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Sialic acid: the missing link between the gut microbiota and the brain

Lead Research Organisation: QUADRAM INSTITUTE BIOSCIENCE
Department Name: Gut Microbes and Health

Abstract

Publications

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Coletto E (2022) The role of the mucin-glycan foraging Ruminococcus gnavus in the communication between the gut and the brain in Gut Microbes

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Coletto E (2023) Role of mucin glycosylation in the gut microbiota-brain axis of core 3 O-glycan deficient mice. in Scientific reports

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Crost EH (2023) Ruminococcus gnavus: friend or foe for human health. in FEMS microbiology reviews

 
Description We found that changes in the glycosylation of the gut lining can have implication on brain function and behaviour in mouse models
Exploitation Route The findings open new avenue of research in gut-brain axis
Sectors Healthcare
URL https://quadram.ac.uk/sweet-memory-how-sugar-proteins-in-gut-mucus-offer-protection-against-cognitive-decline/
 
Description Sialic acid mouse models 
Organisation University of British Columbia
Country Canada 
Sector Academic/University 
PI Contribution Exchange of mouse models
Collaborator Contribution The partner provided transgenic mouse models and associated protocols
Impact Submission of BBSRC responsive mode grant application
Start Year 2022