Development of commercialization platforms for single molecule imaging of GPCR oligomers via super-resolution microscopy
Lead Research Organisation:
Imperial College London
Department Name: Surgery and Cancer
Abstract
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Organisations
People |
ORCID iD |
| Aylin Hanyaloglu (Principal Investigator) |
Publications
Fanelli F
(2020)
Integrated structural modeling and super-resolution imaging resolve GPCR oligomers.
in Progress in molecular biology and translational science
| Description | The goal of this 6 month Pathfinder Award was to carry out market research analysis and assess the intellectual property (IP) landscape for a novel technology to be potentially exploited as a drug discovery platform for a superfamily of receptors called G protein-coupled receptors (GPCRs). Market research identified need requirements, format of interaction and interest from industry, and the potential to protect the technology. Valuable feedback from industry strongly suggested further analysis/studies with additional GPCRs would facilitate uptake/financial investment. Through this process key contacts in pharmaceutical industry have been made and will be further developed. |
| Exploitation Route | The findings from this market research strongly suggest that further funding is to be sought to support basic research studies that assess the applicability of the screening technology to additional GPCRs. These receptors represent the most successful drug target and their number and play central role in health and disease. This would place this project funded by investment in this pathfinder award combined with the additional data would place us in a very strong position for Follow-on Funding schemes at BBSRC and run within Imperial College to develop commercialization of research at the early stages. |
| Sectors | Healthcare,Pharmaceuticals and Medical Biotechnology |
| Description | Directing luteinising hormone receptor activity in vivo: A convergent approach to study GPCR molecular complexes |
| Amount | £1,065,319 (GBP) |
| Funding ID | BB/V006142/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 04/2021 |
| End | 04/2024 |
| Description | PhD consumables grant |
| Amount | £8,440 (GBP) |
| Funding ID | Grant No. 01075/P67019 |
| Organisation | Genesis Research Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 04/2017 |
| End | 03/2018 |