Mechanisms of epigenetic gene silencing caused by the long non-coding Kcnq1ot1 RNA - a key regulator of BWS

Lead Research Organisation: Babraham Institute
Department Name: UNLISTED

Abstract

Imprinted genes are those genes only expressed (copied into RNA) from one of the parental chromosomes. These genes have important roles in embryonic development, growth, and human diseases including cancer. Imprinted genes occur in clusters in the genome, and some clusters are regulated by long non-coding RNAs (RNA which does not code for proteins), which somehow inactivate the genes located next to them in the cluster. This project will investigate the mechanisms by which the non-coding RNA Kcnq1ot1, deregulation of which underlies the human overgrowth and cancer syndrome Beckwith-Wiedemann syndrome, regulates gene silencing. This will include investigations of physical interactions of the RNA with the gene cluster, and the consequent change of higher order organisation of the gene cluster.

Publications

10 25 50
 
Title Dynamic regulation of 5-hydroxymethylcytosine in mouse ES cells and during differentiation 
Description Sequence submitted to online database (ENA/SRA) 
Type Of Material Database/Collection of data 
Year Produced 2011 
Provided To Others? No  
Impact No actual impacts realised to date 
URL http://www.ebi.ac.uk/ena/data/view/ERP000570&display=html