HDHL-Biomarkers: VALID, Valerolactones and healthy Ageing: Linking diet, biomarkers and metabolic health with cognition in older adults

Lead Research Organisation: University of Ulster
Department Name: Sch of Biomedical Sciences

Abstract

Globally, populations are ageing; by 2050 it is estimated that more than 2 billion people will be aged over 60 years. This will be accompanied by an increase in cognitive dysfunction which ranges from mild cognitive impairment to dementia. Certain dietary patterns or nutritional components may have a beneficial role, thus offering potential strategies to prevent or delay the onset of cognitive dysfunction in ageing. (Poly)phenols are one such category, but linking these to cognition and other health outcomes is difficult because they appear in the blood for only a brief period of time (2-4 hours) after consumption of fruits and vegetables, which then limits the development of good blood based biomarkers of dietary consumption as a result. Our study will address this problem; procyanidins commonly found in foods such as tea, cocoa, grapes, nuts and berries, are of specific interest among (poly)phenols, and are almost exclusively broken down by gut bacteria to phenolic acids and valerolactones. These valerolactones are thought to be beneficial to health and have the added advantage that they remain in the blood for longer periods of time (up to 48 hours), thus offering new blood based biomarker(s) to detect dietary consumption of foods such as tea, cocoa, grapes, nuts and berries. In our project we aim to validate gamma-valerolactones as stable blood biomarkers of foods such as tea, cocoa, grapes, nuts and berries and demonstrate their association with markers of inflammation and metabolic health, and ultimately cognitive function, in an ageing European population. To do this, we will utilise data and perform new analysis on samples from the Trinity, Ulster, Department of Agriculture Study (TUDA) cohort study, a unique resource designed to assess nutrition and ageing in 5,186 adults aged 60-102 years recruited from the island of Ireland, and including a range of existing biomarkers, metabolic health status and cognitive measures. In this way, our project will identify and validate gamma-valerolactones as novel biomarkers that are modulated by dietary (poly)phenols and associated with favourable health outcomes in ageing.

Technical Summary

Globally, populations are ageing; with a commensurate increase in cognitive dysfunction. Dietary patterns/nutritional components are recognised to have a beneficial role, thus offering potential strategies to prevent or delay the onset of cognitive dysfunction in ageing. (Poly)phenols are one such category, but linking these to cognition and other health outcomes is problematic because of their transient appearance in plasma which limits the development of robust biomarkers of dietary exposure. Procyanidins, abundant in foods such as tea, cocoa, grapes, nuts and berries, are of specific interest among polyphenols, and are almost exclusively metabolised by colonic bacteria to phenolic acids and valerolactones. The latter are now thought to exert the potential biological effects (i.e. neuroprotective/anti-inflammatory) originally attributed to their parent dietary compounds, but with the advantage of being stable (up to 48h) in plasma, thus offering a new biomarker of dietary exposure to the relevant (poly)phenols. We aim to validate plasma gamma-valerolactones as stable biomarkers of procyanidin-rich foods and demonstrate their association with markers of inflammation and metabolic health, and ultimately cognitive function, in an ageing European population. We will utilise data and perform new analysis on samples from the TUDA cohort study 5,186 adults aged 60-102 years recruited from the island of Ireland, and including a range of existing biomarkers, metabolic health status and cognitive measures. Apart from the existing bio-banked TUDA study, we will access data and samples from 'TUDA 5+', a follow-up study of 1000 participants from the original cohort 5 years after their initial investigation, to determine the role of procyanidin-rich foods in preventing cognitive decline. Our project will identify and validate gamma-valerolactones as novel biomarkers that are modulated by dietary (poly)phenols and associated with favourable health outcomes in ageing.

Planned Impact

VALID will identify and validate novel biomarkers (plasma gamma-valerolactones) that are modulated by dietary polyphenols and associated with favorable cognitive health in older age.

Providing the following impacts.

1) We will provide input to stakeholders, policy-makers, influencers and healthcare regulatory bodies at National and International levels, that have the striking need of taking advantage of up-to-date and easily adoptable scientifically robust recommendations for a correct evidence-based action. The project will help to address healthcare challenges by identifying effective dietary advice and options for intervention with nutritional products specifically designed to promote health and wellness in our ageing population. In addition, the European Commission JRC report recently identified multidisciplinary research into nutrition and brain health in older people as a major priority (Joint Research Centre European Commission, 2014) and called for the use of state-of-the-art technologies to provide a better understanding of the interactions between biological and environmental factors on brain health in ageing. Particularly of interest in this regard is our proposed use of Geographical Information System (GIS), a system that applies geospatial technologies and regional census data to produce socioeconomic profiles of the study regions. This aspect of the proposal could be of particular benefit as it allows for a more robust definition of socio-economic status compared with traditional approaches, and will enable nutritional information to be linked with geographic and socio-economic data, thereby allowing potential health inequalities as people age to be explored.

2) The VALID project will help to address economic healthcare challenges by identifying cost-effective strategies for future systemic and resource allocation decisions. The project is also well aligned with the European Innovation Partnership Strategic Implementation Plan on active and healthy ageing for: 'Prevention of functional decline, both physical and cognitive, in older people'.

3) VALID project is likely to have commercial impact, companies such as Ferrero and DSM will be able to use this information to innovate, developing functional products rich in bioactive compounds tailored to improving cognitive health in the elderly, creating novel IP for exploitation and new markets globally to increase revenue and grow the UK & European economy.

4) The project will also provide a post-doctoral researcher and PhD student with an excellent training opportunity in nutrition science with input from partner organizations at the forefront of nutrition research. The post-doctoral researcher and PhD student will strengthen their career prospects with experience in key cutting-edge skills gained in fundamental and applied science. Such training will strengthen the UK's economic competitiveness by providing a well-educated candidate for the burgeoning food and health area.

Publications

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Angelino D (2019) Fruit and vegetable consumption and health outcomes: an umbrella review of observational studies. in International journal of food sciences and nutrition

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Calder PC (2018) A holistic approach to healthy ageing: how can people live longer, healthier lives? in Journal of human nutrition and dietetics : the official journal of the British Dietetic Association

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Hughes CF (2018) Assessing biomarker status of vitamin B in the laboratory: no simple solution. in Annals of clinical biochemistry

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Laird EJ (2019) Vitamin D Status Is Not Associated With Orthostatic Hypotension in Older Adults. in Hypertension (Dallas, Tex. : 1979)

 
Description Preliminary findings from the VALID project were presented at the 13th European Nutrition Conference of the Federation of European Nutrition Societies (FENS) 2019 conference, held in Dublin, Ireland. The conference took place from 15-18 October 2019 in the Convention Centre Dublin, Ireland.

At a special symposium held at the FENS conference, preliminary results were presented from the VALID project, along with those from the DERiVE project (funded under the same JPI HDHL call). VALID project team members, Prof Daniele Del Rio (University of Parma) and Prof Adrian Moore (Ulster University) presented their work at the DERiVE-VALID Symposium entitled 'Validating novel biomarkers of dietary exposure to Riboflavin and Polyphenols and associated health impacts'. This symposium provided a unique opportunity to showcase both projects and disseminate their early findings.
Exploitation Route The VALID project has provided excellent training and experience to PhD students and early-career researchers in nutrition and health, by utilising the established and successful training platforms within each of the partner institutes, and thus has strengthened the research base.
The scientific publications arising from this research will also provide important benefits to the wider research community by providing comprehensive data reporting important nutrition and health relationships in a very well characterised older Irish population and the potential benefits to health of improving nutritional status for better functional effects and health outcomes.
Sectors Agriculture, Food and Drink,Education,Healthcare,Pharmaceuticals and Medical Biotechnology

URL http://www.jpi-valid.com
 
Description Impact article on nutritional biomarkers for health 'Polyphenols for healthier ageing' Authors: Ward, Mary; McNulty, Helene Source: Impact, Volume 2018, Number 10, December 2018, pp. 83-85(3) Publisher: Science Impact Ltd DOI: https://doi.org/10.21820/23987073.2018.10.83 Impact article targeted at international research & scientific community, stakeholders & policymakers. The article was produced to create awareness of the VALID project and outline the impact objectives: *Gain a better understanding of the role of nutrition in health by developing and validating novel biomarkers of dietary exposure in transnational research studies *Grow capacity, capability and sustainable transnational partnerships in nutrition and health research, led by UK partner in collaboration with partners in the Republic of Ireland and Italy *Demonstrate the functional and metabolic effects of dietary polyphenols on the ageing brain
First Year Of Impact 2018
Sector Agriculture, Food and Drink,Healthcare
Impact Types Societal,Policy & public services

 
Description Prof Helene McNulty: Chair of the Folic Acid Food Fortification Review Group, Food Safety Authority of Ireland, FSAI
Geographic Reach National 
Policy Influence Type Membership of a guideline committee
Impact Prof Helene McNulty was elected as Chair of the Folic Acid Food Fortification Review Group, Food Safety Authority of Ireland, FSAI (2014-2017)
URL https://www.fsai.ie/publications_folic_acid_update/
 
Description Prof Helene McNulty: Member of the Northern Ireland Clinical Trials Unit (NICTU) Advisory Group
Geographic Reach National 
Policy Influence Type Membership of a guideline committee
URL http://www.nictu.hscni.net/about-us/
 
Description Prof Mary Ward; Deputy Director of The Wellcome Trust-Wolfson Northern Ireland Clinical Research Facility (NICRF)
Geographic Reach National 
Policy Influence Type Membership of a guideline committee
URL https://www.qub.ac.uk/research-centres/TheWellcomeTrust-WolfsonNorthernIrelandClinicalResearchFacili...
 
Title Polyphenol food database (Nutritics) 
Description Development of a polyphenol food database in collaboration with Nutritics, Ireland. To assess the polyphenol intakes of older adults using 4-day food diaries. Dietary intake data for a subset of 1000 participants (with corresponding plasma samples) from the TUDA cohort was assessed using a 4-day food diary (for 4 consecutive days, including Saturday and Sunday, to account for the known variation in day-to-day intake) in combination with a food frequency questionnaire (FFQ), an approach previously validated against biomarker data at our center for studying dietary B-vitamin intake (Hoey et al., 2007). By combining both dietary collection methods we are able to more accurately estimate of intake, and relate that to plasma ?-valerolactones levels. Each participant received oral and written instructions on how to complete the food diary to enhance the accuracy of information regarding usual intake of these catechin and procyanidin-rich foods. Food portion sizes were estimated by the participant using household measures and later quantified using published food portion size data. 
Type Of Material Improvements to research infrastructure 
Year Produced 2019 
Provided To Others? No  
Impact This is a project in progress but to date we have developed a polyphenol food database in collaboration with Nitritics, Ireland, to assess the polyphenol intakes of older adults using 4-day food diaries. 
 
Title Polyphenol food frequency questionnaire (FFQ) 
Description Development of a food frequency questionnaire (FFQ) to assess polyphenol intakes in an elderly cohort of European adults (The TUDA cohort). Dietary intake data for a subset of 800 participants (with corresponding plasma samples) from the TUDA cohort were assessed using a food frequency questionnaire (FFQ) to estimate intake of specific polyphenols, and relate that to plasma ?-valerolactones levels. 
Type Of Material Improvements to research infrastructure 
Year Produced 2019 
Provided To Others? No  
Impact Development of a food frequency questionnaire (FFQ) to assess polyphenol intakes in an elderly cohort of European adults (The TUDA cohort). 
 
Description European Deprivation Index - Ulster and INSERM 
Organisation National Institute of Health and Medical Research (INSERM)
Country France 
Sector Academic/University 
PI Contribution The VALID health geography team, under Prof Adrian Moore, has established a collaboration with the Université de Caen Basse-Normandie/ INSERM in France to work on the development of a European Deprivation Index for Northern Ireland and the Republic of Ireland. This collaboration will help to provide a single comparative measurement indicators in the VALID project.
Collaborator Contribution This collaboration will help to provide a single comparative measure of area deprivation for the whole Island and extend the deprivation measurement indicators in the VALID project.
Impact It is intended that the collaboration will contribute to European Project WASABY (http://www.wasabysite.it/index.html) funded from the Directorate General Santé under the European Commission 3rd Health Programme, Call PP-2-5-2016 It's aim is to identify areas with higher breast cancer rates in 10 countries (France, Spain, Portugal, Italy, Slovenia, Lithuania, Belgium, Nothern Ireland, Poland, Germany).
Start Year 2018
 
Description PREVENTOMICS 
Organisation Autonomous University of Barcelona (UAB)
Country Spain 
Sector Academic/University 
PI Contribution New integration of genetic, nutritional and psychological factors and the application of state of the art metabolomics technologies and computational modelling of the metabolome,
Collaborator Contribution This collaboration has been set up to assess the real incidence of disease-inducing factors on the organism, translating this information into personalised dietetic advice for the user, levering on ICT technologies.
Impact N/A
Start Year 2019
 
Description VALID 
Organisation Trinity College Dublin
Country Ireland 
Sector Academic/University 
PI Contribution The Ulster research team contributes to the collaboration in the following ways: Overall project co-ordination across the three participating countries; Provision of experience and expertise in conducting nutrition and health studies in humans (including capability in Ageing research); Application of Geographical Information Systems technology to large human data sets for better understanding of the relationships between health and the environment; Access to the Trinity, Ulster and Department of Agriculture cohort (TUDA), including 5186 participants and providing comprehensive data on general health and lifestyle, dietary data, cognitive assessment data and stored blood samples for further analysis to meet the VALID project outcomes; Access to the TUDA follow-up cohort (n 600) with the above data and blood samples; Development of Standard Operating Procedures (SOPs) for methodologies used across study sites; Provision of centralised training to researchers across study sites on the recruitment and re-sampling of TUDA participants; Analysis of biomarkers of inflammatory and metabolic health status (n 6,000). The VALID project is co-ordinated by Ulster and the overall progress is monitored through regular project meetings involving all partners. To date three meetings have taken place, either face-to-face or by Skype: May 2017; Dec 2017 and Feb 2018.
Collaborator Contribution The team at Trinity College Dublin contributes to the collaboration in the following ways: Provision of expertise and experience in Medical Gerontology; Internationally recognised Centre of Excellence for vitamin research; Access to expertise from Department of Statistics; Access to the Trinity, Ulster and Department of Agriculture cohort (TUDA), including 5186 participants and providing comprehensive data on general health and lifestyle, dietary data, cognitive assessment data and stored blood samples for further analysis to meet the VALID project outcomes); Access to the TUDA follow-up cohort (n 400) with the above data and samples; Analysis of inflammatory and vitamin biomarkers The team at University of Parma contributes to the collaboration in the following ways: Provision of expertise and experience in novel biomarker analysis for nutrients and bioactive metabolites using mass spectrometry; Development of novel methodology for quantifying polyphenols in biological samples; Provision of comprehensive analysis of plasma ?-valerolactones and their metabolites in over 6,000 samples to meet the VALID project outcomes.
Impact For relevant details on published papers: See Publications list (with DOI details) under the Common Outcomes section of this report. For relevant details on conference presentations see Engagement Activities section of this report. Other outcomes achieved to date: 1. Development of a novel method for analysing stable blood biomarkers of dietary polyphenol intake (plasma ?-valerolactones and their metabolites) at the University of Parma. This method is currently being used to analyse TUDA study samples; 2. Development of a new polyphenol food frequency questionnaire suitable for older adults (>70 years) from the UK and Ireland at Ulster University, This is currently being used to assess dietary polyphenol intake. 3. Enhanced research capabilities have been achieved through training delivered to the VALID project researchers, including PhD and MRes students, by more senior members of the research team. In addition, the post-doctorial Research Associates working on the VALID project continue to receive mentorship from senior colleagues. This collaboration is multi-disciplinary. The synergy of the three consortium partners brings together experts in the following disciplines: nutrition, dietetics, food science, food components metabolism and bioactivity, biochemistry, immunology, clinical gerontology and healthcare of older adults, psychology, medical geography and environmental sciences.
Start Year 2017
 
Description VALID 
Organisation University of Parma
Country Italy 
Sector Academic/University 
PI Contribution The Ulster research team contributes to the collaboration in the following ways: Overall project co-ordination across the three participating countries; Provision of experience and expertise in conducting nutrition and health studies in humans (including capability in Ageing research); Application of Geographical Information Systems technology to large human data sets for better understanding of the relationships between health and the environment; Access to the Trinity, Ulster and Department of Agriculture cohort (TUDA), including 5186 participants and providing comprehensive data on general health and lifestyle, dietary data, cognitive assessment data and stored blood samples for further analysis to meet the VALID project outcomes; Access to the TUDA follow-up cohort (n 600) with the above data and blood samples; Development of Standard Operating Procedures (SOPs) for methodologies used across study sites; Provision of centralised training to researchers across study sites on the recruitment and re-sampling of TUDA participants; Analysis of biomarkers of inflammatory and metabolic health status (n 6,000). The VALID project is co-ordinated by Ulster and the overall progress is monitored through regular project meetings involving all partners. To date three meetings have taken place, either face-to-face or by Skype: May 2017; Dec 2017 and Feb 2018.
Collaborator Contribution The team at Trinity College Dublin contributes to the collaboration in the following ways: Provision of expertise and experience in Medical Gerontology; Internationally recognised Centre of Excellence for vitamin research; Access to expertise from Department of Statistics; Access to the Trinity, Ulster and Department of Agriculture cohort (TUDA), including 5186 participants and providing comprehensive data on general health and lifestyle, dietary data, cognitive assessment data and stored blood samples for further analysis to meet the VALID project outcomes); Access to the TUDA follow-up cohort (n 400) with the above data and samples; Analysis of inflammatory and vitamin biomarkers The team at University of Parma contributes to the collaboration in the following ways: Provision of expertise and experience in novel biomarker analysis for nutrients and bioactive metabolites using mass spectrometry; Development of novel methodology for quantifying polyphenols in biological samples; Provision of comprehensive analysis of plasma ?-valerolactones and their metabolites in over 6,000 samples to meet the VALID project outcomes.
Impact For relevant details on published papers: See Publications list (with DOI details) under the Common Outcomes section of this report. For relevant details on conference presentations see Engagement Activities section of this report. Other outcomes achieved to date: 1. Development of a novel method for analysing stable blood biomarkers of dietary polyphenol intake (plasma ?-valerolactones and their metabolites) at the University of Parma. This method is currently being used to analyse TUDA study samples; 2. Development of a new polyphenol food frequency questionnaire suitable for older adults (>70 years) from the UK and Ireland at Ulster University, This is currently being used to assess dietary polyphenol intake. 3. Enhanced research capabilities have been achieved through training delivered to the VALID project researchers, including PhD and MRes students, by more senior members of the research team. In addition, the post-doctorial Research Associates working on the VALID project continue to receive mentorship from senior colleagues. This collaboration is multi-disciplinary. The synergy of the three consortium partners brings together experts in the following disciplines: nutrition, dietetics, food science, food components metabolism and bioactivity, biochemistry, immunology, clinical gerontology and healthcare of older adults, psychology, medical geography and environmental sciences.
Start Year 2017
 
Description DERiVE-VALID Symposium at the FENS 2019 conference 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact At the FENS 2019 conference in Dublin, Ireland, the DERiVE and VALID sister-projects hosted a symposium 'Validating novel biomarkers of dietary exposure to Riboflavin and Polyphenols and associated health impacts: Transnational DERiVE and VALID projects'. The symposium was well received with great participation from the scientific audience.

Prof Daniele Del Rio, from the University of Parma, gave a presentation on 'Dietary polyphenols, circulating valerolactones and cognitive health in older Europeans - The VALID Project' and Prof Adrian Moore, from Ulster University, presented on 'Understanding and promoting cognitive health in ageing through integration of dietary information with physical and social environments in the VALID project'.
Year(s) Of Engagement Activity 2019
 
Description Dr Aoife Caffrey: Science Vlog at the 5th International Conference of JPI HDHL, Brussels, Feb 2019 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact The Vlog contest at the 5th International Conference of JPI HDHL, Brussels, 20 Feb 2019
Working in the field of food, nutrition and health, we all agree that research in this area is of high importance. However, science alone is not enough to change the world! Broad and understandable communication of research projects in order to have an impact on society is essential for excellent science. JPI HDHL stimulates the communication of research projects beyond the scientific field and the "JPI HDHL science vlog contest" contributes to this.
The goal for this contest is to end up with a short, clear vlog of 3 minutes maximum. The top three science Vlogs were presented at the JPI HDHL 5th conference.

JPI HDHL conference website: https://healthydietforhealthylife.eu/index.php/5th-international-conference-of-jpi-hdhl?jjj=1552047542483
Youtube VALID vlog: https://www.youtube.com/watch?v=XAMQ9GniIUo&list=PLbEprY5MqqhyLRQ25OFuTZPE9D_k7zzV_?dex=14&t=0s
Year(s) Of Engagement Activity 2019
URL https://healthydietforhealthylife.eu/index.php/5th-international-conference-of-jpi-hdhl?jjj=15520475...
 
Description Dr Chris Gill: Contribution the Science & Wine blog 'Monthly Assignment Challenge - March' 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Contribution to Science & Wine online blog where the role of Polyphenols specifically those found in wine were discussed in relation to ageing and the role of the VALID project in investigating their role is mentioned.
Year(s) Of Engagement Activity 2018
URL https://www.ciencia-e-vinho.com/2018/03/01/3760/
 
Description Dr Chris Gill: Oral presentation at the International Geneva/Springfield Symposium on Advances in Alzheimer Therapy (AAT) and AD/PDTM Meeting March 2018, Torino, Italy. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Oral Presentation entitled Valerolactones and healthy Ageing: Linking diet, biomarkers and metabolic health with cognition in older adults- the VALID project, given at the International Geneva/Springfield Symposium on Advances in Alzheimer Therapy (AAT) and AD/PDTM Meeting March 2018, Torino, Italy.
Year(s) Of Engagement Activity 2018
 
Description Dr Donato Angelino: Oral presentation at the 3rd Annual International Summit on Medical Nutrition Education and Research, November 2017, Cambridge,UK. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Oral presentation at the 3rd Annual International Summit on Medical Nutrition Education and Research "Polyphenols and Cognitive Performance: a Focus on Dietary Procyanidins", August 2017, Cambridge,UK.
Year(s) Of Engagement Activity 2017
URL https://nnedpromeetings.files.wordpress.com/2016/08/2017-07-18-provisional-programme-web-docx.pdf
 
Description Dr Donato Angelino: Oral presentation at the Italian Society of Human Nutrition, November 2017, Turin, Italy. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other audiences
Results and Impact Oral presentation at the Italian Society of Human Nutrition meeting entitled "Il Progetto Valid: "Valerolactones and Healthy Ageing: Linking Dietary Factors, Nutrient Biomarkers, Metabolic Status and Inflammation with Cognition in Older Adults", November 2017, Turin, Italy.
Year(s) Of Engagement Activity 2017
 
Description Dr Donato Angelino: Poster presentation at The 8th International Conference on Polyphenols and Health, October 2017, Quebec City, Canada 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Poster presentation entitled 'Valerolactones and healthy Ageing: Linking diet, biomarkers and metabolic health with cognition in older adults- the VALID project' The 8th International Conference on Polyphenols and Health, October 2017, Quebec City, Canada.
Year(s) Of Engagement Activity 2017
 
Description Dr Donato Angelino: Presentation at the 2nd Food Bioactives and Health Conference concerning VALID project results, 2018 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact Oral presentation at the 2nd Food Bioactives and Health Conference concerning VALID project results
Year(s) Of Engagement Activity 2018
URL http://www.itqb.unl.pt/fbhc2018
 
Description Dr Donato Angelino: Presentation at the 39th Conference of the Italian Society of Human Nutrition, 2018 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Oral presentation at the 39th Conference of the Italian Society of Human Nutrition concerning VALID project results.
Year(s) Of Engagement Activity 2018
URL http://www.sinu.it/html/cnt/home.asp
 
Description Dr Donato Angelino: Workshop at ILSI Europe Task Force on Nutrition and Mental Performance, 2018 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact 3rd Workshop on "Nutrition for the Ageing Brain: Moving Towards Clinical Applications" organised by the ILSI Europe Task Force on Nutrition and Mental Performance concerning VALID project results.
Year(s) Of Engagement Activity 2018
URL http://ilsi.eu/event/3rd-workshop-on-nutrition-for-the-ageing-brain/
 
Description Impact article on nutritional biomarkers for health 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Impact article targeted at international research & scientific community, stakeholders & policymakers. The article was produced to create awareness of the VALID project and outline the impact objectives:
*Gain a better understanding of the role of nutrition in health by developing and validating novel biomarkers of dietary exposure in transnational research studies
*Grow capacity, capability and sustainable transnational partnerships in nutrition and health research, led by UK partner in collaboration with partners in the Republic of Ireland and Italy.
*Demonstrate the functional and metabolic effects of dietary polyphenols on the ageing brain

The VALID project is funded under the JPI co-funded ERA-HDHL joint call 'Biomarker for nutrition and health'. In line with the JPI's 'A healthy diet for a healthy life' vision to support quality, transnational, collaborative research, the goal of this project is to promote scientific excellence through international collaborations. Go to www.healthydietforhealthylife.eu/index.php/joint-actions/era-hdhl-ja

Published in Science Impact, December 2018, pp. 83-85; https://doi.org/10.21820/23987073.2018.10.83
Year(s) Of Engagement Activity 2018
URL https://doi.org/10.21820/23987073.2018.10.83
 
Description Katie Moore and Ben Parmenter: Participation at the JPI HDHL annual conference; Katie Moore: presented an elevator pitch on the VALID Project at JPI, HDHL conference 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Along with 200 people from various backgrounds, the VALID young scientists participation in the 4th International Conference of JPI HDHL in December 2017. They actively participated and benefited from the Speech like Obama training where during this workshop on public speaking they received practical tips for the pitches about their research projects they were giving later that day. Later that day once of the young scientists gave their elevator pitch on the VALID project.
Year(s) Of Engagement Activity 2017
URL https://jpi-hdhl-conference.b2match.io/
 
Description Katie Moore: Oral communication at the International Congress of Nutrition, October 2017, Buenos Aires, Argentina 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Oral presentation of TUDA results to date under the title 'Role of folate and the metabolically related B-vitamins in brain health in older adults: The TUDA Study' at the International Congress of Nutrition, October 2017, Buenos Aires, Argentina.
Year(s) Of Engagement Activity 2007,2017
 
Description Katie Moore: Oral communication at the Nutrition Society Summer Meeting, June 2017, Queens University Belfast, Northern Ireland. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other audiences
Results and Impact Oral presentation entitled 'Nutrition and the ageing Brain' given at the Nutrition Society Summer Meeting, June 2017, Queens University Belfast, Northern Ireland.
Year(s) Of Engagement Activity 2017
 
Description Prof Adrian Moore: INSERM and Universit√© Caen Normandie, Caen, France, December 2018 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Policymakers/politicians
Results and Impact Prof Adrian Moore 'Creating a European Deprivation Index for the Island of Ireland', INSERM and Université Caen Normandie, Caen, France, December 2018
Year(s) Of Engagement Activity 2018
 
Description Prof Adrian Moore: presentation at the FENS 2019 conference 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact At the DERiVE-VALID Symposium, FENS 2019 conference, Dublin, Ireland, Prof Adrian Moore presented "Understanding and promoting cognitive health in ageing through integration of dietary information with physical and social environments in the VALID project". The symposium was well received with great participation from the FENS conference scientific audience.
Year(s) Of Engagement Activity 2019
URL https://app.oxfordabstracts.com/events/696/program-app/submission/132975
 
Description Prof Daniele Del Rio: 8th Biennial Berry Health Benefits Symposium, Portland, Oregan, USA, May 2019 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Prof Daniele Del Rio 'Phenyl-g-valerolactones and Phenylvaleric Acids, the Main Colonic Metabolites of Flavan-3-ols: Their Relevance in Berry Health Benefits' at the 8th Biennial Berry Health Benefits Symposium, Portland, Oregan, USA, May 2019
Year(s) Of Engagement Activity 2019
 
Description Prof Daniele Del Rio: Conference of the International Society of Nutrigenetics and Nutrigenomics, Cambridge, UK, July 2019 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Prof. Daniele Del Rio, Oral Presentation at the Conference of the International Society of Nutrigenetics and Nutrigenomics, Cambridge, UK on 12-13th July 2019
Year(s) Of Engagement Activity 2019
 
Description Prof Daniele Del Rio: Contribution to Science & Wine online blog 'Monthly Assignment Challenge - February' 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Contribution to Science & Wine online blog where the role of Polyphenols specifically those found in wine were discussed in relation to ageing and the role of the VALID project in investigating their role is mentioned.
Year(s) Of Engagement Activity 2018
URL https://www.ciencia-e-vinho.com/2018/01/22/monthly-assignment-challenge/
 
Description Prof Daniele Del Rio: INNOFOODMED. Bari, Italy, March 2019 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Prof Daniele Del Rio 'Polifenoli e salute: notizie dal fronte della ricerca'. INNOFOODMED. Bari, Italy, March 2019
Year(s) Of Engagement Activity 2019
 
Description Prof Daniele Del Rio: University of Perugia, Italy, April 2019 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Prof Daniele Del Rio 'Il Microbiota come Bersaglio Terapeutico'. University of Perugia, Italy, April 2019
Year(s) Of Engagement Activity 2019
 
Description Prof Daniele Del Rio: presentation at the FENS 2019 conference 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact At the DERiVE-VALID Symposium, FENS 2019 conference, Dublin, Ireland, Prof Daniele Del Rio presented on "Dietary polyphenols, circulating valerolactones and cognitive health in older Europeans - The VALID Project". The symposium was well received with great participation from the FENS conference scientific audience.
Year(s) Of Engagement Activity 2019
URL https://app.oxfordabstracts.com/events/696/program-app/submission/132974
 
Description Prof Helene McNulty was a participant and an invited speaker at the Merck/Seven Seas Roundtable Meeting - 'A holistic approach to healthy ageing: It's more than just your genes', 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Industry/Business
Results and Impact Prof Helene McNulty was a participant and an invited speaker at the Merck/Seven Seas Roundtable Meeting - 'A holistic approach to healthy ageing: It's more than just your genes', London.Gave an oral presentation on 'Brain health for later life - the role of nutrition'
Year(s) Of Engagement Activity 2017
 
Description Prof Helene McNulty: Co-chair of the Executive Committee, 13th FENS European Nutrition Conference, Dublin, Oct 2019 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Prof Helene McNulty was co-chair of the Executive Committee, Federation of European Nutrition Societies 13th European Nutrition Conference, Dublin, Ireland; 15-18 October 2019.
Year(s) Of Engagement Activity 2019
URL http://www.fens2019.org/welcome/letter-from-co-chairs/
 
Description Prof Helene McNulty: Invited speaker and team leader at the Multivitamin/Mineral Supplement Consensus Advisory Board, Philadelphia, USA 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Invited speaker and team leader at the Multivitamin/Mineral Supplement Consensus Advisory Board, Philadelphia, USA, 2017
Year(s) Of Engagement Activity 2017
 
Description Prof Helene McNulty: Invited speaker at the All-Party Parliamentary Group (APPG) on Micronutrients & Health meeting: 'B vitamins and the Ageing Brain'', London, UK. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Invited speaker at the All-Party Parliamentary Group (APPG) on Micronutrients & Health meeting: 'B vitamins and the Ageing Brain'', London, UK.
Year(s) Of Engagement Activity 2017
 
Description Prof Helene McNulty: member of the Northern Ireland Clinical Trials Unit (NCTU) Advisory Group 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Prof Helene McNulty, Member of the Northern Ireland Clinical Trials Unit (NCTU) Advisory Group, Northern Ireland in 2018 ans 2019
Year(s) Of Engagement Activity 2018,2019
 
Description Prof Helene McNulty: presentation at Bioavailability conference, Norwich, UK, Sep 2018 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Invited speaker presentation at Bioavailability 2018: Understanding the bioavailability of micronutrients and bioactive compounds for improved public health, Norwich, UK, 11 Sep 2018.
Presentation: 'The health effects of folic acid fortification'
Year(s) Of Engagement Activity 2018
URL https://www.elsevier.com/events/conferences/bioavailability/programme
 
Description Prof Helene McNulty: presentation at the 5th International Vitamin Conference, Sydney, Australia, 10 Aug 2018 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Invited speaker presentation at the 5th International Vitamin Conference - Vitamins and Wellbeing from Tomb to Womb, Sydney, Australia, 10 Aug 2018
Presentation: 'Relationship between riboflavin MTHFR and hypertension'
Year(s) Of Engagement Activity 2018
URL https://vitaminconference.com/
 
Description Prof Helene McNulty: presentation at the 5th International Vitamin Conference, Sydney, Australia, 9 Aug 2018 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Invited speaker presentation at the 5th International Vitamin Conference - Vitamins and Wellbeing from Tomb to Womb, Sydney, Australia, 9 August 2018
Presentation: 'Effect of B-vitamin supplementation on cognitive performance in older age'
Year(s) Of Engagement Activity 2018
URL https://vitaminconference.com/
 
Description Prof Helene McNulty: presentation at the Dementia 2018 conference, Templepatrick, Northern Ireland, May 2018 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Invited speaker presentation at the Dementia 2018 conference, Templepatrick, Northern Ireland, 17 May 2018
Presentation: 'Nutrition and the Ageing Brain: can specific foods and nutrients preserve better cognition in older adults?'
Year(s) Of Engagement Activity 2018
 
Description Prof Helene McNulty: presentation at the EuroPrevent Congress, European Association of Preventative Cardiology, Ljubljana, Slovenia, April 2018 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Invited speaker presentation at the EuroPrevent Congress, European Association of Preventative Cardiology, Ljubljana, Slovenia, 19 April 2018.
Presentation: 'Role of riboflavin in reducing blood pressure in genetically at-risk adults'
Year(s) Of Engagement Activity 2018
URL http://spo.escardio.org/
 
Description Prof Helene McNulty: presentation at the FASEB Science Research Conference, Nova Scotia, Canada, Aug 2018 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Invited speaker presentation at the FASEB Science Research Conference - Folic Acid, Vitamin B12 and One-Carbon Metabolism, Nova Scotia, Canada, 3 August 2018
Presenation: 'Riboflavin status, MTHFR and blood pressure'
Year(s) Of Engagement Activity 2018
URL http://www.faseb.org/home.aspx
 
Description Prof Helene McNulty: presentation at the IACC Symposium, London, UK, July 2018 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Invited speaker presentation at the IACC Symposium Cellular Coenzymes in Health & Disease, London, UK, 3 July 2018
Presentation: 'Folate and related B vitamins in health & disease from early life to older age'
Year(s) Of Engagement Activity 2018
URL https://www.ucl.ac.uk/research/domains/food-metabolism-society/events/iacc-symposium
 
Description Prof Helene McNulty: presentation at the Nutrition Society Irish Section conference, Coleraine, Northern Ireland, June 2018 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Invited speaker presentation at the Nutrition Society Irish Section conference - Tackling Current Nutritional Issues, Coleraine, Northern Ireland, 20 June 2018
Presentation: 'Folate and related B-vitamins through the lifecycle - public health priorities and challenges'
Year(s) Of Engagement Activity 2018
URL https://www.nutritionsociety.org/events/irish-section-conference-2018-targeted-approaches-tackling-c...
 
Description Prof Helene McNulty: presented at the 12th International Conference on One Carbon Metabolism, B Vitamins and Homocysteine, Spain 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Prof Helene McNulty, "Achieving Optimal Folate Status for Health (in European Populations): natural food folates versus folic acid", 12th International Conference on One Carbon
Metabolism, B Vitamins and Homocysteine, Spain, 9th-13th June 2019
Year(s) Of Engagement Activity 2019
 
Description Prof Mary Ward; Deputy Director of The Wellcome Trust-Wolfson Northern Ireland Clinical Research Facility (NICRF) 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Strategic role with the aim of facilitating research partnerships and collaborative between Ulster University, Queens University Belfast and The Belfast Trust. This also involves working closely with a range of other stakeholders including service users.
Year(s) Of Engagement Activity 2017,2018,2019
URL https://www.qub.ac.uk/research-centres/TheWellcomeTrust-WolfsonNorthernIrelandClinicalResearchFacili...
 
Description Prof Pedro Mena: presentation at the FENS 2019 conference 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Prof Pedro Mena gave an oral presentation at the 13th European Nutrition Conference of the Federation of European Nutrition Societies (FENS) 2019 conference, 'A comprehensive approach to the bioavailability and cardiometabolic effects of the bioactive compounds present in espresso coffee and confectionery-derived coffee' Liffey Meeting Room 3 (Level 1) 10:45 - 12:15 on Wednesday, 16th October, 2019.
Year(s) Of Engagement Activity 2019
URL https://app.oxfordabstracts.com/events/696/program-app/submission/125110
 
Description Profs Mary Ward and JJ Strain: Members of the Organising Committee at the FENS 2019 conference 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Numerous members of the team played key roles in the organisation of the FENS 2019 conference: Prof Mary Ward, Prof JJ Strain were members of the Organising Committee.
Year(s) Of Engagement Activity 2019
 
Description TUDA Information Event 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Study participants or study members
Results and Impact Dr Katie Moore, Prof Helene McNulty, Prof Mary Ward, Dr Chris Gill, Prof Adrian Moore, Dr Aoife Caffrey 'TUDA Information Event', Ulster University, Coleraine on 30 October 2018, 5 November 2018, 30 May 2019 and 10 June 2019.
The TUDA Information Event involved the dissemination of results from the TUDA study to the participants, carers and other patient groups.
Year(s) Of Engagement Activity 2018,2019
 
Description The VALID project website 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact The VALID project website has been established to increased public awareness of the project and will also be a means of disseminating the findings of the project to the public, to date there has been over 2,000 visitors to the website.
Year(s) Of Engagement Activity 2017,2018
URL http://www.jpi-valid.com/