Immune homeostasis and the immune response

Lead Research Organisation: Babraham Institute
Department Name: UNLISTED

Abstract

In older humans and in experimental mouse models the generation of immunological memory after vaccination is defective, leading to impaired immunity. This research objective will focus on characterising the molecular and cellular mechanisms that maintain lymphocyte repertoires and on age-dependent changes in memory cell formation and function. To meet this objective we will study mechanisms of lymphocyte selection and survival and importantly expand our current portfolio to consider the role of non-lymphoid cells in memory cell formation. Here the recent recruitment of Alice Denton, who is a BBSRC Future Leader Fellow studying stromal cells, offers a unique contribution. The mechanisms by which stromal cells promote or inhibit germinal centre responses will be studied and we will address potential mechanisms of trans-differentiation into follicular dendritic cells (FDCs) as well as the senescence-associated secretory phenotype (SASP) of older stromal cells. This work will be further strengthened by collaboration with Dr Simon Cook in the Signalling ISP who is engaged in elucidating the molecular mechanisms of the SASP using model cell lines and gene editing technologies. We will study human and mouse immune responses. The study of mouse models will enable us to dissect cellular responses that are driven by intrinsic versus extrinsic factors - an essential requirement for a mechanistic understanding of the cellular interactions that sustain the repertoire and drive the GC response to produce humoral and cellular memory. Based on published evidence, we suggest that an excess of interferon ã (IFNã) may contribute to defective immune responses at the extremes of age and that a better understanding of the molecular processes limiting IFNã production may enable productive immune responses and avoidance of autoantibody production. The project will also look at interaction between lymphocytes and epithelial or stromal cells as it is fundamental for both immunity and the maintenance of tissue integrity during stress. Epithelial cells form the first cellular barrier between host and environment. In the lung they mediate mucociliary clearance and also important coordinators of immune responses as they produce a variety of cytokines, surfactants and antimicrobial peptides that are able to modulate pathogens and commensals directly, and also recruit leucocytes to tissues to facilitate local immune responses. Stromal cells respond to infection by remodelling the lung tissue to facilitate local immune responses, such as in the formation of germinal centres35. In this objective we seek a deeper understanding of the interactions between epithelial cells, stromal cells and lymphocytes using the lung as a relevant model of immune responses to viruses and bacteria in a complex non-lymphoid tissue. This is important because respiratory infections are poorly tolerated and a better understanding of the cellular and molecular mechanisms of immunity and resilience to infection has the strong potential to bring benefits36. We describe here plans, which build on our investment in these models, to elucidate the role of the PI3K pathway in the molecular regulation of lung epithelial and stromal cell immune function. Our focus on PI3K builds on significant previous work performed by us and others, and our proposed studies will discover new contexts in which this pathway, which links growth factor and nutrient sensing mechanisms to cellular responses, functions. We want to understand more about the immune cell-stromal cell interactions that underpin effective immune responses outside of the specialised environment of lymphoid tissue as this is relevant to the mechanisms of vaccine efficacy. Moreover, this is particularly important to health-span because normal ageing is associated with increased susceptibility to infections of the lung such as Influenza A Virus (IAV) and streptococcal pneumonia (Strep). These pathogens often act in concert, such that infection with flu increases the susceptibility to and severity of a subsequent Strep infection37. The use of co-infection models will strengthen our understanding of physiologically relevant immune responses, as the immune responses elicited in the young by these co-challenges remain incompletely characterised making it very difficult to identify the nature of the defects that occur upon ageing. The reason why resistance to these pathogens drops precipitously upon ageing is poorly understood, but is likely to involve a reduced capacity to produce high affinity antibodies and the defective function of innate immune cell such as neutrophils. Importantly, neutrophils engage in a dialogue with lymphocytes in inflamed tissues and, through the elaboration of cytokines, can influence lymphocyte function and immune memory and support the development of tertiary lymphoid structures in the lung.

Publications

10 25 50
 
Description ISPG funded work has discovered a mechanism that is important for maintaining the naive pool of T lymphocytes, work that has implications for how these cells are depleted using ageing. We continue to make progress with collaborative work with Dutch colleagues and have two manuscripts published which shed light on mechnisms hich may be important in tissue homeostasis. We have generated some multi-omics data that shed light on how transcriptional and post-transcriptional control of gene expression are interlinked. Our most recent ISPG funded work, with key contributions from Alice Denton, has shed light on how germinal centres form in non-lymphoid tissue.
Our Objectives are changing to reflect the departure/retirment of some research group (okkenhuag & Butcher) leaders and the recruitment of four new research group leaders. We incorporated Anne Corcoran's scientific expertise on the effects on ageing on B cell development and on the biology of B cells in general to strengthen the Immunology programme and the UK more generally which is lagging behind internationally in B cell biology, with a dwindling number of laboratories investigating B cells and none at the level of Corcoran in deploying state of the art epigenetic analysis combined with sophisticated mouse models. The Immunology ISP has made further appointments which strengthen its ability to deliver world class research in the fundamental mechanisms of ageing and to strengthen the UKs basic immunology research. Adrian Liston, an established scientists of world renown is recruited to the UK and will contribute to objectives addressing how regulatory T cell maintain tissue homeostasis-a fundamental problem in healthy ageing and will contribute to delivery of specific aims 1 and 2. Claudia Ribeiro de Almeida will bring expertise in molecular biology and B cells further strengthening the programme ensuring a balance between the study of B and T cells and contributing to the delivery of objectives 1 and 2 of the ISP. Sarah Ross will bring expertise in proteomic and CD8 T cells and address questions that will enable the delivery of objective 3 of the Immunology ISP.
Exploitation Route Our work has promoted interest form other academics whose own research is informed by our thinking. As indicated elsewhere the celegene/CRT alliance is an important example of how this thinking can have economic impact
Sectors Healthcare

 
Description The knowledge and know-how of our ISP has led to our recent involvement in a number of collaborations with Industry. The most significant of these in terms of scale is the CRT-Celgene alliance which has brought a very significant investment from Celegene into the UK science sector: as stated by Dr Iain Foulkes, Cancer Research Technology's CEO in December 2017 "This is our largest drug discovery collaboration to date and represents a major endorsement of the reputation and scale of our capacity and expertise in both drug discovery and clinical development by a leading industry partner". A further significant set of activities relates to engagement with Babraham Research Campus companies. These collaborations range from the informal sharing of expertise, reagents and equipment; the movement of people (e.g. graduated PhD students) into company staff positions; more formal collaborations and research contracts. Of note the ISPG holder is the line manager of the Flow cytometry facility manager and has empowered and supported her to develop the flow facility into a permier service provider and training resource. Geoff Butcher acts as establishment license holder and plays a key role in the management of the Biological services Unit and ethical review; and Anne Corcoran played the leading role in the renewal of the Institute Athena Swan Silver Award. The programme has been refreshed by the recruitment of significant new group leader level researchers. Anne Corcoran joined the ISPG in April 2017 and we have subsequently been joined by Sarah Ross who will bring expertise in proteomic and CD8 T cells and address questions that will enable the delivery of the Immunology ISPG projects on the regulation of gene expression; Claudia Ribeiro de Almeida who will bring expertise in molecular biology and B cells further strengthening the programme ensuring a balance between the study of B and T cells and contributing to the delivery of all of the major objectives the ISP; and Adrian Liston, an established international scientist (at ERC investigator level) recruited to the UK from Europe who will contribute to objectives addressing how T cells maintain tissue homeostasis-a fundamental problem of great relevance to healthy ageing. Our ISP has been involved in all of the major engagement activities of the Babraham Institute including Schools open day, the recent Royal Society exhibition "race against the ageing clock" and Launchpad. We believe we can use this experience to develop a new public engagement activity focused on vaccination. We believe this can showcase our research and reach-out to vaccine hesitant individual and group to explain how vaccines work and to discuss candidly the risks. To achieve this, we will partner with the British Society for Immunology which has already taken step in this direction, but needs more support from scientists. We hope that this will have been fully developed and delivered before the final year of the ISPG.
First Year Of Impact 2017
Sector Healthcare,Pharmaceuticals and Medical Biotechnology
Impact Types Economic

 
Description Memberhsip of Bloodwise research grants evaluation panel 2013-2018
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
Impact funding of research relevant to blood cancers
 
Description Membership of Wellcome Science Interview panel
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
URL https://wellcome.ac.uk/funding/science-interview-panel
 
Description microbiome
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description BBSRC GCRF Data & Resources
Amount £171,733 (GBP)
Funding ID BBS/OS/GC/000008A 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 10/2016 
End 07/2017
 
Description BBSRC iCASE
Amount £100,000 (AFN)
Funding ID BB/L016745/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 10/2016 
End 09/2019
 
Description EMBO Young Investigator Award
Amount € 25,000 (EUR)
Organisation European Molecular Biology Organisation 
Sector Learned Society
Country European Union (EU)
Start 01/2017 
End 12/2020
 
Description ERC starting grant
Amount € 1,500,000 (EUR)
Funding ID LS6_637801 
Organisation European Research Council (ERC) 
Sector Public
Country European Union (EU)
Start 06/2015 
End 05/2020
 
Description GCRF Networks in Vaccines Research and Development
Amount £1,000,000 (GBP)
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 11/2017 
End 10/2022
 
Description High-throughput automation of sequencing library generation for Wellcome Trust-funded research at the Babraham Institute
Amount £244,089 (GBP)
Funding ID 208380/Z/17/Z 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2017 
End 01/2018
 
Description Initial Training Networks (ITN): Horizon 2020
Amount € 6,000,000 (EUR)
Funding ID ENLIGHT-TEN - AMD-675395-1 
Organisation European Commission 
Department Horizon 2020
Sector Public
Country European Union (EU)
Start 10/2015 
End 09/2019
 
Description Molecular regulation of NK cell functional maturation by the transcription factor BACH2
Amount £658,607 (GBP)
Funding ID MR/S024468/1 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 06/2019 
End 05/2022
 
Description Resolving mechanisms of gene regulation within the immune system using forward genetics
Amount £200,000 (GBP)
Organisation Lister Institute of Preventive Medicine 
Sector Charity/Non Profit
Country United Kingdom
Start 10/2017 
End 10/2019
 
Description Small Molecule Drug Discovery Award
Amount £300,000 (GBP)
Organisation Cancer Research UK 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2017 
End 01/2020
 
Description University of Cambridge Doctoral Training Programme
Amount £120,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 10/2019 
End 03/2023
 
Title Guidelines for the use of flow cytometry and cell sorting in immunological studies 
Description "Guidelines for the use of flow cytometry and cell sorting in immunological studies" represent a community effort to collect the currently accepted best methods for monitoring most of the variation of the major players of immune system (along with their organelles and functionality) and include standards for data interpretation, as well as cautions about technical issues. One aspect of the guidelines concerns data reproducibility, a topic that has recently attracted considerable attention. Therefore, the guidelines are meant to help researchers avoid potential pitfalls that could drastically alter the interpretation of their data. 
Type Of Material Technology assay or reagent 
Year Produced 2017 
Provided To Others? Yes  
Impact paper has been widely dowloaded, read and cited 
URL https://onlinelibrary.wiley.com/doi/full/10.1002/eji.201646632
 
Title mouse model 
Description We have generated novel mouse models. The details of many of these are available in our peer-reviewed papers. A number of models are still under evaluation 
Type Of Material Model of mechanisms or symptoms - mammalian in vivo 
Year Produced 2017 
Provided To Others? Yes  
Impact see pubished papers 
 
Title protocol online 
Description Acute Streptococcus pneumoniae lung infection: Mouse model and characterisation of the immune response. 
Type Of Material Model of mechanisms or symptoms - mammalian in vivo 
Year Produced 2018 
Provided To Others? Yes  
Impact Streptococcus pneumoniae is a globally important pathogen. We describe a mouse model of S. pneumoniae respiratory tract infection through intranasal administration of bacteria which progress to bacteraemia and systemic disease. This model therefore allows assessment of different stages of infection and can be used to study local and systemic immune responses to vaccines and other treatment strategies. 
URL https://www.nature.com/protocolexchange/protocols/7051
 
Title NGS data 
Description We have submitted numerous NGS datasets including RNAseq, ribosome foot printing, iCLIP, CHIPseq 
Type Of Material Database/Collection of data 
Year Produced 2017 
Provided To Others? Yes  
Impact some data is being reused by us and others 
 
Description Depleting regulatory T (Treg) cells in cancer 
Organisation Cancer Research Technology (CRT)
Country United Kingdom 
Sector Private 
PI Contribution We have generated preliminary data that has formed the basis for a drug development programme aimed at generating new immune based therapies for cancer that work by depleting immunosuppressive regulatory T cells accumulating within tumours
Collaborator Contribution A discussion is currently underway to undertake an industrial collaboration with CRUK-TDL
Impact Not yet delivered
Start Year 2018
 
Description Drug discovery programme targeting the immunosuppressive transcription factor activity of BACH2 
Organisation Cancer Research Technology (CRT)
Country United Kingdom 
Sector Private 
PI Contribution We have previously found that BACH2 promotes tumour immunosuppression by promoting Foxp3+ Treg cell-mediated suppression of CD8+ T cells and IFN-? within tumors (Roychoudhuri et al., J Clin Invest. 2016). This has formed the basis for an on-campus industrial collaboration with Cancer Research Technology (CRT). We aim to develop a cell-based reporter assay for the transcription factor activity of BACH2 in order to perform a high-throughput screen of small molecule inhibitors. The collaboration resulted from a meeting arranged by Martin Turner between LLSD and CRT and was supported by a Babraham Institute Knowledge Exchange and Commercialisation Committee Campus Collaboration Award (£15K). Preliminary data generated formed the basis for a successful application for a CRUK Drug Discovery Award (£300K). We are developing stable reporter cell lines using bioinformatically derived enhancer sequences that are responsive to transcriptional repression by BACH2 and amenable to high-throughput drug screening by our collaborators at CRT.
Collaborator Contribution Performance of a high-throughput drug screen (>200k compounds) using cell-based reporter assays for the transcription factor activity of BACH2 generated in the laboratory.
Impact This collaboration resulted in receipt of further funding - a BI Knowledge Exchange and Commercialisation Committee Campus Collaboration Award (£15K) and a CRUK Drug Discovery Award (£300K)
Start Year 2017
 
Description Human Gimap studies 
Organisation University of Oxford
Department Weatherall Institute of Molecular Medicine (WIMM)
Country United Kingdom 
Sector Public 
PI Contribution Advice, reagents.
Collaborator Contribution We have advised on ongoing studies of Gimap proteins in human immunology and mouse model systems. We have provided specific antibody reagents from our collection.
Impact Progress but no outputs as yet.
Start Year 2016
 
Description Katsikis 2017 onwards 
Organisation Erasmus University Medical Center
Department Immunology (EMC-I)
Country Netherlands 
Sector Hospitals 
PI Contribution collaborative studies of the effects of IAV on lung epithelial cells
Collaborator Contribution expertise
Impact manuscript in submission, another one in preparation
Start Year 2017
 
Description Transcriptional and epigenetic programmes of lung inflammation 
Organisation GlaxoSmithKline (GSK)
Country Global 
Sector Private 
PI Contribution A key commercial collaboration between Rahul Roychoudhuri (RR) and GlaxoSmithKline (GSK)/Epinova, which is now supported by two BBSRC CASE awards, aims to understand the transcriptional and epigenetic programmes that promote lung inflammation. We aim to define transcriptional and epigenetic mechanisms by which airway immune homeostasis is maintained by transcriptional and epigenetic regulators.
Collaborator Contribution Support of CASE awards, co-supervision of PhD students, supply of pharmacological agents for use as tool compounds in assessment of epigenetic regulators
Impact We have gained an understanding of how lung inflammation is restrained by suppression of ILC2 activation and promotion of Treg differentiation by the transcription factor BACH2 and are exploring mechanisms by which BACH2 may regulate epigenetic programmes in T cells
Start Year 2016
 
Description Understanding the molecular and cellular basis for the function of agonist antibody-based immunotherapies 
Organisation F-star Biotechnology Limited
PI Contribution This collaboration with F-Star Biotechnology Limited aims to understand the molecular and cellular basis for the function of agonist antibody-based immunotherapies in cancer. The work, funded by F-Star, will take place in our laboratory and will be undertaken by a funded postdoctoral scientist. The collaboration is facilitated by the proximity of the Institute to F-Star on the Babraham Research Campus
Collaborator Contribution F-Star have fully funded the research collaboration and are providing reagents for the investigations which will be conducted using pre-clinical mouse models.
Impact Immunology Molecular biology Drug development Bioinformatics
Start Year 2019
 
Description Wolkers 
Organisation Sanquin
Country Netherlands 
Sector Charity/Non Profit 
PI Contribution We hosted a student from sanguine. we suppled essential know how and reagents to the project
Collaborator Contribution they developed a model of T cell activation
Impact manuscript submitted
Start Year 2017
 
Title Method of identifying VDJ recombination products 
Description A high-throughput, high resolution DNA-based next generation sequencing assay to interrogate the sequences of VDJ recombined gene products resulting from antigen receptor recombination. Patent licence granted in USA and Europe in 2017. Licence application pending in Japan. Undertaking active marketing, no commercial licensee finalised as yet. 
IP Reference EP2820153 
Protection Patent granted
Year Protection Granted 2017
Licensed No
Impact Collaborations with academic, clinical and commercial interests, resulting in 3 grant applications, one of which was successful
 
Title antibody commercialsation 
Description monoclonal antibody 
IP Reference  
Protection Protection not required
Year Protection Granted 2018
Licensed Yes
Impact Non-Exclusive Licence Agreement with Millipore Corporation until 19/05/2026 to make available Vav2 antibody reagents from the Turner lab
 
Description  
IP Reference  
Protection Protection not required
Year Protection Granted
Licensed Commercial In Confidence
Impact Agreement fully executed 040917 for the supply to Bio-Rad ABD Serotec of two hybridoma cell lines allowing the dissemination of the use of valuable antibody reagents.
 
Description 2016 Babraham Institute Schools Day 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact The Linterman Laboratory hosted school students in the laboratory to teach them the basics of confocal microscopy.
Year(s) Of Engagement Activity 2016
 
Description 2017 Babraham Institute Schools day 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact The Linterman Laboratory hosted school students in the laboratory to teach them the basics of confocal microscopy.
Year(s) Of Engagement Activity 2017
 
Description Babraham Institute Schools Day 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact 12 GCSE and A level students spent a day in our lab, doing a small project. Many asked questions about our research and careers in biology. Positive feedback relayed after the visit by teachers.

The feedback afterwards from the students was that biological research was more interesting and scientists more normal than the students expected.
Year(s) Of Engagement Activity 2010,2011,2013,2014,2015
 
Description Cambridge Bioresource volunteer event, CRUK, Cambridge 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Presented our work on ageing and the response to vaccination to an adult lay audience. This included people who are interested in taking part in research studies.
Year(s) Of Engagement Activity 2016
 
Description Cambridge-Africa lecture 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact A lecture was given to Kenyan Masters students on our research
Year(s) Of Engagement Activity 2017
 
Description FindaPhD.com YouTube 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Undergraduate students
Results and Impact Made a short video for FindaPhD.com as part of a series of inspirational interviews with senior group leaders about their own PhDs. FindaPhD launched this on International Women's Day as a YouTube video, and on their website, Twitter, Facebook. Dozens of positive comments on Twitter and Facebook worldwide within 24 hours, as well as personal requests for advice about PhDs
Year(s) Of Engagement Activity 2018
URL https://youtu.be/PDu5y4s8hGQ
 
Description Invited speaker: Sanofi Immune Memory Symposium 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact Michelle Linterman was invited to present at a conference organised by Sanofi Pasteur at their headquarters in France. The presentation was followed by questions and discussion.
Year(s) Of Engagement Activity 2016
 
Description Launchpad schools project 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Carolyn Rogers in my group, and another student, designed, delivered and judged a new Launchpad science challenge activity for 12 year olds in 3 local schools. This involved designing a project involving understanding DNA and its regulation, delivering it to 3 local schools as a challenge to complete. They advised students on how to make a poster of their findings, and judged each contribution. The winning students from each school were invited to Babraham for a Launchpad visit, which enabled them to consolidate their experience and learn how we study gene regulation at Babraham.
Specific events included Launchpad launch, Launchpad Awards, Launchpad Activity Day and Launchpad filming.
Year(s) Of Engagement Activity 2018
 
Description Lifelab Cambridge walking tour 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Carolyn Rogers, PhD student, organised evening walking tours of historic sites of scientific discovery in the centre or Cambridge. These were very popular, sold out in advance, and with very engaged groups of walkers
Year(s) Of Engagement Activity 2018
 
Description Michelle Linterman gave a talk to public group 'Polynous' 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Michelle Linterman gave an invited talk on on ageing and the immune system to the Polynous group. The 45 minute seminar was followed by 45minutes of animated discussion over tea.
Year(s) Of Engagement Activity 2017
 
Description Mosaic magazine article 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Article by Tom Chivers "How Big Data is Changing Science" including interviews with me and other genomics scientists, giving our perspectives on the explosion of big data science in recent year and the opportunities and challenges this brings. The aim was to illustrate the rapidly changing skill sets needed to understand big data, which senior scientists have not learned and need to keep up with.
Year(s) Of Engagement Activity 2008,2016,2018
 
Description Presentation at GSK Vaccines, Belgium 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact Michelle Linterman was invited to present her lab's work on Ageing and the poor response to vaccination, and meet multiple team leaders at GSK Vaccines. The presentation was also broadcast to the GSK offices in the USA. There was an extensive Q & A session after the presentation, and discussions about the possibility of future collaboration.
Year(s) Of Engagement Activity 2017
 
Description Presentation at Glaxo Smith Kline, Stevenage, United Kingdom 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Industry/Business
Results and Impact Presentations from Michelle Linterman and Alice Denton on the basic biology of the response to vaccination, with a specific focus on the biology of stromal cells. The presentations were followed by a discussion.
Year(s) Of Engagement Activity 2016
 
Description Presentation on the use of mouse models in immunology research 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Presentation of the reasons and uses of research using mouse models in immunology research to a large group of local parishioners visiting the Institute for the talk.
Year(s) Of Engagement Activity 2018
 
Description Royal Society Summer Ageing Clock 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Schools
Results and Impact Carolyn Rogers, PhD student, Sam Rees, PhD student, Peter Chovanec, PhD student, helped out at the Race against the Ageing Clock exhibition at the Royal Society. Over 500 attendees, media coverage, increased understanding from public of ageing processes.
Year(s) Of Engagement Activity 2018
 
Description School visit to the Roychoudhuri laboratory for hands-on experience in flow cytometry and cellular immunology 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact Two groups of six school children were hosted in the laboratory and were provided hands-on experience processing tissues and using flow cytometry to distinguish populations of lymphoid cells in secondary lymphoid organs using multiparameter flow cytometry. Students were also taught basic scientific background relating to the adaptive immune system
Year(s) Of Engagement Activity 2018
 
Description School visit to the Roychoudhuri laboratory for hands-on experience in flow cytometry and cellular immunology 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Schools
Results and Impact Two groups of six school children were hosted in the laboratory and were provided hands-on experience processing tissues and using flow cytometry to distinguish populations of lymphoid cells in secondary lymphoid organs using multiparameter flow cytometry. Students were also taught basic scientific background relating to the adaptive immune system
Year(s) Of Engagement Activity 2019
 
Description School visit to the Roychoudhuri laboratory for hands-on experience in flow cytometry and cellular immunology 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact Two groups of six school children were hosted in the laboratory and were provided hands-on experience processing tissues and using flow cytometry to distinguish populations of lymphoid cells in secondary lymphoid organs using multiparameter flow cytometry. Students were also taught basic scientific background relating to the adaptive immune system
Year(s) Of Engagement Activity 2017
 
Description Schools Day Laboratory visit to Turner's group 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact working with cells and DNA
Year(s) Of Engagement Activity 2018,2019
 
Description SciSoc talk 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Undergraduate students
Results and Impact Gave at talk to the University of Cambridge Scientific Society entitled "How we make a billion antibodies: genetics and epigenetics". Audience included wide range of students and members of the public, in depth discussion about vaccination of the elderly and herd immunity. Engaged with several undergraduates at dinner afterwards and gave scientific and career advice.
Year(s) Of Engagement Activity 2006,2014,2019
 
Description Sixth from student work experience 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Schools
Results and Impact Sam Rees, second year PhD student in the Corcoran lab, hosted a Sixth form student for a week, teaching him molecular and cell culture skills, explaining our research. The student has now applied to University to study Biological Sciences
Year(s) Of Engagement Activity 2018
 
Description SysMod 2017 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact I organised the 2nd meeting of the ISCB Community of Special Interest SysMod. Up to 270 people attended depending on the talk.
Year(s) Of Engagement Activity 2017
 
Description TV interview BBC look East (West) (2017) 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact An interview about our research
Year(s) Of Engagement Activity 2017
 
Description Talk on ageing to local discussion group 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact This was an evening talk to a local discussion group in Great Abington, Cambridgeshire delivered by G.B and Prof Joanna Latimer (University of York) who is a Public Engagement collaborator of the Institute. Our presentation covered both the biology of ageing (illustrated by examples of relevant Babraham science) and sociological aspects of our private and public attitudes to ageing. A wide-ranging and rich discussion took place with the audience of 15-20.
Year(s) Of Engagement Activity 2017
 
Description Talk to the University of the Third age 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Michelle Linterman gave a talk on Ageing and the immune system to member of the University of the Third Age. the seminar was followed by extensive discussion with the audience.
Year(s) Of Engagement Activity 2018
 
Description Video for Find a PhD 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Undergraduate students
Results and Impact Find a PhD.com sat down with some of the UK's top academics to hear their experiences and thoughts on postgraduate study. Dr Michelle Linterman is currently Group Leader in Immunology at The Babraham Institute. In this video she shares some advice for new students. As of 1/3/2019 this video has 27,890 views.
Year(s) Of Engagement Activity 2018
URL https://www.findaphd.com/advice/blog/3180/phd-inspiration-dr-michelle-linterman-the-babraham-institu...
 
Description WT/EBI course in silico systems biology 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact I organised this one-week course, and gave presentations entitled: "What is Systems Biology? Where does it come from?", "The many faces of modelling in biology", "Modelling in systems biology, a few challenges", "From art to engineering: two decades of standards and tools towards digital organisms", "Modelling chemical kinetics" plus a tutorial on stochastic simulations of biological systems.
Year(s) Of Engagement Activity 2017
 
Description eLife Community Webinar - Refreshing approaches to researcher evaluation 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact I animated a webinar discussing various ways to bypass the traditional publication-based evaluation of researchers.
Year(s) Of Engagement Activity 2017
 
Description ethics of animal research 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Schools
Results and Impact Workshop on health ageing and the use of animals in research with French Sixth Form students. Carolyn Rogers, PhD student in the Corcoran group gave a talk on her use of animal models
Year(s) Of Engagement Activity 2018
 
Description media interest 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Publication of paper in Frontiers in Immunology and press release resulted in 3 news articles - in Medindia, Labonline (Australia), Health Canal
Year(s) Of Engagement Activity 2017