Expanding the potency of stem cells with epigenetic modifiers

Lead Research Organisation: Babraham Institute
Department Name: Epigenetics


Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.


10 25 50
Description TET3 was introduced into human embryonic stem cells making them more naive like
Exploitation Route This interesting finding will be published forthwith and this may result in further key insights into human naive pluripotency
Sectors Healthcare

Pharmaceuticals and Medical Biotechnology

Description Patent application on the use of TET on pluripotency expansion. Currently further work in collaboration with a stem cell company to explore the potential of our findings for commercialisation.
Sector Healthcare,Pharmaceuticals and Medical Biotechnology
Description BBSRC LINK Grant
Amount £468,118 (GBP)
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Description Jenny Nichols, Austin Smith 
Organisation University of Cambridge
Country United Kingdom 
Sector Academic/University 
PI Contribution Contributed to conceiving studies. Epigenetic profiling and analysis.
Collaborator Contribution Conceived and conducted studies.
Impact Publications Kalkan et al 2017, Guo et al 2017. Involves embryologists, stem cell biologists, computational biologists, epigeneticists.
Start Year 2016
Title Novel Method 
Description A novel method to manipulate potency of pluripotent cells 
IP Reference US20160186207 
Protection Patent application published
Year Protection Granted 2015
Licensed Commercial In Confidence
Impact In progress