UK-China partnership: Chromosomal Instability aiding Genetic Variants (CIVa) linked to human ageing
Lead Research Organisation:
Queen Mary University of London
Department Name: Sch of Biological & Behavioural Sciences
Abstract
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Publications
Efstathiou C
(2021)
Electrically tunable lenses - eliminating mechanical axial movements during high-speed 3D live imaging.
in Journal of cell science
Song X
(2021)
Counteraction between Astrin-PP1 and Cyclin-B-CDK1 pathways protects chromosome-microtubule attachments independent of biorientation
in Nature Communications
Dang D
(2023)
Deep learning techniques and mathematical modeling allow 3D analysis of mitotic spindle dynamics.
in The Journal of cell biology
| Description | Islam et al., 2024 is a new publication of naturally occurring genetic variants, in ethnic populations, that can drive chromosomal instability seen in cancers. |
| Exploitation Route | Through the workshops organised in Beijing, Tokyo and London, we have collaborative research papers. |
| Sectors | Education Healthcare Other |
| URL | http://www.draviamlab.uk/beijing_workshop.html |
| Description | Cooperativity and forces in molecular interactions governing chromosome stability |
| Amount | £717,412 (GBP) |
| Funding ID | BB/X014975/1 |
| Organisation | Queen Mary University of London |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 01/2024 |
| End | 01/2026 |
| Description | High-throughput Lattice Light Sheet Microscopy : Imaging Across Scales. |
| Amount | £386,205 (GBP) |
| Funding ID | MR/X013847/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2022 |
| End | 03/2023 |
| Description | How are mono-oriented chromosome-microtubule attachments protected to prevent errors in mitosis and associated cellular ageing? |
| Amount | £403,927 (GBP) |
| Funding ID | BB/W002698/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 11/2022 |
| End | 09/2025 |
| Title | AI guided software SpinX |
| Description | AI method to track spindle, chromosome, cell division and movements. |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2023 |
| Provided To Others? | Yes |
| Impact | The software is now deployed in Zeiss Arivis |
| URL | https://doi.org/10.1083/jcb.202111094 |
| Description | Cell Dynamics And Chromosomal Stability Workshop |
| Organisation | Tohoku University |
| Country | Japan |
| Sector | Academic/University |
| PI Contribution | Workshop held with collaborators (UK, Japan, China, Switzerland researchers) |
| Collaborator Contribution | Talks, exchange of ideas. |
| Impact | Manuscript being prepared with Tanaka group, Tohoku. A software solution developed and explained for their purpose. |
| Start Year | 2023 |
| Description | How are mono-oriented chromosome-microtubule attachments protected to prevent errors in mitosis and associated cellular ageing? |
| Organisation | Queen Mary University of London |
| Department | School of Biological and Chemical Science QMUL |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Conducted Super-resolution imaging; trained personnel on timelapse recording; and secured funding to expand the work. |
| Collaborator Contribution | Comparison across model systems; modelling of structures |
| Impact | Funding: https://gtr.ukri.org/projects?ref=BB%2FW002698%2F1 |
| Start Year | 2022 |
| Description | Interview with BBC Radio4 (international via BBC sounds) |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | BBC Radio 4 Today program discussed advances in Cell Biology, Healthcare through microscopy and image analysis supported by breakthroughs in Artificial Intelligence, and long-term live imaging. |
| Year(s) Of Engagement Activity | 2024 |
| URL | https://www.linkedin.com/posts/viji-m-draviam-sastry-ab189a3_ai-drugdevelopment-activity-71476183283... |
| Description | Online seminars with Beijing Agricultural university |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | 30 researchers attended an online meeting to discuss human variants. |
| Year(s) Of Engagement Activity | 2009,2021 |
| Description | Workshop for international visibility |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Dr Wu presented movies generated using the Lattice Light Sheet (LLS7) Microscope (recently funded using the MRC-Alert call) and Elyra super-resolution microscope (funded by the BBSRC Alert call) |
| Year(s) Of Engagement Activity | 2024 |
| URL | http://www.draviamlab.uk/london_workshop_2024_March.html |