Immunological consequences of the interaction of enterohemorrhagic E. coli with the organised lymphoid tissues of the gut
Lead Research Organisation:
Queen Mary University of London
Department Name: Sch of Medicine & Dentistry
Abstract
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Technical Summary
Attaching and effacing Enterohemorrhagic E.coli (EHEC) in cattle and man, enteropathogeneric E.coli in man and rabbits and Citrobacter rodentiumin mice all show tropism for the surface of the organised lymphoid tissue of the gut. Other data suggests that EPEC and intimin can down-regulate or activate cells of the immune system. We propose that the tropism of these bacteria for the organised lymphoid tissue of the gut is to allow the organisms to modulate host responses and compromise mucosal anti-bacterial immunity. In this work we will investigate whether EHEC can modulate dendritic cell (DC) function in human Peyers patches using ex vivo culture models, and investigate their direct interaction with the myeloid dendritic cells which lie below the follicle epithelium and which send processes onto the surface of the follicles.
Publications
Vossenkämper A
(2011)
Always one step ahead: How pathogenic bacteria use the type III secretion system to manipulate the intestinal mucosal immune system.
in Journal of inflammation (London, England)
Vossenkämper A
(2010)
Inhibition of NF-?B signaling in human dendritic cells by the enteropathogenic Escherichia coli effector protein NleE.
in Journal of immunology (Baltimore, Md. : 1950)
Description | That enteropathogenic E.coli inject proteins into human densritic cells to block innate imme signalling |
Exploitation Route | After we made this discovery a chinese group published the mechanism in Nature |
Sectors | Healthcare |