Investigations of the role of spatial organisation of transcription in the generation of cancer-causing chromosomal translocations
Lead Research Organisation:
Babraham Institute
Abstract
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Technical Summary
Chromosomal translocations lead to genes becoming fused together and are frequent causes of many types of cancer. The events that bring genes together during a translocation are poorly understood. This project aims to understand the mechanisms by which genes come together during the translocation process, and may point to novel treatments that could prevent translocations from occurring.
Planned Impact
unavailable
Organisations
People |
ORCID iD |
| Peter Fraser (Principal Investigator) |
Publications
Osborne CS
(2007)
Myc dynamically and preferentially relocates to a transcription factory occupied by Igh.
in PLoS biology
| Description | Gene loci involved in frequent cancer causing translocations are often found in close proximity in nuclear space in normal cells suggesting that non-random 3D genome organization contributes to translocation incidence |
| Exploitation Route | Implications for understanding generation of chromosomal translocations |
| Sectors | Pharmaceuticals and Medical Biotechnology |