Programme in Lipidomic Oncology

Lead Research Organisation: Babraham Institute
Department Name: UNLISTED

Abstract

The control of cell function by changes in gene expression is ultimately reflected in metabolic changes. Lipids are both important metabolites and key regulators in cells. It is now clear that an individual cell can contain thousands of distinct lipid species and that the pattern of these changes in disease. In this project we aim to determine changes that are associated with the progression of cancer and thus identify disease-associated changes which may point to novel sites for therapeutic intervention.

Publications

10 25 50
 
Description This work together with others worldwide contributed to establishing lipidomics as a key methodology in the study of cell function in health and disease. This was through the development of mass spectrometry methodologies and through key nomenclature developments.
Exploitation Route This has provided methods of use to other labs.
Sectors Agriculture, Food and Drink,Pharmaceuticals and Medical Biotechnology

 
Title Pathway analysis 
Description Development of pathway analysis allowing for identification of enzyme activities modulated by cell stimulation, infection or metabolic change utilising novel bioinformatics methods. 
Type Of Material Model of mechanisms or symptoms - mammalian in vivo 
Year Produced 2017 
Provided To Others? Yes  
Impact Identification of potential therapeutic targets to treat infection. 
 
Title LIPID MAPS 
Description LIPID MAPS is a website which hosts tools for analysing lipidomics data and databases of MS data 
Type Of Material Database/Collection of data 
Provided To Others? Yes  
Impact Now the international reference for lipidomics 
URL http://www.lipidmaps.org/
 
Description AZ CRT Lipidomics consortium 
Organisation AstraZeneca
Country United Kingdom 
Sector Private 
PI Contribution Provision of lipidomic analysis of cancer cells and tissues
Collaborator Contribution Consortium to investigate role of lipid metabolising enzymes in malignancy
Impact Schug et al Cancer Cell 27, 57-71
Start Year 2013
 
Description AZ CRT Lipidomics consortium 
Organisation Beatson Institute for Cancer Research
Country United Kingdom 
Sector Academic/University 
PI Contribution Provision of lipidomic analysis of cancer cells and tissues
Collaborator Contribution Consortium to investigate role of lipid metabolising enzymes in malignancy
Impact Schug et al Cancer Cell 27, 57-71
Start Year 2013
 
Description AZ CRT Lipidomics consortium 
Organisation Cancer Research UK
Department Cancer Research UK London Research Institute (LRI)
Country United Kingdom 
Sector Academic/University 
PI Contribution Provision of lipidomic analysis of cancer cells and tissues
Collaborator Contribution Consortium to investigate role of lipid metabolising enzymes in malignancy
Impact Schug et al Cancer Cell 27, 57-71
Start Year 2013
 
Description AZ CRT Lipidomics consortium 
Organisation Imperial College London
Department Department of Surgery and Cancer
Country United Kingdom 
Sector Academic/University 
PI Contribution Provision of lipidomic analysis of cancer cells and tissues
Collaborator Contribution Consortium to investigate role of lipid metabolising enzymes in malignancy
Impact Schug et al Cancer Cell 27, 57-71
Start Year 2013
 
Description AZ CRT Lipidomics consortium 
Organisation University of Oxford
Department Department of Oncology
Country United Kingdom 
Sector Academic/University 
PI Contribution Provision of lipidomic analysis of cancer cells and tissues
Collaborator Contribution Consortium to investigate role of lipid metabolising enzymes in malignancy
Impact Schug et al Cancer Cell 27, 57-71
Start Year 2013