Cancer Research UK Studentship: Defining the function of genes in the immune system

Lead Research Organisation: Babraham Institute

Department Name: UNLISTED

Abstract

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

Technical Summary

The B cell is a crucial component of the normal immune system, however its dysregulation can lead to certain types of leukaemia, lymphoma and myeloma. This project aims to establish the role of a gene called TIS11 in the regulation of cell death and differentiation (specialisation) in the B cell. The main focus will be the generation and analysis of a mouse model in which TIS11 is deleted in B cells. We will also test the effects of overexpression of TIS11 in cultured B cells.

Planned Impact

unavailable

Funded Value:

£147,210

Funded Period:

Sep 06 - Mar 10

Funder:

BBSRC

Project Status:

Closed

Project Category:

Institute Project

Project Reference:

BBS/E/B/0000H190

Principal Investigator:

Martin Turner

Research Topic:

Unclassified

Organisations

Babraham Institute (Lead Research Organisation)

People	ORCID iD
Martin Turner (Principal Investigator)	http://orcid.org/0000-0002-3801-9896

Publications

Author Name

Title Publication Date Published

10 25 50

Galloway A (2016) RNA-binding proteins ZFP36L1 and ZFP36L2 promote cell quiescence. in Science (New York, N.Y.)

Gururajan M (2010) MicroRNA 125b inhibition of B cell differentiation in germinal centers. in International immunology

Hodson D (2010) Deletion of the RNA-binding proteins ZFP36L1 and ZFP36L2 leads to perturbed thymic development and T lymphoblastic leukemia in Nature Immunology

Janas ML (2008) The effect of deleting p110delta on the phenotype and function of PTEN-deficient B cells. in Journal of immunology (Baltimore, Md. : 1950)

Malcolm TI (2016) Anaplastic large cell lymphoma arises in thymocytes and requires transient TCR expression for thymic egress. in Nature communications

Turner M (2012) Regulation of lymphocyte development and function by RNA-binding proteins. in Current opinion in immunology

Turner M (2012) An emerging role of RNA-binding proteins as multifunctional regulators of lymphocyte development and function. in Advances in immunology

Key Findings


Description	We hve discivered key roles for RNA binding proteins in lymphocyte development and homeostasis and as tumour suppressors
Exploitation Route	The rNA binding proteins we have been workedin on have been implicated in autoimmune diseases through GWAS. Alos, it is appreciated thye are tumour suppressors from exome sequencing projects. Our woirk with mice was the first to show a tumour suppressor role.
Sectors	Healthcare