Signalling to the developing epigenome

Lead Research Organisation: Babraham Institute
Department Name: UNLISTED

Abstract

Key signalling events are important in making developmental decisions (eg lineage commitment, gastrulation) and we focus on understanding the connections between signalling systems and the epigenome. Furthermore, it is possible that environmental and nutritional states signal, potentially through the same cascades, to the epigenome, thus resulting in durable and potentially heritable ch anges much later in life and across generations. We are addressing the following objectives: (1) FGF4 and MAPK/ERK signalling in cell fate switch between ES and TS cells and induced changes to the epigenome, (2) the role played by FGF signalling and Pc silencing in gastrulation, (3) the effects of diet on the epigenomes of metabolic control centres in the brain, and (4) signalling pathways in mediating environmental regulation of the epigenome in controlling cardiomyocyte hypertrophy

Publications

10 25 50

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Bachman M (2015) 5-Formylcytosine can be a stable DNA modification in mammals. in Nature chemical biology

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Houseley J (2015) Annual meeting of the EpiGeneSys Network of Excellence--Advancing epigenetics towards systems biology. in BioEssays : news and reviews in molecular, cellular and developmental biology

 
Description External factors such as growth factors are well known to alter a cell's behaviour by triggering specific signalling cascades. We have found that these signalling cascades also directly impact on the epigenome, thereby possibly causing long-lasting changes to the cell's developmental capacity.

Key findings during this award are that we have shown that the stability of DNA methylation differs across the genome when embryonic stem cells (ESCs) are trans-differentiated towards a trophoblast stem cell (TSC)- like fate. The availability of fibroblast growth factor (FGF) reprograms DNA methylation at some loci; however, other loci are particularly refractory to epigenetic reprogramming. We show that this epigenetic memory normally prevents full lineage conversion in stem cell models.

Furthermore, a specific cocktail of transcription factors was identified that, in conjunction with altered growth factor signalling, can induce trophoblast cell fate in fibroblasts. We show that this is likely possible because the epigenetic lineage barriers are less prominent in fibroblasts compared to ESCs. This was the first evidence of direct reprogramming to the trophoblast lineage. We have established a conserved mechanism involving a departure of the cardiomyocyte epigenome from its adult cellular identity to a reprogrammed state that is accompanied by reexpression of fetal genes and pathological hypertrophy. Our results suggest that targeting specific microRNAs and histone methylation loss is a viable therapeutic approach for the treatment of heart disease.
Exploitation Route Our work has been noted and taken up by others as evidenced by publications building on our work.
Sectors Education,Healthcare,Pharmaceuticals and Medical Biotechnology

URL https://www.babraham.ac.uk/our-research/epigenetics
 
Description As part of the wider Babraham Institute strategy, across the course of this ISP we have developed a much broader public engagement strategy, undertaking large prestigious events including two Royal Society exhibits specifically showcasing our work (Epigenetics: DNA is not your destiny and Race Against the Ageing Clock), as well as presentations at local science fairs and engagement with local schools. We have also contributed substantially to transferable skills development, analytical thinking and training, mentoring and career development.
First Year Of Impact 2014
Sector Healthcare
Impact Types Societal,Economic

 
Description Babraham Institute Public Dialogue 2015
Geographic Reach National 
Policy Influence Type Citation in other policy documents
Impact Improved public understanding of biological sciences and the work of the Babraham Institute
URL http://www.babraham.ac.uk/get-involved/partnerships-page/public-dialogue
 
Description CTR Board of Managers (MH)
Geographic Reach Europe 
Policy Influence Type Influenced training of practitioners or researchers
Impact Member, Board of Managers of the Centre for Trophoblast Research, Cambridge assessing funding for targetted PhD studentship and Next Generation fellowship applciations and influencing science strategy within this research area.
 
Description Chair SAB Development and Genetics Unit Institut Curie
Geographic Reach Local/Municipal/Regional 
Policy Influence Type Participation in a advisory committee
Impact Probably the best unit of this type in France
 
Description Chair of SAB Centre for Trophoblast Research University of Cambridge
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
Impact Has changed the perception of placenta and trophoblast in reproduction
 
Description Contribution to POSTnote on genome editing
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
URL http://researchbriefings.parliament.uk/ResearchBriefing/Summary/POST-PN-0541
 
Description European Research Council committee member
Geographic Reach Europe 
Policy Influence Type Participation in a advisory committee
 
Description Gene editing policy
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description H2020 EU-LIFE project "LIBRA", co-lead work package "Gender Equality in Research"
Geographic Reach Europe 
Policy Influence Type Influenced training of practitioners or researchers
Impact Consideration of gender effects in research, appreciation that there may be sex differences in cell lines, animal models and treatment regimes that ought to be taken into consideration when designing studies.
 
Description ISCI (Bar Harbor)
Geographic Reach Multiple continents/international 
Policy Influence Type Participation in a advisory committee
Impact Proposed guidelines for regulatory authorities in USA, UK, EU and Japan for stem cell-based therapies.
 
Description Research Advisory Board, Wellbeing of Women
Geographic Reach National 
Policy Influence Type Participation in advisory committee
Impact I served as member of the scientific advisory committee to the charity Wellbeing of Women, which reviews and makes decisions on grant funding in the general field of reproductive medicine. Some of the work funded through WoW has led to improvements in health care, novel diagnostic methods, etc.
 
Description Review panel member, DFG Clinical Research Unit (Germany) (MH)
Geographic Reach Europe 
Policy Influence Type Membership of a guideline committee
Impact Funding assessment for a major research unit on male infertility which includes improvement of patient treatment options and better patient assessment and stratification. Funding was recommended by teh panel and was implemented.
 
Description Steering board Human Cell Atlas
Geographic Reach Multiple continents/international 
Policy Influence Type Participation in a advisory committee
 
Description 16ALERT: BD FACS-Aria Fusion - strengthening the cell sorting capabilities of Babraham Institute Flow Core to enrich world-class science
Amount £449,452 (GBP)
Funding ID BB/R00076X/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 08/2017 
End 08/2018
 
Description EU BLUEPRINT
Amount £500,000 (GBP)
Organisation European Commission 
Department Seventh Framework Programme (FP7)
Sector Public
Country European Union (EU)
Start  
 
Description EU NoE EpiGeneSys
Amount £400,000 (GBP)
Organisation European Commission 
Sector Public
Country European Union (EU)
Start  
 
Description MRC CASE
Amount £112,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 10/2016 
End 10/2020
 
Description Next Generation Fellowship for postdoctoral researcher Dr Paulina Latos
Amount £167,000 (GBP)
Organisation University of Cambridge 
Department Centre for Trophoblast Research
Sector Academic/University
Country United Kingdom
Start 09/2013 
End 08/2016
 
Description US Partnering Award: Cellular heterogeneity, signalling and decision-making in human pluripotent stem cells
Amount £48,164 (GBP)
Funding ID BB/R021341/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 04/2018 
End 04/2022
 
Title Identification of cell-surface proteins that can distinguish between human pluripotent states 
Description We have developed a new method to identify and flow-sort human naive and primed pluripotent stem cells based on their different cell-surface protein expression. 
Type Of Material Technology assay or reagent 
Year Produced 2017 
Provided To Others? Yes  
Impact We have published our method (Cell Stem Cell, 2017) and we anticipate other researchers to use the method in their own research. 
 
Title Aging Cell 2018 
Description We provide expression (RNA-seq) and epigenetic (ChIP-Seq and BS-Seq) data sets for young adult and aged mouse neural stem cells. The data are accessible at GEO under Accession Number GSE101610. 
Type Of Material Database/Collection of data 
Year Produced 2018 
Provided To Others? Yes  
Impact We anticipate that other researchers will use our published data sets to identify candidate regulators of age-associated neurogenic decline. 
 
Title Cell Reports 2016 
Description This data collection relates to RNA-sequencing data related to our 2016 publication in Cell Reports. The data have been deposited to GEO under accession number GSE76626. 
Type Of Material Database/Collection of data 
Year Produced 2016 
Provided To Others? Yes  
Impact We anticipate that other researchers will use our data. 
 
Title Cell Stem Cell 2017 
Description We have deposited RNA-sequencing data related to our publication in Cell Stem Cell, 2017. The data have been uploaded to GEO under accession number GSE93241. 
Type Of Material Database/Collection of data 
Year Produced 2017 
Provided To Others? Yes  
Impact The data relate to the reprogramming of human pluripotent stem cells. We anticipate that these data will be used by other researchers. 
 
Title ChIP-seq profiles for Tet1 in TSCs (GSE109545) 
Description Chromatin binding profiles of Tet1 protein in trophoblast stem cells (TSCs) 
Type Of Material Database/Collection of data 
Year Produced 2018 
Provided To Others? Yes  
Impact Data allow to determine the functional role of Tet1 in TSCs 
 
Title ChIP-seq profiles for numerous transcription factors in TSCs (E-MTAB-3565) 
Description Chromatin binding profiles for Esrrb, Tfap2c, Lsd1, Nr0b1 and others in TSCs 
Type Of Material Database/Collection of data 
Year Produced 2015 
Provided To Others? No  
Impact Datasets were deposited in publicly available databases. Results helped identify the transcriptional networks operational in trophoblast stem cells, the precursors of the placenta. These insights will be immensely useful for other researchers in the field. 
 
Title DMDD 
Description As part of the Wellcome Trust funded Strategic Award "Deciphering the Mechanisms of Developmental Diseases", we have generated a database in which we collect phenoytping data of the mouse placenta at various gestational stages. 
Type Of Material Database/Collection of data 
Year Produced 2014 
Provided To Others? Yes  
Impact Broad survey of embryonic lethal gene mutations for defects in embryonic and placental development. Efforts will lead, for the first time, to a global overview of the number and identity of genes, and the molecular pathways they regulate, involved in the development of the placenta as an essential organ ensuring reproductive success and health of the baby. 
URL http://www.nimr.mrc.ac.uk/news/deciphering-the-mechanisms-of-developmental-disorders-progress-report...
 
Title Elf5 and Esrrb protein interactomes in TSCs (PXD002183) 
Description IP->MS/MS datasets of interaction partners of the key transcription factors Esrrb and Elf5 in trophoblast stem cells (TSCs). 
Type Of Material Database/Collection of data 
Year Produced 2015 
Provided To Others? No  
Impact Data deposited in publicly accessible databases. Results are instrumental to gain a detailed understanding of how TSCs operate, which will be important to move the field of reproductive biology and pregnancy (normal and pathological) forward. 
URL http://www.ebi.ac.uk/pride/archive/
 
Title Transcriptome datasets of reproductive tissues in ageing females (GSE98901) 
Description RNA-seq datasets of trophoblast, endometrium and deciduae of mouse conceptuses developed in young versus aged females 
Type Of Material Database/Collection of data 
Year Produced 2017 
Provided To Others? Yes  
Impact Significant changes imposed by maternal age on expression profiles of endoemtrial tissue and decidual development. Work shows the impact of the older female on reproductive success, unrelated to oocyte fitness. 
 
Title Webtool for integration of high-throughput datasets and their rapid analysis 
Description Generation of a webtool allowing rapid data analysis of high-througput sequencing datasets. 
Type Of Material Computer model/algorithm 
Year Produced 2018 
Provided To Others? No  
Impact Webtool allows to upload and integrate multiple datasets of different nature (such as ChIP-seq, RNA-seq, DNA methyaltion profiles) and allows to perform rapid multivariate analyses on them to find co-occpuancy, mutual exclusion etc 
 
Title eLife 2017 
Description High-through sequencing data related to our 2017 published in eLife. Data deposited in GEO under accession number GSE86821 
Type Of Material Database/Collection of data 
Year Produced 2017 
Provided To Others? Yes  
Impact We provide the coordinates for promoter-enhancer interactions in human pluripotent cells and differentiated cells. The data will be re-used by other researchers. Too early for measured impacts. 
 
Description Active Motif DNA modification antibody 
Organisation Active Motif
Country United States 
Sector Private 
PI Contribution Commercialisation of DNA modification antibodies we have made
Collaborator Contribution Commercialisation of DNA modification antibodies we have made
Impact Commercially available antibodies
Start Year 2016
 
Description Bioinformatics analysis of ChIP-seq and RNA-seq data 
Organisation EMBL European Bioinformatics Institute (EMBL - EBI)
Country United Kingdom 
Sector Academic/University 
PI Contribution Provided extensive high-throughput sequencing datasets for analysis.
Collaborator Contribution Expert analysis of ChIP-seq data and data mining of existing datasets
Impact Multi-discipliniary, involving mathematical biology and bioinformatics. Joint manuscript submitted October 2014
Start Year 2014
 
Description Bioinformatics analysis of ChIP-seq and RNA-seq data 
Organisation University of Toronto
Country Canada 
Sector Academic/University 
PI Contribution Provided large-scala datasets for analysis.
Collaborator Contribution Analysed the data.
Impact Latos P.A., Sienerth A.R., Murray A., Senner C.E., Muto M., Ikawa M., Oxley D., Burge S., Cox B. and Hemberger M. (2015). Elf5-centered transcription factor hub controls trophoblast stem cell self-renewal and differentiation through stoichiometry-sensitive shifts in target gene networks. Genes & Development, 29: 2435-2448.
Start Year 2014
 
Description Claire Rougeulle 
Organisation Paris Diderot University
Country France 
Sector Academic/University 
PI Contribution We have provided cell lines and contributed experiments to an ongoing collaboration.
Collaborator Contribution Our collaborators have made key discoveries about X-chromosome inactivation in human cells.
Impact Manuscript in preparation.
Start Year 2015
 
Description Deciduoma 
Organisation National Institute of Environmental Health Sciences
Department Reproductive and Developmental Biology Laboratory
Country United States 
Sector Public 
PI Contribution Characterisation of reproductive defects in older females
Collaborator Contribution Decidualisation model to assess the effect in the absence of an implanting embryo
Impact Collaborative publication (PMID: 28874785)
Start Year 2016
 
Description Epigenetic memory in ES-to-TS cell reprogramming 
Organisation Babraham Institute
Country United Kingdom 
Sector Private 
PI Contribution Collaboration with Dr Simon Cook on the impact of Ras-Raf-Erk signalling on ES cell reprogramming towards trophoblast. Designed overall project outline and performed experimental analyses.
Collaborator Contribution Provided plasmid constructs and antibody resources. Provided help and advice on specific Western blotting techniques. Provided ongoing scientific advice.
Impact Cambuli F., Murray A., Dean, W., Dudzinska D., Krueger F., Andrews S., Senner C.E., Cook S. J. and Hemberger M. (2014). Epigenetic memory of the first cell fate decision prevents complete ES cell reprogramming into trophoblast. Nat. Commun., 5: 5538.
Start Year 2012
 
Description Fredrik Lanner 
Organisation Karolinska Institute
Country Sweden 
Sector Academic/University 
PI Contribution We have made new discoveries about human pluripotent states.
Collaborator Contribution Our collaborators have shared data, provided reagents, and participated in a shared project with us.
Impact None
Start Year 2015
 
Description Guiseppe Lupo 
Organisation Sapienza University of Rome
Country Italy 
Sector Academic/University 
PI Contribution We have profiled the epigenome and transcriptome of aged neural stem cells. We have also hosted GL in our laboratory over two summers and provided training in epigenomics techniques.
Collaborator Contribution Our partners derived and characterised young and aged neural stem cells, provide expertise in neural biology, and have given training to us in neural stem cell cultures.
Impact Manuscript in preparation.
Start Year 2014
 
Description Human Cell Atlas 
Organisation Broad Institute
Country United States 
Sector Charity/Non Profit 
PI Contribution Contributed to formulating the white paper of the Human Cell Atlas.
Collaborator Contribution Conceived the project and brought the international consortium together.
Impact The white paper was published Regev et al 2017. It involves single cell biologists and computational and modelling scientists.
Start Year 2016
 
Description Ian Chambers 
Organisation University of Edinburgh
Department MRC Centre for Regenerative Medicine
Country United Kingdom 
Sector Public 
PI Contribution We have identified a new role for the transcription factor Nanog in regulating heterochromatin in mouse embryonic stem cells.
Collaborator Contribution Our collaborators have provided key cell lines, gel shift assays and expertise to the project.
Impact Paper in revision.
Start Year 2014
 
Description Reprogramming of MEFs towards iTSCs and establishment of defined TSC culture conditions 
Organisation University of Bonn
Country Germany 
Sector Academic/University 
PI Contribution Genome-wide DNA methylation analysis of various clones and reprogrammed cells. Bioinformatic analysis of these data. Figures for manuscripts.
Collaborator Contribution Provided DNA for the above analysis. Performed other experiments to bring this project to conclusion.
Impact Kubaczka C., Senner C.E., Araúzo-Bravo M.J., Sharma N., Kuckenberg P., Becker A., Zimmer A., Brüstle O., Peitz M., Hemberger M. and Schorle H. (2014). Derivation and maintenance of murine trophoblast stem cells under defined conditions. Stem Cell Reports, 2: 232-242. Kubaczka C., Senner C.E., Cierlitza M., Araúzo-Bravo M.J., Kuckenberg P., Peitz M., Hemberger M. and Schorle H. (2015). Direct induction of trophoblast stem cells from murine fibroblasts. Cell Stem Cells, 17: 557-568.
Start Year 2012
 
Description Trophoblast Stem Cells 
Organisation University of Cambridge
Country United Kingdom 
Sector Academic/University 
PI Contribution Generation of locus-specific DNA methylation profiles to confirm lineage identity of derived cells.
Collaborator Contribution Establishment of an organoid system that promotes the maintenance of human trophoblast stem/progenitor cells.
Impact Publication in process. This collaboration is multi-disciplinary between pathologists, physiologists and us as epigeneticists, it also involved bio-engineering helping in the design of microfluidics devices.
Start Year 2017
 
Description uNK cells 
Organisation University of Cambridge
Country United Kingdom 
Sector Academic/University 
PI Contribution Characterisaiton of reproductive problems in older females.
Collaborator Contribution Analysis of immune repertoire of implantation sites depending on maternal age.
Impact Collaborative publication (PMID: 28874785).
Start Year 2016
 
Description Babraham Schools Day 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact As part of the annual Babraham Schools' Day, my group hosted 5 GCSE and 5 A level students for half-day practical sessions in the lab.
Year(s) Of Engagement Activity 2017
 
Description Cambridge Science Festival 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Exhibit about Babraham's research at Cambridge Science Festival
Year(s) Of Engagement Activity 2015
 
Description Cambridge Science Festival: Molecular Explorers, Cambridge (UK) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Exhibit at Cambridge Science Festival, engaging with visitors at stall explaining the science and advances made in the area, answering questions and discussing outstanding research goals
Year(s) Of Engagement Activity 2017
 
Description Cold Spring Harbor Laboratory meeting: Stem Cell Biology, New York (USA) (VPG, CS) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Participation in confenrence, poster presentation by both post-doctoral reserachers involved in this activity (VPG and CS) and engagement in discussions and broadening of scientific horizon
Year(s) Of Engagement Activity 2017
 
Description DNA extraction from fruit Babraham Campus visit from Home educated children 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Extract DNA from fruit whilst showing how to "be a scientist" to home schooled children.
Impact: hands on activity to explain the basics of DNA and promote a career in research to home schooled children.
Year(s) Of Engagement Activity 2016
 
Description EMBL Mammalian Genetics and Genomics Conference (MH) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Invited speaker at AMBL Conference Mammalian genetic and Genomic, Heidelberg, Germany
Year(s) Of Engagement Activity 2017
 
Description Epigenetics lecture for Monday Biology Society 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Lecture to introduce the basics and the importance of Epigenetics to Biology GSCE and A-level students.
Impact: improve students' understanding of Epigenetics; promote career in research.
Year(s) Of Engagement Activity 2016
 
Description Epigenetics lecture for Teacher Twilight Session 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact An after-work lecture to introduce the basics and the importance of Epigenetics to Biology teachers.
Impact: prepare teachers into Epigenetics, a subject recently introduced to the curriculae.
Year(s) Of Engagement Activity 2016
 
Description Gene editing (Cambridge) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact 120 people attended a panel discussion about gene editing, with lots of questions from the audience and discussion afterwards, and there were several follow-up conversations from the media and patient groups.
Year(s) Of Engagement Activity 2016
 
Description Genetics Society and BSDB Spring Meeting, Warwick, UK (MH) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Invited speaker at annual spring meeting of the Genetics Society and British Society for Developmental Biology (BSDB) in Warwick, UK (2017)
Year(s) Of Engagement Activity 2017
 
Description IFPA Meeting, Manchester, UK (MH) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Invited talk at IFPA Meeting held in Manchester, UK (2017)
Year(s) Of Engagement Activity 2017
 
Description ISSHP Meeting, Berlin, Germany (MH) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Invited talk at ISSHP Meeting held in Berlin, Germany (2017)
Year(s) Of Engagement Activity 2017
 
Description Keynote speaker, CTR Anniversary Meeting, Cambridge, UK (MH) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Keynote lecture at 10th Anniversary Meeting of the Centre for Trophoblast Research, University of Cambridge (2017)
Year(s) Of Engagement Activity 2017
 
Description Member, Board of Managers at Centre for Trophoblast Research 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? Yes
Geographic Reach International
Primary Audience Supporters
Results and Impact As member of the Board of Managers at the CTR in Cambridge we make decisions on the award of PhD scholarships, postdoctoral fellowships and direct the general focal points of local research activity in the field of placental biology.

PhD students admitted to the University of Cambridge; postdoctoral researchers' career path enhanced
Year(s) Of Engagement Activity 2013,2014,2015,2016
 
Description Podcast with Dr Kat Arney on the impact of placentation and maternal age on reproductive outcome 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Podcast as descibed above
Year(s) Of Engagement Activity 2017
 
Description Postgraduate course Epigenetics in Reproductive Biology, University of Murcia, Spain (VPG) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Postgraduate students
Results and Impact Invited talk and workshop participation as part of postgraduate course on reproductive epigenetics
Year(s) Of Engagement Activity 2016,2017
 
Description Press interview on Maternal methylation inheritance 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Media (as a channel to the public)
Results and Impact Co-interviewee which formed part of a televised clip reporting on a recent publication and its societal/public impact.
Year(s) Of Engagement Activity 2016
 
Description Radio interview DeutschlandFunk 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Radio Interview for DeutschlandFunk on the impact of maternal age on pregnancy success, irrespective of the increased risk of defects in the egg
Year(s) Of Engagement Activity 2017
URL http://www.deutschlandfunk.de/alter-des-uterus-entscheidend-junges-glueck-in-jungen.676.de.html?dram...
 
Description Royal Society 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Schools
Results and Impact Our exhibition enabled a two way dialogue with the public about what we do and why it is important.

I was invited to write an article for "Chemistry and Industry" magazine about our research, which was published in 2012.
Year(s) Of Engagement Activity 2012
 
Description Royal Society Partnering Award - CS + LW, NM, SC 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Successful application for Royal Society Partnering Award. Poster 6 selected 6th form students over the course of 1 week and conducted in-depth research project. Data analysis followed at the pupils' school directly.
Year(s) Of Engagement Activity 2016,2017
 
Description STEM teacher visit 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact As part of a week-long visit to the Institute, my group hosted 3 biology A-level teachers from local schools for involvement in practical work in the lab over a 2-day period.
Year(s) Of Engagement Activity 2016
 
Description School's Day 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? Yes
Geographic Reach Local
Primary Audience Schools
Results and Impact provided basic explanation of early development and the importance of the placenta for growth of a baby; hands-on experience for students in staining and microscopic analysis of a mouse placenta

rose awareness of research activities and importance of basic research to understand common pregnancy-associated diseases
Year(s) Of Engagement Activity 2006,2007,2008,2009,2010
 
Description Schools Day 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact Groups of 5-6 6th-form students take part in a one-day visit to 2 research groups at the Babraham Institute and conduct two small research experiments during that day.
Year(s) Of Engagement Activity 2017,2018
 
Description Schools Day 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Project design, scientific background induction and practical supervision for 6th form students as well as teachers during Annual Schools Day.
Year(s) Of Engagement Activity 2015,2016,2017
 
Description Short talk to LIYSF students 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Schools
Results and Impact Short introduction on our research (epigenetics and nuclear organization) to students attending London International Youth Students Forum (LIYSF).
Impact: introduce students to Epigenetics and promote of scientific career.
Year(s) Of Engagement Activity 2016
 
Description The Ageing Cell Conference, Cambridge, UK (MH) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Invited talk at The Ageing Cell Conference held in Cambridge, UK (2017)
Year(s) Of Engagement Activity 2017
 
Description Twilight teacher training event, Bioscience lite-CRISPR-Cas9 genome editing- technology, applications and implication, Cambridge (UK) (VPG) 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact Talk and Q&A session with high school teachers to update and inform them on state-of-the-art genome editing tools
Year(s) Of Engagement Activity 2017