Identification of te RNA targets of the TIS11b and d tumour suppressors
Lead Research Organisation:
Babraham Institute
Department Name: UNLISTED
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Technical Summary
The control of mRNA stability and translation is widely used by cells to control proliferation, differentiation and apoptosis. The importance of post-transcriptional control is underscored by observations that it is deregulated in malignant diseases including leukaemia and lymphoma. However, our understanding of post-transcriptional control mechanisms, and their relevance to cancer, lags far behind our understanding of transcriptional regulation and signal transduction. Post transcriptional control is an area of investigation that has been relatively neglected in the search for an understanding of oncogenic mechanisms and novel routes to therapy. This proposal seeks to further our understanding of how RNA binding proteins (RBP) regulate fundamental cellular processes and how they are integrated with signaling and transcriptional processes which may be corrupted in cancer.
Planned Impact
unavailable
Organisations
Publications
Bye-A-Jee H
(2018)
The RNA-binding proteins Zfp36l1 and Zfp36l2 act redundantly in myogenesis.
in Skeletal muscle
Galloway A
(2017)
Cell cycle RNA regulons coordinating early lymphocyte development.
in Wiley interdisciplinary reviews. RNA
Galloway A
(2016)
RNA-binding proteins ZFP36L1 and ZFP36L2 promote cell quiescence.
in Science (New York, N.Y.)
Newman R
(2017)
Maintenance of the marginal-zone B cell compartment specifically requires the RNA-binding protein ZFP36L1.
in Nature immunology
Salerno F
(2018)
Translational repression of pre-formed cytokine-encoding mRNA prevents chronic activation of memory T cells.
in Nature immunology
Vogel KU
(2016)
The RNA-Binding Proteins Zfp36l1 and Zfp36l2 Enforce the Thymic ß-Selection Checkpoint by Limiting DNA Damage Response Signaling and Cell Cycle Progression.
in Journal of immunology (Baltimore, Md. : 1950)
| Description | mechanisms controlling cell division. We alos discoverd thta RNA binding proteins control cellular identity amongst B cells. In a collaborative study we found that ZFP36L2 was important for limiting IFNg production by T cells. We also found the RBP were essential in muscle stem cell development and or function. see the published papers for details. also http://www.babraham.ac.uk/news/2016/04/quiescence-B-cells and a novel mechanism of epigentic control of the Marginal zone B cell |
| Exploitation Route | anti-cancer therapy |
| Sectors | Healthcare Pharmaceuticals and Medical Biotechnology |
| URL | http://www.babraham.ac.uk/news/2016/04/quiescence-B-cells |
| Description | Interest in our work has led to the development of a collaboration with Cancer Research Technology and Celgene. This has now been funded |
| Sector | Healthcare,Pharmaceuticals and Medical Biotechnology |
| Impact Types | Economic |
| Description | Investigator Award |
| Amount | £1,300,000 (GBP) |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 03/2017 |
| End | 03/2022 |