Phospholipase D signalling

Lead Research Organisation: Babraham Institute
Department Name: UNLISTED


Cells communicate through the activation of cell surface receptors (a protein that binds to specific molecules). This communication regulates processes such as cell division, survival, migration, differentiation (specialisation), metabolism and contraction. These diverse processes are regulated by a number of signalling pathways in the cell. Considerable research has identified many of these pathways, however, their regulation and the detail of how they control physiological processes remains sketchy. In this project we focus upon pathways regulating the generation of the lipid (fat) messengers phosphatidic acid and lysophosphatidic acid and upon their molecular targets.


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Description The study is showing how PLD signalling and PI3kinase signalling cross talk. The importance through the use of KO mice of PLD in controlling the neutrophil superoxide response and the importance of PLD in the ageing brain are being determined. The use of lipidomics technologies are defining the PLD-regulated changes.
We have uncovered distinct roles for PLD1 and PLD2 in regulating weight gain and fat metabolism under normal and high fat diet conditions.
Exploitation Route understanding how PLD is involved in lipid metabolism may have an input into understanding steatosis
Sectors Chemicals,Pharmaceuticals and Medical Biotechnology

Title PLD2 KO mouse 
Description transgenic mouse 
Type Of Material Model of mechanisms or symptoms - mammalian in vivo 
Year Produced 2012 
Provided To Others? No  
Impact none yet 
Description Invited lecturer to international meetings (average 2-3 per year) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Generated discussion, exchange of ideas and collaborations
Year(s) Of Engagement Activity Pre-2006,2006,2007,2008,2009,2010,2011,2012,2013,2014,2015,2016,2017,2018,2019
Description Schools day 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Schools
Results and Impact 125 pupils attended schools day, talks given to all and lab practicals ran for two small groups.
Year(s) Of Engagement Activity 2018,2019