Physiological importance of phospholipase D signalling

Lead Research Organisation: Babraham Institute
Department Name: UNLISTED


Hormones, neurotransmitters (chemicals released from nerve cells) and growth factors regulate the body's functions by activating processes in cells that produce signals to control the way a cell grows, divides, moves or secretes. One of these signalling pathways involves activation of the enzyme phospholipase D which produces a messenger called phosphatidic acid. Studies in cells in tissue culture have suggested that this pathway is activated in many responses and is involved in processes such as how inflammation is activated, how cells move and how they secrete factors. There is a need to understand how these pathways are regulated and the precise roles played by this signalling event, since distortion of the regulation is implicated in inflammatory disorders and other diseases including cancer. The only way to understand this physiological role is to generate and study a genetically modified mouse model. We will isolate cells from the mice and thereby characterise the role and regulation of the signalling. This work has the potential to identify targets for future therapeutic intervention.


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Description PLD regulates neutrophil superoxide generation (mouse KO studies)

PLD2 is involved in olfaction (mouse KO studies)

PLD is involved in the activation of mTOR with potential link into nutrient sensing and ageing

PLD is involved in the regulation of hepatic lipid metabolism
Exploitation Route At this point basic studies
Sectors Chemicals,Pharmaceuticals and Medical Biotechnology

Description Invited lecturer to international meetings (average 2-3 per year) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Generated discussion, exchange of ideas and collaborations
Year(s) Of Engagement Activity Pre-2006,2006,2007,2008,2009,2010,2011,2012,2013,2014,2015,2016,2017,2018,2019
Description Schools day 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Schools
Results and Impact 125 pupils attended schools day, talks given to all and lab practicals ran for two small groups.
Year(s) Of Engagement Activity 2018,2019