interfaces
Hodgkinson T
(2021)
The use of nanovibration to discover specific and potent bioactive metabolites that stimulate osteogenic differentiation in mesenchymal stem cells.
in Science advances
Kennedy JW
(2021)
Nanovibrational stimulation inhibits osteoclastogenesis and enhances osteogenesis in co-cultures.
in Scientific reports
Moulisová V
(2017)
Engineered microenvironments for synergistic VEGF - Integrin signalling during vascularization.
in Biomaterials
| Description | We have developed a bioreactor that can be used to engineer 3D bone that could be used for drug testing instead of animals. The bioreactor could also be used to produce e.g. tissue engineered bone graft. As part of this project, new applications for the bioreactor have been identified through new collaborations. |
| Exploitation Route | We are moving towards spin-out formation based on a cellular therapy. We are currently working towards a first human trial of cells produced using the technology. The device could be used in multiple research areas as a method of stimulating cells in vitro. New applications are being identified. |
| Sectors | Healthcare Manufacturing including Industrial Biotechology Pharmaceuticals and Medical Biotechnology |
| Description | The results are being used in outreach e.g. Royal Society Summer Exhibition 2016 and 2018. Also, we are building an impact case around our bone technologies of which nanokicking is one. Cells produced by the bioreactor will be used in a human trial in 2023 for bone repair. As part of this bioreactors will be provided to contract manufacturers to produce a cell therapy and have been placed into a GMP manufacturing facility who have started to manufacture cells for pre-clinical testing. We are now trying to licence the bioreactor. |
| First Year Of Impact | 2020 |
| Sector | Healthcare,Manufacturing, including Industrial Biotechology,Pharmaceuticals and Medical Biotechnology |
| Impact Types | Societal |
| Description | GMP manufacture of nanovibrated mesenchymal stem cells |
| Geographic Reach | Europe |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Description | Glasgow Orthopaedic Research Initiative |
| Geographic Reach | National |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Description | Healickick (EU grant) translational day |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Impact | Preparing surgeons for the technologies and getting advice how to best present the technologies in product form |
| Description | Organisation of industry focussed stakeholder day |
| Geographic Reach | National |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Description | Research Together - Patient and Public Involvement and Engagement Day 2023 |
| Geographic Reach | National |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Impact | Patients have fed back very positively about the day and about what they had learnt about emerging science in the area they are interested in and also future technologies. |
| Description | training of practioners and researchers |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Description | 'EPSRC and SFI Centre for Doctoral Training in Engineered Tissues for Discovery, Industry and Medicine |
| Amount | £7,013,578 (GBP) |
| Funding ID | EP/S02347X/1 |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 05/2019 |
| End | 12/2027 |
| Description | (HEALIKICK) - A modular strategy for the repair of critical sized bone fractures |
| Amount | € 5,243,536 (EUR) |
| Funding ID | 874889 |
| Organisation | European Commission |
| Sector | Public |
| Country | European Union (EU) |
| Start | 05/2020 |
| End | 05/2025 |
| Description | BCRT grant awarded to Dr P.M. Tsimbouri |
| Amount | £30,000 (GBP) |
| Organisation | Bone Cancer Research Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 02/2015 |
| End | 07/2015 |
| Description | Developing the Nanokick Bioreactor for Commercialisation and Cell Therapy |
| Amount | £582,280 (GBP) |
| Funding ID | BB/S018808/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 08/2019 |
| End | 09/2022 |
| Description | Doctoral Training Partnership 2020-2021 University of Strathclyde |
| Amount | £41,886 (GBP) |
| Funding ID | EP/T517938/1 |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2022 |
| End | 04/2026 |
| Description | Doctoral Training Partnership 2020-2021 University of Strathclyde, Johnson-Love, Olivia |
| Amount | £40,345 (GBP) |
| Funding ID | EP/T517938/1 |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2020 |
| End | 04/2024 |
| Description | Early diagnosis and intervention of osteoporosis using nanovibrational stimulation |
| Amount | £480,000 (GBP) |
| Funding ID | ST/S000852/1 |
| Organisation | Science and Technologies Facilities Council (STFC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 11/2018 |
| End | 10/2020 |
| Description | Early diagnosis and intervention of osteoporosis using nanovibrational stimulation |
| Amount | £48,807 (GBP) |
| Funding ID | ST/S000852/1 |
| Organisation | Science and Technologies Facilities Council (STFC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 11/2018 |
| End | 10/2021 |
| Description | Engineering growth factor microenvironments - a new therapeutic paradigm for regenerative medicine |
| Amount | £3,661,144 (GBP) |
| Funding ID | EP/P001114/1 |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2016 |
| End | 09/2022 |
| Description | Impact Acceleration Account (IAA)- Consultant to advise on pharmaceutical industry market for Nanokick technology |
| Amount | £20,000 (GBP) |
| Organisation | Science and Technologies Facilities Council (STFC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 01/2017 |
| End | 02/2017 |
| Description | Impact Acceleration Account (IAA)- Nanokicking: Expanding the proposition for the Pharma industry |
| Amount | £10,000 (GBP) |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 01/2018 |
| End | 12/2018 |
| Description | Mechanobiology-based medicine |
| Amount | £302,859 (GBP) |
| Funding ID | EP/W004623/1 |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2021 |
| End | 12/2023 |
| Description | Wellcome Trust ISSF Early Career Researcher Fund |
| Amount | £18,350 (GBP) |
| Organisation | Wellcome Trust |
| Department | Wellcome Trust Institutional Strategic Support Fund |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 03/2018 |
| End | 12/2018 |
| Title | Nanovibrational stimulation for chondrogenesis |
| Description | We have developed a nano vibrational bioreactor that we are currently taking to spin out formation. We have recently identified that we can generate chondrocytes as well as osteoblasts not he bioreactor giving us scope to investigate the use of the technology for cartilage regeneration. |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2019 |
| Provided To Others? | No |
| Impact | We are preparing to protect IP and publish so that we can disclose broadly and identify beta testers. |
| Title | Use of NanoKick Bioreactor for chondrogenic differentiation of MSCs |
| Description | Modification of cell culture method to induce chondrogenic differentiation of MSCs when using the NanoKick Bioreactor. |
| Type Of Material | Model of mechanisms or symptoms - in vitro |
| Year Produced | 2017 |
| Provided To Others? | No |
| Impact | Preliminary data obtained further funding from a Wellcome Trust ISSF Early Career Catalyst Fund (~£18300). |
| Title | Control of cell behaviour through nanovibrational stimulation: nanokicking |
| Description | |
| Type Of Material | Database/Collection of data |
| Year Produced | 2018 |
| Provided To Others? | Yes |
| Title | Nanovibrational stimulation inhibits osteoclastogenesis and enhances osteogenesis in co-cultures |
| Description | Models of bone homeostasis could be useful in drug discovery, particularly if the model is one that replicates bone regeneration with reduction in osteoclast activity. Here we use nanovibrational stimulation to achieve this in a 3D co-culture of primary human osteoprogenitor and osteoclast progenitor cells. We show that 1000 Hz frequency, 40 nm amplitude vibration reduces osteoclast formation and activity in human mononuclear CD14+ve blood cells and enhances osteogenesis/reduces osteoclastogenesis in a co-culture of primary human bone marrow stromal cells and bone marrow hematopoietic cells. Further, we use metabolomics to identify Akt (protein kinase C) as a potential mediator. Akt is known to be involved in bone differentiation via transforming growth factor beta 1 (TGF?1) and bone morphogenetic protein 2 (BMP2) and it has been implicated in reduced osteoclast activity via Guanine nucleotide-binding protein subunit a13 (Ga13). With further validation, our nanovibrational bioreactor could be used to help provide humanised 3D models for drug screening. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2021 |
| Provided To Others? | Yes |
| Impact | New information on bone homeostasis and potential developmentof 3D bone models for drug screening |
| URL | http://researchdata.gla.ac.uk/id/eprint/1230 |
| Description | COllaboration with Atelerix |
| Organisation | Atelerix |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Thi sis a joint PhD project in which we are designing in vitro stem cell niches |
| Collaborator Contribution | Provision and tailoring of hydrogel materials |
| Impact | Early collaboration |
| Start Year | 2021 |
| Description | Collaboration for Synthesis of Osteogenic Metabolites and Chemical Derivatives |
| Organisation | University of Glasgow |
| Department | School of Chemistry |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Identification of interesting metabolites in osteogenesis and in vitro testing of osteogenic potential |
| Collaborator Contribution | Chemical synthesis of metabolite molecules |
| Impact | We will shortly publish results from this collaboration. |
| Start Year | 2017 |
| Description | Collaboration with Anacail (Spin off) |
| Organisation | Anacail Ltd |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | We have stabilized a collaboration with Anacail to sterilize protein coating preserving the bioactivity. This will allow the commercialization of future implants in sterilize conditions. |
| Collaborator Contribution | The have been performing the sterilization of the samples and given ideas. |
| Impact | We have been able to find a range of doses to preserve the bioactivity of the big protein coatings and sterilize the samples at the same time. In the future we are going to be working towards finding the right amount of doses to preserve the bioactivity of smaller molecules (such as growth factors). |
| Start Year | 2017 |
| Description | Collaboration with Bone Cancer Research Trust |
| Organisation | Bone Cancer Research Trust |
| Country | United Kingdom |
| Sector | Charity/Non Profit |
| PI Contribution | We are developing models of sarcoma that are useful for bone cancer research |
| Collaborator Contribution | They are supporting us with training placements, access to patients and advice. |
| Impact | Development of better tissue models and enhanced training. |
| Start Year | 2020 |
| Description | Collaboration with Dr Ciro Chiappini, King's College London |
| Organisation | King's College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Provision of a Nanokick bioreactor |
| Collaborator Contribution | Testing of the device and experience with biological assays |
| Impact | Disciplines: cell engineering, physics. |
| Start Year | 2021 |
| Description | Collaboration with Dr David Hoey, Trinity College Dublin |
| Organisation | Trinity College Dublin |
| Country | Ireland |
| Sector | Academic/University |
| PI Contribution | Provision of a Nanokick bioreactor |
| Collaborator Contribution | Testing of the device and experience with new cellular assays |
| Impact | Disciplines: cell engineering, physics. |
| Start Year | 2021 |
| Description | Collaboration with Dr Jennifer Paxton, University of Edinburgh |
| Organisation | University of Edinburgh |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Provision of bioreactor devices |
| Collaborator Contribution | Cell culture and analysis |
| Impact | Data still being collected |
| Start Year | 2020 |
| Description | Collaboration with Dr Lee Buttery, University of Nottingham |
| Organisation | University of Nottingham |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Provision of a Nanokick bioreactor |
| Collaborator Contribution | Testing of the device and expertise in chemotaxis/osteogenic culture. |
| Impact | Disciplines: Physics, cell engineering |
| Start Year | 2017 |
| Description | Collaboration with Dr Melanie Jimenez, University of Strathclyde) |
| Organisation | University of Strathclyde |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Bioreactor and cell culture |
| Collaborator Contribution | Cell deformability analysis |
| Impact | EPSRC PhD student |
| Start Year | 2022 |
| Description | Collaboration with Dr Paul Brennan, University of Edinburgh |
| Organisation | University of Edinburgh |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Provision of a Nanokick bioreactor |
| Collaborator Contribution | Device testing and expertise in glialblastoma stem cells. |
| Impact | Disciplines: Neuro oncology, cell engineering |
| Start Year | 2018 |
| Description | Collaboration with Dr Tom Hodgkinson, Royal College of Surgeons in Ireland |
| Organisation | Royal College of Surgeons in Ireland |
| Country | Ireland |
| Sector | Academic/University |
| PI Contribution | Provision of a Nanokick bioreactor |
| Collaborator Contribution | Testing of the device and experience with chondrocyte culture. |
| Impact | Disciplines: cell engineering, physics. |
| Start Year | 2020 |
| Description | Collaboration with Dr. Manus Biggs in National University of Ireland, Galway to creat Dual Piezoelectric/Nanovibration system for rapid bone regeneration |
| Organisation | University of Galway |
| Country | Ireland |
| Sector | Academic/University |
| PI Contribution | Combining piezoelectric scaffold provided by Dr Manus group with our nanovibrator for MSCs osteogenic stimulation. |
| Collaborator Contribution | Synthesizing piezoelectric scaffold. |
| Impact | The collaboration just started recently. We will publish a paper in near future. |
| Start Year | 2017 |
| Description | Collaboration with Geistlich |
| Organisation | Geistlich |
| Country | Switzerland |
| Sector | Private |
| PI Contribution | Testing of in vitro cell culture on Geistlich implant materials |
| Collaborator Contribution | Contribution of implant materials from Geistlich |
| Impact | Disciplines involved - Dentistry, cell engineering, materials |
| Start Year | 2018 |
| Description | Collaboration with Histocell |
| Organisation | Histocell |
| Country | Spain |
| Sector | Private |
| PI Contribution | Provision of nanovibration protocols and devices. |
| Collaborator Contribution | GMP manufacturing of cellular therapies. |
| Impact | Disciplines: Cell engineering, physics, GMP manufacturing. |
| Start Year | 2019 |
| Description | Collaboration with Histocell |
| Organisation | Histocell |
| Country | Spain |
| Sector | Private |
| PI Contribution | We are working with Histocell to implement bone cell therapies and novel bone-related materials |
| Collaborator Contribution | Implementation of our technologies in GMP labs and guidance on manufacture, regulation and ethics. |
| Impact | Working towards cell therapies and novel scaffold technologies. |
| Start Year | 2018 |
| Description | Collaboration with Max Planck Institute of Colloids and Interfaces |
| Organisation | Max Planck Society |
| Department | Max Planck Institute of Colloids and Interfaces |
| Country | Germany |
| Sector | Charity/Non Profit |
| PI Contribution | We are providing cells and materials |
| Collaborator Contribution | They are testing our cells and materials |
| Impact | Development of novel cell therapies and biomaterials for bone regeneration |
| Start Year | 2020 |
| Description | Collaboration with Meidrix |
| Organisation | Meidrix |
| Country | Germany |
| Sector | Private |
| PI Contribution | Testing of nanokicked cells with Meidrix collagen materials (Chondrofiller). |
| Collaborator Contribution | Provision of Chondrofiller |
| Impact | Disciplines: Materials, cell engineering |
| Start Year | 2018 |
| Description | Collaboration with Prof Bo Su, University of Bristol |
| Organisation | University of Bristol |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Provision of a Nanokick bioreactor |
| Collaborator Contribution | Testing of the device and expertise in bacterial culture. |
| Impact | Disciplines: Cell engineering, biomaterials |
| Start Year | 2018 |
| Description | Collaboration with Prof Godfrey Smith, University of Glasgow |
| Organisation | University of Glasgow |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Provision of a Nanokick bioreactor |
| Collaborator Contribution | Testing of the device and experience with cardiomyocyte culture. |
| Impact | Disciplines: cell engineering, cardio physiology, physics. |
| Start Year | 2018 |
| Description | Collaboration with Prof Jan De Boer, Technische Universiteit Eindhoven |
| Organisation | Eindhoven University of Technology |
| Country | Netherlands |
| Sector | Academic/University |
| PI Contribution | Provision of a Nanokick bioreactor |
| Collaborator Contribution | Testing of the device and experience with new cell types |
| Impact | Disciplines: cell engineering, physics. |
| Start Year | 2020 |
| Description | Collaboration with Prof Ricardo Garcia, University of Madrid |
| Organisation | Instituto de Ciencia de Materiales de Madrid |
| Country | Spain |
| Sector | Public |
| PI Contribution | Bioreactor and cell culture experiments |
| Collaborator Contribution | AFM analysis and training |
| Impact | None yet |
| Start Year | 2022 |
| Description | Collaboration with Prof Stuart Reid, University of Strathclyde |
| Organisation | University of Strathclyde |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Together, we have designed a new bioreactor and consumables for it. |
| Collaborator Contribution | They design and build the bioreactors. |
| Impact | THis is a long standing collaboration in which we designed and build the nanovibrational bioreactor (originally Nanoforce, now Nanokick). We have worked togther, produced patents and publications as well as securing further funding. |
| Start Year | 2011 |
| Description | Collaboration with Prof Wojciech Chrzanowski, University of Sydney |
| Organisation | University of Sydney |
| Country | Australia |
| Sector | Academic/University |
| PI Contribution | Provision of a Nanokick bioreactor |
| Collaborator Contribution | Testing of the device and experience with new cell types |
| Impact | Disciplines: cell engineering, physics. |
| Start Year | 2021 |
| Description | Collaboration with University of Navarra |
| Organisation | University of Navarra |
| Country | Spain |
| Sector | Academic/University |
| PI Contribution | Provision of cells and materials |
| Collaborator Contribution | testing of cells and materials |
| Impact | Developing bone technologies together |
| Start Year | 2020 |
| Description | Collaboration with University of Valencia |
| Organisation | University of Valencia |
| Country | Spain |
| Sector | Academic/University |
| PI Contribution | We are providing cellular analysis |
| Collaborator Contribution | They are providing the bioreactor and know-how |
| Impact | Development of a new magnetic bioreactor for use in bone cell differentiation |
| Start Year | 2022 |
| Description | Collaboration with the Scottish National Blood Transfusion Service |
| Organisation | NHS National Services Scotland (NSS) |
| Department | Scottish National Blood Transfusion Service |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | Provision of technology for osteogenic cell culture. |
| Collaborator Contribution | Expertise in GMP manufacture of cellular therapies. |
| Impact | Disciplines: GMP manufacture, cell engineering, physics |
| Start Year | 2016 |
| Description | Collaboration with the Scottish National Blood Transfusion Service |
| Organisation | NHS National Services Scotland (NSS) |
| Department | Scottish National Blood Transfusion Service |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | Provision of technology for osteogenic cell culture. |
| Collaborator Contribution | Expertise in GMP manufacture of cellular therapies. |
| Impact | Disciplines: GMP manufacture, cell engineering, physics |
| Start Year | 2016 |
| Description | Souhtampton Collaboration |
| Organisation | University of Southampton |
| Department | Bone and Joint Research Group |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | This is a long term collaboration where cells, materials and expertise are shared to drive research |
| Collaborator Contribution | This is a long term collaboration where cells, materials and expertise are shared to drive research |
| Impact | A large number of papers, grants and IP. |
| Description | Surgical collaboration |
| Organisation | Queen Elizabeth University Hospital |
| Country | United Kingdom |
| Sector | Hospitals |
| PI Contribution | We are working together to provide a human trial of nano vibrated stem cells and advanced biomaterials. |
| Collaborator Contribution | They will perform the surgery / work with the NHS on the trial. |
| Impact | Non yet |
| Start Year | 2023 |
| Title | MECHANICAL BIOREACTOR |
| Description | A mechanical bioreactor for transferring vibrations to cell cultures for the purpose of stimulating various biological processes across a relatively large (relative to the amplitude of the vibrations) sample receiving surface. This bioreactor allows multiple samples to receive identical stimulation, which may enable the process to be significantly scaled up. The invention may be particular applicable to nanoscale vibration amplitudes, where it is non- trivial to design a device that performs this function, because many materials exhibit natural deformation on a scale that would mask or inhibit transfer of nanoscale vibration energy. |
| IP Reference | WO2017029393 |
| Protection | Patent application published |
| Year Protection Granted | 2017 |
| Licensed | No |
| Impact | None yet |
| Title | Nanovibrated mesenchymal stem cells for orthopaedic regeneration |
| Description | Bone primed cells for orthopaedic regeneration |
| Type | Therapeutic Intervention - Cellular and gene therapies |
| Current Stage Of Development | Refinement. Non-clinical |
| Year Development Stage Completed | 2022 |
| Development Status | Actively seeking support |
| Impact | Change in working of GMP cell manufacturer |
| Description | 28th Annual Conference of the European Society for Biomaterials (ESB) 4-8th September 2017, Athens, Greece. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Mr W. Orapiriyakul: Oral presentation at 28th Annual Conference of the European Society for Biomaterials (ESB) 4-8th September 2017, Athens, Greece. |
| Year(s) Of Engagement Activity | 2017 |
| Description | 29th European Conference on Biomaterials (ESB 2018), 9-13th September 2018, Maastricht, Netherlands. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Mr W. Orapiriyakul had a Poster presentation in 29th European Conference on Biomaterials (ESB 2018), 9-13th September 2018, Maastricht, Netherlands. |
| Year(s) Of Engagement Activity | 2018 |
| Description | 5th TERMIS World Congress 2018, 4-7th September 2018, Kyoto, Japan. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | mr W.Orapiriyakul had a Poster presentation in 5th TERMIS World Congress 2018, 4-7th September 2018, Kyoto, Japan. |
| Year(s) Of Engagement Activity | 2018 |
| Description | A talk at Future Investigators of Regenerative Medicine (FIRM) symposium |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | Research talk at a national conference |
| Year(s) Of Engagement Activity | 2022 |
| Description | ARCADIA public engagement |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | ARCadia, was a festival of public events that celebrated the public opening of the ARC from 16-30 September 2022 that attracted almost 7000 people. The general aims were: Collaboration between the university and non-academic groups A mix of disciplines, from the arts to social, physical and life sciences Engaging traditionally marginalised groups, or groups who experience barriers to accessing the university Engaging communities local to the ARC (postcodes G11, G3, G12) 75 free events for all ages were held day and night in the ARC, from schools workshops to cinema screenings, exhibitions, comedy, gaming, talks and even an outdoor ceilidh with dancing dinosaurs. Over 63% of events involved working in partnership with non-academic groups. An astonishing number of people helped organise and run ARCadia events (and our group CeMi was central in this) , including 326 UofG colleagues, 147 students, 239 partner staff, 30 volunteers and for student interns. The event attracted public visitor of all ages throughout the 2 weeks and everyone provided good comments and they would like to be able to experience an event like that in the future. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.gla.ac.uk/myglasgow/news/newsarchive/2022/8november2022/headline_893700_en.html |
| Description | BCRT annual conference July 2017 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Dr Tsimbouri was asked to have a public exhibition at the BCRT annual conference in Birmingam international in July 2017,about the Nanokicking Bioreactor and its potential uses in bone regeneration. |
| Year(s) Of Engagement Activity | 2017 |
| URL | https://www.bcrt.org.uk/get-involved/events-and-challenges/bone-cancer-conference-2017 |
| Description | BLOG CeMi: NANOKICKING STEM CELLS TO GROW NEW BONE |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Dr Monica P. Tsimbouri wrote a blog about the people, work and challenges involved for the recent paper Tsimbouri, Childs et al. Stimulation of 3D osteogenesis by mesenchymal stem cells using a nanovibrational bioreactor. Nat. Biomed. Eng. http://doi.org/10.1038/s41551-017-0127-4 (2017). |
| Year(s) Of Engagement Activity | 2017 |
| URL | https://www.gla.ac.uk/research/az/thecemi/blog/nanokickingstemcellstogrownewbone/ |
| Description | BORS |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | We organised the British Orthopedic Society annual conference in Glasgow. The conference sparked discussion after every talk and new collaborations were initiated between research and clinical groups. |
| Year(s) Of Engagement Activity | 2016 |
| Description | Biomaterials seminar |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | Wich Orapiriyakul, Oral presentation, Biomaterial seminar, University of Glasgow, 1st Nov, 2016 |
| Year(s) Of Engagement Activity | 2016 |
| Description | Biomaterials seminar |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | Mr W Orapiriyakul gave a talk at the Biomaterials seminars session on 13/11/18 |
| Year(s) Of Engagement Activity | 2018 |
| Description | CeMi Seminars talk |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | PhD student Ioanna Rigou presented her work on Chondrogenic induced differentiation using nanovibrations, at the local CEMI seminars on the 14th of November 2023 |
| Year(s) Of Engagement Activity | 2023 |
| Description | CeMi external seminars |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | We have invited external speakers from the UK to to speak and encourage discussion at our seminar series. This is opened up to an online audience so that our colleagues in Strathclyde can contribute. |
| Year(s) Of Engagement Activity | 2022,2023 |
| Description | CeMi seminar |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | PhD student Yusuf Ayten presented at the local Seminar series "The Effect of ECM Modifications on the Potential Targets for Mesenchymal Stem Cells' Senescence" |
| Year(s) Of Engagement Activity | 2023,2024 |
| Description | Cell block science |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Other audiences |
| Results and Impact | Presented at prisoner outreach day at HMP Shotts |
| Year(s) Of Engagement Activity | 2019 |
| Description | Centre for Doctoral Training Retreat |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | Retreat to The Burn for formal PGR student training in entrepreneurship |
| Year(s) Of Engagement Activity | 2021 |
| Description | Centre for the Cellular Microenvironment symposium |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | We organised an open symposium with expert speakers from the UK, EU and US - and from academic and industry |
| Year(s) Of Engagement Activity | 2019 |
| Description | Centre for the Cellular Microenvironment GLORI mini symposium 2022 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Postgraduate students |
| Results and Impact | We organised an open symposium with expert speakers from the UK, EU and US - and from academic and industry |
| Year(s) Of Engagement Activity | 2019,2020,2021 |
| Description | Centre for the Cellular Microenvironment seminar by Dr Monica P. Tsimbouri |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Postgraduate students |
| Results and Impact | We organise seminar series that a variety of people have access to them and attendance ranges from local to international as they are online. |
| Year(s) Of Engagement Activity | 2021 |
| Description | Commercialisation meeting |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Industry/Business |
| Results and Impact | Commercialisation and business consultants met to discuss the commercialisation of the bioreactors. |
| Year(s) Of Engagement Activity | 2020,2023 |
| Description | Conference - Oral Presentation - BORS |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | 2016 BORS conference was organized in Glasgow, were I gave a talk with the title 'Engineering osteogenic coatings' and new collaborations were initiated between research and clinical groups afterwards. |
| Year(s) Of Engagement Activity | 2016 |
| Description | Conference Talk, GLORI |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | GLORI conference meeting, presenting research outcome on bone tissue regeneration with questions and discussion afterwards. |
| Year(s) Of Engagement Activity | 2016 |
| Description | Conference organisation CCE-GLORI 2019 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | The local CCE-GLORI workshop is organised by Dr Monica P. Tsimbouri every year. It is a workshop where postgraduate students present their work to their peers and supervisors and discussion then follows the talks. This is highly beneficial to students and promotes collaboration. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Conference organisation-GLORI2020 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Dr Monica P. Tsimbouri organises GLORI bi-annually. This conference encourages collaboration between the basic sciences, applied sciences, engineering and clinic. This has the aim of bringing the latest ideas in basic materials research into use to deliver the next-generation of orthopaedic care. It combines expertise from orthopaedic surgeons, plastic surgeons, biologists, engineers and chemists. The conference is free for attendance and involves oral and poster presentations from professionals, scientists, clinicians and postgraduate students. It is always well attended. It is sponsored by industry who are also involved in the conference. |
| Year(s) Of Engagement Activity | 2020 |
| Description | Conference presentation |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Wich Orapiriyakul Poster presentation at FEBS Workshop Biological Surfaces and Interfaces: Interface Dynamics, 2nd-7th July 2017, Sant Feliu de Guixols, Catalonia, Spain |
| Year(s) Of Engagement Activity | 2017 |
| URL | https://mimeresearch.com/biointerfaces2017/ |
| Description | Conference presentation |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Wich Orapiriyakul Poster presentation in 10th UK Mesenchymal Stem Cell Meeting, 5th December 2016 York, UK. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Conference presentation |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Wich Orapiriyakul Poster presentation, British Orthopaedic research Society (BORS), UK, 5-6th September 2016, Glasgow, UK |
| Year(s) Of Engagement Activity | 2016 |
| URL | https://www.uofgcce.org/bors-2016 |
| Description | Dr Monica Tsimbouri, Change Champion helping to organise and interface with academics regarding the Advanced Research Centre at UofG |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Other audiences |
| Results and Impact | In the role of a Change Champion deputy my role was to assist in the organisation and planning of the building of a new centre for advanced research within Glasgow university. This centre consists of a large inter disciplinary cohort, to encourage collaboration, and would therefore require a wide degree of specialisations. At these events i was required to interface with companies, academics and univeristy professionals to exchange information and then disseminate this to my own colleagues. |
| Year(s) Of Engagement Activity | 2021 |
| Description | Dr P. Tsimbouri helped organise the: Joint symposium with UCL: Mind & Body Healing October 2020 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other audiences |
| Results and Impact | Dr P. Tsimbouri helped organise, chaired and also delivered an oral presentation to the: Joint symposium with UCL: Mind & Body Healing October 2020. The symposium was open to the scientific community and the general public. Talk presentations were delivered from members of the UofG and UCL research teams on their research work. |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.gla.ac.uk/explore/avenue/noticeboard/headline_744729_en.html |
| Description | European Society for Biomaterials Keynote (Dalby) Talk |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Keynote conference talk |
| Year(s) Of Engagement Activity | 2021 |
| Description | European Society for Biomaterials Talk |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Talk at the ESB conference for Dr Hussain Jaffery |
| Year(s) Of Engagement Activity | 2022 |
| Description | FEBS Workshop Biological Surfaces and Interfaces: Interface Dynamics, 2nd-7th July 2017, Sant Feliu de Guixols, Catalonia, Spain |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Mr W. Orapiriyakul had a Poster presentation at FEBS Workshop Biological Surfaces and Interfaces: Interface Dynamics, 2nd-7th July 2017, Sant Feliu de Guixols, Catalonia, Spain |
| Year(s) Of Engagement Activity | 2017 |
| Description | GLORI 2023 |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | Meeting of the Glasgow Orthopaedic Research Initiative Tuesday 21st March 2023, ARC, GU. An educational and collaborative meeting/workshop between Scientists and Clinicians. This is a repeating workshope every year with the aim to inform everyone about new developemnt on bone regeneration. |
| Year(s) Of Engagement Activity | 2023 |
| Description | GLORI at the CeMi |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | Mr Ian Kennedy presented a talk on "Nanoscale vibrations to modulate osteogenesis" Glasgow Orthopedic Research Initiative 2018 23rd November 2018 |
| Year(s) Of Engagement Activity | 2018 |
| Description | GLORI at the CeMi |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | Tom Hodgkinson, Talk "Identification and in vitro screening of osteogenic metabolites through supplement-free nanovibration-driven mesenchymal stem cell differentiation" Glasgow Orthopedic Research Initiative 2018 23rd November 2018 |
| Year(s) Of Engagement Activity | 2018 |
| Description | GLORI conference organisation |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Planning and Organisation of Dr Monica P Tsimbouri the scientific mentor of the Glasgow Orthopaedic Research Initiative (GLORI). GLORI has been established to encourage collaboration between the basic sciences, applied sciences, engineering and clinic. This has the aim of bringing the latest ideas in basic materials research into use to deliver the next-generation of orthopaedic care. It combines expertise from orthopaedic surgeons, biologists, engineers and chemists not only from Glasgow and Strathclyde Universities but the rest of Scotland too and also with the view to expand to the rest of the UK. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Glasgow Orthopaedic Research Initiative (GLORI 2018), 23d February 2018, Glasgow, UK. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Mr W. Orapiriyakul had a Poster presentation at Glasgow Orthopaedic Research Initiative (GLORI 2018), 23th Febuary 2018, Glasgow, UK. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Glasgow Science Festival: Regenerate |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | The Glasgow Science Festival runs for a few weeks and we did a full day focusing on Stem Cell activities, talking to the general public (mainly children). The aim was teach them how stem cells differentiate. |
| Year(s) Of Engagement Activity | 2021 |
| Description | Glasgow/Strathclyde joint nanokicking meeting |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | This was the first Glasgow/Strathclyde joint nanokicking meeting Organised by Dr Jonathan Williams and Dr Monica P. Tsimbouri, planned for 7th December between 2 and 4 pm, at the ARC GU. The main objective of this first meeting was to make sure everyone is aware of the different nanokicking projects that are going on, and stimulate further ideas and collaborations. Dr Tsimbouri presented work on the development of nanovibrated stem cell therapies. |
| Year(s) Of Engagement Activity | 2023 |
| Description | Glori2018 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Submitted a research abstract, stimulating discussion and chaired a conference session on bone regeneration strategies |
| Year(s) Of Engagement Activity | 2018 |
| Description | Healickick (EU grant) translation day |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Discussion between academics and surgeons around technologies we have developed. |
| Year(s) Of Engagement Activity | 2021 |
| Description | IKEA at home with life sciences |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Dr Monica P. Tsimbouri participated at the IKEA at Home with Life Sciences A team of students, researchers and support staff represented the Institute at IKEA on Saturday 24th November 2018 as part of the MVLS at IKEA event. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.gla.ac.uk/researchinstitutes/biology/newsevents/headline_581051_en.html?utm_medium=email... |
| Description | International Conference presentation |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Wich Orapiriyakul did a Podium presentation at 28th Annual Conference of the European Society for Biomaterials (ESB) 4-8th September 2017, Athens, Greece |
| Year(s) Of Engagement Activity | 2017 |
| URL | http://ESB2017.org |
| Description | International summer school |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | PhD student Ioanna Rigou attended the Bio-TUNE Summer School and delivered a Flash Presentation - 14th July 2023 - University of Gadjah Mada, Yogyakarta, Indonesia |
| Year(s) Of Engagement Activity | 2023 |
| Description | Invited talk at BCRT Scotland day May 2017 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | This was an invited talk for Dr Monica P. Tsimbouri by BCRT in Perth May 16th 2017. The presentation was intended for clinical partitioners as well as patients and carers affected by bone cancers. There was a lot of interest and discussions after the talk and Dr Tsimbouri was asked to give a further presenation in the future. |
| Year(s) Of Engagement Activity | 2017 |
| URL | https://www.bcrt.org.uk/news/2017/may/our-first-scottish-patient-and-carer-day |
| Description | Invited talk at British Orthopaedic Research Society |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Discussed research training of junior surgeons |
| Year(s) Of Engagement Activity | 2021 |
| Description | Invited talk for SULSA/Rheinland-Pfalz Conference |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | ECR talk at the First Scottish - Rheinland-Pfalz Life Sciences and Biotechnology Conference in the "Development of Advanced Therapies and Vaccines" symposium. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Joint TCES/CDT conference |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Industry/Business |
| Results and Impact | Joint Tissue and Cell Engineering conference with the lifETIME CDT. Over 100 academics (PhD's to professor level) were in the audience focussing on research developments of like-minded EPSRC CDTs |
| Year(s) Of Engagement Activity | 2022 |
| Description | Joint conference of the Centres for Doctoral Training - Future Leaders in Regenerative Medicine |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | A joint meeting, hosted by the UK Society for Biomaterials, focussing on research developments of like-minded EPSRC CDTs |
| Year(s) Of Engagement Activity | 2021 |
| Description | Keynote talk (Dalby) at Tissue Engineerign and Regenerative medicien International Society |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Keynote talk at a major conference |
| Year(s) Of Engagement Activity | 2021 |
| Description | Local Talk |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | Wich Orapiriyakul Oral presentation, GLORI 2016, University of Glasgow, 15th Dec 2016 |
| Year(s) Of Engagement Activity | 2016 |
| Description | MVLS talk presentation |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | Yusuf Ayten delivered a Flash Presentation for the new term PhD students - 5 October 2023, College of MVLS, University of Glasgow |
| Year(s) Of Engagement Activity | 2023 |
| Description | Media interest BBC (nanokicking) |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Talk sparked public interest Many interested enquirers. |
| Year(s) Of Engagement Activity | 2012 |
| Description | Media interest BBC (orthopaedic materials) |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Sparked public interest Enquieries from the public |
| Year(s) Of Engagement Activity | 2013 |
| Description | Media interest BBC (stem cell growth) |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Talk sparked public interest Enquieries from the public |
| Year(s) Of Engagement Activity | 2011 |
| Description | Media presentation |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Radio interview for the Today Programme, Radio Scotland and BBC World Service |
| Year(s) Of Engagement Activity | 2016 |
| Description | Monthly technical meeting Healkick/SBCF |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Study participants or study members |
| Results and Impact | These regular focused technical meetings involve presentations and discussions of current work from three projects related to the Sir Bobby Charlton Foundation (SBCF, previously Find A Better Way) funded project. These meetings include throuble-shooting of current methodologies and issues associated, and in-depth knowledge exchange between collaborators. The outcomes of these discussions usually lead to new areas for development and possibilities of new collaborations including industrial engagement arising for UKRI nanokick projects. |
| Year(s) Of Engagement Activity | 2017,2018,2019,2020,2021,2022,2023 |
| Description | NEB community: the story behind the paper |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Dr P.M. Tsimbouri and Dr P. Childs were asked by the NEB community to write a story behind their recent paper Tsimbouri, Childs et al. Stimulation of 3D osteogenesis by mesenchymal stem cells using a nanovibrational bioreactor. Nat. Biomed. Eng. http://doi.org/10.1038/s41551-017-0127-4 (2017). Story title: Growing bone using nanovibration: A reproducible method for mechanically driving stem-cell osteogenesis in 3D culture. |
| Year(s) Of Engagement Activity | 2017 |
| URL | http://go.nature.com/2xVgSNN |
| Description | Nanotoxicology Meeting |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | Invited talk for the Naotoxicology Society |
| Year(s) Of Engagement Activity | 2016 |
| Description | Online lecture produced for Henry Stewart talks |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Online talk: Preclinical translation of mesenchymal stem cell therapies |
| Year(s) Of Engagement Activity | 2021 |
| Description | Oral Presentation at Biomaterials Seminar, University of Glasgow |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presented research on nano vibrational differentiation of mesenchymal stem cells as part of the biomaterials seminar series at the University of Glasgow |
| Year(s) Of Engagement Activity | 2018 |
| Description | Plenary talk at TERMIS |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Matthew Dalby gave a plenary talk on materials for stem cell growth and differentiation |
| Year(s) Of Engagement Activity | 2023 |
| Description | Presentation at Joint ECMage/LifETIME CDT meeting |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | Keynote talk by Matthew Dalby. |
| Year(s) Of Engagement Activity | 2024 |
| Description | Presentation at Wold Biomaterials Congress 2020 - Online |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | A conference presentation: Therapeutic refinement of tissue engineered cellular implants for non-union fracture repair |
| Year(s) Of Engagement Activity | 2020 |
| Description | Press release to announce Find a Better Way funding |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Press release to announce the award of our Find a Better Way Project |
| Year(s) Of Engagement Activity | 2016 |
| Description | Programme grant announcement |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Press release to announce Glasgow EPSRC Programme grant |
| Year(s) Of Engagement Activity | 2016 |
| Description | Public engagement-#Run2Jordan |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | University of Glasgow and Strathclyde came together, and took part in the biggest CeMi fitness challenge to date! The aim was to raise as much as possible, a team from the CeMi run, walked and cycled the distance from Glasgow to the Sir Bobby Charlton Rehabilitation Centre in Amman, Jordan, that is 5436k! #RunToJordan We managed to raise £1,719! |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://glasgow.thecemi.org/2020/08/04/runtojordan/ |
| Description | Public outreach-Royal Society of London Summer Exhibition |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Nanokicking" Royal Society Science summer exhibition in London 2016. We promoted our Nanokicing research to the public and explaining the potential of nanokicking in bone regeneration and also its use as a tool in cancer research. |
| Year(s) Of Engagement Activity | 2016 |
| Description | ResearchTogether: Patients Guiding the Future of Science |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Patients, carers and/or patient groups |
| Results and Impact | The event focused on Patient and Public Involvement and Engagement (PPIE) bringing together patients, researchers, industry, and charities to discuss recent research advancements as well as how to improve research targeting healthcare improvement in the future. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Royal Society Summer Exhibition Press Release |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Press release from the Royal Society about our nanokick exhibit |
| Year(s) Of Engagement Activity | 2016 |
| Description | Royal Society of Chemistry Biomaterials Meeting |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | Conference presentation |
| Year(s) Of Engagement Activity | 2017 |
| Description | SSN invited talk |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | Dr P. M. Tsimbouri was invited to present the use of nanotopography on Titanium orthopedic implants and the use of Nanokicking Bioreactor for bone regeneration and also as a tool for the descovery of metabolic targets in bone cancer for pharma. |
| Year(s) Of Engagement Activity | 2016 |
| Description | Scottish Metabolomics Network |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Postgraduate students |
| Results and Impact | Invited talk |
| Year(s) Of Engagement Activity | 2016 |
| Description | Strategic Board Meetings - SBCF |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Supporters |
| Results and Impact | Poster presentation and subsequent follow-up discussions with board members of related charitable foundation the Sir Bobby Charlton Foundation (formally Find a Better Way). |
| Year(s) Of Engagement Activity | 2019,2020 |
| Description | Strategic and colaborative meetings-SBCF |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Study participants or study members |
| Results and Impact | These regular focused strategy meetings involve presentations and discussions of current work from two projects related to the Sir Bobby Charlton foundation (previouslv Find A Better Wav) funded proiect. These meetings include in-depth knowledge exchange with industrial partners and service providers will help to bring the system to market. The outcomes of these discussions usually lead to new areas for development and possibilities of new collaborations. |
| Year(s) Of Engagement Activity | 2016,2018,2019,2020,2021,2022,2023 |
| Description | Strategic collaborative meeting for SBCF |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | These regular focused strategy meetings involve presentations and discussions of current work from two projects related to the Sir Bobby Charlton foundation (previouslv Find A Better Way) funded proiect. These meetings include in-depth knowledge exchange with industrial partners and service providers will help to bring the system to market. The outcomes of these discussions usually lead to new areas for development and possibilities of new collaborations. |
| Year(s) Of Engagement Activity | 2023,2024 |
| Description | Strategic collaborative meetings - Sir Bobby Charlton Foundation |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Study participants or study members |
| Results and Impact | These regular focused strategy meetings involve presentations and discussions of current work from two projects related to the Sir Bobby Charlton Foundation (SBCF, previously Find A Better Way) funded project. These meetings include in-depth knowledge exchange with industrial partners and service providers we are collaborating with to bring the system to market. The outcomes of these discussions usually lead to new areas for development and possibilities of new collaborations. |
| Year(s) Of Engagement Activity | 2019,2020 |
| Description | Strategic collaborative meetings - Sir Bobby Charlton Foundation |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Study participants or study members |
| Results and Impact | These regular focused strategy meetings involve presentations and discussions of current work from two projects related to the Sir Bobby Charlton Foundation (SBCF, previously Find A Better Way) funded project. These meetings include in-depth knowledge exchange with industrial partners and service providers we are collaborating with to bring the system to market. The outcomes of these discussions usually lead to new areas for development and possibilities of new collaborations. |
| Year(s) Of Engagement Activity | 2019,2020,2021 |
| Description | TCES 2010 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | Yes |
| Type Of Presentation | paper presentation |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | Dr Monica P Tsimbouri. exiting discussion after talk Interested parties continued discussion |
| Year(s) Of Engagement Activity | 2010 |
| Description | TCES 2012 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | Yes |
| Type Of Presentation | paper presentation |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | Dr P Tsimbouri. talk sparked questions and discussion afterwards Engagement with company Reps and received very good discount on equipment. |
| Year(s) Of Engagement Activity | 2012 |
| Description | TERMIS EU 2011 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | Yes |
| Type Of Presentation | paper presentation |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Dr Monica P Tsimbouri. Talk sparked questions and discussion afterwards There was further discussion during a later session about my talk |
| Year(s) Of Engagement Activity | 2011 |
| Description | Talk at GLORI2018 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Dr Monica P Tsimbouri delivered a talk on behalf of Prof Dalby at GLORI2018 |
| Year(s) Of Engagement Activity | 2018 |
| Description | Talk in Portugal |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited talk for Dalby at University of Aviero |
| Year(s) Of Engagement Activity | 2022 |
| Description | The University Network ((TUN) |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Dr Monica P. Tsimbouri was invited by the The University Network ((TUN), a global media company for college students available in 108 languages) to write an article about the nanokicking project. (https://www.tun.com/blog/nanokicking-technology-bone-growth-development/) |
| Year(s) Of Engagement Activity | 2017 |
| URL | https://www.tun.com/blog/nanokicking-technology-bone-growth-development |
| Description | UKSB |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | Yes |
| Type Of Presentation | paper presentation |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | Dr M. P. Tsimbouri. Interesting discussion following presentation Discussion lead to problem solving for a fellow scientist |
| Year(s) Of Engagement Activity | 2010 |
| Description | lifETIME CDT student day |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | Stakeholders in the Centre for Doctoral Training engage with CDT students to enhance student training and careers. This is followed by discussion with the CDT advisory board. |
| Year(s) Of Engagement Activity | 2021,2022 |
| Description | school workshop: Bones and bone cells, 2017 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Dr P.M. Tsimbouri has organised a full day workshop for P5,P6 and P7 school pupils at the Milngavie primary school. The workshop involves presentation slides and Q/A session with the children about the skeleton, bones and bone cells. This followed by hands on experience looking at fixed cells using bright field microscopes. The children were given colour-in pages and also word searches to take home. |
| Year(s) Of Engagement Activity | 2015,2017 |
| Description | workshop training |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | PhD student Ioanna Rigou visited a collaborators lab in Ireland (RCSI) 11th - 13th of December 2023- Collaboration, with a previous lab member and also training in a new technique (OCT) and new assays ( sGAG/Alcian blue-metabolic activity of chondrocytes/sGAG productivity) important for the next steps of the chondrogenic differentiatioon using nanovibrations project. |
| Year(s) Of Engagement Activity | 2023 |