HDHL-Biomarkers: Early life programming of childhood health (ALPHABET)
Lead Research Organisation:
University of Southampton
Department Name: Human Development and Health
Abstract
The rising prevalence of obesity, cardiometabolic disease, asthma, osteoporosis and neurodevelopmental disorders over recent decades cannot be fully explained by genetic or adult lifestyle factors. Increasing evidence suggests that early life exposure to environmental factors influences offspring health. According to the Developmental Origins of Health and Disease (DOHaD) hypothesis transient environmental exposures during critical periods of development (e.g. fetal and early infant phases of life) can elicit lifelong effects on offspring health. Epigenetic phenomena have been proposed as mechanisms by which detrimental fetal or early life exposures, such as suboptimal nutrition during pregnancy or early childhood, may affect offspring phenotype and risk of adverse health years after exposure. Maternal diet during pregnancy is a modifiable behaviour that could impact on maternal, neonatal and child health. However the specific dietary requirements during pregnancy for optimal fetal growth and development are unknown. Furthermore studies addressing the hypothesis of fetal programming have focused on maternal intake of single nutrients during pregnancy. Nutrients are not consumed in isolation, thus examining the combined effects of multiple dietary components reflecting the whole diet could have important public health implications. There is a clear need for primary prevention of obesity, related cardiometabolic conditions and other chronic non-communicable diseases based on the DOHaD paradigm. This project aims to advance the state-of-the-art by significantly expanding the knowledge base regarding interactions between biomarkers of diet, epigenetics and offspring health. Utilising biological samples and data from existing European longitudinal birth cohorts at the international forefront of lifecourse epidemiology we will investigate the complex relationships between maternal diet (defined by dietary quality and a novel index of dietary inflammatory potential), offspring health outcomes (including adiposity, bone, cardiometabolic, respiratory and neurodevelopmental health) and epigenetic patterns (DNA methylation) from birth throughout childhood. Better understanding of nutritional and epigenetic biomarkers of offspring health will afford opportunities to refine dietary exposure measures and to aid development of more effective evidence-based public health strategies with an emphasis on advocating a healthy diet in pre-pregnancy, pregnancy and early postnatal life, to reduce obesity, improve health and attenuate development of a range of adverse health outcomes in future generations.
Technical Summary
There is a clear need for primary prevention of obesity, related cardiometabolic conditions and other chronic non-communicable diseases based on the DOHaD paradigm. This project aims to advance the state-of-the-art by significantly expanding the knowledge base regarding interactions between biomarkers of diet, epigenetics and offspring health. Utilising biological samples and data from existing European longitudinal birth cohorts at the international forefront of lifecourse epidemiology we will investigate the complex relationships between maternal diet (defined by dietary quality and a novel index of dietary inflammatory potential), offspring health outcomes (including adiposity, bone, cardiometabolic, respiratory and neurodevelopmental health) and epigenetic patterns (DNA methylation) from birth throughout childhood. Better understanding of nutritional and epigenetic biomarkers of offspring health will afford opportunities to refine dietary exposure measures and to aid development of more effective evidence-based public health strategies with
an emphasis on advocating a healthy diet in pre-pregnancy, pregnancy and early postnatal life, to reduce obesity, improve health and attenuate development of a range of adverse health outcomes in future generations.
an emphasis on advocating a healthy diet in pre-pregnancy, pregnancy and early postnatal life, to reduce obesity, improve health and attenuate development of a range of adverse health outcomes in future generations.
Planned Impact
Given the research focus, the potential long term health and socio-economic impacts may be significant considering the health service and societal costs associated with obesity alone, currently and for future generations. Our results will improve understanding of the relationships between maternal nutrition, pregnancy outcome and subsequent child health. For example improved dietary quality and/or reduced pro-inflammatory dietary status achieved through revision of existing guidelines or development of new guidelines for optimal nutrition in pregnancy or development of functional foods may lead to beneficial health effects on women of reproductive years and their offspring which may have long term effects on their health into adulthood.
People |
ORCID iD |
| Nicholas Harvey (Principal Investigator) |
Publications
Aubert AM
(2022)
Predictors of maternal dietary quality and dietary inflammation during pregnancy: An individual participant data meta-analysis of seven European cohorts from the ALPHABET consortium.
in Clinical nutrition (Edinburgh, Scotland)
Braithwaite VS
(2019)
The Effect of Vitamin D Supplementation on Hepcidin, Iron Status, and Inflammation in Pregnant Women in the United Kingdom.
in Nutrients
Cleal J
(2024)
Feldman and Pike' s Vitamin D
Curtis E
(2018)
Early-life dietary and epigenetic influences on childhood musculoskeletal health: Update on the UK component of the ALPHABET project
in Nutrition Bulletin
Curtis EM
(2019)
Gestational Vitamin D Supplementation Leads to Reduced Perinatal RXRA DNA Methylation: Results From the MAVIDOS Trial.
in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
| Title | ASBMR webinar (NCH) |
| Description | Webinar on abstract writing |
| Type Of Art | Film/Video/Animation |
| Year Produced | 2018 |
| Impact | Improved abstract writing |
| Title | IOF Webinar (NCH,CC) |
| Description | IOF CTF webinars |
| Type Of Art | Film/Video/Animation |
| Year Produced | 2020 |
| Impact | IOF CTF webinars |
| Title | IOF webinars NHC, CC |
| Description | Webinar on osteoporosis prevention |
| Type Of Art | Film/Video/Animation |
| Year Produced | 2018 |
| Impact | Improved care |
| Title | ROS Osteoporosis Research Roadmap video |
| Description | ROS Osteoporosis Research Roadmap video |
| Type Of Art | Film/Video/Animation |
| Year Produced | 2020 |
| Impact | Increased awareness of osteoporosis |
| Description | Methylation at the CDKN2A gene in umbilical cord is associated with offspring bone mass in childhood. (Curtis et al., JBMR 2017). Pregnancy vitamin D supplementation leads to reduced perinatal RXRA methylation (Curtis et al., JBMR 2019) Vitamin D content of OTC vitamin D and multivitamin supplements is often less than DH recommended amount (Moon et al., Arch Dis Childhood 2019) Bone turnover markers in pregnancy associated with maternal vitamin D status and offspring bone mass (Curtis et al., AJCN 2021) Pregnancy dietary inflammatory index inversely associated with offspring bone mass (2022) |
| Exploitation Route | Further Collaboration to use constituent cohorts is envisaged |
| Sectors | Agriculture Food and Drink Education Healthcare Government Democracy and Justice Manufacturing including Industrial Biotechology Pharmaceuticals and Medical Biotechnology |
| Description | Findings will inform potential novel biomarkers for adverse bone development and thus risk assessment strategies. They will also inform novel mechanisms of bone development. |
| First Year Of Impact | 2017 |
| Description | Co-authorship of European guidance on osteoporosis in men (ESCEO) |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Participation in a guidance/advisory committee |
| Description | Co-authorship of European position on Real World Evidence in osteoporosis |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Participation in a guidance/advisory committee |
| Description | Co-authorship of Royal Osteoporosis Society APPG enquiry into FLS (NCH) 2021 |
| Geographic Reach | National |
| Policy Influence Type | Membership of a guideline committee |
| Description | Co-authorship of Royal Osteoporosis Society APPG enquiry into Primary fracture prevention(NCH) 2022 |
| Geographic Reach | National |
| Policy Influence Type | Contribution to a national consultation/review |
| Description | Co-authorship of Royal Osteoporosis Society APPG enquiry into Primary fracture prevention(NCH) 2022 |
| Geographic Reach | National |
| Policy Influence Type | Contribution to a national consultation/review |
| Description | European guidance on very high fracture risk (NCH, CC) |
| Geographic Reach | Europe |
| Policy Influence Type | Membership of a guideline committee |
| Description | House of Commons launch of A Strategy for Preconception Care |
| Geographic Reach | National |
| Policy Influence Type | Contribution to new or improved professional practice |
| Description | Improving preconception health to prevent ill-health and reduce disparities across generations |
| Geographic Reach | National |
| Policy Influence Type | Contribution to a national consultation/review |
| Description | Maternity Disparities Taskforce Meeting - (KMG 2024) |
| Geographic Reach | National |
| Policy Influence Type | Participation in a guidance/advisory committee |
| URL | https://policymogul.com/key-updates/28287/maternity-disparities-taskforce-meets-to-improve-pre-pregn... |
| Description | Membership of a guideline committee on the safety of drug therapies in osteoarthritis - with ESCEO |
| Geographic Reach | Europe |
| Policy Influence Type | Membership of a guideline committee |
| Impact | The European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO) recommendations for on drugs to be used in osteoarthritis: A consensus statement from a working group on the safety of anti-osteoarthritis medications I led a systematic review on the safety of COX-2 inhibitors and opioids in OA. This is due to be published in April 2019. |
| Description | National Osteoporosis Guideline Group Advisory Committee (NCH, CC) |
| Geographic Reach | National |
| Policy Influence Type | Membership of a guideline committee |
| Description | Scientific Advisory Committee on Diet and Nutrition- Public Health England Vitamin D Guidance (NCH) |
| Geographic Reach | National |
| Policy Influence Type | Citation in other policy documents |
| Description | Capital equipment grant (DXA scanner) |
| Amount | £142,000 (GBP) |
| Organisation | National Institute for Health Research |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2024 |
| End | 03/2025 |
| Description | Developmental origins of child neurodevelopment: Novel approaches to clinical risk prediction using an international metadataset. |
| Amount | £364,324 (GBP) |
| Funding ID | MR/V029169/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 11/2021 |
| End | 10/2027 |
| Description | Does maternal gestational vitamin D supplementation influence offspring DNA methylation in childhood? |
| Amount | £29,984 (GBP) |
| Funding ID | SGL023\1072 |
| Organisation | Academy of Medical Sciences (AMS) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 07/2020 |
| End | 12/2021 |
| Description | Does pregnancy vitamin D supplementation alter trajectories of body composition and bone mineralisation from early childhood to adolescence? Follow-up of a randomised placebo-controlled trial. |
| Amount | £187,294 (GBP) |
| Funding ID | GN2969 |
| Organisation | Action Medical Research |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 03/2023 |
| End | 03/2026 |
| Description | Does pregnancy vitamin D supplementation alter trajectories of body composition and bone mineralisation from early childhood to adolescence? Follow-up of a randomised placebo-controlled trial. |
| Amount | £187,294 (GBP) |
| Funding ID | GN2969 |
| Organisation | Action Medical Research |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 05/2023 |
| End | 06/2026 |
| Description | MRC Capital Award |
| Amount | £134,000 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2018 |
| End | 03/2019 |
| Description | MRC Capital Funding |
| Amount | £310,000 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2017 |
| End | 03/2018 |
| Description | MRC Capital Prioritisation Award |
| Amount | £134,000 (GBP) |
| Organisation | University of Southampton |
| Department | MRC Lifecourse Epidemiology Unit |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 03/2019 |
| End | 03/2022 |
| Description | MRC Capital award 2020 2021 Scanco XtremeCT2 |
| Amount | £325,000 (GBP) |
| Funding ID | 4050776844 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2020 |
| End | 03/2023 |
| Description | MRC LEU Extension |
| Amount | £1,800,000 (GBP) |
| Funding ID | MRC LEU |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2020 |
| End | 06/2021 |
| Description | MRC LEU Extension |
| Amount | £1,500,000 (GBP) |
| Funding ID | MRC LEU |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2020 |
| End | 10/2020 |
| Description | NIHR Clinical Lectureship |
| Amount | £250,000 (GBP) |
| Funding ID | CL-2020-26-002 |
| Organisation | National Institute for Health Research |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2021 |
| End | 11/2026 |
| Description | NIHR Southampton BRC PhD studentship |
| Amount | £70,000 (GBP) |
| Organisation | National Institute for Health Research |
| Sector | Public |
| Country | United Kingdom |
| Start | 08/2024 |
| End | 09/2027 |
| Description | Nutritional determinants of skeletal development and bone loss: an investigation using a novel computer vision assessment of bone microarchitecture |
| Amount | £36,000 (GBP) |
| Organisation | University of Southampton |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 08/2022 |
| End | 09/2025 |
| Description | PhD studentship (Computer vision in bone develoment) |
| Amount | £35,000 (GBP) |
| Organisation | University of Southampton |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 09/2022 |
| End | 10/2025 |
| Description | Preventing broken bones in older people: from research to policy to practice |
| Amount | £29,566 (GBP) |
| Funding ID | MRF-145-0011-DG-HARV-C0913 |
| Organisation | Medical Research Council (MRC) |
| Department | Medical Research Foundation |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 03/2022 |
| End | 09/2022 |
| Description | Programme 3: Early development and risk of adult musculoskeletal disease |
| Amount | £1,809,000 (GBP) |
| Funding ID | MC_PC_21003 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 06/2021 |
| End | 03/2026 |
| Description | UKRI WCL Capital funding 2020 2021 DXA and MSK Scanning Suite |
| Amount | £216,857 (GBP) |
| Funding ID | 4050801857 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2020 |
| End | 03/2021 |
| Title | MAVIDOS trial dataset - 4 year and 7 year followup |
| Description | MAVIDOS - a randomised controlled trial of vitamin D supplementation in pregnancy. Datasets created included followup of the participants at aged 4 and 7 years (also funded through separate Versus Arthritis grant). Followup included questionnaire data about child health, diet and physical activity, child anthropometry, DXA scans of child (and mum in 4 year followup), HR periperhal quantititative CT scans of the tibia (at age 7 years), blood samples collected where possible Epigenetic arrays (Illumina Infinium EPIC 850k array) on umbilical cord samples collected at birth. Pyrosequencing of the RXRA locus (a key locus in vitamin D signalling), with demonstration of differences in DNA methylation between the supplementation / placebo groups. Genotyping of mother- offspring pairs. Data currently held by MRC Lifecourse Epidemiology Unit, however may be used in consortia studies in future through application to the MRC Lifecourse Epidemiology Unit. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2019 |
| Provided To Others? | Yes |
| Impact | Evidence of a lasting benefit of maternal vitamin D supplementation of childhood bone health at age 4, a difference of 0.18SD in Bone Mineral Density between groups (7 year followup ongoing), evidence of differences in DNA methylation in umbilical cord samples between placebo and supplemented groups, providing underlying mechanism. |
| Title | SPRING Trial |
| Description | SPRING Trial |
| Type Of Material | Database/Collection of data |
| Year Produced | 2021 |
| Provided To Others? | No |
| Impact | SPRING Trial |
| Description | ALPHABET |
| Organisation | University College Dublin |
| Country | Ireland |
| Sector | Academic/University |
| PI Contribution | WP5, bone outcomes |
| Collaborator Contribution | Consortium |
| Impact | Ongoing |
| Start Year | 2017 |
| Description | ALPHABET |
| Organisation | University of Bristol |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | WP5, bone outcomes |
| Collaborator Contribution | Consortium |
| Impact | Ongoing |
| Start Year | 2017 |
| Title | MAVIDOS trial vitamin D intervention |
| Description | Vitamin D supplementation |
| Type | Preventative Intervention - Nutrition and Chemoprevention |
| Current Stage Of Development | Wide-scale adoption |
| Year Development Stage Completed | 2021 |
| Development Status | Under active development/distribution |
| Clinical Trial? | Yes |
| Impact | Maternal vitamin D supplementation led to greater bone mass in the offspring for winter births |
| Title | SPRING Pregnancy vitamin D supplementation trial |
| Description | Trial of vitamin D supplementation during pregnancy |
| Type | Preventative Intervention - Nutrition and Chemoprevention |
| Current Stage Of Development | Wide-scale adoption |
| Year Development Stage Completed | 2021 |
| Development Status | Under active development/distribution |
| Clinical Trial? | Yes |
| Impact | Trial of vitamin D supplementation during pregnancy |
| Description | A talk at CIMA/CMAR Joint Meeting, Birmingham |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | CIMA/CMAR Network Meeting/Presentation |
| Year(s) Of Engagement Activity | 2023 |
| Description | ASBMR online (EC) 2021 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presentation at ASBMR, USA |
| Year(s) Of Engagement Activity | 2021 |
| Description | ASBMR presentation (BC) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Beth Curtis presented MAVIDOS 4 year bone results |
| Year(s) Of Engagement Activity | 2019 |
| Description | ASBMR-ECTS debate EC 2021 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | ASBMR-ECTS debate EC 2021 |
| Year(s) Of Engagement Activity | 2021 |
| Description | Abstract Writing Masterclass |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | Nick Harvey presented the MRC National Musculoskeletal Ageing Network abstract writing seminar, which took place on December 13th 2022. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Abstract presentation ASBMR online 2020 (EC) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Abstract presentation ASBMR online 2020 (EC) |
| Year(s) Of Engagement Activity | 2020 |
| Description | Abstract presentation ASBMR online 2020 (NCH) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Abstract presentation ASBMR online 2020 (NCH) |
| Year(s) Of Engagement Activity | 2020 |
| Description | Almost half of six-year-olds are not active enough |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Press release relating to our publication - A study with families in Southampton found 47 percent of six-year-olds did not meet the recommended daily guidelines for physical activity. The study was carried out pre-pandemic by researchers at the universities of Southampton and Cambridge. All families who took part were involved in the ongoing Southampton Women's Survey. Children who are active are more likely to be active adults, reducing their risk of obesity and many lifestyle-related diseases later in life. They need to be active for their muscles and bones to develop properly. Being active also improves their ability to concentrate, boosts their mood and leads to better educational performance at school. Yet the results from this study, published in the Journal of Physical Activity & Health, suggest almost half of children are not active enough. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.southamptonbrc.nihr.ac.uk/post/almost-half-of-six-year-olds-not-active-enough |
| Description | Article for University of Southampton Medically Speaking Blog |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Article witten for Medically Speaking Blog, University of Southampton |
| Year(s) Of Engagement Activity | 2023 |
| Description | Article written by Nick Harvey in UoS Enews |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Professor Nick Harvey wrote an article for the University of Southampton Enews in which he wrote about the welcome return to face-face- meetings; the opportunity for in-person participation in the American Society for Bone and Mineral Research Annual Scientific Conference in Austin, Texas and to be able to catch up with colleagues and friends from all over the world. He also mentioned that the new term brings progression of a major initiative in UK musculoskeletal science with the consolidation of the strategic framework for our UKRI MRC National Musculoskeletal Ageing Network. The network will be led by the University of Southampton. He also added that it was great to see the exciting news of the UK Biobank Repeat Imaging Study recently made public. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Association of Physicians Annual meeting |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presentation of MAVIDOS CTX data by Beth Curtis |
| Year(s) Of Engagement Activity | 2019 |
| Description | BRS ECTS Liverpool |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Speech at BRS ECTS Liverpool |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://boneresearchsociety.org/meetings/198/ |
| Description | BSRA MRC National Musculoskeletal Ageing Network joint symposium 2023 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Policymakers/politicians |
| Results and Impact | BSRA MRC National Musculoskeletal Ageing Network joint symposium 2023 |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://bsra.org.uk/events/bsra-asm-2023/ |
| Description | Bone Research Society Annual Scientific Meeting |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Beth Curtis presentation on bone turnover in MAVIDOS at BRS |
| Year(s) Of Engagement Activity | 2019 |
| Description | Bone Research Society Event Speaker and Organising Committee |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Part of the organising committee for the Bone Research Society Conference in Winchester from 27th - 30th June 2018. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Calcium and Vitamin D supplementation are not associated with risk of incident ischemic cardiac events or death: findings from the UK Biobank Cohort - press release |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Press release created a lot of media interest for this paper. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Chair ASBMR IOF joint session at ASBMR 2021 (NCH) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Chair ASBMR IOF joint session at ASBMR 2021 (NCH) |
| Year(s) Of Engagement Activity | 2021 |
| Description | Childhood obesity linked with mother's unhealthy diet before pregnancy |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Press release - New research led by the University of Southampton shows supporting women to eat a healthy diet pre-pregnancy could reduce risk of obesity for their children. Rates of childhood obesity are increasing worldwide. In the UK, nearly a quarter of under-fives are overweight or obese. This increases to more than a third by the time children start secondary school. Children who are obese are more likely to be obese adults, with long-term consequences for their health. Unhealthy diets are an important factor that contribute to this. Research, led by Southampton's Dr Sarah Crozier, has found children aged eight or nine were more likely to be obese if their mother had a poor diet during - and before - pregnancy. The research identifies these as critical times, when initiatives to reduce childhood obesity may be more effective. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.southamptonbrc.nihr.ac.uk/post/childhood-obesity-linked-with-mother-s-unhealthy-diet-bef... |
| Description | DOHAD Conference 2022 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Cyrus attended the DOHAD International Conference. This was held between 27th-31st August 2022. Over 1,000 people attended. |
| Year(s) Of Engagement Activity | 2022 |
| Description | DOHAD Society webinar |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | DOHAD Society webinar |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://dohadsoc.org/webinars/ |
| Description | ECTS Congress |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Professor Cooper was an invited Speaker at this three day conference, which took place between 22-24th October 2020. |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.ects2020.org/ |
| Description | EGG Consortium |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Professor Cyrus Cooper attended this meeting in May 2020. |
| Year(s) Of Engagement Activity | 2020 |
| URL | http://www.egg-consortium.org/ |
| Description | European Geriatric Medical Society |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | speech/presentation for EUGMS |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://eugms2023.com/ |
| Description | Faculty of Medicine Conference, University of Southampton |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | Professor Cooper attended this Conference on 8th October 2020. |
| Year(s) Of Engagement Activity | 2020 |
| Description | Findings from the paper 'Calcium and Vitamin D supplementation are not associated with risk of incident ischemic cardiac events or death' appeared in the Hippocratic Post and other media |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Findings from the paper 'Calcium and Vitamin D supplementation are not associated with risk of incident ischemic cardiac events or death: Findings from the UK biobank cohort. J Bone Miner Res. 2018 May;33(5):803-811. doi: 10.1002/jbmr.3375, epub 2018 Feb 8'. appeared in the Hippocratic Post, on other websites, on 3 facebook pages, 34 tweets, and 1 blog. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Gestational vitamin D supplementation leads to reduced perinatal RXRA DNA methylation: results from the MAVIDOS trial - press release |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | https://www.southampton.ac.uk/medicine/news/2018/11/vitamin-d-baby-genes.page; https://onlinelibrary.wiley.com/doi/epdf/10.1002/jbmr.3603 Gestational vitamin D supplementation leads to reduced perinatal RXRA DNA methylation: results from the MAVIDOS trial. Journal of Bone and Mineral Research. 2018 doi.10.1002/jbmr.3603 Curtis EM, Krstic N, Cook E, D'Angelo S, Crozier SR, Moon RJ, Murray R, Garratt Em, Costello P, Cleal J et al (inc Godfrey K, Cooper C and Harvey N). |
| Year(s) Of Engagement Activity | 2018 |
| Description | Gestational vitamin D supplementation: observation mechanism and intervention in the MAVIDOS trial. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | Nick Harvey gave a talk at the BSR Science Forum on 18th February 2022. Up to 50 people attended. |
| Year(s) Of Engagement Activity | 2022 |
| Description | IOF CTF Webinar (NCH) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | IOF CTF Webinar |
| Year(s) Of Engagement Activity | 2018 |
| Description | IOF symposium at DVO Congress, Salzburg |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Policymakers/politicians |
| Results and Impact | IOF at DVO conference |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://www.emedevents.com/c/medical-conferences-2023/annual-congress-dvo-osteology-2023 |
| Description | International publicity around vitamin D supplement study (NCH, RJM), including live BBC Scotland interview (NCH) |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | International publicity around vitamin D supplement study (NCH, RJM), including live BBC Scotland interview (NCH) |
| Year(s) Of Engagement Activity | 2019 |
| Description | Invited ASBMR Webinar (NCH) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited ASBMR Webinar (NCH) |
| Year(s) Of Engagement Activity | 2018 |
| Description | Invited Chair joint IOF SIBOMM session (NCH) 2021 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited Chair joint IOF SIBOMM session (NCH) 2021 |
| Year(s) Of Engagement Activity | 2021 |
| Description | Invited Presentation on vitamin D in pregnancy (NCH); 6th International Maternal Fetal Health congress Turkey |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presentation on vitamin D in pregnancy (NCH); 6th International Maternal Fetal Health congress Turkey |
| Year(s) Of Engagement Activity | 2018 |
| Description | Invited plenary presentation, Mellanby Bone Conference |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited plenary presentation, Mellanby Bone Conference |
| Year(s) Of Engagement Activity | 2017 |
| Description | Invited presentation BRADOO 2021 (NCH) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited presentation BRADOO 2021 (NCH) |
| Year(s) Of Engagement Activity | 2021 |
| Description | Invited presentation WCO 2020 (CC) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited presentation WCO 2020 (CC) |
| Year(s) Of Engagement Activity | 2020 |
| Description | Invited presentation at Belgian Bone Club 2022 (NCH) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited presentation at Belgian Bone Club 2022 (NCH) |
| Year(s) Of Engagement Activity | 2022 |
| Description | Invited presentation at SICOT (NCH) 21 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited presentation at SICOT (NCH) 21 |
| Year(s) Of Engagement Activity | 2021 |
| Description | Invited presentation on vitamin D in pregnancy and lifecourse epidemiology of bone development (NCH, Bone Research Society Annual Meeting) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited presentation on vitamin D in pregnancy and lifecourse epidemiology of bone development (NCH, Bone Research Society Annual Meeting) |
| Year(s) Of Engagement Activity | 2018 |
| Description | Irish Osteoporosis Conference |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Professor Cooper was an Invited Speaker at the conference, which was held on 1st October 2020 |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.irishosteoporosis.ie/annual-medical-conference-2020/ |
| Description | Launch of WHO-ESCEO |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Nick Harvey attended the launch of this event in Geneva, Switzerland on 23rd February 2023. There were over 1,000 attendees. |
| Year(s) Of Engagement Activity | 2023 |
| Description | Lay presentation |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Nick Harvey delivered a lay presentation on Osteoporosis to the Patient Partner Group at the St Francis Surgery in Hedge End, Southampton. Around 100 people attended. |
| Year(s) Of Engagement Activity | 2023 |
| Description | LifeLab - Meet the Scientist |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Dr Beth Curtis spoke to 28 year 9 students from Hounsdown School about the work she carries out in her role of doctor. |
| Year(s) Of Engagement Activity | 2019 |
| Description | MRC National Musculoskeletal Ageing Network ECR/MCR developmental sessions |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | MRC National Musculoskeletal Ageing Network ECR/MCR developmental sessions |
| Year(s) Of Engagement Activity | 2022 |
| Description | MRC National Musculoskeletal Ageing Network Seminars |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | MRC National Musculoskeletal Ageing Network Seminars |
| Year(s) Of Engagement Activity | 2022 |
| Description | MTP WCO (EC) 2021 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Meet The Expert session at World Congress and Osteoporosis |
| Year(s) Of Engagement Activity | 2021 |
| Description | MTP WCO 2020 (NCH) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Meet the professor session at World Congress in Osteoporosis (NCH) |
| Year(s) Of Engagement Activity | 2020 |
| Description | MTP WCO 2021 (NCH) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Meet The Professor session at World Congress in Osteoporosis 2021 |
| Year(s) Of Engagement Activity | 2021 |
| Description | Media Attention for paper published in PLoS Medicine Maternal B-vitamin and vitamin D (KMG 2024) |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Godfrey KM, Titcombe P, El-Heis S, Albert BB, Huiwen Tham E, Barton SJ, Kenealy T, Foong-Fong Chong M, Nield H, Chong YS, Chan S-Y, Cutfield W.S, Nipper Study Group. Maternal B-vitamin and vitamin D status before, during, and after pregnancy and the influence of supplementation preconception and during pregnancy: Prespecified secondary analysis of the NiPPeR double-blind randomized controlled trial. PLOS Medicine. Https://doi.org/10.137/journal.pmed.1004260 December 5 2023. UoS Media report gave media stats showing this paper reached 96 media outlets worldwide, 40 UK newspapers and TV/radio, it was published by media in Europe, the USA, Canada, India, China and Africa. More than 10 million people saw it globally. It was published by The Guardian, The Times, the Daily Mail and the Independent. There was a Science Media Centre Brieifing with two academic responses to the paper with comments used by six newspapers. Internet; Social Media (Facebook 2121, LInkedIn 2,501, X previously twitter 1,753 reaching 6,269 people) |
| Year(s) Of Engagement Activity | 2023 |
| Description | MyAge London |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | MyAge published a roadmap to help shape the future of muscle resilience research |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://www.ukanet.org.uk/myage/news-events/ |
| Description | Online Presentation |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Nick Harvey gave an online presentation for USA BoneECHO on 28th January 2023. This was attended by over 1,000 people. |
| Year(s) Of Engagement Activity | 2023 |
| Description | Oral presentation, Association of Physicians of Great Britain and Ireland Annual Meeting, UCL |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | 25 minute presentation - DNA methylation at the RXRA promoter at birth is associated with gestational vitamin D supplementation: results from the MAVIDOS trial, followed by discussion with eminent physicans from the UK and Ireland. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Oral presentation, Bone Research Society Conference, Bristol |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Oral presentation: "RXRA promoter DNA methylation at birth is associated with gestational vitamin D supplementation: results from the MAVIDOS trial " and discussion with experts in the field, points for further investigation and analysis raised |
| Year(s) Of Engagement Activity | 2017 |
| Description | Oral presentation, Developmental Origins of Health and Disease Conference, Rotterdam |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Oral presentation, Developmental Origins of Health and Disease Conference, Rotterdam on research project entitled "Perinatal RXRA DNA methylation is altered by maternal gestational vitamin D supplementation: findings from the MAVIDOS trial". This led to questions and discussions regarding future work. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Plenary invited presentation Managing Osteoporosis Conference |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Plenary invited presentation Managing Osteoporosis Conference |
| Year(s) Of Engagement Activity | 2017 |
| Description | Plenary invited presentation at DOHAD World Congress (NCH) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Plenary invited presentation at DOHAD World Congress |
| Year(s) Of Engagement Activity | 2017 |
| Description | Plenary poster presentation at American Society for Bone and Mineral Research Congress |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Plenary poster presentation at American Society for Bone and Mineral Research Congress - the influence of vitamin D on maternal bone resorption in the MAVIDOS trial |
| Year(s) Of Engagement Activity | 2018 |
| Description | Plenary poster presentation, American Society for Bone and Mineral Research conference, Denver, Colorado |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Plenary poster presenation and discussion with various interested researchers, sparking questions and opportunities for collaboration, American Society for Bone and Mineral Research conference, Denver, Colorado |
| Year(s) Of Engagement Activity | 2017 |
| Description | Plenary presentation, International Conference on Children's Bone Health, Wurzburg (NCH) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Plenary presentation, International Conference on Children's Bone Health, Wurzburg (NCH) |
| Year(s) Of Engagement Activity | 2017 |
| Description | Poster presentation - Optimising bone health throughout life - at the Royal Osteoporosis Society Academy Launch |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Supporters |
| Results and Impact | At the launch of the Royal Osteoprosis Society, I was invited to present a poster "Optimising bone health throughout life", showcasing some research funded by the ROS (the MAVIDOS trial). This was attended by a diverse audience including the Duchess of Cornwall, a variety of donors, patient group representatives and policymakers. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Presentation at American Society for Bone and Mineral Research Annual Scientific meeting (EMC) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presentation at American Society for Bone and Mineral Research Annual Scientific meeting (EMC) |
| Year(s) Of Engagement Activity | 2017 |
| Description | Presentation at American Society for Bone and Mineral Research Annual Scientific meeting (NCH) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presentation at American Society for Bone and Mineral Research Annual Scientific meeting (NCH) |
| Year(s) Of Engagement Activity | 2017 |
| Description | Presentation at Association of Physicians Meeting |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presentation at Association of Physicians Meeting |
| Year(s) Of Engagement Activity | 2017 |
| Description | Presentation at BSR (EC) 2021 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presentation at British Society for Rheumatology |
| Year(s) Of Engagement Activity | 2021 |
| Description | Presentation at DOHAD World Congress (EMC) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presentation at DOHAD World Congress (EMC) |
| Year(s) Of Engagement Activity | 2017 |
| Description | Presentation at UK Association of Physicians Meeting (EMC) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presentation at Association of Physicians Meeting |
| Year(s) Of Engagement Activity | 2017 |
| Description | Presentation at WCO 2021 (NCH) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presentation at World Congress in Osteoporosis 2021 |
| Year(s) Of Engagement Activity | 2021 |
| Description | Presentation on bone turnover and vitamin D in pregnancy (MAVIDOS, E Curtis) American Society for Bone and Mineral Research meeting, Montreal |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presentation on bone turnover and vitamin D in pregnancy (MAVIDOS, E Curtis) American Society for Bone and Mineral Research meeting, Montreal |
| Year(s) Of Engagement Activity | 2018 |
| Description | Presentation on bone turnover and vitamin D in pregnancy (MAVIDOS, E Curtis) Bone Research Society meeting |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presentation on bone turnover and vitamin D in pregnancy (MAVIDOS, E Curtis) Bone Research Society meeting |
| Year(s) Of Engagement Activity | 2018 |
| Description | Presentation on bone turnover in mothers in the MAVIDOS trial |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presentation on bone turnover in mothers in the MAVIDOS trial |
| Year(s) Of Engagement Activity | 2018 |
| Description | Presentation on vitamin D, bone turnover in pregnancy and offspring bone mass in MAVIDOS (E Curtis) at World Congress in Osteoporosis |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presentation on vitamin D, bone turnover in pregnancy and offspring bone mass in MAVIDOS (E Curtis) at World Congress in Osteoporosis |
| Year(s) Of Engagement Activity | 2018 |
| Description | Presentation on vitamin D, epigenetics and bone mass in MAVIDOS (E Curtis), World Congress in Osteoporosis |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presentation on vitamin D, epigenetics and bone mass in MAVIDOS (E Curtis), World Congress in Osteoporosis |
| Year(s) Of Engagement Activity | 2018 |
| Description | Presentation to National Osteoporosis Society local patient support group - Southampton |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Patients, carers and/or patient groups |
| Results and Impact | Presentation to National Osteoporosis Society local patient support group - Southampton |
| Year(s) Of Engagement Activity | 2018 |
| Description | Presentations at WCO (EC) 2021 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presentation at World Congress in osteoporosis |
| Year(s) Of Engagement Activity | 2021 |
| Description | Press Release "Reduce risk of childhood obesity thrugh good nutrition before and during pregnancy says scientists" (KMG 2024) |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | An article relating to Lyons-Reid J, Derraik JGB, Kennealy T, Albert BB, Nieves MR, Monnard CR, Titcombe P, Nield H, Barton SJ, El-Heis S, Tham E, Godrey KM, Chan S-Y, Cutfield WS, Nipper Study Group. Impact of preconception and antenatal supplementation with myo-inositol, probiotics, and micronurients on offspring BMI and weight gain over the first 2 years. BMC Medicine 2024 22:39 entitled "Reduce risk of childhood obesity through good nutrition before and during pregnancy, says scientists" appeared in the University of Southampton News, and ENews, it was also mentioned by NIHR and Medical Daily. |
| Year(s) Of Engagement Activity | 2024 |
| Description | Press Release and publication of paper |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Press release for the paper entitled "Is the skull responsive to bone mineralisation stimuli in children? published in the journal Bone. There was some media attention following the publication of this paper. The press release was entitled "Skulls stay strong despite worse diets" |
| Year(s) Of Engagement Activity | 2022 |
| Description | Press Release of published paper |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | There were a number of online citings following a press release entitled "Three coffees a day could help keep the doctor away." This was to do with an article published in European Journal of Preventive Cardiology entitled: Light to moderated coffee consumption is associated with lower risk of death: UK Biobank Study. Simon J, Fung K, et al. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Press release for published paper |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | A press release came out on 12th August 2022 for the paper entitled "Menopausal hormone therapy reduces the risk of fracture regardless of falls risk or baseline FRAX probability - results from the Women's Health Initiative hormone therapy trials." The paper was published in Osteoporosis International. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Preventing broken bones in older people: from research to policy to practice |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | The University Faculty of Medicine print a Research Roundup Newsletter. These newsletters aim to celebrate success, provide research updates and give information on upcoming opportunities. The second of these newsletters was written by Professor Nick Harvey. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Public engagement session on osteoporosis with primary care patients |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Speech on Osteoporosis to St Thomas's Practice |
| Year(s) Of Engagement Activity | 2019,2023 |
| Description | ROS APPG Report |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Royal Osteoporosis Society All Party Parliamentary Group in Osteoporosis Enquiry into primary fracture prevention, partly supported by MRF grant |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://strwebprdmedia.blob.core.windows.net/media/vxuhotlh/appg-on-osteoporosis-and-bone-health-inq... |
| Description | ROS Academy Functional Genomics Workshop NCH CC 2020 |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | ROS Academy Functional Genomics Workshop NCH CC 2020 |
| Year(s) Of Engagement Activity | 2020 |
| Description | ROS Academy Launch event, London |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Launch of ROS Research Academy (Vice-Chair Prof Harvey) |
| Year(s) Of Engagement Activity | 2019 |
| Description | ROS Academy Microbiome Workshop NCH CC 2020 |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | ROS Academy Microbiome Workshop NCH CC 2020 |
| Year(s) Of Engagement Activity | 2020 |
| Description | ROS Conference Abstract Committee Meeting |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Professor Cooper attended this meeting on 28th July 2020. |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://theros.org.uk/healthcare-professionals/osteoporosis-conference/ |
| Description | ROS Members and Volunteers Committee 2021 (NCH) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Patients, carers and/or patient groups |
| Results and Impact | ROS Members and Volunteers Committee 2021 (NCH) |
| Year(s) Of Engagement Activity | 2021 |
| Description | ROS Online conference 2020 (CC) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | ROS Online conference 2020 (CC) |
| Year(s) Of Engagement Activity | 2020 |
| Description | ROS Online conference 2020 (NCH) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | ROS Online conference 2020 (NCH) |
| Year(s) Of Engagement Activity | 2020 |
| Description | ROS legacy event (NCH) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Patients, carers and/or patient groups |
| Results and Impact | ROS legacy event (NCH) |
| Year(s) Of Engagement Activity | 2019 |
| Description | ROS microbiome & musculoskeletal health function workshop |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Professor Cooper took part in the Workshop, which was held on 2nd October 2020. |
| Year(s) Of Engagement Activity | 2020 |
| Description | Radio Interview on BBC (KMG 2024) |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Keith Godfrey was interviewed on BBC Radio News which was broadcast in the early evening and at lunchtime. During his interview he called on councils to do more to support new mothers to stay physically active. He led a study on the activity of 800 women in Southampton and found fewer than half were getting enough moderate to vigorous physical activity. |
| Year(s) Of Engagement Activity | 2023 |
| Description | Royal Osteoporosis Society |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | speech and presentation |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://theros.org.uk/healthcare-professionals/courses-and-cpd/osteoporosis-conference/ |
| Description | Royal Osteoporosis Society Virtual Conference |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Professor Cooper was a Speaker at the Conference, held on December 1st 2020. |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://theros.org.uk/healthcare-professionals/osteoporosis-conference/ |
| Description | Royal Osteoporosis Society public event 2021 (NCH) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Working group vitamin D ESCEO 21 (NCH) |
| Year(s) Of Engagement Activity | 2021 |
| Description | Southampton General Hospital Open Day |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | We offered two activities suitable for adults and children - measuring grip strength and making an x-ray of the hand with clay. The open day was extremely well attended and we had great interest in both the activities and also our research ongoing within the Unit, particularly among undergraduate students and their parents. People reported changes in their views and opinions and asked for further information. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Southampton experts publish new book |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Press release - Professors Keith Godfrey and Mark Hanson have co-edited a new book published by Cambridge University Press. Developmental Origins of Health and Disease (DOHaD) explores the relationship between early life experiences and adult health. It highlights scientific and clinical advances since a first edition was published in 2006. There have been important breakthroughs in areas such as epigenetics and environmental influences. There is also a new focus on the preconception period and the significance of paternal health. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.southamptonbrc.nihr.ac.uk/post/southampton-experts-publish-new-book |
| Description | Southampton to lead new national research network |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Press release - Southampton researchers will lead one of several new national UKRI research networks helping tackle challenges in ageing. The MyAge network will focus on pathways of muscle development, differentiation and decline. Over the course of the two-year project, scientists aim to build new directions and collaborations for future research. They will also develop a roadmap of changes that can help people live independently for longer. The 11 new national networks are funded by the Biotechnology and Biological Sciences Research Council (BBSRC) and Medical Research Council (MRC). MyAge is directed in Southampton by Professor Keith Godfrey, Professor Karen Lillycrop and Professor Peter JS Smith. It is also led by Professor Carolyn Greig (Birmingham), Dr Kambiz Alavian (Imperial College), and Dr Mathew Piasecki (Nottingham). |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.southamptonbrc.nihr.ac.uk/post/southampton-to-lead-new-national-research-network |
| Description | Talk at Bone Research Society Conference |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Talk on the influence of maternal vitamin D supplementation on bone turnover in the MAVIDOS trial |
| Year(s) Of Engagement Activity | 2018 |
| Description | Talk at Southampton Medical and Health Research Conference June 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | Dr Beth Curtis gave a talk on bone turnover in pregnancy and how it is linked to vitamin D supplementation and maternal bone health, at the Southampton Medical and Health Research Conference. Pictures and comments about Beth's talk appeared on social media. |
| Year(s) Of Engagement Activity | 2019 |
| Description | The American Society for Bone and Mineral Research |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presentation The American Society for Bone and Mineral Research |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://www.asbmr.org/annual-meeting |
| Description | University of Southampton Science and Engineering Day |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Nick Harvey was part of a team from the MRC LEU that took part in this event. The event was well attended with members of the public showing great interest. |
| Year(s) Of Engagement Activity | 2022 |
| Description | WCO-IOF-ESCEO Conference - Virtual |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Professor Nick Harvey, Deputy Director of MRC LEU gave the Plenary Lecture 2 entitled 'Update of the management of patients at imminent fracture risk at the WCO-IOF-ESCEO conference on 24th March 2022, which was held virtually. This was attended by over 1,000 people. |
| Year(s) Of Engagement Activity | 2022 |
| Description | WCO-IOF-ESCEO conference |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Professor Cooper was Chairperson at the Conference, which was held online in April 2020, rather than August 2020. |
| Year(s) Of Engagement Activity | 2020 |
| URL | http://2020.wco-iof-esceo.org/ |
| Description | WCO-IOF-ESCEO, Krakow from 16th to 22nd April Conference |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Helped organise and co-ordinate the WCO-IOF-ESCEO conferences in Poland from 16th to 22nd April 2018. |
| Year(s) Of Engagement Activity | 2018 |
| Description | WORLD CONGRESS ON OSTEOPOROSIS, OSTEOARTHRITIS AND MUSCULOSKELETAL DISEASES |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presentaiton of IOF Presidents Award |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://www.wco-iof-esceo.org/ |
| Description | Wellcome Trust Award |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | £1.6 m Wellcome Trust award and using data from the UK Biobank, is intended to reduce the impact of these common musculoskeletal disorders by providing a basis for improved means of disease prediction, prevention and treatment. The project, led by Jon Tobias, Professor of Rheumatology at Bristol Medical School, will involve a collaboration between researchers from the University of Southampton, as well as Bristol, Manchester, Aberdeen, Cardiff and Queensland Universities. News of this award attracted media attention and was on a number of websites. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Working group on phosphate disorders ES CEO 2021 (NCH) |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Working group vitamin D ESCEO 21 (NCH) |
| Year(s) Of Engagement Activity | 2021 |
| Description | Working group vitamin D ESCEO 21 (NCH) |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Working group vitamin D ESCEO 21 (NCH) |
| Year(s) Of Engagement Activity | 2021 |
| Description | World Congress in Osteoporosis 2019 (BC) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presentation of MAVIDOS results by Dr Beth Curtis |
| Year(s) Of Engagement Activity | 2019 |