HDHL-Biomarkers: Fatty Acid Metabolism - Interlinking Diet with Cardiometabolic Health (FAME)

Lead Research Organisation: University of East Anglia
Department Name: Norwich Medical School

Abstract

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

Technical Summary

The overall objective is to use existing biobanked samples and dietary and phenotype data from cohort studies and randomized controlled trials to,
a) identify novel lipidomics biomarkers of cardiometabolic health which could replace or be used in addition to fatty acid profiles as more sensitive biomarkers of status and of future cardiometabolic clinical events,
b) establish relationships between whole diets and specific foods with tissue status of fatty acids as explanatory factors for diet relationships with cardiometabolic health, and
c) to investigate genetic determinants of fatty acid status and metabolism which modify the physiological effects of dietary intake.

WORKPLAN
WP1. Lipid metabolites from lipidomics as novel biomarkers of cardiometabolic health will be identified based on follow-up of prospective studies on type 2 diabetes with exploration and cross-validation (EPIC-Potsdam cohort and CORDIOPREV trial). Potential for dietary modification of identified biomarkers will be tested in well-controlled trials involving FA modification (DIVAS, LIPGENE, RESET, SATGENE).
WP2. Specific SFA and trans-FA and novel lipid biomarkers will be tested as biomarkers of dairy fat intake in a wellcontrolled
trial (RESET) and subsequently evaluated as markers of cardiometabolic health (DIVAS, SATGENE, RESET) and long-term cardiometabolic risk (EPIC-Potsdam, CORDIOPREV, PREDIMED [n=7447])
WP3. Polyphenols and candidate genes as determinants of response to FA intake will be evaluated in the PREDIMED trial and EPIC-Potsdam cohort and subsequently validated in well-controlled trials on FA (LIPGENE, SATGENE) and polyphenol (FLAVURS) modification.

EXPECTED RESULTS
Results of the project may contribute to the refinement of current food and nutrients based dietary guidelines, e.g. with regard to dairy intake, PUFA intake and plant-based diets and the targeting of intervention strategies aimed at improved cardiometabolic health to those most likely to benefit

Planned Impact

N/A

Publications

10 25 50
 
Description 1. Early indications are that statins and alcohol intake influence the concentration of the beneficial long chain n-3 fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in humans
2. ALOX is a protein involved in the concentration of polyunsaturated fatty acid into highly active lipids called oxylipins. We have recently established that common genetic variation in ALOX can affect fatty acid status and how we response to EPA/DHA (fish oil) intervention.
3. We have identified a comprehensive list of gene variants which are now testing in a number of UK datasets, namely Twins UK and the seAFOod Polyp Prevention Trial
4. We have identified the common APOE genotype to influence the production of bioactive lipids, the oxylipins from EPA and DHA
Exploitation Route 1. The dietary PUFA-tissue lipidomic status- cardiometabolic phenotype data to emerge from the consortium will advance the overall academic knowledge base in the area
2. Inform public health policy and new product development in the areas of dietary fatty acid and health
3. The BBSRC work is part of a larger EU JPI initiative involving 5 partners from 3 countries. A major achievement from the award has been the establishment of our lipidomics consortium which we believe will be sustained following the completion of the current work programme
Sectors Agriculture, Food and Drink,Education,Healthcare,Pharmaceuticals and Medical Biotechnology

 
Description Cyprus Research Promotion Foundation (RPF)_reviewer of grant
Geographic Reach Europe 
Policy Influence Type Participation in a advisory committee
URL http://www.research.org.cy/
 
Description Lipidmoic analysis of brain samples 
Organisation Metabolon Inc
Country United States 
Sector Private 
PI Contribution Supply of brain tissues pre- and post-intervention
Collaborator Contribution Commercial lipidomic analysis
Impact NA
Start Year 2017
 
Description Albert Latner Public Lecture: Fish oils and brain health: what dose does what in whom? 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Annual Albert Latner lecture in Clinical Biochemistry_Newcastle
Year(s) Of Engagement Activity 2019
URL https://www.ncl.ac.uk/events/noticeboard/item/fishoilsandbrainhealthwhatdosedoeswhatinwhom.html
 
Description BNF 50th Anniversary conference: Who is shaping the food choices of the future?, 14th November 2017, London 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Celebration of 5o years of successful collaborations between academia, educationists, policy makers etc.
Year(s) Of Engagement Activity 2017
URL http://www.futureoffood.ox.ac.uk/events/who-shaping-food-choices-future-bnf-50th-anniversary-confere...
 
Description British Nutrition Foundation Webinar_Long chain n-3 PUFA, cardiovascular and cognitive health 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Live nutrition webinar
Year(s) Of Engagement Activity 2017
URL https://www.nutrition.org.uk/component/rseventspro/event/44-a-plaice-for-fish-in-the-diet-free-lunch...
 
Description EIRA Healthy Ageing: Research to Application 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact To consider the translation of research into policy and practice
Year(s) Of Engagement Activity 2019
URL https://www.uea.ac.uk/medicine/engagement/blog/-/blogs/eira-healthy-ageing-research-to-application-e...
 
Description Genes and nutrition, Nutrigenetics and Personalised Approaches to Dietary Advice 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact A presentation on nutrigenetics and health and how it relates to Public Health Policy and new product innovation
Year(s) Of Engagement Activity 2018
 
Description International Life Sciences Scientific Advisor 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact I am a member of a scientific advisor group for ILSI Europe which is a tripartite organisation, between academics, industry and policy makers.
Year(s) Of Engagement Activity 2020
URL https://ilsi.eu/about-us/
 
Description Maintaining health and wellbeing during lockdown_PODCAST 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact A PODCAST delivered by Professor Anne Marie Minihane (UEA), Dr Valerie Gladwell (Essex) and Dr Glen Davison (Kent) discuss what we mean by wellbeing, how lockdown has impacted on it, and what we can do to keep healthy and well in the current situation.
Year(s) Of Engagement Activity 2020
URL https://easternarc.ac.uk/podcasts/episode-5-maintaining-health-and-wellbeing-during-lockdown/
 
Description Presentation at industry focussed conference at to Universites, Sappora Japan 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact Series of presentation and visits to Japanese Universities and companies
Year(s) Of Engagement Activity 2017
URL http://icnim.jpn.org/e/conference/25icnim.php
 
Description Primary school interactive session on healthy eating 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Afternoon of discussion and cooking health foods
Year(s) Of Engagement Activity 2017
URL http://www.littlemeltonprimaryschool.co.uk/science-week/
 
Description Public Lecture: Nutrition, Brain Vitality and Dementia 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact A UEA organised public lecture in Regent St Cinema London
Year(s) Of Engagement Activity 2019
URL https://www.youtube.com/watch?v=oxqEeImQ_8Q
 
Description The Big Fat Debate, Nutrition Bulletin Article, Jan 2018 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Article for issue on dietary fat, aimed for education, and increased public awareness
Year(s) Of Engagement Activity 2017
URL https://www.nutrition.org.uk/bnf-publications/bulletin/1113-nbudietaryfats.html
 
Description UK Public Bioanalyst Course in Reading, UK 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Workshop at training even for Association of Public Analyst members
Year(s) Of Engagement Activity 2017