US Partnering Award: Skeletal muscle nitrate metabolism in older age
Lead Research Organisation:
UNIVERSITY OF EXETER
Department Name: Sport and Health Sciences
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Publications
Kadach S
(2023)
15 N -labeled dietary nitrate supplementation increases human skeletal muscle nitrate concentration and improves muscle torque production
in Acta Physiologica
Kadach S
(2022)
Time course of human skeletal muscle nitrate and nitrite concentration changes following dietary nitrate ingestion.
in Nitric oxide : biology and chemistry
Park JW
(2021)
Preparation of Rat Skeletal Muscle Homogenates for Nitrate and Nitrite Measurements.
in Journal of visualized experiments : JoVE
Piknova B
(2022)
Skeletal Muscle Nitrate as a Regulator of Systemic Nitric Oxide Homeostasis.
in Exercise and sport sciences reviews
Wylie LJ
(2019)
Human skeletal muscle nitrate store: influence of dietary nitrate supplementation and exercise.
in The Journal of physiology
Description | Our work has expanded on findings in animals to show how ingested dietary nitrate is metabolised and distributed in the tissues of humans. In particular, we have shown that skeletal muscle serves as a nitrate store and that higher nitrate levels following nitrate ingestion is associated with greater muscle force production. |
Exploitation Route | We have applied to BBSRC for follow-up funding to expand our work into other populations (especially older humans). Improved functional/exercise capacity in older humans, consequent to nutritional intervention, would be an extremely important outcome that could be taken forward by the food or pharmaceutical industries to enhance health in older age. |
Sectors | Agriculture, Food and Drink,Healthcare,Leisure Activities, including Sports, Recreation and Tourism,Pharmaceuticals and Medical Biotechnology |
Description | Skeletal muscle nitrate metabolism as a modulator of cardiovascular health in ageing (Ref: 3978) |
Amount | £100,000 (GBP) |
Funding ID | 2579026 |
Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
Sector | Public |
Country | United Kingdom |
Start | 09/2021 |
End | 09/2025 |
Title | Measuring nitrate and nitrite in skeletal muscle |
Description | Using methods developed in rats - https://pubmed.ncbi.nlm.nih.gov/34398151/ - working with our partners, we have now scaled and refined a procedure for measuring nitrate and nitrite ions in human skeletal muscle. |
Type Of Material | Technology assay or reagent |
Year Produced | 2021 |
Provided To Others? | Yes |
Impact | Other groups are now using the same techniques such that the field is expanding. |
URL | https://pubmed.ncbi.nlm.nih.gov/34398151/ |
Description | Press release and media interest in a publication |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | A University of Exeter press release resulted in 61 further news reports which contributed to an AltMetric score of 509 for the following article: 15 N-labeled dietary nitrate supplementation increases human skeletal muscle nitrate concentration and improves muscle torque production. Kadach S, Park JW, Stoyanov Z, Black MI, Vanhatalo A, Burnley M, Walter PJ, Cai H, Schechter AN, Piknova B, Jones AM. Acta Physiol (Oxf). 2023 Mar;237(3):e13924. doi: 10.1111/apha.13924. |
Year(s) Of Engagement Activity | 2023 |
URL | https://www.exeter.ac.uk/news/research/title_956715_en.html |