Structural investigation of pesticidal proteins for insect control
Lead Research Organisation:
CARDIFF UNIVERSITY
Department Name: School of Biosciences
Abstract
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People |
ORCID iD |
| Colin Berry (Principal Investigator) |
Publications
| Description | We have gained understanding of two important processes related to the mechanism of action of tow different insecticidal proteins: We have solved a structure of on insecticidal protein bound to its receptor. This gives crucial insight into the specificity of the protein for its target insect For a different insecticidal protein we have solved its structure in the pore form that gives it activity. This also explains why the mechanism of this protein is different from other proteins. Manuscripts are in preparation for publication. |
| Exploitation Route | Understanding the activity of these insecticidal proteins will help us in developing them further use in the field to control insect pests of agriculture and human health importance. It will also give us insights that may be important in overcoming resistance. |
| Sectors | Agriculture Food and Drink Manufacturing including Industrial Biotechology |
| Description | Monash collaboration |
| Organisation | Monash University |
| Country | Australia |
| Sector | Academic/University |
| PI Contribution | This collaboration is the central collaboration that the International Partnership was set up to develop. I have provided clones and proteins for analysis in addition to research expertise and knowledge of the field. |
| Collaborator Contribution | Partners have also contributed clones and proteins along with access to facilities, including cryoEM and expertise. |
| Impact | Too early but several publications expected |
| Start Year | 2022 |