Biophysical studies of the structure/function of antimicrobial peptides and enzymes isolated from extremophile organisms
Lead Research Organisation:
Birkbeck, University of London
Department Name: Biological Sciences
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Publications
Felizatti AP
(2020)
Interactions of amphipathic a-helical MEG proteins from Schistosomamansoni with membranes.
in Biochimica et biophysica acta. Biomembranes
Kumagai PS
(2019)
Unveiling the binding and orientation of the antimicrobial peptide Plantaricin 149 in zwitterionic and negatively charged membranes.
in European biophysics journal : EBJ
Kumagai PS
(2018)
Characterization of esterase activity from an Acetomicrobium hydrogeniformans enzyme with high structural stability in extreme conditions.
in Extremophiles : life under extreme conditions
Lopes JL
(2016)
Environmental Factors Modulating the Stability and Enzymatic Activity of the Petrotoga mobilis Esterase (PmEst).
in PloS one
Lopes Jose Luiz S.
(2016)
Spectral Properties of "Disordered'' and Polyproline II Structures Defined by Circular Dichroism Spectroscopy
in BIOPHYSICAL JOURNAL
Orcia D
(2017)
Interaction of an esophageal MEG protein from schistosomes with a human S100 protein involved in inflammatory response.
in Biochimica et biophysica acta. General subjects
Sait LG
(2020)
Cannabidiol interactions with voltage-gated sodium channels.
in eLife
Yoneda JS
(2017)
Differential dehydration effects on globular proteins and intrinsically disordered proteins during film formation.
in Protein science : a publication of the Protein Society
| Description | 1)research on extremophile proteins 2) training of Brazilian scientists at workshops, visits from Brazilian scientists to the UK for collaborative studies 3) approval for a new SRCD beamline to be built at the Brazil synchrotron jointly designed by UK and brazil partners 4) 2020 - building of a new sRCD beamline at the Sirius synchrotron in Brazil |
| Exploitation Route | students and postdocs have gained new skills that they can pass on to others; new instrumentation at Brazil Synchrotron for further joint projects by us and others this work has lead to the Brazilian synchrotron building a new SRCD beamline |
| Sectors | Agriculture Food and Drink Pharmaceuticals and Medical Biotechnology |
| Description | design of new SRCD beamline in Brazil that will be open to use by other countries (including the UK); update: this new beamline was approved for construction in 2020 and was opened in 2022. i gave one of the plenary lectures at the opening ceremony. joint publications with brazil colleagues. |
| First Year Of Impact | 2018 |
| Sector | Agriculture, Food and Drink,Pharmaceuticals and Medical Biotechnology,Other |
| Impact Types | Policy & public services |
| Description | Binding and interactions of Brazilian toxins to voltage-gated sodium channels: The Rational Search for New Drugs |
| Amount | £12,648 (GBP) |
| Funding ID | BB/T01153X/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 01/2020 |
| End | 01/2022 |
| Description | Brazil Senior Visiting Fellowship |
| Amount | R$ 115,240 (BRL) |
| Organisation | National Council for Scientific and Technological Development (CNPq) |
| Sector | Public |
| Country | Brazil |
| Start | 03/2014 |
| End | 02/2016 |
| Title | design of a new SRCD beamline for Sirius synchtrotron in Brazil |
| Description | design of a new SRCD beamline to be built at the Sirius synchrotron in Brazil |
| Type Of Material | Improvements to research infrastructure |
| Year Produced | 2020 |
| Provided To Others? | Yes |
| Impact | further collaborations and new collaboration grant between UK and Brazil |
| Description | Collaboration with University of Sao Paulo |
| Organisation | Universidade de São Paulo |
| Department | Physics Institute of São Carlos |
| Country | Brazil |
| Sector | Academic/University |
| PI Contribution | i have been involved in helping my brazilian collaborators prepare a proposal for an SRCD beamline at the Brazilian synchrotron |
| Collaborator Contribution | we have worked together on the proposal and planning |
| Impact | several publications, a long term partnership leading to several BBSRC partnering grants, development of a new SRCD beamline at the Brazilian synchrotron, submission and funding of a new BBSRC partnering award |
| Start Year | 2012 |
| Description | Running training workshops for students, postdocs and industrial scientists on CD spectroscopy |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Teaching Lectures and Practicals in multi-day workshops to provide new skills training and ideas and information for researchers both nationally and internationally |
| Year(s) Of Engagement Activity | Pre-2006,2006,2007,2008,2009,2010,2011,2012,2013,2014,2015,2016,2017,2018 |
| Description | Talks at UK and international sites and meetings: Brazil Synchrotron Symposium, ), University of Vienna Austria (Chemistry Dept), Biochemical Society Training Course (Aston University, UK) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Talks about Tools and Resources developed in the course of this grant at Universities and International meetings, including the headline talk at the inauguration of the Brazil Synchrotron SRCD beamline (CEDRO) held for the international community of SRCD users and potential users, The Biochemical Society training course on Membrane Proteins at Aston University, the chemistry dept at the University of Vienna. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Teaching at National and International Workshops for students and postdocs on the tools and resources we have developed |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Training workshops on CD spectroscopy in the UK (Leeds and Birmingham), at meetings in the US (NIH Biophysics Course), at the EBSA Biophysics Workshop in France, and the IUPAB Workshop in Cuba. |
| Year(s) Of Engagement Activity | 2018,2019,2020 |
| Description | Teaching workshops for students, faculty and industrial scientists |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | A series of workshops on methods of analysis for CD spectroscopy given at national and international meetings and workshops, usually 2-3 days, including hands-on computing practicals. for phd and masters students, postdocs, professors and other academics and industry |
| Year(s) Of Engagement Activity | 2009,2010,2011,2012,2013,2014,2015,2016,2017,2018 |