How changes in nutrient availability are sensed and shape metabolism and growth
Lead Research Organisation:
Babraham Institute
Department Name: UNLISTED
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Technical Summary
In mammals nutrient signalling is a multi-layered network that embraces physiological, cellular (eg autophagy, see objective 4) and organ systems (eg neural). The network maintains the internal environment in the face of changes in the availability of nutrients, simultaneously adjusts metabolism to mitigate against those changes and tailors cell growth throughout the body to fit the nutritional circumstances. We remain ignorant of many molecular details and systems-levels principles by which this system works. There is increasing interest in the possibility of slowing or reversing the effects ageing by dietary manipulation and/or use of pharmaceuticals such as rapamycin (an mTOR inhibitor), PI3K inhibitors or metformin (an indirect activator of AMPK) that act to suppress nutrient signalling. To proceed down this road rationally it is important we understand the molecular basis of any strategy to minimise unwanted side effects. At the centre of nutrient signalling is mTOR, a protein kinase and integrator of signals relaying information about a cells current environmental conditions, including nutrients (most conserved and powerful are amino acids but also; cellular energy status as read-out by AMPK and nutrientsensitive growth factors such as insulin, IGF-1 and EGF), stresses and the cell cycle29. If cellular conditions are satisfactory mTOR is active and coordinates, via direct phosphorylation of targets and indirectly via many changes in gene transcription, increased lipid, nucleotide, protein and carbohydrate synthesis and ATP and NADH production (collectively termed anabolic metabolism) to support growth. If conditions are unfavourable mTOR is inactivated and engages a huge range of processes to adapt, including increased autophagy and reduced anabolic metabolic activity (collectively termed catabolic metabolism). Work with many model organisms supports the concept that the anabolic mode reduces, and the catabolic mode extends, life span.
Planned Impact
unavailable
Organisations
- Babraham Institute (Lead Research Organisation)
- Francis Crick Institute (Collaboration)
- Cancer Research Technology (CRT) (Collaboration)
- University College London (Collaboration)
- National Institute of Health and Medical Research (INSERM) (Collaboration)
- The Wellcome Trust Sanger Institute (Collaboration)
- UNIVERSITY OF CAMBRIDGE (Collaboration)
- AstraZeneca (Collaboration)
- Manchester University (Collaboration)
- Cardiff University (Collaboration)
- Vernalis (Collaboration)
- Cold Spring Harbor Laboratory (CSHL) (Collaboration)
- Yale University (Collaboration)
- UNIVERSITY OF LEEDS (Collaboration)
- University of Toronto (Collaboration)
- UNIVERSITY OF LIVERPOOL (Collaboration)
- GlaxoSmithKline (GSK) (Collaboration)
- Vrije Universiteit Brussel (Collaboration)
- UNIVERSITY OF DUNDEE (Collaboration)
Publications
Abeliovich H
(2023)
Where is the field of autophagy research heading?
in Autophagy
Baig H
(2020)
Synthetic biology open language visual (SBOL visual) version 2.2.
in Journal of integrative bioinformatics
Barneda D
(2022)
Acyl chain selection couples the consumption and synthesis of phosphoinositides.
in The EMBO journal
Barneda D
(2019)
How is the acyl chain composition of phosphoinositides created and does it matter?
in Biochemical Society Transactions
Beal J
(2019)
Communicating Structure and Function in Synthetic Biology Diagrams.
in ACS synthetic biology
Bussi C
(2018)
Alpha-synuclein fibrils recruit TBK1 and OPTN to lysosomal damage sites and induce autophagy in microglial cells.
in Journal of cell science
Cabral-Dias R
(2022)
Fyn and TOM1L1 are recruited to clathrin-coated pits and regulate Akt signaling.
in The Journal of cell biology
Carinci M
(2021)
TFG binds LC3C to regulate ULK1 localization and autophagosome formation.
in The EMBO journal
Cassidy LD
(2020)
Temporal inhibition of autophagy reveals segmental reversal of ageing with increased cancer risk.
in Nature communications
| Description | 1) We have developed new methods and guidelines for the acquisition, organisation and exploitation of biological data and models, including lipidomics and the analysis of autophagy. 2) We have shown that the key controller of cell growth and metabolism, PTEN, that is also known to be a tumour suppressor and was already understood to be a PIP3-3-phosphatase is also a PI(3,4)P2 3-phosphatase (published in Molecular Cell). This hitherto unappreciated activity means that PTEN also controls a growing list of cellular processes that are known to be controlled by PI(3,4)P2 directly, including call invasion (relevant to tumour progression). This has major implications for understanding of cell growth and metabolism and the process of tumour progression. This has further built on long standing collaborations between AstraZeneca and the Signalling laboratores at the Babraham Institute. 3) We have shown that a dietary manipulation, reduced food intake, known to extend life span in mice, leads to correlated changes in specific DNA methylation patterns and lipid metabolism (published in the journals Genome Biology and Nature Metabolism) 4) We have made key contributions to the construction of a metabolic model of C.elegans, including studys on how C.elegans metabolism undergoes fundamental shifts during ageing (Frontiers in Molecular Biosciences). 5). We have shown that nutrient-dependent regulation of mTORC1 (a critical regulator of autophagy, protein and lipid synthesis) is switched during mitosis so that mTORC1 comes under the control of CDK1. We speculate that all mTORC1-dependent metabolic regulation shifts to be controlled by CDK1 during mitosis (published in Molecular Cell and Trends in Cell Biology) 6) NAD+ is a key cofactor in hundreds of normal metabolic reactions but the levels of NAD+ decline with age. To investigate the consequences of declining NAD+ we have used highly specific inhibitors of a critical NAD+ synthesis pathway. We have found that reductions in NAD+ activate an enzyme called AMPK, which in turn inhibits mTOR and drives cell death (work ongoing). 7) We have found that nutrient starvation causes phosphorylation and activation of members of the DYRK family of protein kinases and are currently investigating their role in nutrient signalling (work ongoing). 8) We have revealed rules governing the inter-subunit interactions and selective associations of class IA PI3Ks with receptors and their adaptor proteins. This has begun to clarify why certain receptors, like the insulin and IGF receptors selectively activate PI3K signalling and are implicated in processes that determine the rate of ageing (published in Proc Natl Acad Sci U S A) 9) In a collaboration with colleagues at BI we have found that the levels of IRS1 (the primary adaptor of the insulin receptor that activates class IA PI3Ks) are, almost uniquely in the whole genome, down regulated at both transcriptional and protein levels during ageing in the B-lymphocyte compartment and could indicate this is a primary determinant of the ageing phenotype of B-cells (published in Genome Biology). 10) Using a mycolactone inhibitor of the SEC61 translocon we have identified a novel a protective autophagic response controlled by EIF2S1-dependent translation that does not require ULK1 activity |
| Exploitation Route | The work we have delivered will aid further work modelling biology, understanding metabolism and how that is influenced by age. Our results are of direct interest to the pharmaceutical sector interested in treating cancer and we have used our range of contacts to spread understanding of these opportunities. |
| Sectors | Education Healthcare Pharmaceuticals and Medical Biotechnology |
| Description | Through dialogue with a number of our industrial partners the above findings are already being integrated into the knowledge base and planning of the commercial sector. We have a substantial collaboration that is part funded by the MRC and part funded by AZ investigating the organisation and regulation of the insulin/PI3K signalling/ glucose uptake pathway and how it changes as normal homeostasis begins to fail in the early, precancerous, stages of tumour progression. Further collaborations with industry, that are built upon the work in this area, are addressing the role of the ERK pathway and inhibitors thereof in tumour progression and the acquisition of drug resistance in collaboration with AstraZeneca and Astex Pharmaceuticals. We are also in discussion with several companies through the Milner Therapeutics Consortium to explore drug discovery possibilities in autophagy. |
| Sector | Education,Healthcare,Pharmaceuticals and Medical Biotechnology |
| Impact Types | Economic |
| Description | Babraham Institute Representative on Translational Research at EU Life, a consortium of EU Life Sciences Institutes |
| Geographic Reach | Europe |
| Policy Influence Type | Membership of a guideline committee |
| URL | http://eu-life.eu/ |
| Title | Assay of PI(3,4)P2 in cells/tissues |
| Description | We developed a novel approach to quantify PI(3,4)P2 in biological extracts using mass spec based approaches. This knowledge has been transferred to other lipidomics facilities |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2017 |
| Provided To Others? | Yes |
| Impact | Used to assay the impact of tool compounds developed by PHARMA as activators of SHIP phosphatases that might be useful anti-inflammatories or anti-cancer drugs. |
| Title | Creation of PI3K avi-tag mice |
| Description | We introduced a 15 amino-acid Avi-tag into the C-terminus of endogenous genes encoding regulatory (p85alpha or p85beta) or catalytic (p110alpha, p110beta or p110delta) subunits of the Class IA PI3K family in mice. We also engineered expression of an optimised BirA (prokaryotic biotin ligase) expression cassette into the ROSA locus in mice and interbred these with the above Avi-tag mice. These mouse strains allow isolation of biotinylated Class IA PI3K subunits from mouse tissues and cell lines derived from them. |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2018 |
| Provided To Others? | Yes |
| Impact | First publications: PMID: 30442661 |
| Title | HEK293 cells stably expressing GFP-ATG13 and Histone 2B-mCherry |
| Description | HEK293 cells stably expressing GFP-ATG13 and Histone 2B-mCherry. These cells allow live cell imaging of the earliest stages of autophagosome synthesis (GFP-ATG13) during mitosis or interphase (H2B-mCherry) |
| Type Of Material | Cell line |
| Year Produced | 2020 |
| Provided To Others? | Yes |
| Impact | These cells were part of a study that showed defintively that autophagy is repressed during mitosis An mTORC1-to-CDK1 Switch Maintains Autophagy Suppression during Mitosis. Odle RI, Walker SA, Oxley D, Kidger AM, Balmanno K, Gilley R, Okkenhaug H, Florey O, Ktistakis NT, Cook SJ. Mol Cell. 2020 Jan 16;77(2):228-240.e7. doi: 10.1016/j.molcel.2019.10.016 |
| URL | https://pubmed.ncbi.nlm.nih.gov/31733992/ |
| Title | Inducible DYRK1B cells |
| Description | HEK293 cells lines engineered to exhibit Tet-inducible expression of the DYRK1B protein kinase |
| Type Of Material | Cell line |
| Provided To Others? | No |
| Impact | New knowledge of the biological function of the DYRK1B protein kinase, including new substrates. New research papers New collaborations |
| Title | Inducible DYRK2 cell line |
| Description | HEK293 cells lines engineered to exhibit Tet-inducible expression of the DYRK2 protein kinase |
| Type Of Material | Cell line |
| Provided To Others? | No |
| Impact | New knowledge of DYRK2 Identification of new substrates of DYRK2 |
| Title | Mice expressing Avi-tagged PI3K subunits and BirA |
| Description | Mice expressing endogenous C-terminally avi-tagged p85s (alpha and beta) and p110s (alpha, beta and delta) and mammalised BirA (from the ROSA26 locus) were generated. |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2018 |
| Provided To Others? | Yes |
| Impact | The tools have enabled the first studies of the underlying basis of selective interactions between PI3K subunits and with receptor RTKS in vivo. The molecular tools and mice have been transferred to other labs. These events have supported rational approaches to inhibition of PI3Ks as a therapeutic approach in inflammation and cancer. |
| Title | Mouse models with manipulated PLEKHS1 |
| Description | Mice expressing endogenous avi-tagged PLEKHS1 were created using CRISPR/cas9 mediated targeting in zygotes. Mice in which the PLEKHS1 locus was conditionally manipulated were created using a "knock-out first" allele created by the EUCOMM consortium pipeline. |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2018 |
| Provided To Others? | No |
| Impact | The mice are being characterised. |
| Title | Prex1 and Prex2 catalytically inactive mouse strains - Elpida Tsonou |
| Description | Elpida Tsonou has used CRISPR to generate knock-in mouse strains that render Prex1 and Prex2 Rac-GEFs catalytically inactive |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2019 |
| Provided To Others? | No |
| Impact | Publications expected within a couple of years |
| Title | ipsc autophagy deletion |
| Description | Generated ips cells deleted for the autophagy gene ATG13 |
| Type Of Material | Cell line |
| Year Produced | 2023 |
| Provided To Others? | Yes |
| Impact | Useful reagent for screening autophagy inducing compounds |
| Title | DYRK1B phosphoproteomics data set |
| Description | Using HEK293 cells exhibiting inducible expression of the DYRK1B protein kinase (HD1B cells) we have performed Phospho-SILAC mess spectrometry to identify DYRK1B-inducible phosphoproteins. Some of these turn out to be direct DYRK1B substrates |
| Type Of Material | Database/Collection of data |
| Year Produced | 2017 |
| Provided To Others? | No |
| Impact | This data set has allowed us to identify new DYRK1B substrates and so has provided new insights into the function of this protein kinases in controlling gene expression and autophagy. The dataset will ultimately be released and freely available when the first mansucript is published |
| Title | DYRK1B transcriptome gene data set |
| Description | RNA-seq data set derived from HEK293 cells which exhibit Tet-regulated DYRK1B expression Reports genome wide changes in abundance and splicing patterns in response to DYRK1B expression |
| Type Of Material | Database/Collection of data |
| Provided To Others? | No |
| Impact | Too soon for impacts. Data currently being analsyed |
| Title | DYRK2 Transcriptome gene data set |
| Description | RNA-seq data set derived from HEK293 cells which exhibit Tet-regulated DYRK2 expression Reports genome wide changes in abundance and splicing patterns in response to DYRK2 expression |
| Type Of Material | Database/Collection of data |
| Provided To Others? | No |
| Impact | Too soon for impacts. Data currently being analysed |
| Title | DYRK2 phosphoproteomics dataset |
| Description | Using HEK293 cells exhibiting inducible expression of the DYRK2 protein kinase (HD2 cells) we have performed Phospho-SILAC mess spectrometry to identify DYRK2-inducible phosphoproteins. Some of these turn out to be direct DYRK2 substrates |
| Type Of Material | Database/Collection of data |
| Year Produced | 2017 |
| Provided To Others? | No |
| Impact | This dataset has allowed us to identify DYRK2-inducible phosphoproteins, including new substrates, providing new insghts into the function of the DYRK2 protein in gene expression, autophagy/proteostasis and cell motility |
| Title | Malek 2017 |
| Description | Computational model of phosphatase activities acting on PIP2 and PIP3 in signalling. |
| Type Of Material | Computer model/algorithm |
| Year Produced | 2017 |
| Provided To Others? | Yes |
| Impact | New understanding of the role of tumor suppressor PTEN on PI(3,4)P2 |
| URL | https://identifiers.org/biomodels.db/MODEL1704190000 |
| Description | Angus Nairn |
| Organisation | Yale University |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Computational analysis of data and mathematical modeling |
| Collaborator Contribution | Experimental data |
| Impact | We discovered the molecular mechanisms by which Protein Kinase A regulates the inhibitory activity of ARPP-16 on Protein Phosphatase 2A. This is a multi-disciplinary collaboration involving experimental and computational biology. |
| Start Year | 2015 |
| Description | Botelho collaboration |
| Organisation | University of Toronto |
| Country | Canada |
| Sector | Academic/University |
| PI Contribution | Measured phosphoinositides and provided advice about interpretation |
| Collaborator Contribution | Genetic models |
| Impact | bioRxiv publication currently |
| Start Year | 2019 |
| Description | Cancer Research Horizons - Autotaxin inhibitors |
| Organisation | Cancer Research Technology (CRT) |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | PhD student performed experiments and Babraham Institute performed lipidomics analysis. Wrote manuscript. |
| Collaborator Contribution | Supervision of PhD student, performed experiments, wrote manuscript. |
| Impact | Manuscript (submitted) and training. |
| Start Year | 2018 |
| Description | Collaboration on new targets of neurodegeneration involving autophagy |
| Organisation | University of Cambridge |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Identify targets using cell biological assays |
| Collaborator Contribution | Provide relevant assays |
| Impact | not yet |
| Start Year | 2021 |
| Description | Dario Alessi - SGK |
| Organisation | University of Dundee |
| Department | MRC Protein Phosphorylation and Ubiquitylation Unit |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We provided advice and measured PIP3 in samples provided by partner. |
| Collaborator Contribution | Access to unpublished data relevant to project |
| Impact | Multidisciplinary, mass spectrometry, genetics, cancer, cell biology. |
| Start Year | 2018 |
| Description | David Adams |
| Organisation | The Wellcome Trust Sanger Institute |
| Department | Human Genetics |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Measurements of phosphoinositdes and biochemical analysis of signalling, interpretation of data |
| Collaborator Contribution | Genome wide screen for genes essential for cancer progression |
| Impact | Building collaboration looking at role of cds2 in rare subset of cancers. |
| Start Year | 2021 |
| Description | Eline Mol and Laura Ligthart |
| Organisation | Vrije Universiteit Brussel |
| Country | Belgium |
| Sector | Academic/University |
| PI Contribution | We trained 2 dutch students who worked remotely in phosphoinositide research data analysis and bioinformatic analysis to contribute towards their degrees. |
| Collaborator Contribution | They analysed raw data obtained from various assys in the lab studying plekhs1 function and performed bioinformatics analysis of Plekhs1. |
| Impact | Data analysed will contribute to a paper, students obtained high marks for their project work and passed degrees with high marks |
| Start Year | 2020 |
| Description | GSK |
| Organisation | GlaxoSmithKline (GSK) |
| Country | Global |
| Sector | Private |
| PI Contribution | Text-mining of scientific literature and mathematical modelling of drug action. |
| Collaborator Contribution | Provision of datasets and software tools. |
| Impact | Analysis of systems pharmacology in the scientific literature, identification of gaps. Systems pharmacology model of two antibody-based drugs. |
| Start Year | 2013 |
| Description | Jean-Antoine Girault |
| Organisation | National Institute of Health and Medical Research (INSERM) |
| Country | France |
| Sector | Academic/University |
| PI Contribution | Analysis of data, and predictive modelling |
| Collaborator Contribution | Provision of experimental datasets |
| Impact | We analysed the differences between transcriptomes of D1 and D2 receptor-containing neurons of the basal ganglia, proposed master regulators and unravelled a new signalling system regulating neuronal identity. This is a multi-disciplinary collaboration involving experimental and computational biology. |
| Start Year | 2016 |
| Description | Linda Partridge |
| Organisation | University College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We contributed to the planning of mouse ageing experiments. We have analysed samples generated in the collaborators lab using lipidomic techniques. |
| Collaborator Contribution | They housed ageing mice and generated samples fo various tissues. |
| Impact | Publications, eg Hahn etal 2017, listed in our outputs. |
| Start Year | 2015 |
| Description | Lloyd Trotmann |
| Organisation | Cold Spring Harbor Laboratory (CSHL) |
| Department | Cancer Centre |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | We have performed proteomic and cellular studies of PTEN deficient mouse prostate tissue |
| Collaborator Contribution | They performed PET imaging of glucose uptake into mouse prostate tissues control and cancer models |
| Impact | Shared results and discussion about further work |
| Start Year | 2018 |
| Description | Martin Lowe |
| Organisation | Manchester University |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Analysis of phosphoinositides and data interpretation |
| Collaborator Contribution | Analysis of cell biology associated in INPP5B |
| Impact | Paper under review |
| Start Year | 2018 |
| Description | MedImmune |
| Organisation | AstraZeneca |
| Department | MedImmune |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Medimmune CASE studentship |
| Collaborator Contribution | Medimmune CASE studentship |
| Impact | ongoing joint experiments |
| Start Year | 2014 |
| Description | Novel targets of autophagy using structural information and AI |
| Organisation | University of Cambridge |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | A collaboration with two academic labs in the UK and Australia, together with a biotechnology company in Singapore in order to identify and characterize small molecules that activate selective autophagy against specific targets. My contribution thus far is in identifying ways to select targets, and to select the autophagy machinery that needs to be activated. |
| Collaborator Contribution | The academic partners provide additional information on target selection and validation. The commercial partners provide AI support and chemical synthesis capability. |
| Impact | We are in early steps of discussions and target selection |
| Start Year | 2021 |
| Description | Paradoxical effects on RAF inhibitors on cell proliferation and viability |
| Organisation | University of Liverpool |
| Department | Institute of Integrative Biology |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We have dicovered that a range of RAF kinase inhibitors drive cell cycle arrest and even cell death that is independent of their ability to regulate activity of the RAF-MEK-ERK signalling pathway. We are seeking to understand how they do this. Is it an 'on target' effect of RAF inhibtion or does it reflect activity against another target? |
| Collaborator Contribution | Our collaborators are experts in kinase enzymology with unique expertise in biochemsitry and biophysics. They will monitor kinase inhibtor-protein interactions and also interrogate binding to potential candidates by in silico analysis. |
| Impact | Too early for any tangible outcomes |
| Start Year | 2020 |
| Description | Patrick Eyers - University of Liverpool |
| Organisation | University of Liverpool |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We have contributed experimentally and intellectually to the partnership. |
| Collaborator Contribution | University of Liverpool team has provided expertise in kinase biology and experimental data |
| Impact | Drafting a manuscript |
| Start Year | 2021 |
| Description | Peter Parker PKB kinases |
| Organisation | Francis Crick Institute |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We have discussed a project in the Parker lab involving the potential for kinases , other than PDK1 , to be phosphorylating T308 in PKB. We supplied advice over assays and purified recombinant PKB from SF9 cells to enable them to conduct assays based on those we have published. |
| Collaborator Contribution | Provided us with access to their unpublished data on the subject of regulation of PKB. |
| Impact | Multi-disciplinary involving structural biology , biochemistry, cell biology, modelling and biophysics. |
| Start Year | 2020 |
| Description | Sabina Cosulich - Acyl chain composition of phosphoinositides |
| Organisation | AstraZeneca |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | We have taken the intellectual lead in a collaboration with Dr Sabina Cosulich at AstraZeneca UK to explore the physiological function of the acyl chain compostion of phosphoinositides in mammalian cells. |
| Collaborator Contribution | Sabina Cosulich employed David Barneda on a post-doctoral fellowship at AstraZeneca from 09/16 to 09/19. David split his time working in our lab and AstraZeneca working on this project. We were subsequently awarded a BBSRC grant to employ David Barneda at Babraham from 10/19 - 09/22 to continue this collaboration. |
| Impact | PTEN Regulates PI(3,4)P2 Signaling Downstream of Class I PI3K. Malek M, Kielkowska A, Chessa T, Anderson KE, Barneda D, Pir P, Nakanishi H, Eguchi S, Koizumi A, Sasaki J, Juvin V, Kiselev VY, Niewczas I, Gray A, Valayer A, Spensberger D, Imbert M, Felisbino S, Habuchi T, Beinke S, Cosulich S, Le Novère N, Sasaki T, Clark J, Hawkins PT, Stephens LR. Mol Cell. 2017 Nov 2;68(3):566-580.e10. doi: 10.1016/j.molcel.2017.09.024. Epub 2017 Oct 19. How is the acyl chain composition of phosphoinositides created and does it matter? Barneda D, Cosulich S, Stephens L, Hawkins P. Biochem Soc Trans. 2019 Oct 31;47(5):1291-1305. doi: 10.1042/BST20190205. Follow on funding: BBSRC BB/T002530/1 Multidisciplinary: mass spectrometry, organic chemistry, cell biology |
| Start Year | 2016 |
| Description | Sabina Cosulich- prostate project |
| Organisation | AstraZeneca |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | We have researched into the possible role of PLEKHS1 in prostate tumour progression |
| Collaborator Contribution | Access to unpublished data, advise, and funding via an MRC MICA award |
| Impact | The results thus far are revealing a new approach to targeting the pi3k pathway and are being prepared for publication in 2020. |
| Start Year | 2016 |
| Description | Small molecule activators of the ISR - Leeds |
| Organisation | University of Leeds |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We have identified small molecule activators of the ISR, their likely mechanism of action and their likely molecular target |
| Collaborator Contribution | Prof Richard Bayliss has constructed models of the small molecules binding to the proposed target based on available crystal structures |
| Impact | A manuscript is in preparation |
| Start Year | 2023 |
| Description | Small molecule activators of the Integrated Stress Response (ISR) - Liverpool |
| Organisation | University of Liverpool |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We have identified novel small molecule activators of the Integrated Stress Response (ISR), a pathway involved in cellular health and longevity. Patrick Eyers and Niall Kenneth have provided expertise and conducted experiments to identify the mechanism by which these molecules active the ISR |
| Collaborator Contribution | Intellectual - suggesting possible targets Practical - performing experiments |
| Impact | A manuscript is in preparation |
| Start Year | 2023 |
| Description | Valerie O Donnell |
| Organisation | Cardiff University |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Analysis and identification of phosphoinositides |
| Collaborator Contribution | Lipidomics and data and analysis |
| Impact | Submission of grant application to support further work at including Babraham, Cardiff |
| Start Year | 2021 |
| Description | Vernalis Research Cambridge |
| Organisation | Vernalis |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Wrote iCase studentship application, recruited joint PhD student Elizabeth Hampson, supervision of student and carrying out of project |
| Collaborator Contribution | Provision of time and expertise and industrial placement, |
| Impact | Recently established collaboration, no outputs yet |
| Start Year | 2017 |
| Title | Modulating plekhs1 activity in a cell |
| Description | That modulation of plekhs1 activity may be a useful strategy in reducing tumour progression |
| IP Reference | 2304156.9 |
| Protection | Patent / Patent application |
| Year Protection Granted | 2023 |
| Licensed | No |
| Impact | Further funding leading to funded collaboration with AstraZeneca |
| Title | SBpipe |
| Description | This package contains a collection of pipelines for dynamic modelling of biological systems. It aims to automate common processes and speed up productivity for tasks such as model simulation, single and double parameter scan, and parameter estimation. |
| Type Of Technology | Software |
| Year Produced | 2017 |
| Open Source License? | Yes |
| Impact | Streamlined model identifiability and parameter estimation in systems biology modelling. |
| URL | https://pdp10.github.io/sbpipe/ |
| Title | Spiper |
| Description | R package that provides an API for our software SBPIPE, a tool for analysing repetitive parameter estimations and simulations of mathematical models. |
| Type Of Technology | Software |
| Year Produced | 2017 |
| Open Source License? | Yes |
| Impact | Spiper makes using SBPIPE directly from the R environment, one of the most used environments in computational biology. |
| URL | https://github.com/pdp10/sbpiper |
| Description | 6th Form Conference |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Schools |
| Results and Impact | Further education students present research posters which are judged by researcher staff following conversations around their work. Presentation on research and career journey was given to all students will a Q&A following |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.babraham.ac.uk/events/2022/07/sixth-form-conference-2022-healthy-ageing |
| Description | Cambridge Science Festival , David Barneda |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Cambridge science festival presentation/ discussion on the role of science in society |
| Year(s) Of Engagement Activity | 2019 |
| Description | Comberton Village college AA, TC and PTH |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | A carrels in bioscience discussion involving a group leader, a post doc and a PhD student from our lab. They meet with a yr 12 (17yrs old) cohort at Comberton VC a local school. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Comment to daily mail |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | "As Nicholas Ktistakis explains: 'When we go into periods of fasting, we force the autophagy system to go into overdrive to break down parts of the cell to make energy. But this also starts to burn through all the detritus and eliminate bad things that make the cell less effective. 'Some scientists who work in this area follow a 5:2 diet, where you fast for two days a week. Or for a similar effect, cut back to 40 per cent of what you normally eat for two weeks every once in a while. I try this two-week reduced intake every few months.' Excerpt from the article where Nicholas Ktistakis spoke to Thea Jourdan." |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.dailymail.co.uk/health/article-10461405/The-simple-scientific-daily-tweaks-leading-scien... |
| Description | Deep dive autophagy discussion |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | Provided expert opinion on whether autophagy is a good investment area |
| Year(s) Of Engagement Activity | 2019 |
| Description | Escape room installation used in 2 events |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | A "signalling" escape room installation that was presented at the Latitude Music Festival, and the Cambridge science Festival |
| Year(s) Of Engagement Activity | 2019,2020 |
| Description | Evaluation of PhD Programme, Vienna Biocenter |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Evaluated the PhD programme of the Vienna Biomecal to decide on further funding for the next 5 years |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://training.vbc.ac.at/phd-program/ |
| Description | Evaluation of three Biology Departments in Greece (Ioannina, Larissa, Thessaloniki) |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Part of a 3 member panel evaluating for one week each of those Departmemts so they can continue to provide Undergraduate and Graduate Degrees |
| Year(s) Of Engagement Activity | 2019,2020 |
| Description | Featured in ASBMB conference preview: New kids on the signaling block |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Highlighted as an upcoming researcher in the signaling field. https://www.asbmb.org/asbmb-today/science/092721/new-kids-on-the-signaling-block |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.asbmb.org/asbmb-today/science/092721/new-kids-on-the-signaling-block |
| Description | How to read research papers |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | Discussion with Bristol university PhD studetns about reading and analysing research papers. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Launchpad activity day |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Activity day associated with launch pad initiative |
| Year(s) Of Engagement Activity | 2018 |
| Description | Launchpad filming |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Filming associated with Launchpad activity |
| Year(s) Of Engagement Activity | 2020 |
| Description | Launchpad filming |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Part of the filming was at Babraham |
| Year(s) Of Engagement Activity | 2018 |
| Description | Launchpad launch event |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Event launch started the activity |
| Year(s) Of Engagement Activity | 2018 |
| Description | Lifelab |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Schools |
| Results and Impact | The event attracted a total audience of 1765 |
| Year(s) Of Engagement Activity | 2018 |
| Description | Meet a Bioscientist |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Schools |
| Results and Impact | Virtual research and career talk with extended Q&A |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.babraham.ac.uk/blog/meet-a-bioscientist-2022 |
| Description | Meet a Bioscientist |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | Virtual research and career talk with extended Q&A |
| Year(s) Of Engagement Activity | 2022 |
| Description | Member of the Science Advisry Board of PhoreMost |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Industry/Business |
| Results and Impact | Offer advice and insight into drug discovery prpocess for PhoreMost, an SME based on the Babraham Research Campus |
| Year(s) Of Engagement Activity | 2020,2021 |
| URL | https://www.phoremost.com |
| Description | Member of visiting group at University of Athens Biology Department |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Part of the five-year evaluation of the Biology undergraduate and graduate programme at University of Athens. 4-member panel, one week visit, |
| Year(s) Of Engagement Activity | 2018 |
| Description | Online article |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Reporter Paul Brackely writes about the new partnership between Nicholas Ktistakis and other Milner Consortium partners. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.cambridgeindependent.co.uk/business/win-win-as-milner-institute-brokers-pharma-trio-to-e... |
| Description | Participation in Public Engagement event on genome editing - part of the Cambridge Science Festival |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | A debate/dialgoue open to the pulbic entitled 'Genome editing: How far should we go' |
| Year(s) Of Engagement Activity | 2018 |
| Description | Presentation to the EMBL-EBI Industry program |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Industry/Business |
| Results and Impact | Presentation to the EMBL-EBI Industry program, representing pharma and agri-food industry, on the use of genome scale metabolic models for personalised medicine. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Production of research video |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Produced an animated video overview of current and ongoing research around PI3K and wider cell signalling. Video published on Institute youtube account and promoted to public audiences as well as other sector stakeholders. |
| Year(s) Of Engagement Activity | 2021 |
| Description | Protein challenge , Simon Rudge |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | hands on lab work. |
| Year(s) Of Engagement Activity | 2021 |
| Description | Research Access Programme Student Placement |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Undergraduate students |
| Results and Impact | Higher education student carried out 5 week online summer placement learning a variety of techniques and data analysis methods. They reported an increase in knowledge, skills, and a broadening of their understanding of careers in science as well as how academic research functions |
| Year(s) Of Engagement Activity | 2021 |
| Description | Research Experience |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | A work experience day for an A-level biology student from a local school. The student undertook hands on practicals to gain lab experience and also explored research of the lab. The student also spent some time with the imaging facility to gain insight into how that facility of the Institute functions |
| Year(s) Of Engagement Activity | 2023 |
| Description | Research experience day for key stage 4&5 students - Babraham Institute Schools Day |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Schools |
| Results and Impact | "At Schools' Day, students from schools all over Cambridgeshire and beyond gather at the Institute to discover more about our world-leading bioscience research. Led by Institute researchers, secondary and sixth-form students complete hands-on lab projects. Often using equipment not available within schools, Schools' Day aims to enthuse, inspire and motivate students and provide insight into what life is really like in the lab. Schools' Day is for students in Years 10-13. Typically, up to 5 students per school or sixth form may attend, although more places may be offered if capacity allows. There is active outreach done to promote the opportunity to schools and students from areas of high deprivation and an associated travel bursary to enable this targeted audience approach." |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://www.babraham.ac.uk/blog/SchoolsDay-2023 |
| Description | Research experience placement for A-level biology student- Summer placement |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | A two week work experience placement for an A-level biology student from a local school. The student shadowed in the lab and undertook a number of practical experiments to gain understanding of our research and a number of fundamental research techniques |
| Year(s) Of Engagement Activity | 2023 |
| Description | Research talk for 6th Form Students |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Gave a research talk to 6th Form students covering research and career route, as well as, introducing the students to the practical experiments they would be undertaking as part of the Protein Challenge project. This was part of the Protein Challenge project where students undertake a 6 week research project themed around Institute research. They learn a number of practical scientific methods as well as gaining valuable transferable skills on how to present and communicate science to audiences |
| Year(s) Of Engagement Activity | 2023 |
| Description | Review of Research Unit "Mechanisms of Lysosomal Homeostasis", Germany |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Evaluated a Research Consortium composed of several laboratories in Germany applying to DFG (the major funder in Germany) for a multiyear grant involving 10 laboratories |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://for2625-lysosomes.de/ |
| Description | Royal society summer exhibition |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Exhibits interactively presenting the work in the signalling programme where presented at the Royal Soc, audience of approx 10000 over 7 days |
| Year(s) Of Engagement Activity | 2018 |
| Description | Samual Ward College Careers Fair |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Discussed science careers and cell signalling research with key stage 3 , 4 and 5 students. Used interactives to spark conversations around research, as well as, pipetting activity to introduce students to lab based skills |
| Year(s) Of Engagement Activity | 2022 |
| Description | Sawston School student work experience |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | One week work experience placement for 6th form aged student. Engaged with lab research, the wider Institute and science careers |
| Year(s) Of Engagement Activity | 2022 |
| Description | School visit |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Schools |
| Results and Impact | "At Schools' Day, students from schools all over Cambridgeshire and beyond gather at the Institute to discover more about our world-leading bioscience research. Led by Institute researchers, secondary and sixth-form students complete hands-on lab projects. Often using equipment not available within schools, Schools' Day aims to enthuse, inspire and motivate students and provide insight into what life is really like in the lab. Schools' Day is for students in Years 10-13. Typically, up to 5 students per school or sixth form may attend, although more places may be offered if capacity allows. There is active outreach done to promote the opportunity to schools and students from areas of high deprivation and an associated travel bursary to enable this targeted audience approach." |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://www.babraham.ac.uk/blog/SchoolsDay-2023 |
| Description | School visits |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | The students were enthused about the topic of my presentation and this led to dialogue and discussion about several issues including new cancer therapies, evolution of drug resistance in cancer, the use of animals in research. Anecdotally, the institute received requests for summer placement students following this visit. |
| Year(s) Of Engagement Activity | 2014,2015,2016,2017,2018,2019 |
| Description | Schools day 2018 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | Schools day projects presented, executed and discussed with students |
| Year(s) Of Engagement Activity | 2018 |
| Description | Schools day 2019 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Schools |
| Results and Impact | School children from across the country attended an event at Babraham |
| Year(s) Of Engagement Activity | 2018 |
| Description | Schools day Feb 2018 Babraham Institute |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | Discussion, question/answer and experiment to show how neutrophils contribute to immune defence and a broader dialogue about the societal signifcance of research and the types of jobs that can be involved. |
| Year(s) Of Engagement Activity | 2014,2015,2016,2017,2018 |
| Description | Schools day event at BI 2020 |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | Schoold event where we presented to teachers and students a project involving human neutrophil biology. |
| Year(s) Of Engagement Activity | 2020 |
| Description | Schools talk and Q&A |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Schools |
| Results and Impact | Virtual research and career talk with extended Q&A |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.babraham.ac.uk/blog/meet-a-bioscientist-2022 |
| Description | Science Open Day |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Schools |
| Results and Impact | Students visited the lab and undertook small lab-based proejcts supervised by students/post-docs and myself. I explained the research that we do and discussed ethical issues such as the use of animals in research. This precipitated excellent discussion and dialogue. We received excellent feedback from the schools involved and requests for further outreach activities |
| Year(s) Of Engagement Activity | 2013,2014,2015,2016,2017,2018,2019,2020 |
| Description | Social Mobility Foundation Student Mentoring |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Schools |
| Results and Impact | Mentoring provided to a sixth form student from an area of low social mobility through the Social Mobility Foundation's mentoring scheme. Conversations were had around career route and research interests to inform and inspire. |
| Year(s) Of Engagement Activity | 2020,2021 |
| Description | Sophianum (dutch school) visit to BI |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Schools |
| Results and Impact | Visit from dutch school to learn about international context of research and BI and its impacts. |
| Year(s) Of Engagement Activity | 2020 |
| Description | SysMod 2017 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | I organised the 2nd meeting of the ISCB Community of Special Interest SysMod. Up to 270 people attended depending on the talk. |
| Year(s) Of Engagement Activity | 2017 |
| Description | University of Michigan Protein Folding Diseases Seminar Series |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | gave a talk on my research |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://vimeo.com/477740122 |
| Description | Visits by Teachers |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | My lab has hosted 6th form Biology teachers who were visiting my Institution during Half Term to update their knowledge as part of their CPD |
| Year(s) Of Engagement Activity | 2016,2017,2018,2019,2020 |
| Description | WT/EBI course in silico systems biology |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | I organised this one-week course, and gave presentations entitled: "What is Systems Biology? Where does it come from?", "The many faces of modelling in biology", "Modelling in systems biology, a few challenges", "From art to engineering: two decades of standards and tools towards digital organisms", "Modelling chemical kinetics" plus a tutorial on stochastic simulations of biological systems. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Work Experience students |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | School students came into our department to shadow researchers and get involved in discussions about research and see our facilities. |
| Year(s) Of Engagement Activity | 2018 |
| Description | eLife Community Webinar - Refreshing approaches to researcher evaluation |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | I animated a webinar discussing various ways to bypass the traditional publication-based evaluation of researchers. |
| Year(s) Of Engagement Activity | 2017 |
| Description | science spotlight public talk |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | On line presentation targeted to adult community groups in an area of deprivation |
| Year(s) Of Engagement Activity | 2021 |
| Description | stem insights teachers |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | STEM teachers attended an event at Babraham designed to give them insight into the process of research and careers in research. |
| Year(s) Of Engagement Activity | 2018 |
| Description | student poster |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Facilitated a poster presentation session where students from a local 6th Form college presented scientific posters communicating a research project they had undertaken. This involved discussing research with students and linking to Institute research as well as providing feedback on scientific poster design. This was part of the Protein Challenge project where students undertake a 6 week research project themed around Institute research. They learn a number of practical scientific methods as well as gaining valuable transferable skills on how to present and communicate science to audiences |
| Year(s) Of Engagement Activity | 2023 |