HDHL-Biomarkers: Early life programming of childhood health (ALPHABET)

Lead Research Organisation: University of Southampton
Department Name: Human Development and Health

Abstract

The rising prevalence of obesity, cardiometabolic disease, asthma, osteoporosis and neurodevelopmental disorders over recent decades cannot be fully explained by genetic or adult lifestyle factors. Increasing evidence suggests that early life exposure to environmental factors influences offspring health. According to the Developmental Origins of Health and Disease (DOHaD) hypothesis transient environmental exposures during critical periods of development (e.g. fetal and early infant phases of life) can elicit lifelong effects on offspring health. Epigenetic phenomena have been proposed as mechanisms by which detrimental fetal or early life exposures, such as suboptimal nutrition during pregnancy or early childhood, may affect offspring phenotype and risk of adverse health years after exposure. Maternal diet during pregnancy is a modifiable behaviour that could impact on maternal, neonatal and child health. However the specific dietary requirements during pregnancy for optimal fetal growth and development are unknown. Furthermore studies addressing the hypothesis of fetal programming have focused on maternal intake of single nutrients during pregnancy. Nutrients are not consumed in isolation, thus examining the combined effects of multiple dietary components reflecting the whole diet could have important public health implications. There is a clear need for primary prevention of obesity, related cardiometabolic conditions and other chronic non-communicable diseases based on the DOHaD paradigm. This project aims to advance the state-of-the-art by significantly expanding the knowledge base regarding interactions between biomarkers of diet, epigenetics and offspring health. Utilising biological samples and data from existing European longitudinal birth cohorts at the international forefront of lifecourse epidemiology we will investigate the complex relationships between maternal diet (defined by dietary quality and a novel index of dietary inflammatory potential), offspring health outcomes (including adiposity, bone, cardiometabolic, respiratory and neurodevelopmental health) and epigenetic patterns (DNA methylation) from birth throughout childhood. Better understanding of nutritional and epigenetic biomarkers of offspring health will afford opportunities to refine dietary exposure measures and to aid development of more effective evidence-based public health strategies with an emphasis on advocating a healthy diet in pre-pregnancy, pregnancy and early postnatal life, to reduce obesity, improve health and attenuate development of a range of adverse health outcomes in future generations.

Technical Summary

There is a clear need for primary prevention of obesity, related cardiometabolic conditions and other chronic non-communicable diseases based on the DOHaD paradigm. This project aims to advance the state-of-the-art by significantly expanding the knowledge base regarding interactions between biomarkers of diet, epigenetics and offspring health. Utilising biological samples and data from existing European longitudinal birth cohorts at the international forefront of lifecourse epidemiology we will investigate the complex relationships between maternal diet (defined by dietary quality and a novel index of dietary inflammatory potential), offspring health outcomes (including adiposity, bone, cardiometabolic, respiratory and neurodevelopmental health) and epigenetic patterns (DNA methylation) from birth throughout childhood. Better understanding of nutritional and epigenetic biomarkers of offspring health will afford opportunities to refine dietary exposure measures and to aid development of more effective evidence-based public health strategies with
an emphasis on advocating a healthy diet in pre-pregnancy, pregnancy and early postnatal life, to reduce obesity, improve health and attenuate development of a range of adverse health outcomes in future generations.

Planned Impact

Given the research focus, the potential long term health and socio-economic impacts may be significant considering the health service and societal costs associated with obesity alone, currently and for future generations. Our results will improve understanding of the relationships between maternal nutrition, pregnancy outcome and subsequent child health. For example improved dietary quality and/or reduced pro-inflammatory dietary status achieved through revision of existing guidelines or development of new guidelines for optimal nutrition in pregnancy or development of functional foods may lead to beneficial health effects on women of reproductive years and their offspring which may have long term effects on their health into adulthood.

Publications

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publication icon
Curtis EM (2019) Gestational Vitamin D Supplementation Leads to Reduced Perinatal RXRA DNA Methylation: Results From the MAVIDOS Trial. in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

 
Title ASBMR webinar (NCH) 
Description Webinar on abstract writing 
Type Of Art Film/Video/Animation 
Year Produced 2018 
Impact Improved abstract writing 
 
Title IOF Webinar (NCH,CC) 
Description IOF CTF webinars 
Type Of Art Film/Video/Animation 
Year Produced 2020 
Impact IOF CTF webinars 
 
Title IOF webinars NHC, CC 
Description Webinar on osteoporosis prevention 
Type Of Art Film/Video/Animation 
Year Produced 2018 
Impact Improved care 
 
Title ROS Osteoporosis Research Roadmap video 
Description ROS Osteoporosis Research Roadmap video 
Type Of Art Film/Video/Animation 
Year Produced 2020 
Impact Increased awareness of osteoporosis 
 
Description Methylation at the CDKN2A gene in umbilical cord is associated with offspring bone mass in childhood. (Curtis et al., JBMR 2017).

Pregnancy vitamin D supplementation leads to reduced perinatal RXRA methylation (Curtis et al., JBMR 2019)

Vitamin D content of OTC vitamin D and multivitamin supplements is often less than DH recommended amount (Moon et al., Arch Dis Childhood 2019)

Bone turnover markers in pregnancy associated with maternal vitamin D status and offspring bone mass (Curtis et al., AJCN 2021)

Pregnancy dietary inflammatory index inversely associated with offspring bone mass (2022)
Exploitation Route Further Collaboration to use constituent cohorts is envisaged
Sectors Agriculture, Food and Drink,Education,Healthcare,Government, Democracy and Justice,Manufacturing, including Industrial Biotechology,Pharmaceuticals and Medical Biotechnology

 
Description Findings will inform potential novel biomarkers for adverse bone development and thus risk assessment strategies. They will also inform novel mechanisms of bone development.
First Year Of Impact 2017
 
Description Co-authorship of Royal Osteoporosis Society APPG enquiry into FLS (NCH) 2021
Geographic Reach National 
Policy Influence Type Membership of a guideline committee
 
Description Membership of a guideline committee on the safety of drug therapies in osteoarthritis - with ESCEO
Geographic Reach Europe 
Policy Influence Type Membership of a guideline committee
Impact The European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO) recommendations for on drugs to be used in osteoarthritis: A consensus statement from a working group on the safety of anti-osteoarthritis medications I led a systematic review on the safety of COX-2 inhibitors and opioids in OA. This is due to be published in April 2019.
 
Description National Osteoporosis Guideline Group Advisory Committee (NCH, CC)
Geographic Reach National 
Policy Influence Type Membership of a guideline committee
 
Description Scientific Advisory Committee on Diet and Nutrition- Public Health England Vitamin D Guidance (NCH)
Geographic Reach National 
Policy Influence Type Citation in other policy documents
 
Description Developmental origins of child neurodevelopment: Novel approaches to clinical risk prediction using an international metadataset.
Amount £364,324 (GBP)
Funding ID MR/V029169/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 11/2021 
End 10/2027
 
Description Does maternal gestational vitamin D supplementation influence offspring DNA methylation in childhood?
Amount £29,984 (GBP)
Funding ID SGL023\1072 
Organisation Academy of Medical Sciences (AMS) 
Sector Charity/Non Profit
Country United Kingdom
Start 08/2020 
End 12/2021
 
Description Does pregnancy vitamin D supplementation alter trajectories of body composition and bone mineralisation from early childhood to adolescence? Follow-up of a randomised placebo-controlled trial.
Amount £187,294 (GBP)
Funding ID GN2969 
Organisation Action Medical Research 
Sector Charity/Non Profit
Country United Kingdom
Start 06/2023 
End 06/2026
 
Description MRC Capital Award
Amount £134,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 03/2018 
End 03/2019
 
Description MRC Capital Funding
Amount £310,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 04/2017 
End 03/2018
 
Description MRC Capital Prioritisation Award
Amount £134,000 (GBP)
Organisation University of Southampton 
Department MRC Lifecourse Epidemiology Unit
Sector Academic/University
Country United Kingdom
Start 03/2019 
End 03/2022
 
Description MRC Capital award 2020 2021 Scanco XtremeCT2
Amount £325,000 (GBP)
Funding ID 4050776844 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 03/2020 
End 03/2023
 
Description MRC LEU Extension
Amount £1,800,000 (GBP)
Funding ID MRC LEU 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 10/2020 
End 06/2021
 
Description MRC LEU Extension
Amount £1,500,000 (GBP)
Funding ID MRC LEU 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 04/2020 
End 10/2020
 
Description MRC National Musculoskeletal Network
Amount £150,847 (GBP)
Funding ID MC_PC_21022 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 02/2022 
End 02/2024
 
Description Nutritional determinants of skeletal development and bone loss: an investigation using a novel computer vision assessment of bone microarchitecture
Amount £36,000 (GBP)
Organisation University of Southampton 
Sector Academic/University
Country United Kingdom
Start 09/2022 
End 09/2025
 
Description Preventing broken bones in older people: from research to policy to practice
Amount £29,566 (GBP)
Funding ID MRF-145-0011-DG-HARV-C0913 
Organisation Medical Research Council (MRC) 
Department Medical Research Foundation
Sector Charity/Non Profit
Country United Kingdom
Start 03/2022 
End 09/2022
 
Description Programme 3: Early development and risk of adult musculoskeletal disease
Amount £1,809,000 (GBP)
Funding ID MC_PC_21003 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 07/2021 
End 03/2026
 
Description UKRI WCL Capital funding 2020 2021 DXA and MSK Scanning Suite
Amount £216,857 (GBP)
Funding ID 4050801857 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 10/2020 
End 03/2021
 
Title MAVIDOS trial dataset - 4 year and 7 year followup 
Description MAVIDOS - a randomised controlled trial of vitamin D supplementation in pregnancy. Datasets created included followup of the participants at aged 4 and 7 years (also funded through separate Versus Arthritis grant). Followup included questionnaire data about child health, diet and physical activity, child anthropometry, DXA scans of child (and mum in 4 year followup), HR periperhal quantititative CT scans of the tibia (at age 7 years), blood samples collected where possible Epigenetic arrays (Illumina Infinium EPIC 850k array) on umbilical cord samples collected at birth. Pyrosequencing of the RXRA locus (a key locus in vitamin D signalling), with demonstration of differences in DNA methylation between the supplementation / placebo groups. Genotyping of mother- offspring pairs. Data currently held by MRC Lifecourse Epidemiology Unit, however may be used in consortia studies in future through application to the MRC Lifecourse Epidemiology Unit. 
Type Of Material Database/Collection of data 
Year Produced 2019 
Provided To Others? Yes  
Impact Evidence of a lasting benefit of maternal vitamin D supplementation of childhood bone health at age 4, a difference of 0.18SD in Bone Mineral Density between groups (7 year followup ongoing), evidence of differences in DNA methylation in umbilical cord samples between placebo and supplemented groups, providing underlying mechanism. 
 
Title SPRING Trial 
Description SPRING Trial 
Type Of Material Database/Collection of data 
Year Produced 2021 
Provided To Others? No  
Impact SPRING Trial 
 
Description ALPHABET 
Organisation University College Dublin
Country Ireland 
Sector Academic/University 
PI Contribution WP5, bone outcomes
Collaborator Contribution Consortium
Impact Ongoing
Start Year 2017
 
Description ALPHABET 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution WP5, bone outcomes
Collaborator Contribution Consortium
Impact Ongoing
Start Year 2017
 
Title MAVIDOS trial vitamin D intervention 
Description Vitamin D supplementation 
Type Preventative Intervention - Nutrition and Chemoprevention
Current Stage Of Development Wide-scale adoption
Year Development Stage Completed 2021
Development Status Under active development/distribution
Clinical Trial? Yes
Impact Maternal vitamin D supplementation led to greater bone mass in the offspring for winter births 
 
Title SPRING Pregnancy vitamin D supplementation trial 
Description Trial of vitamin D supplementation during pregnancy 
Type Preventative Intervention - Nutrition and Chemoprevention
Current Stage Of Development Wide-scale adoption
Year Development Stage Completed 2021
Development Status Under active development/distribution
Clinical Trial? Yes
Impact Trial of vitamin D supplementation during pregnancy 
 
Description ASBMR online (EC) 2021 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Presentation at ASBMR, USA
Year(s) Of Engagement Activity 2021
 
Description ASBMR presentation (BC) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Beth Curtis presented MAVIDOS 4 year bone results
Year(s) Of Engagement Activity 2019
 
Description ASBMR-ECTS debate EC 2021 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact ASBMR-ECTS debate EC 2021
Year(s) Of Engagement Activity 2021
 
Description Abstract presentation ASBMR online 2020 (EC) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Abstract presentation ASBMR online 2020 (EC)
Year(s) Of Engagement Activity 2020
 
Description Abstract presentation ASBMR online 2020 (NCH) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Abstract presentation ASBMR online 2020 (NCH)
Year(s) Of Engagement Activity 2020
 
Description Association of Physicians Annual meeting 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Presentation of MAVIDOS CTX data by Beth Curtis
Year(s) Of Engagement Activity 2019
 
Description Bone Research Society Annual Scientific Meeting 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Beth Curtis presentation on bone turnover in MAVIDOS at BRS
Year(s) Of Engagement Activity 2019
 
Description Bone Research Society Event Speaker and Organising Committee 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Part of the organising committee for the Bone Research Society Conference in Winchester from 27th - 30th June 2018.
Year(s) Of Engagement Activity 2018
 
Description Calcium and Vitamin D supplementation are not associated with risk of incident ischemic cardiac events or death: findings from the UK Biobank Cohort - press release 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Press release created a lot of media interest for this paper.
Year(s) Of Engagement Activity 2018
 
Description Chair ASBMR IOF joint session at ASBMR 2021 (NCH) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Chair ASBMR IOF joint session at ASBMR 2021 (NCH)
Year(s) Of Engagement Activity 2021
 
Description ECTS Congress 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Professor Cooper was an invited Speaker at this three day conference, which took place between 22-24th October 2020.
Year(s) Of Engagement Activity 2020
URL https://www.ects2020.org/
 
Description EGG Consortium 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Professor Cyrus Cooper attended this meeting in May 2020.
Year(s) Of Engagement Activity 2020
URL http://www.egg-consortium.org/
 
Description Faculty of Medicine Conference, University of Southampton 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact Professor Cooper attended this Conference on 8th October 2020.
Year(s) Of Engagement Activity 2020
 
Description Findings from the paper 'Calcium and Vitamin D supplementation are not associated with risk of incident ischemic cardiac events or death' appeared in the Hippocratic Post and other media 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Findings from the paper 'Calcium and Vitamin D supplementation are not associated with risk of incident ischemic cardiac events or death: Findings from the UK biobank cohort. J Bone Miner Res. 2018 May;33(5):803-811. doi: 10.1002/jbmr.3375, epub 2018 Feb 8'. appeared in the Hippocratic Post, on other websites, on 3 facebook pages, 34 tweets, and 1 blog.
Year(s) Of Engagement Activity 2018
 
Description Gestational vitamin D supplementation leads to reduced perinatal RXRA DNA methylation: results from the MAVIDOS trial - press release 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact https://www.southampton.ac.uk/medicine/news/2018/11/vitamin-d-baby-genes.page; https://onlinelibrary.wiley.com/doi/epdf/10.1002/jbmr.3603
Gestational vitamin D supplementation leads to reduced perinatal RXRA DNA methylation: results from the MAVIDOS trial. Journal of Bone and Mineral Research. 2018 doi.10.1002/jbmr.3603
Curtis EM, Krstic N, Cook E, D'Angelo S, Crozier SR, Moon RJ, Murray R, Garratt Em, Costello P, Cleal J et al (inc Godfrey K, Cooper C and Harvey N).
Year(s) Of Engagement Activity 2018
 
Description IOF CTF Webinar (NCH) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact IOF CTF Webinar
Year(s) Of Engagement Activity 2018
 
Description International publicity around vitamin D supplement study (NCH, RJM), including live BBC Scotland interview (NCH) 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact International publicity around vitamin D supplement study (NCH, RJM), including live BBC Scotland interview (NCH)
Year(s) Of Engagement Activity 2019
 
Description Invited ASBMR Webinar (NCH) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Invited ASBMR Webinar (NCH)
Year(s) Of Engagement Activity 2018
 
Description Invited Chair joint IOF SIBOMM session (NCH) 2021 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Invited Chair joint IOF SIBOMM session (NCH) 2021
Year(s) Of Engagement Activity 2021
 
Description Invited Presentation on vitamin D in pregnancy (NCH); 6th International Maternal Fetal Health congress Turkey 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Presentation on vitamin D in pregnancy (NCH); 6th International Maternal Fetal Health congress Turkey
Year(s) Of Engagement Activity 2018
 
Description Invited plenary presentation, Mellanby Bone Conference 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Invited plenary presentation, Mellanby Bone Conference
Year(s) Of Engagement Activity 2017
 
Description Invited presentation BRADOO 2021 (NCH) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Invited presentation BRADOO 2021 (NCH)
Year(s) Of Engagement Activity 2021
 
Description Invited presentation WCO 2020 (CC) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Invited presentation WCO 2020 (CC)
Year(s) Of Engagement Activity 2020
 
Description Invited presentation at Belgian Bone Club 2022 (NCH) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Invited presentation at Belgian Bone Club 2022 (NCH)
Year(s) Of Engagement Activity 2022
 
Description Invited presentation at SICOT (NCH) 21 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Invited presentation at SICOT (NCH) 21
Year(s) Of Engagement Activity 2021
 
Description Invited presentation on vitamin D in pregnancy and lifecourse epidemiology of bone development (NCH, Bone Research Society Annual Meeting) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Invited presentation on vitamin D in pregnancy and lifecourse epidemiology of bone development (NCH, Bone Research Society Annual Meeting)
Year(s) Of Engagement Activity 2018
 
Description Irish Osteoporosis Conference 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Professor Cooper was an Invited Speaker at the conference, which was held on 1st October 2020
Year(s) Of Engagement Activity 2020
URL https://www.irishosteoporosis.ie/annual-medical-conference-2020/
 
Description LifeLab - Meet the Scientist 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Dr Beth Curtis spoke to 28 year 9 students from Hounsdown School about the work she carries out in her role of doctor.
Year(s) Of Engagement Activity 2019
 
Description MTP WCO (EC) 2021 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Meet The Expert session at World Congress and Osteoporosis
Year(s) Of Engagement Activity 2021
 
Description MTP WCO 2020 (NCH) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Meet the professor session at World Congress in Osteoporosis (NCH)
Year(s) Of Engagement Activity 2020
 
Description MTP WCO 2021 (NCH) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Meet The Professor session at World Congress in Osteoporosis 2021
Year(s) Of Engagement Activity 2021
 
Description Oral presentation, Association of Physicians of Great Britain and Ireland Annual Meeting, UCL 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact 25 minute presentation - DNA methylation at the RXRA promoter at birth is associated with gestational vitamin D supplementation: results from the MAVIDOS trial, followed by discussion with eminent physicans from the UK and Ireland.
Year(s) Of Engagement Activity 2017
 
Description Oral presentation, Bone Research Society Conference, Bristol 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Oral presentation: "RXRA promoter DNA methylation at birth is associated with gestational vitamin D supplementation: results from the MAVIDOS trial " and discussion with experts in the field, points for further investigation and analysis raised
Year(s) Of Engagement Activity 2017
 
Description Oral presentation, Developmental Origins of Health and Disease Conference, Rotterdam 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Oral presentation, Developmental Origins of Health and Disease Conference, Rotterdam on research project entitled "Perinatal RXRA DNA methylation is altered by maternal gestational vitamin D supplementation: findings from the MAVIDOS trial". This led to questions and discussions regarding future work.
Year(s) Of Engagement Activity 2017
 
Description Plenary invited presentation Managing Osteoporosis Conference 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Plenary invited presentation Managing Osteoporosis Conference
Year(s) Of Engagement Activity 2017
 
Description Plenary invited presentation at DOHAD World Congress (NCH) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Plenary invited presentation at DOHAD World Congress
Year(s) Of Engagement Activity 2017
 
Description Plenary poster presentation at American Society for Bone and Mineral Research Congress 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Plenary poster presentation at American Society for Bone and Mineral Research Congress - the influence of vitamin D on maternal bone resorption in the MAVIDOS trial
Year(s) Of Engagement Activity 2018
 
Description Plenary poster presentation, American Society for Bone and Mineral Research conference, Denver, Colorado 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Plenary poster presenation and discussion with various interested researchers, sparking questions and opportunities for collaboration, American Society for Bone and Mineral Research conference, Denver, Colorado
Year(s) Of Engagement Activity 2017
 
Description Plenary presentation, International Conference on Children's Bone Health, Wurzburg (NCH) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Plenary presentation, International Conference on Children's Bone Health, Wurzburg (NCH)
Year(s) Of Engagement Activity 2017
 
Description Poster presentation - Optimising bone health throughout life - at the Royal Osteoporosis Society Academy Launch 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Supporters
Results and Impact At the launch of the Royal Osteoprosis Society, I was invited to present a poster "Optimising bone health throughout life", showcasing some research funded by the ROS (the MAVIDOS trial). This was attended by a diverse audience including the Duchess of Cornwall, a variety of donors, patient group representatives and policymakers.
Year(s) Of Engagement Activity 2019
 
Description Presentation at American Society for Bone and Mineral Research Annual Scientific meeting (EMC) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Presentation at American Society for Bone and Mineral Research Annual Scientific meeting (EMC)
Year(s) Of Engagement Activity 2017
 
Description Presentation at American Society for Bone and Mineral Research Annual Scientific meeting (NCH) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Presentation at American Society for Bone and Mineral Research Annual Scientific meeting (NCH)
Year(s) Of Engagement Activity 2017
 
Description Presentation at Association of Physicians Meeting 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Presentation at Association of Physicians Meeting
Year(s) Of Engagement Activity 2017
 
Description Presentation at BSR (EC) 2021 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Presentation at British Society for Rheumatology
Year(s) Of Engagement Activity 2021
 
Description Presentation at DOHAD World Congress (EMC) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Presentation at DOHAD World Congress (EMC)
Year(s) Of Engagement Activity 2017
 
Description Presentation at UK Association of Physicians Meeting (EMC) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Presentation at Association of Physicians Meeting
Year(s) Of Engagement Activity 2017
 
Description Presentation at WCO 2021 (NCH) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Presentation at World Congress in Osteoporosis 2021
Year(s) Of Engagement Activity 2021
 
Description Presentation on bone turnover and vitamin D in pregnancy (MAVIDOS, E Curtis) American Society for Bone and Mineral Research meeting, Montreal 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Presentation on bone turnover and vitamin D in pregnancy (MAVIDOS, E Curtis) American Society for Bone and Mineral Research meeting, Montreal
Year(s) Of Engagement Activity 2018
 
Description Presentation on bone turnover and vitamin D in pregnancy (MAVIDOS, E Curtis) Bone Research Society meeting 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Presentation on bone turnover and vitamin D in pregnancy (MAVIDOS, E Curtis) Bone Research Society meeting
Year(s) Of Engagement Activity 2018
 
Description Presentation on bone turnover in mothers in the MAVIDOS trial 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Presentation on bone turnover in mothers in the MAVIDOS trial
Year(s) Of Engagement Activity 2018
 
Description Presentation on vitamin D, bone turnover in pregnancy and offspring bone mass in MAVIDOS (E Curtis) at World Congress in Osteoporosis 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Presentation on vitamin D, bone turnover in pregnancy and offspring bone mass in MAVIDOS (E Curtis) at World Congress in Osteoporosis
Year(s) Of Engagement Activity 2018
 
Description Presentation on vitamin D, epigenetics and bone mass in MAVIDOS (E Curtis), World Congress in Osteoporosis 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Presentation on vitamin D, epigenetics and bone mass in MAVIDOS (E Curtis), World Congress in Osteoporosis
Year(s) Of Engagement Activity 2018
 
Description Presentation to National Osteoporosis Society local patient support group - Southampton 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Patients, carers and/or patient groups
Results and Impact Presentation to National Osteoporosis Society local patient support group - Southampton
Year(s) Of Engagement Activity 2018
 
Description Presentations at WCO (EC) 2021 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Presentation at World Congress in osteoporosis
Year(s) Of Engagement Activity 2021
 
Description ROS Academy Functional Genomics Workshop NCH CC 2020 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact ROS Academy Functional Genomics Workshop NCH CC 2020
Year(s) Of Engagement Activity 2020
 
Description ROS Academy Launch event, London 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Launch of ROS Research Academy (Vice-Chair Prof Harvey)
Year(s) Of Engagement Activity 2019
 
Description ROS Academy Microbiome Workshop NCH CC 2020 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact ROS Academy Microbiome Workshop NCH CC 2020
Year(s) Of Engagement Activity 2020
 
Description ROS Conference Abstract Committee Meeting 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Professor Cooper attended this meeting on 28th July 2020.
Year(s) Of Engagement Activity 2020
URL https://theros.org.uk/healthcare-professionals/osteoporosis-conference/
 
Description ROS Members and Volunteers Committee 2021 (NCH) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Patients, carers and/or patient groups
Results and Impact ROS Members and Volunteers Committee 2021 (NCH)
Year(s) Of Engagement Activity 2021
 
Description ROS Online conference 2020 (CC) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact ROS Online conference 2020 (CC)
Year(s) Of Engagement Activity 2020
 
Description ROS Online conference 2020 (NCH) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact ROS Online conference 2020 (NCH)
Year(s) Of Engagement Activity 2020
 
Description ROS legacy event (NCH) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Patients, carers and/or patient groups
Results and Impact ROS legacy event (NCH)
Year(s) Of Engagement Activity 2019
 
Description ROS microbiome & musculoskeletal health function workshop 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Professor Cooper took part in the Workshop, which was held on 2nd October 2020.
Year(s) Of Engagement Activity 2020
 
Description Royal Osteoporosis Society Virtual Conference 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Professor Cooper was a Speaker at the Conference, held on December 1st 2020.
Year(s) Of Engagement Activity 2020
URL https://theros.org.uk/healthcare-professionals/osteoporosis-conference/
 
Description Royal Osteoporosis Society public event 2021 (NCH) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Working group vitamin D ESCEO 21 (NCH)
Year(s) Of Engagement Activity 2021
 
Description Southampton General Hospital Open Day 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact We offered two activities suitable for adults and children - measuring grip strength and making an x-ray of the hand with clay. The open day was extremely well attended and we had great interest in both the activities and also our research ongoing within the Unit, particularly among undergraduate students and their parents. People reported changes in their views and opinions and asked for further information.
Year(s) Of Engagement Activity 2018
 
Description Talk at Bone Research Society Conference 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Talk on the influence of maternal vitamin D supplementation on bone turnover in the MAVIDOS trial
Year(s) Of Engagement Activity 2018
 
Description Talk at Southampton Medical and Health Research Conference June 2019 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Dr Beth Curtis gave a talk on bone turnover in pregnancy and how it is linked to vitamin D supplementation and maternal bone health, at the Southampton Medical and Health Research Conference. Pictures and comments about Beth's talk appeared on social media.
Year(s) Of Engagement Activity 2019
 
Description WCO-IOF-ESCEO conference 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Professor Cooper was Chairperson at the Conference, which was held online in April 2020, rather than August 2020.
Year(s) Of Engagement Activity 2020
URL http://2020.wco-iof-esceo.org/
 
Description WCO-IOF-ESCEO, Krakow from 16th to 22nd April Conference 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Helped organise and co-ordinate the WCO-IOF-ESCEO conferences in Poland from 16th to 22nd April 2018.
Year(s) Of Engagement Activity 2018
 
Description Wellcome Trust Award 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact £1.6 m Wellcome Trust award and using data from the UK Biobank, is intended to reduce the impact of these common musculoskeletal disorders by providing a basis for improved means of disease prediction, prevention and treatment. The project, led by Jon Tobias, Professor of Rheumatology at Bristol Medical School, will involve a collaboration between researchers from the University of Southampton, as well as Bristol, Manchester, Aberdeen, Cardiff and Queensland Universities.

News of this award attracted media attention and was on a number of websites.
Year(s) Of Engagement Activity 2018
 
Description Working group on phosphate disorders ES CEO 2021 (NCH) 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Working group vitamin D ESCEO 21 (NCH)
Year(s) Of Engagement Activity 2021
 
Description Working group vitamin D ESCEO 21 (NCH) 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Working group vitamin D ESCEO 21 (NCH)
Year(s) Of Engagement Activity 2021
 
Description World Congress in Osteoporosis 2019 (BC) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Presentation of MAVIDOS results by Dr Beth Curtis
Year(s) Of Engagement Activity 2019