HDHL-Biomarkers: Early life programming of childhood health (ALPHABET)
Lead Research Organisation:
University of Southampton
Department Name: Human Development and Health
Abstract
The rising prevalence of obesity, cardiometabolic disease, asthma, osteoporosis and neurodevelopmental disorders over recent decades cannot be fully explained by genetic or adult lifestyle factors. Increasing evidence suggests that early life exposure to environmental factors influences offspring health. According to the Developmental Origins of Health and Disease (DOHaD) hypothesis transient environmental exposures during critical periods of development (e.g. fetal and early infant phases of life) can elicit lifelong effects on offspring health. Epigenetic phenomena have been proposed as mechanisms by which detrimental fetal or early life exposures, such as suboptimal nutrition during pregnancy or early childhood, may affect offspring phenotype and risk of adverse health years after exposure. Maternal diet during pregnancy is a modifiable behaviour that could impact on maternal, neonatal and child health. However the specific dietary requirements during pregnancy for optimal fetal growth and development are unknown. Furthermore studies addressing the hypothesis of fetal programming have focused on maternal intake of single nutrients during pregnancy. Nutrients are not consumed in isolation, thus examining the combined effects of multiple dietary components reflecting the whole diet could have important public health implications. There is a clear need for primary prevention of obesity, related cardiometabolic conditions and other chronic non-communicable diseases based on the DOHaD paradigm. This project aims to advance the state-of-the-art by significantly expanding the knowledge base regarding interactions between biomarkers of diet, epigenetics and offspring health. Utilising biological samples and data from existing European longitudinal birth cohorts at the international forefront of lifecourse epidemiology we will investigate the complex relationships between maternal diet (defined by dietary quality and a novel index of dietary inflammatory potential), offspring health outcomes (including adiposity, bone, cardiometabolic, respiratory and neurodevelopmental health) and epigenetic patterns (DNA methylation) from birth throughout childhood. Better understanding of nutritional and epigenetic biomarkers of offspring health will afford opportunities to refine dietary exposure measures and to aid development of more effective evidence-based public health strategies with an emphasis on advocating a healthy diet in pre-pregnancy, pregnancy and early postnatal life, to reduce obesity, improve health and attenuate development of a range of adverse health outcomes in future generations.
Technical Summary
There is a clear need for primary prevention of obesity, related cardiometabolic conditions and other chronic non-communicable diseases based on the DOHaD paradigm. This project aims to advance the state-of-the-art by significantly expanding the knowledge base regarding interactions between biomarkers of diet, epigenetics and offspring health. Utilising biological samples and data from existing European longitudinal birth cohorts at the international forefront of lifecourse epidemiology we will investigate the complex relationships between maternal diet (defined by dietary quality and a novel index of dietary inflammatory potential), offspring health outcomes (including adiposity, bone, cardiometabolic, respiratory and neurodevelopmental health) and epigenetic patterns (DNA methylation) from birth throughout childhood. Better understanding of nutritional and epigenetic biomarkers of offspring health will afford opportunities to refine dietary exposure measures and to aid development of more effective evidence-based public health strategies with
an emphasis on advocating a healthy diet in pre-pregnancy, pregnancy and early postnatal life, to reduce obesity, improve health and attenuate development of a range of adverse health outcomes in future generations.
an emphasis on advocating a healthy diet in pre-pregnancy, pregnancy and early postnatal life, to reduce obesity, improve health and attenuate development of a range of adverse health outcomes in future generations.
Planned Impact
Given the research focus, the potential long term health and socio-economic impacts may be significant considering the health service and societal costs associated with obesity alone, currently and for future generations. Our results will improve understanding of the relationships between maternal nutrition, pregnancy outcome and subsequent child health. For example improved dietary quality and/or reduced pro-inflammatory dietary status achieved through revision of existing guidelines or development of new guidelines for optimal nutrition in pregnancy or development of functional foods may lead to beneficial health effects on women of reproductive years and their offspring which may have long term effects on their health into adulthood.
People |
ORCID iD |
Nicholas Harvey (Principal Investigator) |
Publications
Aubert AM
(2022)
Predictors of maternal dietary quality and dietary inflammation during pregnancy: An individual participant data meta-analysis of seven European cohorts from the ALPHABET consortium.
in Clinical nutrition (Edinburgh, Scotland)
Braithwaite VS
(2019)
The Effect of Vitamin D Supplementation on Hepcidin, Iron Status, and Inflammation in Pregnant Women in the United Kingdom.
in Nutrients
Cleal J
(2024)
Feldman and Pike' s Vitamin D
Curtis E
(2018)
Early-life dietary and epigenetic influences on childhood musculoskeletal health: Update on the UK component of the ALPHABET project
in Nutrition Bulletin
Curtis EM
(2018)
Maternal vitamin D supplementation during pregnancy.
in British medical bulletin
Curtis EM
(2019)
Gestational Vitamin D Supplementation Leads to Reduced Perinatal RXRA DNA Methylation: Results From the MAVIDOS Trial.
in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Curtis EM
(2017)
Perinatal DNA Methylation at CDKN2A Is Associated With Offspring Bone Mass: Findings From the Southampton Women's Survey.
in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Curtis EM
(2021)
Bone turnover in pregnancy, measured by urinary CTX, is influenced by vitamin D supplementation and is associated with maternal bone health: findings from the Maternal Vitamin D Osteoporosis Study (MAVIDOS) trial.
in The American journal of clinical nutrition
El-Heis S
(2022)
Maternal antenatal vitamin D supplementation and offspring risk of atopic eczema in the first 4 years of life: evidence from a randomized controlled trial.
in The British journal of dermatology
El-Heis S
(2022)
Maternal antenatal vitamin D supplementation and offspring risk of atopic eczema in the first 4 years of life: evidence from a randomized controlled trial.
in The British journal of dermatology
Harvey NC
(2021)
Vitamin D supplementation and COVID-19 disease: safety but unproven efficacy-reply to Dr Helga Rhein.
in Aging clinical and experimental research
Ireland A
(2018)
Breech presentation is associated with lower bone mass and area: findings from the Southampton Women's Survey.
in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
Johansson H
(2021)
FRAX-based fracture probabilities in South Africa.
in Archives of osteoporosis
Krstic N
(2022)
Early life vitamin D depletion and mechanical loading determine methylation changes in the RUNX2, RXRA, and osterix promoters in mice.
in Genes & nutrition
Mensink-Bout SM
(2022)
Maternal diet in pregnancy and child's respiratory outcomes: an individual participant data meta-analysis of 18 000 children.
in The European respiratory journal
Moon R
(2024)
Feldman and Pike' s Vitamin D
Moon R
(2024)
Feldman and Pike' s Vitamin D
Moon RJ
(2023)
Does antenatal cholecalciferol supplementation affect the mode or timing of delivery? Post hoc analyses of the MAVIDOS randomized controlled trial.
in Journal of public health (Oxford, England)
Moon RJ
(2020)
Vitamin D, and Maternal and Child Health.
in Calcified tissue international
Moon RJ
(2022)
Is the skull responsive to bone mineralisation stimuli in children?
in Bone
Moon RJ
(2023)
Parent-Offspring Associations in Body Composition: Findings From the Southampton Women's Survey Prospective Cohort Study.
in The Journal of clinical endocrinology and metabolism
Moon RJ
(2023)
Does antenatal cholecalciferol supplementation affect the mode or timing of delivery? Post hoc analyses of the MAVIDOS randomized controlled trial.
in Journal of public health (Oxford, England)
Moon RJ
(2023)
The effect of pregnancy vitamin D supplementation on offspring bone mineral density in childhood: a systematic review and meta-analysis.
in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
Moon RJ
(2021)
The importance of maternal pregnancy vitamin D for offspring bone health: learnings from the MAVIDOS trial.
in Therapeutic advances in musculoskeletal disease
Moon RJ
(2022)
Maternal and Fetal Genetic Variation in Vitamin D Metabolism and Umbilical Cord Blood 25-Hydroxyvitamin D.
in The Journal of clinical endocrinology and metabolism
Naureen G
(2021)
A surrogate FRAX model for Pakistan.
in Archives of osteoporosis
Phillips CM
(2019)
Dietary Inflammatory Index and Non-Communicable Disease Risk: A Narrative Review.
in Nutrients
Woolford S
(2019)
Prenatal influences on bone health in children
in Expert Review of Endocrinology & Metabolism
Woolford S
(2022)
Associations Between Late Pregnancy Dietary Inflammatory Index ( DII ) and Offspring Bone Mass: A Meta-Analysis of the Southampton Women's Survey ( SWS ) and the Avon Longitudinal Study of Parents and Children ( ALSPAC )
in Journal of Bone and Mineral Research
Woolford SJ
(2022)
Associations Between Late Pregnancy Dietary Inflammatory Index (DII) and Offspring Bone Mass: A Meta-Analysis of the Southampton Women's Survey (SWS) and the Avon Longitudinal Study of Parents and Children (ALSPAC).
in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Title | ASBMR webinar (NCH) |
Description | Webinar on abstract writing |
Type Of Art | Film/Video/Animation |
Year Produced | 2018 |
Impact | Improved abstract writing |
Title | IOF Webinar (NCH,CC) |
Description | IOF CTF webinars |
Type Of Art | Film/Video/Animation |
Year Produced | 2020 |
Impact | IOF CTF webinars |
Title | IOF webinars NHC, CC |
Description | Webinar on osteoporosis prevention |
Type Of Art | Film/Video/Animation |
Year Produced | 2018 |
Impact | Improved care |
Title | ROS Osteoporosis Research Roadmap video |
Description | ROS Osteoporosis Research Roadmap video |
Type Of Art | Film/Video/Animation |
Year Produced | 2020 |
Impact | Increased awareness of osteoporosis |
Description | Methylation at the CDKN2A gene in umbilical cord is associated with offspring bone mass in childhood. (Curtis et al., JBMR 2017). Pregnancy vitamin D supplementation leads to reduced perinatal RXRA methylation (Curtis et al., JBMR 2019) Vitamin D content of OTC vitamin D and multivitamin supplements is often less than DH recommended amount (Moon et al., Arch Dis Childhood 2019) Bone turnover markers in pregnancy associated with maternal vitamin D status and offspring bone mass (Curtis et al., AJCN 2021) Pregnancy dietary inflammatory index inversely associated with offspring bone mass (2022) |
Exploitation Route | Further Collaboration to use constituent cohorts is envisaged |
Sectors | Agriculture, Food and Drink,Education,Healthcare,Government, Democracy and Justice,Manufacturing, including Industrial Biotechology,Pharmaceuticals and Medical Biotechnology |
Description | Findings will inform potential novel biomarkers for adverse bone development and thus risk assessment strategies. They will also inform novel mechanisms of bone development. |
First Year Of Impact | 2017 |
Description | Co-authorship of Royal Osteoporosis Society APPG enquiry into FLS (NCH) 2021 |
Geographic Reach | National |
Policy Influence Type | Membership of a guideline committee |
Description | Membership of a guideline committee on the safety of drug therapies in osteoarthritis - with ESCEO |
Geographic Reach | Europe |
Policy Influence Type | Membership of a guideline committee |
Impact | The European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO) recommendations for on drugs to be used in osteoarthritis: A consensus statement from a working group on the safety of anti-osteoarthritis medications I led a systematic review on the safety of COX-2 inhibitors and opioids in OA. This is due to be published in April 2019. |
Description | National Osteoporosis Guideline Group Advisory Committee (NCH, CC) |
Geographic Reach | National |
Policy Influence Type | Membership of a guideline committee |
Description | Scientific Advisory Committee on Diet and Nutrition- Public Health England Vitamin D Guidance (NCH) |
Geographic Reach | National |
Policy Influence Type | Citation in other policy documents |
Description | Developmental origins of child neurodevelopment: Novel approaches to clinical risk prediction using an international metadataset. |
Amount | £364,324 (GBP) |
Funding ID | MR/V029169/1 |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 11/2021 |
End | 10/2027 |
Description | Does maternal gestational vitamin D supplementation influence offspring DNA methylation in childhood? |
Amount | £29,984 (GBP) |
Funding ID | SGL023\1072 |
Organisation | Academy of Medical Sciences (AMS) |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 07/2020 |
End | 12/2021 |
Description | Does pregnancy vitamin D supplementation alter trajectories of body composition and bone mineralisation from early childhood to adolescence? Follow-up of a randomised placebo-controlled trial. |
Amount | £187,294 (GBP) |
Funding ID | GN2969 |
Organisation | Action Medical Research |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 05/2023 |
End | 06/2026 |
Description | MRC Capital Award |
Amount | £134,000 (GBP) |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 03/2018 |
End | 03/2019 |
Description | MRC Capital Funding |
Amount | £310,000 (GBP) |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 03/2017 |
End | 03/2018 |
Description | MRC Capital Prioritisation Award |
Amount | £134,000 (GBP) |
Organisation | University of Southampton |
Department | MRC Lifecourse Epidemiology Unit |
Sector | Academic/University |
Country | United Kingdom |
Start | 03/2019 |
End | 03/2022 |
Description | MRC Capital award 2020 2021 Scanco XtremeCT2 |
Amount | £325,000 (GBP) |
Funding ID | 4050776844 |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 03/2020 |
End | 03/2023 |
Description | MRC LEU Extension |
Amount | £1,500,000 (GBP) |
Funding ID | MRC LEU |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 03/2020 |
End | 10/2020 |
Description | MRC LEU Extension |
Amount | £1,800,000 (GBP) |
Funding ID | MRC LEU |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 09/2020 |
End | 06/2021 |
Description | MRC National Musculoskeletal Network |
Amount | £150,847 (GBP) |
Funding ID | MC_PC_21022 |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 02/2022 |
End | 02/2024 |
Description | Nutritional determinants of skeletal development and bone loss: an investigation using a novel computer vision assessment of bone microarchitecture |
Amount | £36,000 (GBP) |
Organisation | University of Southampton |
Sector | Academic/University |
Country | United Kingdom |
Start | 08/2022 |
End | 09/2025 |
Description | Preventing broken bones in older people: from research to policy to practice |
Amount | £29,566 (GBP) |
Funding ID | MRF-145-0011-DG-HARV-C0913 |
Organisation | Medical Research Council (MRC) |
Department | Medical Research Foundation |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 03/2022 |
End | 09/2022 |
Description | Programme 3: Early development and risk of adult musculoskeletal disease |
Amount | £1,809,000 (GBP) |
Funding ID | MC_PC_21003 |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 06/2021 |
End | 03/2026 |
Description | UKRI WCL Capital funding 2020 2021 DXA and MSK Scanning Suite |
Amount | £216,857 (GBP) |
Funding ID | 4050801857 |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 09/2020 |
End | 03/2021 |
Title | MAVIDOS trial dataset - 4 year and 7 year followup |
Description | MAVIDOS - a randomised controlled trial of vitamin D supplementation in pregnancy. Datasets created included followup of the participants at aged 4 and 7 years (also funded through separate Versus Arthritis grant). Followup included questionnaire data about child health, diet and physical activity, child anthropometry, DXA scans of child (and mum in 4 year followup), HR periperhal quantititative CT scans of the tibia (at age 7 years), blood samples collected where possible Epigenetic arrays (Illumina Infinium EPIC 850k array) on umbilical cord samples collected at birth. Pyrosequencing of the RXRA locus (a key locus in vitamin D signalling), with demonstration of differences in DNA methylation between the supplementation / placebo groups. Genotyping of mother- offspring pairs. Data currently held by MRC Lifecourse Epidemiology Unit, however may be used in consortia studies in future through application to the MRC Lifecourse Epidemiology Unit. |
Type Of Material | Database/Collection of data |
Year Produced | 2019 |
Provided To Others? | Yes |
Impact | Evidence of a lasting benefit of maternal vitamin D supplementation of childhood bone health at age 4, a difference of 0.18SD in Bone Mineral Density between groups (7 year followup ongoing), evidence of differences in DNA methylation in umbilical cord samples between placebo and supplemented groups, providing underlying mechanism. |
Title | SPRING Trial |
Description | SPRING Trial |
Type Of Material | Database/Collection of data |
Year Produced | 2021 |
Provided To Others? | No |
Impact | SPRING Trial |
Description | ALPHABET |
Organisation | University College Dublin |
Country | Ireland |
Sector | Academic/University |
PI Contribution | WP5, bone outcomes |
Collaborator Contribution | Consortium |
Impact | Ongoing |
Start Year | 2017 |
Description | ALPHABET |
Organisation | University of Bristol |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | WP5, bone outcomes |
Collaborator Contribution | Consortium |
Impact | Ongoing |
Start Year | 2017 |
Title | MAVIDOS trial vitamin D intervention |
Description | Vitamin D supplementation |
Type | Preventative Intervention - Nutrition and Chemoprevention |
Current Stage Of Development | Wide-scale adoption |
Year Development Stage Completed | 2021 |
Development Status | Under active development/distribution |
Clinical Trial? | Yes |
Impact | Maternal vitamin D supplementation led to greater bone mass in the offspring for winter births |
Title | SPRING Pregnancy vitamin D supplementation trial |
Description | Trial of vitamin D supplementation during pregnancy |
Type | Preventative Intervention - Nutrition and Chemoprevention |
Current Stage Of Development | Wide-scale adoption |
Year Development Stage Completed | 2021 |
Development Status | Under active development/distribution |
Clinical Trial? | Yes |
Impact | Trial of vitamin D supplementation during pregnancy |
Description | ASBMR online (EC) 2021 |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Presentation at ASBMR, USA |
Year(s) Of Engagement Activity | 2021 |
Description | ASBMR presentation (BC) |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Beth Curtis presented MAVIDOS 4 year bone results |
Year(s) Of Engagement Activity | 2019 |
Description | ASBMR-ECTS debate EC 2021 |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | ASBMR-ECTS debate EC 2021 |
Year(s) Of Engagement Activity | 2021 |
Description | Abstract presentation ASBMR online 2020 (EC) |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Abstract presentation ASBMR online 2020 (EC) |
Year(s) Of Engagement Activity | 2020 |
Description | Abstract presentation ASBMR online 2020 (NCH) |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Abstract presentation ASBMR online 2020 (NCH) |
Year(s) Of Engagement Activity | 2020 |
Description | Association of Physicians Annual meeting |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Presentation of MAVIDOS CTX data by Beth Curtis |
Year(s) Of Engagement Activity | 2019 |
Description | Bone Research Society Annual Scientific Meeting |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Beth Curtis presentation on bone turnover in MAVIDOS at BRS |
Year(s) Of Engagement Activity | 2019 |
Description | Bone Research Society Event Speaker and Organising Committee |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Part of the organising committee for the Bone Research Society Conference in Winchester from 27th - 30th June 2018. |
Year(s) Of Engagement Activity | 2018 |
Description | Calcium and Vitamin D supplementation are not associated with risk of incident ischemic cardiac events or death: findings from the UK Biobank Cohort - press release |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Press release created a lot of media interest for this paper. |
Year(s) Of Engagement Activity | 2018 |
Description | Chair ASBMR IOF joint session at ASBMR 2021 (NCH) |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Chair ASBMR IOF joint session at ASBMR 2021 (NCH) |
Year(s) Of Engagement Activity | 2021 |
Description | ECTS Congress |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Professor Cooper was an invited Speaker at this three day conference, which took place between 22-24th October 2020. |
Year(s) Of Engagement Activity | 2020 |
URL | https://www.ects2020.org/ |
Description | EGG Consortium |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Professor Cyrus Cooper attended this meeting in May 2020. |
Year(s) Of Engagement Activity | 2020 |
URL | http://www.egg-consortium.org/ |
Description | Faculty of Medicine Conference, University of Southampton |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Professional Practitioners |
Results and Impact | Professor Cooper attended this Conference on 8th October 2020. |
Year(s) Of Engagement Activity | 2020 |
Description | Findings from the paper 'Calcium and Vitamin D supplementation are not associated with risk of incident ischemic cardiac events or death' appeared in the Hippocratic Post and other media |
Form Of Engagement Activity | A magazine, newsletter or online publication |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Media (as a channel to the public) |
Results and Impact | Findings from the paper 'Calcium and Vitamin D supplementation are not associated with risk of incident ischemic cardiac events or death: Findings from the UK biobank cohort. J Bone Miner Res. 2018 May;33(5):803-811. doi: 10.1002/jbmr.3375, epub 2018 Feb 8'. appeared in the Hippocratic Post, on other websites, on 3 facebook pages, 34 tweets, and 1 blog. |
Year(s) Of Engagement Activity | 2018 |
Description | Gestational vitamin D supplementation leads to reduced perinatal RXRA DNA methylation: results from the MAVIDOS trial - press release |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Media (as a channel to the public) |
Results and Impact | https://www.southampton.ac.uk/medicine/news/2018/11/vitamin-d-baby-genes.page; https://onlinelibrary.wiley.com/doi/epdf/10.1002/jbmr.3603 Gestational vitamin D supplementation leads to reduced perinatal RXRA DNA methylation: results from the MAVIDOS trial. Journal of Bone and Mineral Research. 2018 doi.10.1002/jbmr.3603 Curtis EM, Krstic N, Cook E, D'Angelo S, Crozier SR, Moon RJ, Murray R, Garratt Em, Costello P, Cleal J et al (inc Godfrey K, Cooper C and Harvey N). |
Year(s) Of Engagement Activity | 2018 |
Description | IOF CTF Webinar (NCH) |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | IOF CTF Webinar |
Year(s) Of Engagement Activity | 2018 |
Description | International publicity around vitamin D supplement study (NCH, RJM), including live BBC Scotland interview (NCH) |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Media (as a channel to the public) |
Results and Impact | International publicity around vitamin D supplement study (NCH, RJM), including live BBC Scotland interview (NCH) |
Year(s) Of Engagement Activity | 2019 |
Description | Invited ASBMR Webinar (NCH) |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Invited ASBMR Webinar (NCH) |
Year(s) Of Engagement Activity | 2018 |
Description | Invited Chair joint IOF SIBOMM session (NCH) 2021 |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Invited Chair joint IOF SIBOMM session (NCH) 2021 |
Year(s) Of Engagement Activity | 2021 |
Description | Invited Presentation on vitamin D in pregnancy (NCH); 6th International Maternal Fetal Health congress Turkey |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Presentation on vitamin D in pregnancy (NCH); 6th International Maternal Fetal Health congress Turkey |
Year(s) Of Engagement Activity | 2018 |
Description | Invited plenary presentation, Mellanby Bone Conference |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Invited plenary presentation, Mellanby Bone Conference |
Year(s) Of Engagement Activity | 2017 |
Description | Invited presentation BRADOO 2021 (NCH) |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Invited presentation BRADOO 2021 (NCH) |
Year(s) Of Engagement Activity | 2021 |
Description | Invited presentation WCO 2020 (CC) |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Invited presentation WCO 2020 (CC) |
Year(s) Of Engagement Activity | 2020 |
Description | Invited presentation at Belgian Bone Club 2022 (NCH) |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Invited presentation at Belgian Bone Club 2022 (NCH) |
Year(s) Of Engagement Activity | 2022 |
Description | Invited presentation at SICOT (NCH) 21 |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Invited presentation at SICOT (NCH) 21 |
Year(s) Of Engagement Activity | 2021 |
Description | Invited presentation on vitamin D in pregnancy and lifecourse epidemiology of bone development (NCH, Bone Research Society Annual Meeting) |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Invited presentation on vitamin D in pregnancy and lifecourse epidemiology of bone development (NCH, Bone Research Society Annual Meeting) |
Year(s) Of Engagement Activity | 2018 |
Description | Irish Osteoporosis Conference |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Professor Cooper was an Invited Speaker at the conference, which was held on 1st October 2020 |
Year(s) Of Engagement Activity | 2020 |
URL | https://www.irishosteoporosis.ie/annual-medical-conference-2020/ |
Description | LifeLab - Meet the Scientist |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Schools |
Results and Impact | Dr Beth Curtis spoke to 28 year 9 students from Hounsdown School about the work she carries out in her role of doctor. |
Year(s) Of Engagement Activity | 2019 |
Description | MTP WCO (EC) 2021 |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Meet The Expert session at World Congress and Osteoporosis |
Year(s) Of Engagement Activity | 2021 |
Description | MTP WCO 2020 (NCH) |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Meet the professor session at World Congress in Osteoporosis (NCH) |
Year(s) Of Engagement Activity | 2020 |
Description | MTP WCO 2021 (NCH) |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Meet The Professor session at World Congress in Osteoporosis 2021 |
Year(s) Of Engagement Activity | 2021 |
Description | Oral presentation, Association of Physicians of Great Britain and Ireland Annual Meeting, UCL |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | 25 minute presentation - DNA methylation at the RXRA promoter at birth is associated with gestational vitamin D supplementation: results from the MAVIDOS trial, followed by discussion with eminent physicans from the UK and Ireland. |
Year(s) Of Engagement Activity | 2017 |
Description | Oral presentation, Bone Research Society Conference, Bristol |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Oral presentation: "RXRA promoter DNA methylation at birth is associated with gestational vitamin D supplementation: results from the MAVIDOS trial " and discussion with experts in the field, points for further investigation and analysis raised |
Year(s) Of Engagement Activity | 2017 |
Description | Oral presentation, Developmental Origins of Health and Disease Conference, Rotterdam |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Oral presentation, Developmental Origins of Health and Disease Conference, Rotterdam on research project entitled "Perinatal RXRA DNA methylation is altered by maternal gestational vitamin D supplementation: findings from the MAVIDOS trial". This led to questions and discussions regarding future work. |
Year(s) Of Engagement Activity | 2017 |
Description | Plenary invited presentation Managing Osteoporosis Conference |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Plenary invited presentation Managing Osteoporosis Conference |
Year(s) Of Engagement Activity | 2017 |
Description | Plenary invited presentation at DOHAD World Congress (NCH) |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Plenary invited presentation at DOHAD World Congress |
Year(s) Of Engagement Activity | 2017 |
Description | Plenary poster presentation at American Society for Bone and Mineral Research Congress |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Plenary poster presentation at American Society for Bone and Mineral Research Congress - the influence of vitamin D on maternal bone resorption in the MAVIDOS trial |
Year(s) Of Engagement Activity | 2018 |
Description | Plenary poster presentation, American Society for Bone and Mineral Research conference, Denver, Colorado |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Plenary poster presenation and discussion with various interested researchers, sparking questions and opportunities for collaboration, American Society for Bone and Mineral Research conference, Denver, Colorado |
Year(s) Of Engagement Activity | 2017 |
Description | Plenary presentation, International Conference on Children's Bone Health, Wurzburg (NCH) |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Plenary presentation, International Conference on Children's Bone Health, Wurzburg (NCH) |
Year(s) Of Engagement Activity | 2017 |
Description | Poster presentation - Optimising bone health throughout life - at the Royal Osteoporosis Society Academy Launch |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Supporters |
Results and Impact | At the launch of the Royal Osteoprosis Society, I was invited to present a poster "Optimising bone health throughout life", showcasing some research funded by the ROS (the MAVIDOS trial). This was attended by a diverse audience including the Duchess of Cornwall, a variety of donors, patient group representatives and policymakers. |
Year(s) Of Engagement Activity | 2019 |
Description | Presentation at American Society for Bone and Mineral Research Annual Scientific meeting (EMC) |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Presentation at American Society for Bone and Mineral Research Annual Scientific meeting (EMC) |
Year(s) Of Engagement Activity | 2017 |
Description | Presentation at American Society for Bone and Mineral Research Annual Scientific meeting (NCH) |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Presentation at American Society for Bone and Mineral Research Annual Scientific meeting (NCH) |
Year(s) Of Engagement Activity | 2017 |
Description | Presentation at Association of Physicians Meeting |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Presentation at Association of Physicians Meeting |
Year(s) Of Engagement Activity | 2017 |
Description | Presentation at BSR (EC) 2021 |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Presentation at British Society for Rheumatology |
Year(s) Of Engagement Activity | 2021 |
Description | Presentation at DOHAD World Congress (EMC) |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Presentation at DOHAD World Congress (EMC) |
Year(s) Of Engagement Activity | 2017 |
Description | Presentation at UK Association of Physicians Meeting (EMC) |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Presentation at Association of Physicians Meeting |
Year(s) Of Engagement Activity | 2017 |
Description | Presentation at WCO 2021 (NCH) |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Presentation at World Congress in Osteoporosis 2021 |
Year(s) Of Engagement Activity | 2021 |
Description | Presentation on bone turnover and vitamin D in pregnancy (MAVIDOS, E Curtis) American Society for Bone and Mineral Research meeting, Montreal |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Presentation on bone turnover and vitamin D in pregnancy (MAVIDOS, E Curtis) American Society for Bone and Mineral Research meeting, Montreal |
Year(s) Of Engagement Activity | 2018 |
Description | Presentation on bone turnover and vitamin D in pregnancy (MAVIDOS, E Curtis) Bone Research Society meeting |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Presentation on bone turnover and vitamin D in pregnancy (MAVIDOS, E Curtis) Bone Research Society meeting |
Year(s) Of Engagement Activity | 2018 |
Description | Presentation on bone turnover in mothers in the MAVIDOS trial |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Presentation on bone turnover in mothers in the MAVIDOS trial |
Year(s) Of Engagement Activity | 2018 |
Description | Presentation on vitamin D, bone turnover in pregnancy and offspring bone mass in MAVIDOS (E Curtis) at World Congress in Osteoporosis |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Presentation on vitamin D, bone turnover in pregnancy and offspring bone mass in MAVIDOS (E Curtis) at World Congress in Osteoporosis |
Year(s) Of Engagement Activity | 2018 |
Description | Presentation on vitamin D, epigenetics and bone mass in MAVIDOS (E Curtis), World Congress in Osteoporosis |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Presentation on vitamin D, epigenetics and bone mass in MAVIDOS (E Curtis), World Congress in Osteoporosis |
Year(s) Of Engagement Activity | 2018 |
Description | Presentation to National Osteoporosis Society local patient support group - Southampton |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Patients, carers and/or patient groups |
Results and Impact | Presentation to National Osteoporosis Society local patient support group - Southampton |
Year(s) Of Engagement Activity | 2018 |
Description | Presentations at WCO (EC) 2021 |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Presentation at World Congress in osteoporosis |
Year(s) Of Engagement Activity | 2021 |
Description | ROS Academy Functional Genomics Workshop NCH CC 2020 |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | ROS Academy Functional Genomics Workshop NCH CC 2020 |
Year(s) Of Engagement Activity | 2020 |
Description | ROS Academy Launch event, London |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Media (as a channel to the public) |
Results and Impact | Launch of ROS Research Academy (Vice-Chair Prof Harvey) |
Year(s) Of Engagement Activity | 2019 |
Description | ROS Academy Microbiome Workshop NCH CC 2020 |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | ROS Academy Microbiome Workshop NCH CC 2020 |
Year(s) Of Engagement Activity | 2020 |
Description | ROS Conference Abstract Committee Meeting |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Professor Cooper attended this meeting on 28th July 2020. |
Year(s) Of Engagement Activity | 2020 |
URL | https://theros.org.uk/healthcare-professionals/osteoporosis-conference/ |
Description | ROS Members and Volunteers Committee 2021 (NCH) |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Patients, carers and/or patient groups |
Results and Impact | ROS Members and Volunteers Committee 2021 (NCH) |
Year(s) Of Engagement Activity | 2021 |
Description | ROS Online conference 2020 (CC) |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | ROS Online conference 2020 (CC) |
Year(s) Of Engagement Activity | 2020 |
Description | ROS Online conference 2020 (NCH) |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | ROS Online conference 2020 (NCH) |
Year(s) Of Engagement Activity | 2020 |
Description | ROS legacy event (NCH) |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Patients, carers and/or patient groups |
Results and Impact | ROS legacy event (NCH) |
Year(s) Of Engagement Activity | 2019 |
Description | ROS microbiome & musculoskeletal health function workshop |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Professor Cooper took part in the Workshop, which was held on 2nd October 2020. |
Year(s) Of Engagement Activity | 2020 |
Description | Royal Osteoporosis Society Virtual Conference |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Professor Cooper was a Speaker at the Conference, held on December 1st 2020. |
Year(s) Of Engagement Activity | 2020 |
URL | https://theros.org.uk/healthcare-professionals/osteoporosis-conference/ |
Description | Royal Osteoporosis Society public event 2021 (NCH) |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Public/other audiences |
Results and Impact | Working group vitamin D ESCEO 21 (NCH) |
Year(s) Of Engagement Activity | 2021 |
Description | Southampton General Hospital Open Day |
Form Of Engagement Activity | Participation in an open day or visit at my research institution |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Public/other audiences |
Results and Impact | We offered two activities suitable for adults and children - measuring grip strength and making an x-ray of the hand with clay. The open day was extremely well attended and we had great interest in both the activities and also our research ongoing within the Unit, particularly among undergraduate students and their parents. People reported changes in their views and opinions and asked for further information. |
Year(s) Of Engagement Activity | 2018 |
Description | Talk at Bone Research Society Conference |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Talk on the influence of maternal vitamin D supplementation on bone turnover in the MAVIDOS trial |
Year(s) Of Engagement Activity | 2018 |
Description | Talk at Southampton Medical and Health Research Conference June 2019 |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Professional Practitioners |
Results and Impact | Dr Beth Curtis gave a talk on bone turnover in pregnancy and how it is linked to vitamin D supplementation and maternal bone health, at the Southampton Medical and Health Research Conference. Pictures and comments about Beth's talk appeared on social media. |
Year(s) Of Engagement Activity | 2019 |
Description | WCO-IOF-ESCEO conference |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Professor Cooper was Chairperson at the Conference, which was held online in April 2020, rather than August 2020. |
Year(s) Of Engagement Activity | 2020 |
URL | http://2020.wco-iof-esceo.org/ |
Description | WCO-IOF-ESCEO, Krakow from 16th to 22nd April Conference |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Helped organise and co-ordinate the WCO-IOF-ESCEO conferences in Poland from 16th to 22nd April 2018. |
Year(s) Of Engagement Activity | 2018 |
Description | Wellcome Trust Award |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Media (as a channel to the public) |
Results and Impact | £1.6 m Wellcome Trust award and using data from the UK Biobank, is intended to reduce the impact of these common musculoskeletal disorders by providing a basis for improved means of disease prediction, prevention and treatment. The project, led by Jon Tobias, Professor of Rheumatology at Bristol Medical School, will involve a collaboration between researchers from the University of Southampton, as well as Bristol, Manchester, Aberdeen, Cardiff and Queensland Universities. News of this award attracted media attention and was on a number of websites. |
Year(s) Of Engagement Activity | 2018 |
Description | Working group on phosphate disorders ES CEO 2021 (NCH) |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Working group vitamin D ESCEO 21 (NCH) |
Year(s) Of Engagement Activity | 2021 |
Description | Working group vitamin D ESCEO 21 (NCH) |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Working group vitamin D ESCEO 21 (NCH) |
Year(s) Of Engagement Activity | 2021 |
Description | World Congress in Osteoporosis 2019 (BC) |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Presentation of MAVIDOS results by Dr Beth Curtis |
Year(s) Of Engagement Activity | 2019 |