How changes in nutrient availability are sensed and shape metabolism and growth

Lead Research Organisation: Babraham Institute
Department Name: UNLISTED

Abstract

In mammals nutrient signalling is a multi-layered network that embraces physiological, cellular (eg autophagy, see objective 4) and organ systems (eg neural). The network maintains the internal environment in the face of changes in the availability of nutrients, simultaneously adjusts metabolism to mitigate against those changes and tailors cell growth throughout the body to fit the nutritional circumstances. We remain ignorant of many molecular details and systems-levels principles by which this system works. There is increasing interest in the possibility of slowing or reversing the effects ageing by dietary manipulation and/or use of pharmaceuticals such as rapamycin (an mTOR inhibitor), PI3K inhibitors or metformin (an indirect activator of AMPK) that act to suppress nutrient signalling. To proceed down this road rationally it is important we understand the molecular basis of any strategy to minimise unwanted side effects. At the centre of nutrient signalling is mTOR, a protein kinase and integrator of signals relaying information about a cells current environmental conditions, including nutrients (most conserved and powerful are amino acids but also; cellular energy status as read-out by AMPK and nutrientsensitive growth factors such as insulin, IGF-1 and EGF), stresses and the cell cycle29. If cellular conditions are satisfactory mTOR is active and coordinates, via direct phosphorylation of targets and indirectly via many changes in gene transcription, increased lipid, nucleotide, protein and carbohydrate synthesis and ATP and NADH production (collectively termed anabolic metabolism) to support growth. If conditions are unfavourable mTOR is inactivated and engages a huge range of processes to adapt, including increased autophagy and reduced anabolic metabolic activity (collectively termed catabolic metabolism). Work with many model organisms supports the concept that the anabolic mode reduces, and the catabolic mode extends, life span.

Publications

10 25 50
 
Description 1) We have developed new methods and guidelines for the acquisition, organisation and exploitation of biological data and models.
2) We have shown that the key controller of cell growth and metabolism, PTEN, that is also known to be a tumour suppressor and was already understood to be a PIP3-3-phosphatase is also a PI(3,4)P2 3-phosphatase. This additional hitherto unappreciated activity means that PTEN also controls a growing list of cellular processes that are known to be controlled by PI(3,4)P2 directly, including call invasion (relevant to tumour progression). This has major implications for understanding of cell growth and metabolism and the process of tumour progression.
3) We have shown that a dietary manipulation, reduced food intake, known to extend life span in mice, leads to correlated changes in specific DNA methylation patterns and lipid metabolism.
4) We have made key contributions to the construction of a metabolic model of C.elegans.
5) NAD+ is a key cofactor in hundreds of normal metabolic reactions but the levels of NAD+ decline with age. To investigate the consequences of declining NAD+ we have used highly specific inhibitors of a critical NAD+ synthesis pathway. We have found that reductions in NAD+ activate an enzyme called AMPK, which in turn inhibits mTOR and drives cell death.
6) We have found that nutrient starvation causes phosphorylation and activation of members of the DYRK family of protein kinases and are currently investigating their role in nutrient signalling.
7) We have revealed rules governing the inter-subunit interactions and selective associations of class IA PI3Ks with receptors and their adaptor proteins. This has begun to clarify why certain receptors, like the insulin and IGF receptors selectively activate PI3K signalling and are implicated in processes that determine the rate of ageing.
8) In a collaboration with colleagues at BI we have found that the levels of IRS1 (the primary adaptor of the insulin receptor that activates class IA PI3Ks) are, almost uniquely in the whole genome, down regulated at both transcriptional and protein levels during ageing in the B-lymphocyte compartment and could indicate this is a primary determinant of the ageing phenotype of B-cells.
Exploitation Route The work we have delivered will aid further work modelling biology, understanding metabolism and how that is influenced by age. Our results are of direct interest to the pharmaceutical sector interested in treating cancer and we have used our range of contacts to spread understanding of these opportunities.
Sectors Healthcare,Pharmaceuticals and Medical Biotechnology

 
Description Through dialogue with a number of our industrial partners the above findings are already being integrated into the knowledge base and planning of the commercial sector. We have a substantial collaboration that is part funded by the MRC and part funded by AZ investigating the organisation and regulation of the insulin/PI3K signalling/ glucose uptake pathway and how it changes as normal homeostasis begins to fail in the early, precancerous, stages of tumour progression. Further collaborations with industry, that are built upon the work in this area, are addressing the role of the ERK pathway and inhibitors thereof in tumour progression and the acquisition of drug resistance in collaboration with AstraZeneca and Astex Pharmaceuticals.
First Year Of Impact 2017
Sector Healthcare,Pharmaceuticals and Medical Biotechnology
Impact Types Economic

 
Description Babraham Institute Representative on Translational Research at EU Life, a consortium of EU Life Sciences Institutes
Geographic Reach Europe 
Policy Influence Type Membership of a guideline committee
URL http://eu-life.eu/
 
Description Membership of Scientific Advisory Board for Cancer Research Technology
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description Scientific Advisory Board for CRUK Programme Grant awarded to Northern Institute for Cancer Research, Univeristy of Newcastle
Geographic Reach Local/Municipal/Regional 
Policy Influence Type Participation in a advisory committee
 
Title Assay of PI(3,4)P2 in cells/tissues 
Description We developed a novel approach to quantify PI(3,4)P2 in biological extracts using mass spec based approaches. This knowledge has been transferred to other lipidomics facilities 
Type Of Material Technology assay or reagent 
Year Produced 2017 
Provided To Others? Yes  
Impact Used to assay the impact of tool compounds developed by PHARMA as activators of SHIP phosphatases that might be useful anti-inflammatories or anti-cancer drugs. 
 
Title Creation of PI3K avi-tag mice 
Description We introduced a 15 amino-acid Avi-tag into the C-terminus of endogenous genes encoding regulatory (p85alpha or p85beta) or catalytic (p110alpha, p110beta or p110delta) subunits of the Class IA PI3K family in mice. We also engineered expression of an optimised BirA (prokaryotic biotin ligase) expression cassette into the ROSA locus in mice and interbred these with the above Avi-tag mice. These mouse strains allow isolation of biotinylated Class IA PI3K subunits from mouse tissues and cell lines derived from them. 
Type Of Material Model of mechanisms or symptoms - mammalian in vivo 
Year Produced 2018 
Provided To Others? Yes  
Impact First publications: PMID: 30442661 
 
Title Inducible DYRK1B cells 
Description HEK293 cells lines engineered to exhibit Tet-inducible expression of the DYRK1B protein kinase 
Type Of Material Cell line 
Provided To Others? No  
Impact New knowledge of the biological function of the DYRK1B protein kinase, including new substrates. New research papers New collaborations 
 
Title Inducible DYRK2 cell line 
Description HEK293 cells lines engineered to exhibit Tet-inducible expression of the DYRK2 protein kinase 
Type Of Material Cell line 
Provided To Others? No  
Impact New knowledge of DYRK2 Identification of new substrates of DYRK2 
 
Title Mice expressing Avi-tagged PI3K subunits and BirA 
Description Mice expressing endogenous C-terminally avi-tagged p85s (alpha and beta) and p110s (alpha, beta and delta) and mammalised BirA (from the ROSA26 locus) were generated. 
Type Of Material Model of mechanisms or symptoms - mammalian in vivo 
Year Produced 2018 
Provided To Others? Yes  
Impact The tools have enabled the first studies of the underlying basis of selective interactions between PI3K subunits and with receptor RTKS in vivo. The molecular tools and mice have been transferred to other labs. These events have supported rational approaches to inhibition of PI3Ks as a therapeutic approach in inflammation and cancer. 
 
Title Mouse models with manipulated PLEKHS1 
Description Mice expressing endogenous avi-tagged PLEKHS1 were created using CRISPR/cas9 mediated targeting in zygotes. Mice in which the PLEKHS1 locus was conditionally manipulated were created using a "knock-out first" allele created by the EUCOMM consortium pipeline. 
Type Of Material Model of mechanisms or symptoms - mammalian in vivo 
Year Produced 2018 
Provided To Others? No  
Impact The mice are being characterised. 
 
Title Prex1 and Prex2 catalytically inactive mouse strains - Elpida Tsonou 
Description Elpida Tsonou has used CRISPR to generate knock-in mouse strains that render Prex1 and Prex2 Rac-GEFs catalytically inactive 
Type Of Material Model of mechanisms or symptoms - mammalian in vivo 
Year Produced 2019 
Provided To Others? No  
Impact Publications expected within a couple of years 
 
Title DYRK1B phosphoproteomics data set 
Description Using HEK293 cells exhibiting inducible expression of the DYRK1B protein kinase (HD1B cells) we have performed Phospho-SILAC mess spectrometry to identify DYRK1B-inducible phosphoproteins. Some of these turn out to be direct DYRK1B substrates 
Type Of Material Database/Collection of data 
Year Produced 2017 
Provided To Others? No  
Impact This data set has allowed us to identify new DYRK1B substrates and so has provided new insights into the function of this protein kinases in controlling gene expression and autophagy. The dataset will ultimately be released and freely available when the first mansucript is published 
 
Title DYRK1B transcriptome gene data set 
Description RNA-seq data set derived from HEK293 cells which exhibit Tet-regulated DYRK1B expression Reports genome wide changes in abundance and splicing patterns in response to DYRK1B expression 
Type Of Material Database/Collection of data 
Provided To Others? No  
Impact Too soon for impacts. Data currently being analsyed 
 
Title DYRK2 Transcriptome gene data set 
Description RNA-seq data set derived from HEK293 cells which exhibit Tet-regulated DYRK2 expression Reports genome wide changes in abundance and splicing patterns in response to DYRK2 expression 
Type Of Material Database/Collection of data 
Provided To Others? No  
Impact Too soon for impacts. Data currently being analysed 
 
Title DYRK2 phosphoproteomics dataset 
Description Using HEK293 cells exhibiting inducible expression of the DYRK2 protein kinase (HD2 cells) we have performed Phospho-SILAC mess spectrometry to identify DYRK2-inducible phosphoproteins. Some of these turn out to be direct DYRK2 substrates 
Type Of Material Database/Collection of data 
Year Produced 2017 
Provided To Others? No  
Impact This dataset has allowed us to identify DYRK2-inducible phosphoproteins, including new substrates, providing new insghts into the function of the DYRK2 protein in gene expression, autophagy/proteostasis and cell motility 
 
Title Malek 2017 
Description Computational model of phosphatase activities acting on PIP2 and PIP3 in signalling. 
Type Of Material Computer model/algorithm 
Year Produced 2017 
Provided To Others? Yes  
Impact New understanding of the role of tumor suppressor PTEN on PI(3,4)P2 
URL https://identifiers.org/biomodels.db/MODEL1704190000
 
Description Angus Nairn 
Organisation Yale University
Country United States 
Sector Academic/University 
PI Contribution Computational analysis of data and mathematical modeling
Collaborator Contribution Experimental data
Impact We discovered the molecular mechanisms by which Protein Kinase A regulates the inhibitory activity of ARPP-16 on Protein Phosphatase 2A. This is a multi-disciplinary collaboration involving experimental and computational biology.
Start Year 2015
 
Description Dario Alessi - SGK 
Organisation University of Dundee
Department MRC Protein Phosphorylation and Ubiquitylation Unit
Country United Kingdom 
Sector Academic/University 
PI Contribution We provided advice and measured PIP3 in samples provided by partner.
Collaborator Contribution Access to unpublished data relevant to project
Impact Multidisciplinary, mass spectrometry, genetics, cancer, cell biology.
Start Year 2018
 
Description GSK 
Organisation GlaxoSmithKline (GSK)
Country Global 
Sector Private 
PI Contribution Text-mining of scientific literature and mathematical modelling of drug action.
Collaborator Contribution Provision of datasets and software tools.
Impact Analysis of systems pharmacology in the scientific literature, identification of gaps. Systems pharmacology model of two antibody-based drugs.
Start Year 2013
 
Description Jean-Antoine Girault 
Organisation National Institute of Health and Medical Research (INSERM)
Country France 
Sector Academic/University 
PI Contribution Analysis of data, and predictive modelling
Collaborator Contribution Provision of experimental datasets
Impact We analysed the differences between transcriptomes of D1 and D2 receptor-containing neurons of the basal ganglia, proposed master regulators and unravelled a new signalling system regulating neuronal identity. This is a multi-disciplinary collaboration involving experimental and computational biology.
Start Year 2016
 
Description Linda Partridge 
Organisation University College London
Country United Kingdom 
Sector Academic/University 
PI Contribution We contributed to the planning of mouse ageing experiments. We have analysed samples generated in the collaborators lab using lipidomic techniques.
Collaborator Contribution They housed ageing mice and generated samples fo various tissues.
Impact Publications, eg Hahn etal 2017, listed in our outputs.
Start Year 2015
 
Description Lloyd Trotmann 
Organisation Cold Spring Harbor Laboratory (CSHL)
Department Cancer Centre
Country United States 
Sector Academic/University 
PI Contribution We have performed proteomic and cellular studies of PTEN deficient mouse prostate tissue
Collaborator Contribution They performed PET imaging of glucose uptake into mouse prostate tissues control and cancer models
Impact Shared results and discussion about further work
Start Year 2018
 
Description MedImmune 
Organisation MedImmune
Department MedImmune Cambridge
Country United Kingdom 
Sector Private 
PI Contribution Medimmune CASE studentship
Collaborator Contribution Medimmune CASE studentship
Impact ongoing joint experiments
Start Year 2014
 
Description Peter Parker PKB kinases 
Organisation Francis Crick Institute
Country United Kingdom 
Sector Academic/University 
PI Contribution We have discussed a project in the Parker lab involving the potential for kinases , other than PDK1 , to be phosphorylating T308 in PKB. We supplied advice over assays and purified recombinant PKB from SF9 cells to enable them to conduct assays based on those we have published.
Collaborator Contribution Provided us with access to their unpublished data on the subject of regulation of PKB.
Impact Multi-disciplinary involving structural biology , biochemistry, cell biology, modelling and biophysics.
Start Year 2020
 
Description Sabina Cosulich - Acyl chain composition of phosphoinositides 
Organisation AstraZeneca
Country United Kingdom 
Sector Private 
PI Contribution We have taken the intellectual lead in a collaboration with Dr Sabina Cosulich at AstraZeneca UK to explore the physiological function of the acyl chain compostion of phosphoinositides in mammalian cells.
Collaborator Contribution Sabina Cosulich employed David Barneda on a post-doctoral fellowship at AstraZeneca from 09/16 to 09/19. David split his time working in our lab and AstraZeneca working on this project. We were subsequently awarded a BBSRC grant to employ David Barneda at Babraham from 10/19 - 09/22 to continue this collaboration.
Impact PTEN Regulates PI(3,4)P2 Signaling Downstream of Class I PI3K. Malek M, Kielkowska A, Chessa T, Anderson KE, Barneda D, Pir P, Nakanishi H, Eguchi S, Koizumi A, Sasaki J, Juvin V, Kiselev VY, Niewczas I, Gray A, Valayer A, Spensberger D, Imbert M, Felisbino S, Habuchi T, Beinke S, Cosulich S, Le Novère N, Sasaki T, Clark J, Hawkins PT, Stephens LR. Mol Cell. 2017 Nov 2;68(3):566-580.e10. doi: 10.1016/j.molcel.2017.09.024. Epub 2017 Oct 19. How is the acyl chain composition of phosphoinositides created and does it matter? Barneda D, Cosulich S, Stephens L, Hawkins P. Biochem Soc Trans. 2019 Oct 31;47(5):1291-1305. doi: 10.1042/BST20190205. Follow on funding: BBSRC BB/T002530/1 Multidisciplinary: mass spectrometry, organic chemistry, cell biology
Start Year 2016
 
Description Sabina Cosulich- prostate project 
Organisation AstraZeneca
Country United Kingdom 
Sector Private 
PI Contribution We have researched into the possible role of PLEKHS1 in prostate tumour progression
Collaborator Contribution Access to unpublished data, advise, and funding via an MRC MICA award
Impact The results thus far are revealing a new approach to targeting the pi3k pathway and are being prepared for publication in 2020.
Start Year 2016
 
Description Vernalis Research Cambridge 
Organisation Vernalis
Country United Kingdom 
Sector Private 
PI Contribution Wrote iCase studentship application, recruited joint PhD student Elizabeth Hampson, supervision of student and carrying out of project
Collaborator Contribution Provision of time and expertise and industrial placement,
Impact Recently established collaboration, no outputs yet
Start Year 2017
 
Title SBpipe 
Description This package contains a collection of pipelines for dynamic modelling of biological systems. It aims to automate common processes and speed up productivity for tasks such as model simulation, single and double parameter scan, and parameter estimation. 
Type Of Technology Software 
Year Produced 2017 
Open Source License? Yes  
Impact Streamlined model identifiability and parameter estimation in systems biology modelling. 
URL https://pdp10.github.io/sbpipe/
 
Title Spiper 
Description R package that provides an API for our software SBPIPE, a tool for analysing repetitive parameter estimations and simulations of mathematical models. 
Type Of Technology Software 
Year Produced 2017 
Open Source License? Yes  
Impact Spiper makes using SBPIPE directly from the R environment, one of the most used environments in computational biology. 
URL https://github.com/pdp10/sbpiper
 
Description Cambridge Science Festival , David Barneda 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Cambridge science festival presentation/ discussion on the role of science in society
Year(s) Of Engagement Activity 2019
 
Description Deep dive autophagy discussion 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact Provided expert opinion on whether autophagy is a good investment area
Year(s) Of Engagement Activity 2019
 
Description Escape room installation used in 2 events 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact A "signalling" escape room installation that was presented at the Latitude Music Festival, and the Cambridge science Festival
Year(s) Of Engagement Activity 2019,2020
 
Description How to read research papers 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact Discussion with Bristol university PhD studetns about reading and analysing research papers.
Year(s) Of Engagement Activity 2018
 
Description Launchpad activity day 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Activity day associated with launch pad initiative
Year(s) Of Engagement Activity 2018
 
Description Launchpad filming 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Filming associated with Launchpad activity
Year(s) Of Engagement Activity 2020
 
Description Launchpad filming 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Part of the filming was at Babraham
Year(s) Of Engagement Activity 2018
 
Description Launchpad launch event 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Event launch started the activity
Year(s) Of Engagement Activity 2018
 
Description Lifelab 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Schools
Results and Impact The event attracted a total audience of 1765
Year(s) Of Engagement Activity 2018
 
Description Member of visiting group at University of Athens Biology Department 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact Part of the five-year evaluation of the Biology undergraduate and graduate programme at University of Athens. 4-member panel, one week visit,
Year(s) Of Engagement Activity 2018
 
Description Participation in Public Engagement event on genome editing - part of the Cambridge Science Festival 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact A debate/dialgoue open to the pulbic entitled 'Genome editing: How far should we go'
Year(s) Of Engagement Activity 2018
 
Description Presentation to the EMBL-EBI Industry program 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Industry/Business
Results and Impact Presentation to the EMBL-EBI Industry program, representing pharma and agri-food industry, on the use of genome scale metabolic models for personalised medicine.
Year(s) Of Engagement Activity 2018
 
Description Royal society summer exhibition 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Exhibits interactively presenting the work in the signalling programme where presented at the Royal Soc, audience of approx 10000 over 7 days
Year(s) Of Engagement Activity 2018
 
Description School visits 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact The students were enthused about the topic of my presentation and this led to dialogue and discussion about several issues including new cancer therapies, evolution of drug resistance in cancer, the use of animals in research.


Anecdotally, the institute received requests for summer placement students following this visit.
Year(s) Of Engagement Activity 2014,2015,2016,2017,2018,2019
 
Description Schools day 2018 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact Schools day projects presented, executed and discussed with students
Year(s) Of Engagement Activity 2018
 
Description Schools day 2019 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Schools
Results and Impact School children from across the country attended an event at Babraham
Year(s) Of Engagement Activity 2018
 
Description Schools day Feb 2018 Babraham Institute 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact Discussion, question/answer and experiment to show how neutrophils contribute to immune defence and a broader dialogue about the societal signifcance of research and the types of jobs that can be involved.
Year(s) Of Engagement Activity 2014,2015,2016,2017,2018
 
Description Schools day event at BI 2020 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact Schoold event where we presented to teachers and students a project involving human neutrophil biology.
Year(s) Of Engagement Activity 2020
 
Description Science Open Day 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact Students visited the lab and undertook small lab-based proejcts supervised by students/post-docs and myself. I explained the research that we do and discussed ethical issues such as the use of animals in research.
This precipitated excellent discussion and dialogue.

We received excellent feedback from the schools involved and requests for further outreach activities
Year(s) Of Engagement Activity 2013,2014,2015,2016,2017,2018,2019,2020
 
Description Sophianum (dutch school) visit to BI 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Schools
Results and Impact Visit from dutch school to learn about international context of research and BI and its impacts.
Year(s) Of Engagement Activity 2020
 
Description SysMod 2017 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact I organised the 2nd meeting of the ISCB Community of Special Interest SysMod. Up to 270 people attended depending on the talk.
Year(s) Of Engagement Activity 2017
 
Description Visits by Teachers 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact I hosted 6th form Biology teachers (one PhD trained, the other MSc trained) who were visiting my Institution during Half Term to update their knowledge as part of their CPD
Year(s) Of Engagement Activity 2016,2017,2018,2019,2020
 
Description WT/EBI course in silico systems biology 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact I organised this one-week course, and gave presentations entitled: "What is Systems Biology? Where does it come from?", "The many faces of modelling in biology", "Modelling in systems biology, a few challenges", "From art to engineering: two decades of standards and tools towards digital organisms", "Modelling chemical kinetics" plus a tutorial on stochastic simulations of biological systems.
Year(s) Of Engagement Activity 2017
 
Description Work Experience students 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact School students came into our department to shadow researchers and get involved in discussions about research and see our facilities.
Year(s) Of Engagement Activity 2018
 
Description eLife Community Webinar - Refreshing approaches to researcher evaluation 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact I animated a webinar discussing various ways to bypass the traditional publication-based evaluation of researchers.
Year(s) Of Engagement Activity 2017
 
Description stem insights teachers 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact STEM teachers attended an event at Babraham designed to give them insight into the process of research and careers in research.
Year(s) Of Engagement Activity 2018