Expanding the potency of stem cells with epigenetic modifiers
Lead Research Organisation:
Babraham Institute
Department Name: Epigenetics
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
People |
ORCID iD |
Wolf Reik (Principal Investigator) |
Publications
Eckersley-Maslin MA
(2016)
MERVL/Zscan4 Network Activation Results in Transient Genome-wide DNA Demethylation of mESCs.
in Cell reports
Description | TET3 was introduced into human embryonic stem cells making them more naive like |
Exploitation Route | This interesting finding will be published forthwith and this may result in further key insights into human naive pluripotency |
Sectors | Healthcare Pharmaceuticals and Medical Biotechnology |
Description | Patent application on the use of TET on pluripotency expansion. Currently further work in collaboration with a stem cell company to explore the potential of our findings for commercialisation. |
Sector | Healthcare,Pharmaceuticals and Medical Biotechnology |
Description | BBSRC LINK Grant |
Amount | £468,118 (GBP) |
Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
Sector | Public |
Country | United Kingdom |
Start |
Description | Jenny Nichols, Austin Smith |
Organisation | University of Cambridge |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Contributed to conceiving studies. Epigenetic profiling and analysis. |
Collaborator Contribution | Conceived and conducted studies. |
Impact | Publications Kalkan et al 2017, Guo et al 2017. Involves embryologists, stem cell biologists, computational biologists, epigeneticists. |
Start Year | 2016 |
Title | Novel Method |
Description | A novel method to manipulate potency of pluripotent cells |
IP Reference | US20160186207 |
Protection | Patent application published |
Year Protection Granted | 2015 |
Licensed | Commercial In Confidence |
Impact | In progress |